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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 23719

FusionGeneSummary for NCOR1_PIGL

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOR1_PIGL
Fusion gene ID: 23719
HgeneTgene
Gene symbol

NCOR1

PIGL

Gene ID

9611

9487

Gene namenuclear receptor corepressor 1phosphatidylinositol glycan anchor biosynthesis class L
SynonymsN-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoRCHIME
Cytomap

17p12-p11.2

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1N-acetylglucosaminyl-phosphatidylinositol de-N-acetylaseN-acetylglucosaminylphosphatidylinositol deacetylasePIG-Lphosphatidylinositol glycan, class Lphosphatidylinositol-glycan biosynthesis class L protein
Modification date2018052320180519
UniProtAcc

O75376

Q9Y2B2

Ensembl transtripts involved in fusion geneENST00000268712, ENST00000395851, 
ENST00000395857, ENST00000395848, 
ENST00000583226, 		ENST00000581006, 
ENST00000498772, ENST00000225609, 
ENST00000395844, ENST00000463810, 
Fusion gene scores* DoF score18 X 14 X 10=25205 X 2 X 5=50
# samples 165
** MAII scorelog2(16/2520*10)=-3.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: NCOR1 [Title/Abstract] AND PIGL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOR1

GO:0046329

negative regulation of JNK cascade

11931768


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVREADTCGA-F5-6864-01ANCOR1chr17

16062074

-PIGLchr17

16203202

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000268712ENST00000581006NCOR1chr17

16062074

-PIGLchr17

16203202

+
In-frameENST00000268712ENST00000498772NCOR1chr17

16062074

-PIGLchr17

16203202

+
In-frameENST00000268712ENST00000225609NCOR1chr17

16062074

-PIGLchr17

16203202

+
In-frameENST00000268712ENST00000395844NCOR1chr17

16062074

-PIGLchr17

16203202

+
5CDS-intronENST00000268712ENST00000463810NCOR1chr17

16062074

-PIGLchr17

16203202

+
Frame-shiftENST00000395851ENST00000581006NCOR1chr17

16062074

-PIGLchr17

16203202

+
Frame-shiftENST00000395851ENST00000498772NCOR1chr17

16062074

-PIGLchr17

16203202

+
Frame-shiftENST00000395851ENST00000225609NCOR1chr17

16062074

-PIGLchr17

16203202

+
Frame-shiftENST00000395851ENST00000395844NCOR1chr17

16062074

-PIGLchr17

16203202

+
5CDS-intronENST00000395851ENST00000463810NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-3CDSENST00000395857ENST00000581006NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-3CDSENST00000395857ENST00000498772NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-3CDSENST00000395857ENST00000225609NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-3CDSENST00000395857ENST00000395844NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-intronENST00000395857ENST00000463810NCOR1chr17

16062074

-PIGLchr17

16203202

+
Frame-shiftENST00000395848ENST00000581006NCOR1chr17

16062074

-PIGLchr17

16203202

+
Frame-shiftENST00000395848ENST00000498772NCOR1chr17

16062074

-PIGLchr17

16203202

+
Frame-shiftENST00000395848ENST00000225609NCOR1chr17

16062074

-PIGLchr17

16203202

+
Frame-shiftENST00000395848ENST00000395844NCOR1chr17

16062074

-PIGLchr17

16203202

+
5CDS-intronENST00000395848ENST00000463810NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-3CDSENST00000583226ENST00000581006NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-3CDSENST00000583226ENST00000498772NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-3CDSENST00000583226ENST00000225609NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-3CDSENST00000583226ENST00000395844NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-intronENST00000583226ENST00000463810NCOR1chr17

16062074

-PIGLchr17

16203202

+

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FusionProtFeatures for NCOR1_PIGL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOR1

O75376

PIGL

Q9Y2B2

Mediates transcriptional repression by certain nuclearreceptors. Part of a complex which promotes histone deacetylationand the formation of repressive chromatin structures which mayimpede the access of basal transcription factors. Participates inthe transcriptional repressor activity produced by BCL6.{ECO:0000269|PubMed:14527417}. Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646174_2162442441Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545174_2162442338Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-64658_642442441Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-31958_64135915Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-54558_642442338Compositional biasNote=Poly-Gln

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646299_3282442441Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646501_5572442441Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319174_216135915Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319299_328135915Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319501_557135915Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545299_3282442338Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545501_5572442338Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6461032_10352442441Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6461707_17122442441Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6461952_19632442441Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646593_6032442441Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646607_6172442441Compositional biasNote=Pro-rich
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3191032_1035135915Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3191707_1712135915Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3191952_1963135915Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319593_603135915Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319607_617135915Compositional biasNote=Pro-rich
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5451032_10352442338Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5451707_17122442338Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5451952_19632442338Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545593_6032442338Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545607_6172442338Compositional biasNote=Pro-rich
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646435_4862442441DomainSANT 1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646623_6742442441DomainSANT 2
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319435_486135915DomainSANT 1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319623_674135915DomainSANT 2
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545435_4862442338DomainSANT 1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545623_6742442338DomainSANT 2
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6461933_19372442441MotifNote=CORNR box 1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6462055_20592442441MotifNote=CORNR box 2
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6462263_22672442441MotifNote=CORNR box 3
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3191933_1937135915MotifNote=CORNR box 1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3192055_2059135915MotifNote=CORNR box 2
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3192263_2267135915MotifNote=CORNR box 3
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5451933_19372442338MotifNote=CORNR box 1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5452055_20592442338MotifNote=CORNR box 2
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5452263_22672442338MotifNote=CORNR box 3
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6462032_21152442441RegionID1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6462212_22732442441RegionID2
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3192032_2115135915RegionID1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3192212_2273135915RegionID2
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5452032_21152442338RegionID1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5452212_22732442338RegionID2
TgenePIGLchr17:16062074chr17:16203202ENST00000225609+1723_252111253Topological domainCytoplasmic
TgenePIGLchr17:16062074chr17:16203202ENST00000225609+172_22111253TransmembraneHelical


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FusionGeneSequence for NCOR1_PIGL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NCOR1_ENST00000268712_chr17_16062074_-_PIGL_ENST00000581006_chr17_16203202_+_283aa
MSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRPQERRTSYE
PFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNASPSKLSKEE
LIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRGFPRXPRHAVGHRARGQSPPSAHRSE

>In-frame_NCOR1_ENST00000268712_chr17_16062074_-_PIGL_ENST00000498772_chr17_16203202_+_327aa
MSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRPQERRTSYE
PFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNASPSKLSKEE
LIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRGFPRXPRHAVGHRARGQSPPSAHRSE

>In-frame_NCOR1_ENST00000268712_chr17_16062074_-_PIGL_ENST00000225609_chr17_16203202_+_385aa
MSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRPQERRTSYE
PFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNASPSKLSKEE
LIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRGFPRXPRHAVGHRARGQSPPSAHRSE
WHQSGGDFRCRGSKWPQQSHCSVCSCEGPALRREVTXRVLCAHASVCECAAQVHLPSGSALVSASYAGCPLRAQQQRSGTGQESHVLPPQ

>In-frame_NCOR1_ENST00000268712_chr17_16062074_-_PIGL_ENST00000395844_chr17_16203202_+_377aa
MSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRPQERRTSYE
PFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNASPSKLSKEE
LIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRGFPRXPRHAVGHRARGQSPPSAHRSE
WHQSGGDFRCRGSKWPQQSHCSVCSCEGALCSRFSLXMCCASTSPFWICPCLCFIRRMSSSCSTAKKWHRPRKPCPATAASSSGSAASTL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NCOR1_ENST00000268712_chr17_16062074_-_PIGL_ENST00000581006_chr17_16203202_+_850nt
ATGTCAAGTTCAGGTTATCCTCCCAACCAAGGAGCATTCAGCACAGAACAAAGTCGTTATCCTCCTCACTCTGTCCAGTATACATTTCCC
AACACCCGCCACCAGCAGGAGTTCGCAGTCCCTGATTATCGTTCCTCTCATCTTGAAGTGAGTCAGGCATCACAGCTTTTGCAGCAACAG
CAGCAGCAACAGCTTCGAAGGCGACCTTCCTTGCTTTCAGAATTTCACCCAGGTTCTGACAGGCCTCAAGAAAGGAGAACTAGTTATGAA
CCGTTTCATCCAGGCCCATCCCCAGTGGATCATGATTCACTGGAATCGAAGCGACCACGTCTGGAACAGGTTTCTGATTCTCATTTTCAG
CGTGTCAGTGCTGCGGTTTTGCCTTTAGTGCACCCGCTGCCAGAAGGGCTGAGGGCTTCTGCAGATGCTAAGAAGGATCCAGCATTCGGA
GGCAAACATGAAGCTCCATCCTCTCCAATTTCGGGGCAACCATGTGGAGATGATCAAAATGCTTCACCTTCAAAACTCTCAAAGGAAGAG
TTAATACAGAGTATGGATCGTGTAGATCGAGAAATTGCAAAAGTAGAACAGCAGATCCTTAAACTGAAAAAGAAACAACAACAGCTTGAA
GAAGAGGCAGCTAAACCTCCTGAGCCTGAGAAGCCCGTGTCCCCTCCTCCTGTGGAGCAGAAACACCGCAGTATTGTCCAAATTATTTAT
GATGAGAATCGGGGATTTCCCAGATGACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAA

>In-frame_NCOR1_ENST00000268712_chr17_16062074_-_PIGL_ENST00000498772_chr17_16203202_+_982nt
ATGTCAAGTTCAGGTTATCCTCCCAACCAAGGAGCATTCAGCACAGAACAAAGTCGTTATCCTCCTCACTCTGTCCAGTATACATTTCCC
AACACCCGCCACCAGCAGGAGTTCGCAGTCCCTGATTATCGTTCCTCTCATCTTGAAGTGAGTCAGGCATCACAGCTTTTGCAGCAACAG
CAGCAGCAACAGCTTCGAAGGCGACCTTCCTTGCTTTCAGAATTTCACCCAGGTTCTGACAGGCCTCAAGAAAGGAGAACTAGTTATGAA
CCGTTTCATCCAGGCCCATCCCCAGTGGATCATGATTCACTGGAATCGAAGCGACCACGTCTGGAACAGGTTTCTGATTCTCATTTTCAG
CGTGTCAGTGCTGCGGTTTTGCCTTTAGTGCACCCGCTGCCAGAAGGGCTGAGGGCTTCTGCAGATGCTAAGAAGGATCCAGCATTCGGA
GGCAAACATGAAGCTCCATCCTCTCCAATTTCGGGGCAACCATGTGGAGATGATCAAAATGCTTCACCTTCAAAACTCTCAAAGGAAGAG
TTAATACAGAGTATGGATCGTGTAGATCGAGAAATTGCAAAAGTAGAACAGCAGATCCTTAAACTGAAAAAGAAACAACAACAGCTTGAA
GAAGAGGCAGCTAAACCTCCTGAGCCTGAGAAGCCCGTGTCCCCTCCTCCTGTGGAGCAGAAACACCGCAGTATTGTCCAAATTATTTAT
GATGAGAATCGGGGATTTCCCAGATGACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAA
TGGCATCAATCTGGTGGTGACTTTCGATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGCCCTGCA

>In-frame_NCOR1_ENST00000268712_chr17_16062074_-_PIGL_ENST00000225609_chr17_16203202_+_1156nt
ATGTCAAGTTCAGGTTATCCTCCCAACCAAGGAGCATTCAGCACAGAACAAAGTCGTTATCCTCCTCACTCTGTCCAGTATACATTTCCC
AACACCCGCCACCAGCAGGAGTTCGCAGTCCCTGATTATCGTTCCTCTCATCTTGAAGTGAGTCAGGCATCACAGCTTTTGCAGCAACAG
CAGCAGCAACAGCTTCGAAGGCGACCTTCCTTGCTTTCAGAATTTCACCCAGGTTCTGACAGGCCTCAAGAAAGGAGAACTAGTTATGAA
CCGTTTCATCCAGGCCCATCCCCAGTGGATCATGATTCACTGGAATCGAAGCGACCACGTCTGGAACAGGTTTCTGATTCTCATTTTCAG
CGTGTCAGTGCTGCGGTTTTGCCTTTAGTGCACCCGCTGCCAGAAGGGCTGAGGGCTTCTGCAGATGCTAAGAAGGATCCAGCATTCGGA
GGCAAACATGAAGCTCCATCCTCTCCAATTTCGGGGCAACCATGTGGAGATGATCAAAATGCTTCACCTTCAAAACTCTCAAAGGAAGAG
TTAATACAGAGTATGGATCGTGTAGATCGAGAAATTGCAAAAGTAGAACAGCAGATCCTTAAACTGAAAAAGAAACAACAACAGCTTGAA
GAAGAGGCAGCTAAACCTCCTGAGCCTGAGAAGCCCGTGTCCCCTCCTCCTGTGGAGCAGAAACACCGCAGTATTGTCCAAATTATTTAT
GATGAGAATCGGGGATTTCCCAGATGACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAA
TGGCATCAATCTGGTGGTGACTTTCGATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGCCCTGCA
CTCAGAAGGGAAGTTACCTAAAGGGTGCTCTGTGCTCACGCTTCAGTCTGTGAATGTGCTGCGCAAGTACATCTCCCTTCTGGATCTGCC
CTTGTCTCTGCTTCATACGCAGGATGTCCTCTTCGTGCTCAACAGCAAAGAAGTGGCACAGGCCAAGAAAGCCATGTCCTGCCACCGCAG

