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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23711

FusionGeneSummary for NCOR1_ACACA

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOR1_ACACA
Fusion gene ID: 23711
HgeneTgene
Gene symbol

NCOR1

ACACA

Gene ID

9611

31

Gene namenuclear receptor corepressor 1acetyl-CoA carboxylase alpha
SynonymsN-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoRACAC|ACACAD|ACC|ACC1|ACCA
Cytomap

17p12-p11.2

17q12

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1acetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alpha
Modification date2018052320180522
UniProtAcc

O75376

Q13085

Ensembl transtripts involved in fusion geneENST00000268712, ENST00000395851, 
ENST00000395857, ENST00000395848, 
ENST00000583226, 
ENST00000353139, 
ENST00000360679, ENST00000394406, 
ENST00000335166, ENST00000416895, 
ENST00000361253, ENST00000588142, 
ENST00000589665, 
Fusion gene scores* DoF score18 X 14 X 10=252010 X 9 X 5=450
# samples 169
** MAII scorelog2(16/2520*10)=-3.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/450*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCOR1 [Title/Abstract] AND ACACA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOR1

GO:0046329

negative regulation of JNK cascade

11931768


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A1IN-01ANCOR1chr17

15960828

-ACACAchr17

35627752

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000268712ENST00000353139NCOR1chr17

15960828

-ACACAchr17

35627752

-
Frame-shiftENST00000268712ENST00000360679NCOR1chr17

15960828

-ACACAchr17

35627752

-
Frame-shiftENST00000268712ENST00000394406NCOR1chr17

15960828

-ACACAchr17

35627752

-
Frame-shiftENST00000268712ENST00000335166NCOR1chr17

15960828

-ACACAchr17

35627752

-
5CDS-intronENST00000268712ENST00000416895NCOR1chr17

15960828

-ACACAchr17

35627752

-
5CDS-intronENST00000268712ENST00000361253NCOR1chr17

15960828

-ACACAchr17

35627752

-
5CDS-intronENST00000268712ENST00000588142NCOR1chr17

15960828

-ACACAchr17

35627752

-
5CDS-intronENST00000268712ENST00000589665NCOR1chr17

15960828

-ACACAchr17

35627752

-
Frame-shiftENST00000395851ENST00000353139NCOR1chr17

15960828

-ACACAchr17

35627752

-
Frame-shiftENST00000395851ENST00000360679NCOR1chr17

15960828

-ACACAchr17

35627752

-
Frame-shiftENST00000395851ENST00000394406NCOR1chr17

15960828

-ACACAchr17

35627752

-
Frame-shiftENST00000395851ENST00000335166NCOR1chr17

15960828

-ACACAchr17

35627752

-
5CDS-intronENST00000395851ENST00000416895NCOR1chr17

15960828

-ACACAchr17

35627752

-
5CDS-intronENST00000395851ENST00000361253NCOR1chr17

15960828

-ACACAchr17

35627752

-
5CDS-intronENST00000395851ENST00000588142NCOR1chr17

15960828

-ACACAchr17

35627752

-
5CDS-intronENST00000395851ENST00000589665NCOR1chr17

15960828

-ACACAchr17

35627752

-
Frame-shiftENST00000395857ENST00000353139NCOR1chr17

15960828

-ACACAchr17

35627752

-
Frame-shiftENST00000395857ENST00000360679NCOR1chr17

15960828

-ACACAchr17

35627752

-
Frame-shiftENST00000395857ENST00000394406NCOR1chr17

15960828

-ACACAchr17

35627752

-
Frame-shiftENST00000395857ENST00000335166NCOR1chr17

15960828

-ACACAchr17

35627752

-
5CDS-intronENST00000395857ENST00000416895NCOR1chr17

15960828

-ACACAchr17

35627752

-
5CDS-intronENST00000395857ENST00000361253NCOR1chr17

15960828

-ACACAchr17

35627752

-
5CDS-intronENST00000395857ENST00000588142NCOR1chr17

15960828

-ACACAchr17

35627752

-
5CDS-intronENST00000395857ENST00000589665NCOR1chr17

15960828

-ACACAchr17

35627752

-
intron-3CDSENST00000395848ENST00000353139NCOR1chr17

15960828

-ACACAchr17

35627752

-
intron-3CDSENST00000395848ENST00000360679NCOR1chr17

15960828

-ACACAchr17

35627752

-
intron-3CDSENST00000395848ENST00000394406NCOR1chr17

15960828

-ACACAchr17

35627752

-
intron-3CDSENST00000395848ENST00000335166NCOR1chr17

15960828

-ACACAchr17

35627752

-
intron-intronENST00000395848ENST00000416895NCOR1chr17

15960828

-ACACAchr17

35627752

-
intron-intronENST00000395848ENST00000361253NCOR1chr17

15960828

-ACACAchr17

35627752

-
intron-intronENST00000395848ENST00000588142NCOR1chr17

15960828

-ACACAchr17

35627752

-
intron-intronENST00000395848ENST00000589665NCOR1chr17

15960828

-ACACAchr17

35627752

-
intron-3CDSENST00000583226ENST00000353139NCOR1chr17

15960828

-ACACAchr17

35627752

-
intron-3CDSENST00000583226ENST00000360679NCOR1chr17

15960828

-ACACAchr17

35627752

-
intron-3CDSENST00000583226ENST00000394406NCOR1chr17

15960828

-ACACAchr17

35627752

-
intron-3CDSENST00000583226ENST00000335166NCOR1chr17

15960828

-ACACAchr17

35627752

-
intron-intronENST00000583226ENST00000416895NCOR1chr17

15960828

-ACACAchr17

35627752

-
intron-intronENST00000583226ENST00000361253NCOR1chr17

15960828

-ACACAchr17

35627752

-
intron-intronENST00000583226ENST00000588142NCOR1chr17

15960828

-ACACAchr17

35627752

-
intron-intronENST00000583226ENST00000589665NCOR1chr17

15960828

-ACACAchr17

35627752

-

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FusionProtFeatures for NCOR1_ACACA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOR1

