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Fusion gene ID: 23717 |
FusionGeneSummary for NCOR1_HIC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NCOR1_HIC1 | Fusion gene ID: 23717 | Hgene | Tgene | Gene symbol | NCOR1 | HIC1 | Gene ID | 9611 | 3090 |
| Gene name | nuclear receptor corepressor 1 | HIC ZBTB transcriptional repressor 1 | |
| Synonyms | N-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoR | ZBTB29|ZNF901|hic-1 | |
| Cytomap | 17p12-p11.2 | 17p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1 | hypermethylated in cancer 1 proteinhypermethylated in cancer 1zinc finger and BTB domain-containing protein 29 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O75376 | Q14526 | |
| Ensembl transtripts involved in fusion gene | ENST00000268712, ENST00000395851, ENST00000395857, ENST00000395848, ENST00000583226, | ENST00000399849, ENST00000322941, | |
| Fusion gene scores | * DoF score | 18 X 14 X 10=2520 | 1 X 1 X 1=1 |
| # samples | 16 | 1 | |
| ** MAII score | log2(16/2520*10)=-3.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: NCOR1 [Title/Abstract] AND HIC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NCOR1 | GO:0046329 | negative regulation of JNK cascade | 11931768 |
| Tgene | HIC1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12052894|15231840 |
| Tgene | HIC1 | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | 16269335 |
| Tgene | HIC1 | GO:0030178 | negative regulation of Wnt signaling pathway | 16724116 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CHOL | TCGA-W5-AA31-01A | NCOR1 | chr17 | 15973479 | - | HIC1 | chr17 | 1959965 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000268712 | ENST00000399849 | NCOR1 | chr17 | 15973479 | - | HIC1 | chr17 | 1959965 | + |
| 5CDS-5UTR | ENST00000268712 | ENST00000322941 | NCOR1 | chr17 | 15973479 | - | HIC1 | chr17 | 1959965 | + |
| 5CDS-5UTR | ENST00000395851 | ENST00000399849 | NCOR1 | chr17 | 15973479 | - | HIC1 | chr17 | 1959965 | + |
| 5CDS-5UTR | ENST00000395851 | ENST00000322941 | NCOR1 | chr17 | 15973479 | - | HIC1 | chr17 | 1959965 | + |
| 5CDS-5UTR | ENST00000395857 | ENST00000399849 | NCOR1 | chr17 | 15973479 | - | HIC1 | chr17 | 1959965 | + |
| 5CDS-5UTR | ENST00000395857 | ENST00000322941 | NCOR1 | chr17 | 15973479 | - | HIC1 | chr17 | 1959965 | + |
| intron-5UTR | ENST00000395848 | ENST00000399849 | NCOR1 | chr17 | 15973479 | - | HIC1 | chr17 | 1959965 | + |
| intron-5UTR | ENST00000395848 | ENST00000322941 | NCOR1 | chr17 | 15973479 | - | HIC1 | chr17 | 1959965 | + |
| intron-5UTR | ENST00000583226 | ENST00000399849 | NCOR1 | chr17 | 15973479 | - | HIC1 | chr17 | 1959965 | + |
| intron-5UTR | ENST00000583226 | ENST00000322941 | NCOR1 | chr17 | 15973479 | - | HIC1 | chr17 | 1959965 | + |
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FusionProtFeatures for NCOR1_HIC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NCOR1 | HIC1 |
| Mediates transcriptional repression by certain nuclearreceptors. Part of a complex which promotes histone deacetylationand the formation of repressive chromatin structures which mayimpede the access of basal transcription factors. Participates inthe transcriptional repressor activity produced by BCL6.