>In-frame_NCOR1_ENST00000268712_chr17_16062074_-_PIGL_ENST00000395844_chr17_16203202_+_1132nt
ATGTCAAGTTCAGGTTATCCTCCCAACCAAGGAGCATTCAGCACAGAACAAAGTCGTTATCCTCCTCACTCTGTCCAGTATACATTTCCC
AACACCCGCCACCAGCAGGAGTTCGCAGTCCCTGATTATCGTTCCTCTCATCTTGAAGTGAGTCAGGCATCACAGCTTTTGCAGCAACAG
CAGCAGCAACAGCTTCGAAGGCGACCTTCCTTGCTTTCAGAATTTCACCCAGGTTCTGACAGGCCTCAAGAAAGGAGAACTAGTTATGAA
CCGTTTCATCCAGGCCCATCCCCAGTGGATCATGATTCACTGGAATCGAAGCGACCACGTCTGGAACAGGTTTCTGATTCTCATTTTCAG
CGTGTCAGTGCTGCGGTTTTGCCTTTAGTGCACCCGCTGCCAGAAGGGCTGAGGGCTTCTGCAGATGCTAAGAAGGATCCAGCATTCGGA
GGCAAACATGAAGCTCCATCCTCTCCAATTTCGGGGCAACCATGTGGAGATGATCAAAATGCTTCACCTTCAAAACTCTCAAAGGAAGAG
TTAATACAGAGTATGGATCGTGTAGATCGAGAAATTGCAAAAGTAGAACAGCAGATCCTTAAACTGAAAAAGAAACAACAACAGCTTGAA
GAAGAGGCAGCTAAACCTCCTGAGCCTGAGAAGCCCGTGTCCCCTCCTCCTGTGGAGCAGAAACACCGCAGTATTGTCCAAATTATTTAT
GATGAGAATCGGGGATTTCCCAGATGACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAA
TGGCATCAATCTGGTGGTGACTTTCGATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGTGCTCTG
TGCTCACGCTTCAGTCTGTGAATGTGCTGCGCAAGTACATCTCCCTTCTGGATCTGCCCTTGTCTCTGCTTCATACGCAGGATGTCCTCT
TCGTGCTCAACAGCAAAGAAGTGGCACAGGCCAAGAAAGCCATGTCCTGCCACCGCAGCCAGCTCCTCTGGTTCCGCCGCCTCTACATTA


