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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23715

FusionGeneSummary for NCOR1_DPM1

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOR1_DPM1
Fusion gene ID: 23715
HgeneTgene
Gene symbol

NCOR1

DPM1

Gene ID

9611

8813

Gene namenuclear receptor corepressor 1dolichyl-phosphate mannosyltransferase subunit 1, catalytic
SynonymsN-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoRCDGIE|MPDS
Cytomap

17p12-p11.2

20q13.13

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1dolichol-phosphate mannosyltransferase subunit 1DPM synthase complex, catalytic subunitDPM synthase subunit 1MPD synthase subunit 1dolichol monophosphate mannose synthasedolichol-phosphate mannose synthase subunit 1dolichyl-phosphate beta-D-mannosyl
Modification date2018052320180523
UniProtAcc

O75376

O60762

Ensembl transtripts involved in fusion geneENST00000268712, ENST00000395851, 
ENST00000395857, ENST00000395848, 
ENST00000583226, 
ENST00000466152, 
ENST00000371588, ENST00000371582, 
ENST00000371583, 
Fusion gene scores* DoF score18 X 14 X 10=25205 X 7 X 3=105
# samples 167
** MAII scorelog2(16/2520*10)=-3.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCOR1 [Title/Abstract] AND DPM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOR1

GO:0046329

negative regulation of JNK cascade

11931768

TgeneDPM1

GO:0006506

GPI anchor biosynthetic process

9535917|9724629|10835346

TgeneDPM1

GO:0019348

dolichol metabolic process

9535917|9724629

TgeneDPM1

GO:0035268

protein mannosylation

9535917

TgeneDPM1

GO:0035269

protein O-linked mannosylation

9535917


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A0B2-01ANCOR1chr17

16055260

-DPM1chr20

49571822

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000268712ENST00000466152NCOR1chr17

16055260

-DPM1chr20

49571822

-
5CDS-5UTRENST00000268712ENST00000371588NCOR1chr17

16055260

-DPM1chr20

49571822

-
5CDS-5UTRENST00000268712ENST00000371582NCOR1chr17

16055260

-DPM1chr20

49571822

-
5CDS-5UTRENST00000268712ENST00000371583NCOR1chr17

16055260

-DPM1chr20

49571822

-
5CDS-5UTRENST00000395851ENST00000466152NCOR1chr17

16055260

-DPM1chr20

49571822

-
5CDS-5UTRENST00000395851ENST00000371588NCOR1chr17

16055260

-DPM1chr20

49571822

-
5CDS-5UTRENST00000395851ENST00000371582NCOR1chr17

16055260

-DPM1chr20

49571822

-
5CDS-5UTRENST00000395851ENST00000371583NCOR1chr17

16055260

-DPM1chr20

49571822

-
intron-5UTRENST00000395857ENST00000466152NCOR1chr17

16055260

-DPM1chr20

49571822

-
intron-5UTRENST00000395857ENST00000371588NCOR1chr17

16055260

-DPM1chr20

49571822

-
intron-5UTRENST00000395857ENST00000371582NCOR1chr17

16055260

-DPM1chr20

49571822

-
intron-5UTRENST00000395857ENST00000371583NCOR1chr17

16055260

-DPM1chr20

49571822

-
5CDS-5UTRENST00000395848ENST00000466152NCOR1chr17

16055260

-DPM1chr20

49571822

-
5CDS-5UTRENST00000395848ENST00000371588NCOR1chr17

16055260

-DPM1chr20

49571822

-
5CDS-5UTRENST00000395848ENST00000371582NCOR1chr17

16055260

-DPM1chr20

49571822

-
5CDS-5UTRENST00000395848ENST00000371583NCOR1chr17

16055260

-DPM1chr20

49571822

-
intron-5UTRENST00000583226ENST00000466152NCOR1chr17

16055260

-DPM1chr20

49571822

-
intron-5UTRENST00000583226ENST00000371588NCOR1chr17

16055260

-DPM1chr20

49571822

-
intron-5UTRENST00000583226ENST00000371582NCOR1chr17

16055260

-DPM1chr20

49571822

-
intron-5UTRENST00000583226ENST00000371583NCOR1chr17

16055260

-DPM1chr20

49571822

-

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FusionProtFeatures for NCOR1_DPM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOR1