{ECO:0000269|PubMed:14527417}. | Transcriptional repressor. Recognizes and binds to theconsensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumorsuppressor. May be involved in development of head, face, limbsand ventral body wall. Involved in down-regulation of SIRT1 andthereby is involved in regulation of p53/TP53-dependent apoptoticDNA-damage responses. The specific target gene promoterassociation seems to be depend on corepressors, such as CTBP1 orCTBP2 and MTA1. The regulation of SIRT1 transcription in responseto nutrient deprivation seems to involve CTBP1. In cooperationwith MTA1 (indicative for an association with the NuRD complex)represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2specifically in quiescent cells. Involved in regulation of the Wntsignaling pathway probably by association with TCF7L2 andpreventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 andATOH1 which involves ARID1A, indicative for the participation of adistinct SWI/SNF-type chromatin-remodeling complex. Probablyrepresses transcription from ACKR3, FGFBP1 and EFNA1.{ECO:0000269|PubMed:12052894, ECO:0000269|PubMed:15231840,ECO:0000269|PubMed:16269335, ECO:0000269|PubMed:16690027,ECO:0000269|PubMed:16724116, ECO:0000269|PubMed:17213307,ECO:0000269|PubMed:18347096, ECO:0000269|PubMed:19486893,ECO:0000269|PubMed:19525223, ECO:0000269|PubMed:20154726,ECO:0000269|PubMed:20547755}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NCOR1_HIC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NCOR1_HIC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NCOR1 | NELFE, AR, KDM4A, HSPA4, CORO2A, HDAC3, GPS2, TBL1XR1, KIF11, ZBTB33, TRIM33, CHD1, CLK1, PTMA, TBL1X, HDAC9, TAB2, NFKB1, HDAC4, HDAC7, HDAC5, PML, SIN3A, SKI, PHB, PPARD, BCL6, NCOR2, SMARCB1, SMARCA4, SAP30, SRCAP, SMARCC2, SMARCC1, SF3B3, SF3A1, TRIM28, CBFA2T3, RUNX1T1, NCOA1, NR3C1, PDCD2, ZMYND11, MYOD1, TXNRD2, PPARA, RARG, RARA, ZBTB16, HEY2, HTT, NR1D1, NR1D2, MECP2, VDR, ESR1, DZIP3, THRA, KDM5C, REST, ZBTB7A, THRB, PGR, DACH1, BACH1, TP53, ATXN3, CREBBP, EP300, NR1I2, NR1H4, SIRT1, PRAM1, CNOT2, PIAS1, UBE2I, CBFA2T2, SPEN, HIST1H3A, SAFB, SAFB2, NR1H3, NR1H2, PPP1CA, PPP1CB, PPP1CC, PPARG, ATXN1L, NCOA3, POU1F1, SP1, CEBPB, NFE2L2, HIST1H4A, ETS1, ETS2, THAP7, NFKBIA, ETV6, RUNX1, COPS2, RXRA, SKIL, HESX1, SNW1, TAF9, GTF2B, TAF6, MYB, BAZ1A, EMD, IRF5, CDKN1A, SOX2, KDM5B, NRD1, ERBB4, ATXN1, RBBP4, SMARCA2, SMARCE1, HMGXB4, BPTF, SMARCD1, CHUK, YWHAZ, C1D, CXADR, CSNK2A1, SMAD4, SQSTM1, JUN, CREB1, PHB2, RFPL4B, QPRT, KLF5, MYC, EWSR1, FGFR1OP, NINL, KIF5B, KPNA1, RAB5A, KIF18A, SGOL1, EXOSC1, FOXK1, FOXK2, TEAD4, FBXW7, ITGAV, EYA2, TBL1Y, HNRNPLL, C6orf141, CDC16, IL17RA, ZSCAN5A, NCAPH2, OLFM2, USP44, TRIM25 | HIC1 | HIC1, CTBP1, CTBP2, ARID1A, UBE2I, SENP3, PIAS1, PIAS2, SIRT1, HDAC4, MTA1, MBD3, CHD3, RBBP4, PHF19, PHF1, EZH2, SUZ12, EED, HIC2, STAT3, PIAS4, PIAS3, SP1, TCF7L2, MECOM, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NCOR1_HIC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NCOR1_HIC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NCOR1 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Hgene | NCOR1 | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
| Hgene | NCOR1 | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | NCOR1 | C0017636 | Glioblastoma | 1 | CTD_human |
| Hgene | NCOR1 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Hgene | NCOR1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | HIC1 | C0017185 | Gastrointestinal Neoplasms | 1 | CTD_human |
| Tgene | HIC1 | C0025149 | Medulloblastoma | 1 | CTD_human |
| Tgene | HIC1 | C0032584 | polyps | 1 | CTD_human |
| Tgene | HIC1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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