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Fusion gene ID: 23716 |
FusionGeneSummary for NCOR1_FBXO3 |
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Fusion gene information | Fusion gene name: NCOR1_FBXO3 | Fusion gene ID: 23716 | Hgene | Tgene | Gene symbol | NCOR1 | FBXO3 | Gene ID | 9611 | 26273 |
Gene name | nuclear receptor corepressor 1 | F-box protein 3 | |
Synonyms | N-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoR | FBA|FBX3 | |
Cytomap | 17p12-p11.2 | 11p13 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1 | F-box only protein 3F-box protein FBX3 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O75376 | Q9UK99 | |
Ensembl transtripts involved in fusion gene | ENST00000268712, ENST00000395851, ENST00000395857, ENST00000395848, ENST00000583226, | ENST00000526785, ENST00000265651, ENST00000530401, ENST00000531080, ENST00000532057, ENST00000534136, ENST00000448981, ENST00000533103, | |
Fusion gene scores | * DoF score | 18 X 14 X 10=2520 | 4 X 3 X 1=12 |
# samples | 16 | 4 | |
** MAII score | log2(16/2520*10)=-3.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NCOR1 [Title/Abstract] AND FBXO3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NCOR1 | GO:0046329 | negative regulation of JNK cascade | 11931768 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-D8-A1JD-01A | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000268712 | ENST00000526785 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-5UTR | ENST00000268712 | ENST00000265651 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-intron | ENST00000268712 | ENST00000530401 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-intron | ENST00000268712 | ENST00000531080 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-intron | ENST00000268712 | ENST00000532057 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-intron | ENST00000268712 | ENST00000534136 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-intron | ENST00000268712 | ENST00000448981 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-5UTR | ENST00000268712 | ENST00000533103 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-5UTR | ENST00000395851 | ENST00000526785 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-5UTR | ENST00000395851 | ENST00000265651 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-intron | ENST00000395851 | ENST00000530401 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-intron | ENST00000395851 | ENST00000531080 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-intron | ENST00000395851 | ENST00000532057 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-intron | ENST00000395851 | ENST00000534136 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-intron | ENST00000395851 | ENST00000448981 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-5UTR | ENST00000395851 | ENST00000533103 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-5UTR | ENST00000395857 | ENST00000526785 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-5UTR | ENST00000395857 | ENST00000265651 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-intron | ENST00000395857 | ENST00000530401 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-intron | ENST00000395857 | ENST00000531080 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-intron | ENST00000395857 | ENST00000532057 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-intron | ENST00000395857 | ENST00000534136 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-intron | ENST00000395857 | ENST00000448981 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
5CDS-5UTR | ENST00000395857 | ENST00000533103 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
intron-5UTR | ENST00000395848 | ENST00000526785 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
intron-5UTR | ENST00000395848 | ENST00000265651 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
intron-intron | ENST00000395848 | ENST00000530401 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
intron-intron | ENST00000395848 | ENST00000531080 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
intron-intron | ENST00000395848 | ENST00000532057 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
intron-intron | ENST00000395848 | ENST00000534136 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
intron-intron | ENST00000395848 | ENST00000448981 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
intron-5UTR | ENST00000395848 | ENST00000533103 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
intron-5UTR | ENST00000583226 | ENST00000526785 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
intron-5UTR | ENST00000583226 | ENST00000265651 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
intron-intron | ENST00000583226 | ENST00000530401 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
intron-intron | ENST00000583226 | ENST00000531080 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
intron-intron | ENST00000583226 | ENST00000532057 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
intron-intron | ENST00000583226 | ENST00000534136 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
intron-intron | ENST00000583226 | ENST00000448981 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
intron-5UTR | ENST00000583226 | ENST00000533103 | NCOR1 | chr17 | 15960828 | - | FBXO3 | chr11 | 33792376 | - |
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FusionProtFeatures for NCOR1_FBXO3 |
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Hgene | Tgene |
NCOR1 | FBXO3 |
Mediates transcriptional repression by certain nuclearreceptors. Part of a complex which promotes histone deacetylationand the formation of repressive chromatin structures which mayimpede the access of basal transcription factors. Participates inthe transcriptional repressor activity produced by BCL6.{ECO:0000269|PubMed:14527417}. | Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates theubiquitination of HIPK2 and probably that of EP300, leading torapid degradation by the proteasome. In the presence of PML, HIPK2ubiquitination still occurs, but degradation is prevented. PML,HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. {ECO:0000269|PubMed:18809579}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NCOR1_FBXO3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NCOR1_FBXO3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NCOR1 | NELFE, AR, KDM4A, HSPA4, CORO2A, HDAC3, GPS2, TBL1XR1, KIF11, ZBTB33, TRIM33, CHD1, CLK1, PTMA, TBL1X, HDAC9, TAB2, NFKB1, HDAC4, HDAC7, HDAC5, PML, SIN3A, SKI, PHB, PPARD, BCL6, NCOR2, SMARCB1, SMARCA4, SAP30, SRCAP, SMARCC2, SMARCC1, SF3B3, SF3A1, TRIM28, CBFA2T3, RUNX1T1, NCOA1, NR3C1, PDCD2, ZMYND11, MYOD1, TXNRD2, PPARA, RARG, RARA, ZBTB16, HEY2, HTT, NR1D1, NR1D2, MECP2, VDR, ESR1, DZIP3, THRA, KDM5C, REST, ZBTB7A, THRB, PGR, DACH1, BACH1, TP53, ATXN3, CREBBP, EP300, NR1I2, NR1H4, SIRT1, PRAM1, CNOT2, PIAS1, UBE2I, CBFA2T2, SPEN, HIST1H3A, SAFB, SAFB2, NR1H3, NR1H2, PPP1CA, PPP1CB, PPP1CC, PPARG, ATXN1L, NCOA3, POU1F1, SP1, CEBPB, NFE2L2, HIST1H4A, ETS1, ETS2, THAP7, NFKBIA, ETV6, RUNX1, COPS2, RXRA, SKIL, HESX1, SNW1, TAF9, GTF2B, TAF6, MYB, BAZ1A, EMD, IRF5, CDKN1A, SOX2, KDM5B, NRD1, ERBB4, ATXN1, RBBP4, SMARCA2, SMARCE1, HMGXB4, BPTF, SMARCD1, CHUK, YWHAZ, C1D, CXADR, CSNK2A1, SMAD4, SQSTM1, JUN, CREB1, PHB2, RFPL4B, QPRT, KLF5, MYC, EWSR1, FGFR1OP, NINL, KIF5B, KPNA1, RAB5A, KIF18A, SGOL1, EXOSC1, FOXK1, FOXK2, TEAD4, FBXW7, ITGAV, EYA2, TBL1Y, HNRNPLL, C6orf141, CDC16, IL17RA, ZSCAN5A, NCAPH2, OLFM2, USP44, TRIM25 | FBXO3 | RBX1, TNFAIP3, CUL3, CUL1, COPS5, NEDD8, PML, SKP1, HIPK2, EP300, HSP90AA1, DCP2, IDS, SMURF1, MCM2, CDC73, AIRE, PTPDC1, FBXO3, INO80B, ZNHIT2, FBXL2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NCOR1_FBXO3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NCOR1_FBXO3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NCOR1 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Hgene | NCOR1 | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
Hgene | NCOR1 | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | NCOR1 | C0017636 | Glioblastoma | 1 | CTD_human |
Hgene | NCOR1 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | NCOR1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |