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Fusion gene ID: 23721 |
FusionGeneSummary for NCOR1_RDX |
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Fusion gene information | Fusion gene name: NCOR1_RDX | Fusion gene ID: 23721 | Hgene | Tgene | Gene symbol | NCOR1 | RDX | Gene ID | 9611 | 5962 |
Gene name | nuclear receptor corepressor 1 | radixin | |
Synonyms | N-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoR | DFNB24 | |
Cytomap | 17p12-p11.2 | 11q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1 | radixin | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O75376 | P35241 | |
Ensembl transtripts involved in fusion gene | ENST00000268712, ENST00000395851, ENST00000395857, ENST00000395848, ENST00000583226, | ENST00000528498, ENST00000528900, ENST00000405097, ENST00000530301, ENST00000343115, ENST00000544551, | |
Fusion gene scores | * DoF score | 18 X 14 X 10=2520 | 8 X 8 X 3=192 |
# samples | 16 | 8 | |
** MAII score | log2(16/2520*10)=-3.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NCOR1 [Title/Abstract] AND RDX [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NCOR1 | GO:0046329 | negative regulation of JNK cascade | 11931768 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW373603 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000268712 | ENST00000528498 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000268712 | ENST00000528900 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000268712 | ENST00000405097 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000268712 | ENST00000530301 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-3UTR | ENST00000268712 | ENST00000343115 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000268712 | ENST00000544551 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000395851 | ENST00000528498 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000395851 | ENST00000528900 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000395851 | ENST00000405097 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000395851 | ENST00000530301 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-3UTR | ENST00000395851 | ENST00000343115 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000395851 | ENST00000544551 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000395857 | ENST00000528498 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000395857 | ENST00000528900 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000395857 | ENST00000405097 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000395857 | ENST00000530301 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-3UTR | ENST00000395857 | ENST00000343115 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000395857 | ENST00000544551 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000395848 | ENST00000528498 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000395848 | ENST00000528900 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000395848 | ENST00000405097 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000395848 | ENST00000530301 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-3UTR | ENST00000395848 | ENST00000343115 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000395848 | ENST00000544551 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000583226 | ENST00000528498 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000583226 | ENST00000528900 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000583226 | ENST00000405097 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000583226 | ENST00000530301 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-3UTR | ENST00000583226 | ENST00000343115 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
intron-intron | ENST00000583226 | ENST00000544551 | NCOR1 | chr17 | 16055297 | + | RDX | chr11 | 110102093 | - |
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FusionProtFeatures for NCOR1_RDX |
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Hgene | Tgene |
NCOR1 | RDX |
Mediates transcriptional repression by certain nuclearreceptors. Part of a complex which promotes histone deacetylationand the formation of repressive chromatin structures which mayimpede the access of basal transcription factors. Participates inthe transcriptional repressor activity produced by BCL6.{ECO:0000269|PubMed:14527417}. | Probably plays a crucial role in the binding of thebarbed end of actin filaments to the plasma membrane. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NCOR1_RDX |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NCOR1_RDX |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NCOR1_RDX |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NCOR1_RDX |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NCOR1 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Hgene | NCOR1 | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
Hgene | NCOR1 | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | NCOR1 | C0017636 | Glioblastoma | 1 | CTD_human |
Hgene | NCOR1 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | NCOR1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | RDX | C0008370 | Cholestasis | 1 | CTD_human |
Tgene | RDX | C1970239 | DEAFNESS, AUTOSOMAL RECESSIVE, 24 | 1 | CTD_human;UNIPROT |