* Fusion transcript sequences (Full-length transcript).
>In-frame_NCOR1_ENST00000268712_chr17_16062074_-_PIGL_ENST00000581006_chr17_16203202_+_1191nt
GGAGGGAGAGGGGTTGAGTCAAGATGGCGGCCAAGGTGGCGAAGCAGCAGCCGCGGCGGCGGCGGCGGCTGGAGTGAGCGTCCGACTCGC
CGCGCCGAACGAGGTCCCGGTGTAGGGCCGCGCGCCGTGGCCGCGTCCCACTCCTCAGGCCGGGGCGCACGTCGGCTCCCACGCTTAGCC
AGCTCCCGGTGGTTTCCTAGAAACATGATTGTTTATTGGCATTGATCTCACAGTCTGGTGAGGACTTCTTTACTGATAATGTCAAGTTCA
GGTTATCCTCCCAACCAAGGAGCATTCAGCACAGAACAAAGTCGTTATCCTCCTCACTCTGTCCAGTATACATTTCCCAACACCCGCCAC
CAGCAGGAGTTCGCAGTCCCTGATTATCGTTCCTCTCATCTTGAAGTGAGTCAGGCATCACAGCTTTTGCAGCAACAGCAGCAGCAACAG
CTTCGAAGGCGACCTTCCTTGCTTTCAGAATTTCACCCAGGTTCTGACAGGCCTCAAGAAAGGAGAACTAGTTATGAACCGTTTCATCCA
GGCCCATCCCCAGTGGATCATGATTCACTGGAATCGAAGCGACCACGTCTGGAACAGGTTTCTGATTCTCATTTTCAGCGTGTCAGTGCT
GCGGTTTTGCCTTTAGTGCACCCGCTGCCAGAAGGGCTGAGGGCTTCTGCAGATGCTAAGAAGGATCCAGCATTCGGAGGCAAACATGAA
GCTCCATCCTCTCCAATTTCGGGGCAACCATGTGGAGATGATCAAAATGCTTCACCTTCAAAACTCTCAAAGGAAGAGTTAATACAGAGT
ATGGATCGTGTAGATCGAGAAATTGCAAAAGTAGAACAGCAGATCCTTAAACTGAAAAAGAAACAACAACAGCTTGAAGAAGAGGCAGCT
AAACCTCCTGAGCCTGAGAAGCCCGTGTCCCCTCCTCCTGTGGAGCAGAAACACCGCAGTATTGTCCAAATTATTTATGATGAGAATCGG
GGATTTCCCAGATGACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCT
GAAAGACAGAGCAAATTCCAGATTGTGAGCAGCCACCTGCATCCTCTATGCCTGAGCGGCCCAGCCATGAGAGCCAGCCGACCCCACAGA

>In-frame_NCOR1_ENST00000268712_chr17_16062074_-_PIGL_ENST00000498772_chr17_16203202_+_1584nt
GGAGGGAGAGGGGTTGAGTCAAGATGGCGGCCAAGGTGGCGAAGCAGCAGCCGCGGCGGCGGCGGCGGCTGGAGTGAGCGTCCGACTCGC
CGCGCCGAACGAGGTCCCGGTGTAGGGCCGCGCGCCGTGGCCGCGTCCCACTCCTCAGGCCGGGGCGCACGTCGGCTCCCACGCTTAGCC
AGCTCCCGGTGGTTTCCTAGAAACATGATTGTTTATTGGCATTGATCTCACAGTCTGGTGAGGACTTCTTTACTGATAATGTCAAGTTCA
GGTTATCCTCCCAACCAAGGAGCATTCAGCACAGAACAAAGTCGTTATCCTCCTCACTCTGTCCAGTATACATTTCCCAACACCCGCCAC
CAGCAGGAGTTCGCAGTCCCTGATTATCGTTCCTCTCATCTTGAAGTGAGTCAGGCATCACAGCTTTTGCAGCAACAGCAGCAGCAACAG
CTTCGAAGGCGACCTTCCTTGCTTTCAGAATTTCACCCAGGTTCTGACAGGCCTCAAGAAAGGAGAACTAGTTATGAACCGTTTCATCCA
GGCCCATCCCCAGTGGATCATGATTCACTGGAATCGAAGCGACCACGTCTGGAACAGGTTTCTGATTCTCATTTTCAGCGTGTCAGTGCT
GCGGTTTTGCCTTTAGTGCACCCGCTGCCAGAAGGGCTGAGGGCTTCTGCAGATGCTAAGAAGGATCCAGCATTCGGAGGCAAACATGAA
GCTCCATCCTCTCCAATTTCGGGGCAACCATGTGGAGATGATCAAAATGCTTCACCTTCAAAACTCTCAAAGGAAGAGTTAATACAGAGT
ATGGATCGTGTAGATCGAGAAATTGCAAAAGTAGAACAGCAGATCCTTAAACTGAAAAAGAAACAACAACAGCTTGAAGAAGAGGCAGCT
AAACCTCCTGAGCCTGAGAAGCCCGTGTCCCCTCCTCCTGTGGAGCAGAAACACCGCAGTATTGTCCAAATTATTTATGATGAGAATCGG
GGATTTCCCAGATGACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCT
GGTGGTGACTTTCGATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGCCCTGCACTCAGAAGGGAA
GTTACCTAAAGGTAAGGCTTGTTCCTTTTGCAAAGGGCCACAAGATACTGTCCCTCTGAGAAACTTATGAGGGGGAAATTTGCAAATCCA
CAGAGAGCTGCCCTCAGCCGAGCAGAGGCAGTGGTTGGGGAGGCCGCCACACTCTTCCTGACTCACCTCAAGGTACCTGGCAGGTTGTAT
CTACCAGCAAGTGCCTGCCTGCAGGGCCACCTCTGGATGAGTGGGGAGGCCAGGTTTGCCCCTCAACCTGTCTAGCTTTTTCACAGGGTG
GATGTTTTACACCTCTGGTATTCTTCCAGTCTGAACTCAATCCCATCCCCCAACCAATTAGGCAGGTTGTAAATGACTGCTGGGTGCTTG