O75376

DPM1

O60762

Mediates transcriptional repression by certain nuclearreceptors. Part of a complex which promotes histone deacetylationand the formation of repressive chromatin structures which mayimpede the access of basal transcription factors. Participates inthe transcriptional repressor activity produced by BCL6.{ECO:0000269|PubMed:14527417}. Transfers mannose from GDP-mannose to dolicholmonophosphate to form dolichol phosphate mannose (Dol-P-Man) whichis the mannosyl donor in pathways leading to N-glycosylation,glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NCOR1_DPM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NCOR1_DPM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NCOR1NELFE, AR, KDM4A, HSPA4, CORO2A, HDAC3, GPS2, TBL1XR1, KIF11, ZBTB33, TRIM33, CHD1, CLK1, PTMA, TBL1X, HDAC9, TAB2, NFKB1, HDAC4, HDAC7, HDAC5, PML, SIN3A, SKI, PHB, PPARD, BCL6, NCOR2, SMARCB1, SMARCA4, SAP30, SRCAP, SMARCC2, SMARCC1, SF3B3, SF3A1, TRIM28, CBFA2T3, RUNX1T1, NCOA1, NR3C1, PDCD2, ZMYND11, MYOD1, TXNRD2, PPARA, RARG, RARA, ZBTB16, HEY2, HTT, NR1D1, NR1D2, MECP2, VDR, ESR1, DZIP3, THRA, KDM5C, REST, ZBTB7A, THRB, PGR, DACH1, BACH1, TP53, ATXN3, CREBBP, EP300, NR1I2, NR1H4, SIRT1, PRAM1, CNOT2, PIAS1, UBE2I, CBFA2T2, SPEN, HIST1H3A, SAFB, SAFB2, NR1H3, NR1H2, PPP1CA, PPP1CB, PPP1CC, PPARG, ATXN1L, NCOA3, POU1F1, SP1, CEBPB, NFE2L2, HIST1H4A, ETS1, ETS2, THAP7, NFKBIA, ETV6, RUNX1, COPS2, RXRA, SKIL, HESX1, SNW1, TAF9, GTF2B, TAF6, MYB, BAZ1A, EMD, IRF5, CDKN1A, SOX2, KDM5B, NRD1, ERBB4, ATXN1, RBBP4, SMARCA2, SMARCE1, HMGXB4, BPTF, SMARCD1, CHUK, YWHAZ, C1D, CXADR, CSNK2A1, SMAD4, SQSTM1, JUN, CREB1, PHB2, RFPL4B, QPRT, KLF5, MYC, EWSR1, FGFR1OP, NINL, KIF5B, KPNA1, RAB5A, KIF18A, SGOL1, EXOSC1, FOXK1, FOXK2, TEAD4, FBXW7, ITGAV, EYA2, TBL1Y, HNRNPLL, C6orf141, CDC16, IL17RA, ZSCAN5A, NCAPH2, OLFM2, USP44, TRIM25DPM1BRF2, ZBTB16, DPM2, DPM3, MYC, STUB1, CLN3, FBXO6, ILK, HUWE1, TDO2, BMI1, EGFR, AATK, ARAF, NTRK1, TUBG1, ELMSAN1, FBXW7, MCM2, PHF12, WWP2, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCOR1_DPM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NCOR1_DPM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOR1C0005695Bladder Neoplasm1CTD_human
HgeneNCOR1C0007138Carcinoma, Transitional Cell1CTD_human
HgeneNCOR1C0014175Endometriosis1CTD_human
HgeneNCOR1C0017636Glioblastoma1CTD_human
HgeneNCOR1C0023903Liver neoplasms1CTD_human
HgeneNCOR1C1458155Mammary Neoplasms1CTD_human
TgeneDPM1C1837396CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ie3CTD_human;ORPHANET;UNIPROT