O75376

ACACA

Q13085

Mediates transcriptional repression by certain nuclearreceptors. Part of a complex which promotes histone deacetylationand the formation of repressive chromatin structures which mayimpede the access of basal transcription factors. Participates inthe transcriptional repressor activity produced by BCL6.{ECO:0000269|PubMed:14527417}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NCOR1_ACACA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NCOR1_ACACA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NCOR1NELFE, AR, KDM4A, HSPA4, CORO2A, HDAC3, GPS2, TBL1XR1, KIF11, ZBTB33, TRIM33, CHD1, CLK1, PTMA, TBL1X, HDAC9, TAB2, NFKB1, HDAC4, HDAC7, HDAC5, PML, SIN3A, SKI, PHB, PPARD, BCL6, NCOR2, SMARCB1, SMARCA4, SAP30, SRCAP, SMARCC2, SMARCC1, SF3B3, SF3A1, TRIM28, CBFA2T3, RUNX1T1, NCOA1, NR3C1, PDCD2, ZMYND11, MYOD1, TXNRD2, PPARA, RARG, RARA, ZBTB16, HEY2, HTT, NR1D1, NR1D2, MECP2, VDR, ESR1, DZIP3, THRA, KDM5C, REST, ZBTB7A, THRB, PGR, DACH1, BACH1, TP53, ATXN3, CREBBP, EP300, NR1I2, NR1H4, SIRT1, PRAM1, CNOT2, PIAS1, UBE2I, CBFA2T2, SPEN, HIST1H3A, SAFB, SAFB2, NR1H3, NR1H2, PPP1CA, PPP1CB, PPP1CC, PPARG, ATXN1L, NCOA3, POU1F1, SP1, CEBPB, NFE2L2, HIST1H4A, ETS1, ETS2, THAP7, NFKBIA, ETV6, RUNX1, COPS2, RXRA, SKIL, HESX1, SNW1, TAF9, GTF2B, TAF6, MYB, BAZ1A, EMD, IRF5, CDKN1A, SOX2, KDM5B, NRD1, ERBB4, ATXN1, RBBP4, SMARCA2, SMARCE1, HMGXB4, BPTF, SMARCD1, CHUK, YWHAZ, C1D, CXADR, CSNK2A1, SMAD4, SQSTM1, JUN, CREB1, PHB2, RFPL4B, QPRT, KLF5, MYC, EWSR1, FGFR1OP, NINL, KIF5B, KPNA1, RAB5A, KIF18A, SGOL1, EXOSC1, FOXK1, FOXK2, TEAD4, FBXW7, ITGAV, EYA2, TBL1Y, HNRNPLL, C6orf141, CDC16, IL17RA, ZSCAN5A, NCAPH2, OLFM2, USP44, TRIM25ACACABRCA1, CHGB, PRKAA2, MLLT3, MLLT1, NPM1, AKR1B10, SIRT1, ARRB1, SIRT7, UBE2N, ATXN1, INPPL1, CBL, UBASH3B, PIK3R2, SHC1, AP2M1, ERCC6L, IKBKAP, CA9, VCP, FN1, IFIT1, FBXO6, CCT3, COPB1, DCAF6, EPB41L1, KIF5B, NUP50, PSMB7, SMEK1, EEF2K, STK25, PHKG2, ADRBK1, CSNK1A1, CSNK1E, PRKAA1, STK3, ILK, RPS6KA1, RIOK2, PRKAB1, PRKAG1, FUS, ENO1, MOV10, NXF1, MDM2, SUZ12, RNF2, BMI1, EGFR, SOCS6, SGCZ, C20orf195, PSG1, ARHGAP25, LIPH, IARS, PSMB2, PSMC6, PSMD2, NTRK1, PTEN, NDUFA4, C15orf48, COQ9, ZNF746, OAS2, LGALS3BP, C4orf26, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCOR1_ACACA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneACACAQ13085DB00121BiotinAcetyl-CoA carboxylase 1small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for NCOR1_ACACA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOR1C0005695Bladder Neoplasm1CTD_human
HgeneNCOR1C0007138Carcinoma, Transitional Cell1CTD_human
HgeneNCOR1C0014175Endometriosis1CTD_human
HgeneNCOR1C0017636Glioblastoma1CTD_human
HgeneNCOR1C0023903Liver neoplasms1CTD_human
HgeneNCOR1C1458155Mammary Neoplasms1CTD_human
TgeneACACAC0018801Heart failure1CTD_human
TgeneACACAC2239176Liver carcinoma1CTD_human