>In-frame_NCOR1_ENST00000268712_chr17_16062074_-_PIGL_ENST00000225609_chr17_16203202_+_1775nt
GGAGGGAGAGGGGTTGAGTCAAGATGGCGGCCAAGGTGGCGAAGCAGCAGCCGCGGCGGCGGCGGCGGCTGGAGTGAGCGTCCGACTCGC
CGCGCCGAACGAGGTCCCGGTGTAGGGCCGCGCGCCGTGGCCGCGTCCCACTCCTCAGGCCGGGGCGCACGTCGGCTCCCACGCTTAGCC
AGCTCCCGGTGGTTTCCTAGAAACATGATTGTTTATTGGCATTGATCTCACAGTCTGGTGAGGACTTCTTTACTGATAATGTCAAGTTCA
GGTTATCCTCCCAACCAAGGAGCATTCAGCACAGAACAAAGTCGTTATCCTCCTCACTCTGTCCAGTATACATTTCCCAACACCCGCCAC
CAGCAGGAGTTCGCAGTCCCTGATTATCGTTCCTCTCATCTTGAAGTGAGTCAGGCATCACAGCTTTTGCAGCAACAGCAGCAGCAACAG
CTTCGAAGGCGACCTTCCTTGCTTTCAGAATTTCACCCAGGTTCTGACAGGCCTCAAGAAAGGAGAACTAGTTATGAACCGTTTCATCCA
GGCCCATCCCCAGTGGATCATGATTCACTGGAATCGAAGCGACCACGTCTGGAACAGGTTTCTGATTCTCATTTTCAGCGTGTCAGTGCT
GCGGTTTTGCCTTTAGTGCACCCGCTGCCAGAAGGGCTGAGGGCTTCTGCAGATGCTAAGAAGGATCCAGCATTCGGAGGCAAACATGAA
GCTCCATCCTCTCCAATTTCGGGGCAACCATGTGGAGATGATCAAAATGCTTCACCTTCAAAACTCTCAAAGGAAGAGTTAATACAGAGT
ATGGATCGTGTAGATCGAGAAATTGCAAAAGTAGAACAGCAGATCCTTAAACTGAAAAAGAAACAACAACAGCTTGAAGAAGAGGCAGCT
AAACCTCCTGAGCCTGAGAAGCCCGTGTCCCCTCCTCCTGTGGAGCAGAAACACCGCAGTATTGTCCAAATTATTTATGATGAGAATCGG
GGATTTCCCAGATGACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCT
GGTGGTGACTTTCGATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGCCCTGCACTCAGAAGGGAA
GTTACCTAAAGGGTGCTCTGTGCTCACGCTTCAGTCTGTGAATGTGCTGCGCAAGTACATCTCCCTTCTGGATCTGCCCTTGTCTCTGCT
TCATACGCAGGATGTCCTCTTCGTGCTCAACAGCAAAGAAGTGGCACAGGCCAAGAAAGCCATGTCCTGCCACCGCAGCCAGCTCCTCTG
GTTCCGCCGCCTCTACATTATCTTCTCCCGGTACATGAGAATCAACTCACTGAGCTTCCTCTGAAGCCTTGAAGGGTTTTCAGATCCAAG
GAACAAAGGGGAAAATAGACAAAGGAGTGCAGAGGACCTGGCCTGGCACTGGCTTATTTACCTGAGCTCAAGGAGATCCCCGCTGGAGCA
GCCTCTGCAAAAGGGAGCCCATGTAGGCCAGGGGCTGTCCAAACTCCAGCTTCTTCCCCTGGGAAAAAACCCAAAGAACCAAAAACAAAC
CACCCCAAGGATAATAATAGCTACACTGCTAGCTTCTCAAGTTCTTGTGAAAAACAATTTACATAATGACACAGTAGATGTGGAACACCT

>In-frame_NCOR1_ENST00000268712_chr17_16062074_-_PIGL_ENST00000395844_chr17_16203202_+_1895nt
GGAGGGAGAGGGGTTGAGTCAAGATGGCGGCCAAGGTGGCGAAGCAGCAGCCGCGGCGGCGGCGGCGGCTGGAGTGAGCGTCCGACTCGC
CGCGCCGAACGAGGTCCCGGTGTAGGGCCGCGCGCCGTGGCCGCGTCCCACTCCTCAGGCCGGGGCGCACGTCGGCTCCCACGCTTAGCC
AGCTCCCGGTGGTTTCCTAGAAACATGATTGTTTATTGGCATTGATCTCACAGTCTGGTGAGGACTTCTTTACTGATAATGTCAAGTTCA
GGTTATCCTCCCAACCAAGGAGCATTCAGCACAGAACAAAGTCGTTATCCTCCTCACTCTGTCCAGTATACATTTCCCAACACCCGCCAC
CAGCAGGAGTTCGCAGTCCCTGATTATCGTTCCTCTCATCTTGAAGTGAGTCAGGCATCACAGCTTTTGCAGCAACAGCAGCAGCAACAG
CTTCGAAGGCGACCTTCCTTGCTTTCAGAATTTCACCCAGGTTCTGACAGGCCTCAAGAAAGGAGAACTAGTTATGAACCGTTTCATCCA
GGCCCATCCCCAGTGGATCATGATTCACTGGAATCGAAGCGACCACGTCTGGAACAGGTTTCTGATTCTCATTTTCAGCGTGTCAGTGCT
GCGGTTTTGCCTTTAGTGCACCCGCTGCCAGAAGGGCTGAGGGCTTCTGCAGATGCTAAGAAGGATCCAGCATTCGGAGGCAAACATGAA
GCTCCATCCTCTCCAATTTCGGGGCAACCATGTGGAGATGATCAAAATGCTTCACCTTCAAAACTCTCAAAGGAAGAGTTAATACAGAGT
ATGGATCGTGTAGATCGAGAAATTGCAAAAGTAGAACAGCAGATCCTTAAACTGAAAAAGAAACAACAACAGCTTGAAGAAGAGGCAGCT
AAACCTCCTGAGCCTGAGAAGCCCGTGTCCCCTCCTCCTGTGGAGCAGAAACACCGCAGTATTGTCCAAATTATTTATGATGAGAATCGG
GGATTTCCCAGATGACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCT
GGTGGTGACTTTCGATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGTGCTCTGTGCTCACGCTTC
AGTCTGTGAATGTGCTGCGCAAGTACATCTCCCTTCTGGATCTGCCCTTGTCTCTGCTTCATACGCAGGATGTCCTCTTCGTGCTCAACA
GCAAAGAAGTGGCACAGGCCAAGAAAGCCATGTCCTGCCACCGCAGCCAGCTCCTCTGGTTCCGCCGCCTCTACATTATCTTCTCCCGGT
ACATGAGAATCAACTCACTGAGCTTCCTCTGAAGCCTTGAAGGGTTTTCAGATCCAAGGAACAAAGGGGAAAATAGACAAAGGAGTGCAG
AGGACCTGGCCTGGCACTGGCTTATTTACCTGAGCTCAAGGAGATCCCCGCTGGAGCAGCCTCTGCAAAAGGGAGCCCATGTAGGCCAGG
GGCTGTCCAAACTCCAGCTTCTTCCCCTGGGAAAAAACCCAAAGAACCAAAAACAAACCACCCCAAGGATAATAATAGCTACACTGCTAG
CTTCTCAAGTTCTTGTGAAAAACAATTTACATAATGACACAGTAGATGTGGAACACCTAGCCCAGTGCCTGGGCAGGTCCCTATTATCAT
AAATGAACATAAAAGTGCTCTAAAAACACTCCACAGATGTGACTTTTACATTGTTTCCAAAGCAGGTTCACCAAAAACACATACACAAAA
TGCAACAGTGTGTGTTGAATTGGTTCAATCATAATTCCTTTGATTTTTCTTGTATCAGAATGTGGGTCTAGGAAAAACTTGCTCTATTTA


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FusionGenePPI for NCOR1_PIGL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NCOR1NELFE, AR, KDM4A, HSPA4, CORO2A, HDAC3, GPS2, TBL1XR1, KIF11, ZBTB33, TRIM33, CHD1, CLK1, PTMA, TBL1X, HDAC9, TAB2, NFKB1, HDAC4, HDAC7, HDAC5, PML, SIN3A, SKI, PHB, PPARD, BCL6, NCOR2, SMARCB1, SMARCA4, SAP30, SRCAP, SMARCC2, SMARCC1, SF3B3, SF3A1, TRIM28, CBFA2T3, RUNX1T1, NCOA1, NR3C1, PDCD2, ZMYND11, MYOD1, TXNRD2, PPARA, RARG, RARA, ZBTB16, HEY2, HTT, NR1D1, NR1D2, MECP2, VDR, ESR1, DZIP3, THRA, KDM5C, REST, ZBTB7A, THRB, PGR, DACH1, BACH1, TP53, ATXN3, CREBBP, EP300, NR1I2, NR1H4, SIRT1, PRAM1, CNOT2, PIAS1, UBE2I, CBFA2T2, SPEN, HIST1H3A, SAFB, SAFB2, NR1H3, NR1H2, PPP1CA, PPP1CB, PPP1CC, PPARG, ATXN1L, NCOA3, POU1F1, SP1, CEBPB, NFE2L2, HIST1H4A, ETS1, ETS2, THAP7, NFKBIA, ETV6, RUNX1, COPS2, RXRA, SKIL, HESX1, SNW1, TAF9, GTF2B, TAF6, MYB, BAZ1A, EMD, IRF5, CDKN1A, SOX2, KDM5B, NRD1, ERBB4, ATXN1, RBBP4, SMARCA2, SMARCE1, HMGXB4, BPTF, SMARCD1, CHUK, YWHAZ, C1D, CXADR, CSNK2A1, SMAD4, SQSTM1, JUN, CREB1, PHB2, RFPL4B, QPRT, KLF5, MYC, EWSR1, FGFR1OP, NINL, KIF5B, KPNA1, RAB5A, KIF18A, SGOL1, EXOSC1, FOXK1, FOXK2, TEAD4, FBXW7, ITGAV, EYA2, TBL1Y, HNRNPLL, C6orf141, CDC16, IL17RA, ZSCAN5A, NCAPH2, OLFM2, USP44, TRIM25PIGLMEIS2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6461501_24402442441C1D
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3191501_2440135915C1D
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5451501_24402442338C1D
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646988_18162442441ETO
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319988_1816135915ETO
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545988_18162442338ETO
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646254_3122442441SIN3A/B
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319254_312135915SIN3A/B
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545254_3122442338SIN3A/B
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6461_3732442441ZBTB33 and HEXIM1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3191_373135915ZBTB33 and HEXIM1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5451_3732442338ZBTB33 and HEXIM1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCOR1_PIGL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NCOR1_PIGL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOR1C0005695Bladder Neoplasm1CTD_human
HgeneNCOR1C0007138Carcinoma, Transitional Cell1CTD_human
HgeneNCOR1C0014175Endometriosis1CTD_human
HgeneNCOR1C0017636Glioblastoma1CTD_human
HgeneNCOR1C0023903Liver neoplasms1CTD_human
HgeneNCOR1C1458155Mammary Neoplasms1CTD_human
TgenePIGLC1848392Zunich neuroectodermal syndrome1ORPHANET;UNIPROT