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Fusion gene ID: 23692 |
FusionGeneSummary for NCOA5_CDH4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NCOA5_CDH4 | Fusion gene ID: 23692 | Hgene | Tgene | Gene symbol | NCOA5 | CDH4 | Gene ID | 57727 | 1002 |
| Gene name | nuclear receptor coactivator 5 | cadherin 4 | |
| Synonyms | CIA|bA465L10.6 | CAD4|R-CAD|RCAD | |
| Cytomap | 20q13.12 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear receptor coactivator 5NCoA-5coactivator independent of AF-2 | cadherin-4R-cadherincadherin 4, type 1, R-cadherin (retinal)cadherin 4, type 1, preproproteinretinal cadherin | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9HCD5 | P55283 | |
| Ensembl transtripts involved in fusion gene | ENST00000290231, | ENST00000360469, ENST00000543233, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 10 X 6 X 6=360 |
| # samples | 4 | 10 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NCOA5 [Title/Abstract] AND CDH4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A091-01A | NCOA5 | chr20 | 44708026 | - | CDH4 | chr20 | 60318619 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000290231 | ENST00000360469 | NCOA5 | chr20 | 44708026 | - | CDH4 | chr20 | 60318619 | + |
| 5CDS-5UTR | ENST00000290231 | ENST00000543233 | NCOA5 | chr20 | 44708026 | - | CDH4 | chr20 | 60318619 | + |
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FusionProtFeatures for NCOA5_CDH4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NCOA5 | CDH4 |
| Nuclear receptor coregulator that can have bothcoactivator and corepressor functions. Interacts with nuclearreceptors for steroids (ESR1 and ESR2) independently of thesteroid binding domain (AF-2) of the ESR receptors, and with theorphan nuclear receptor NR1D2. Involved in the coactivation ofnuclear steroid receptors (ER) as well as the corepression of MYCin response to 17-beta-estradiol (E2).{ECO:0000269|PubMed:15073177}. | Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types. May play an important role inretinal development. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 873_888 | 56 | 917 | Compositional bias | Note=Ser-rich |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 873_888 | -18 | 843 | Compositional bias | Note=Ser-rich |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 170_277 | 56 | 917 | Domain | Cadherin 1 |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 278_392 | 56 | 917 | Domain | Cadherin 2 |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 393_507 | 56 | 917 | Domain | Cadherin 3 |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 508_613 | 56 | 917 | Domain | Cadherin 4 |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 614_724 | 56 | 917 | Domain | Cadherin 5 |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 170_277 | -18 | 843 | Domain | Cadherin 1 |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 278_392 | -18 | 843 | Domain | Cadherin 2 |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 393_507 | -18 | 843 | Domain | Cadherin 3 |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 508_613 | -18 | 843 | Domain | Cadherin 4 |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 614_724 | -18 | 843 | Domain | Cadherin 5 |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 170_734 | 56 | 917 | Topological domain | Extracellular |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 757_916 | 56 | 917 | Topological domain | Cytoplasmic |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 170_734 | -18 | 843 | Topological domain | Extracellular |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 757_916 | -18 | 843 | Topological domain | Cytoplasmic |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 735_756 | 56 | 917 | Transmembrane | Helical |
| Tgene | >CDH4 | chr20:44708026 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 735_756 | -18 | 843 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NCOA5 | chr20:44708026 | chr20:60318619 | ENST00000290231 | - | 2 | 8 | 7_150 | 12 | 580 | Compositional bias | Note=Arg/Asp-rich (mixed charge) |
| Hgene | >NCOA5 | chr20:44708026 | chr20:60318619 | ENST00000290231 | - | 2 | 8 | 345_349 | 12 | 580 | Motif | Note=LXXLL motif |
| Hgene | >NCOA5 | chr20:44708026 | chr20:60318619 | ENST00000290231 | - | 2 | 8 | 1_158 | 12 | 580 | Region | Note=Transcription repression |
| Hgene | >NCOA5 | chr20:44708026 | chr20:60318619 | ENST00000290231 | - | 2 | 8 | 458_579 | 12 | 580 | Region | Note=Transcription activation |
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FusionGeneSequence for NCOA5_CDH4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NCOA5_ENST00000290231_chr20_44708026_-_CDH4_ENST00000360469_chr20_60318619_+_873aa MNTAPSRPSPTRSQVQQLCGDQGDTIXDQQHGLQSWGRWDSLRHPGAAGPLRAGGVHGDCMGQPDSREMGRRGAVAGGPDLVPALWTQAA ERKEGRGSGPLSASEGHPAAVAPAPERQRAEAAQTGLGHPAHQRARELARALPAAAREDPVRQRQXHPHPVQHHGSGRRPAPHGGLQHXL HVRPDVRHKAHGPGGARLLPPPSPRCGHEWQQGGEPHRPVHLRHRHEXQPPXVHQPGLQRLRGRGLQARHLRDDRHGQRCXRQHHGQRDG AVPDRDPDPTEPVPEYVHHQQRDWRYRHSGGWPGPRESSAVHSHRSGHRYGRKSQLWPLKHSHSHHHGDRCEXQPARIYRQHVCRGGPRK PRGDRGRKPHGDGPRSAPLSKLECRLPHHQWGSIRALQRPHRPRNQRGHGHRGEGSRLRAQQSFHADSDGVQPGAPGQRNPDVLPVHGRG DHLHHGHQRGSLLPLKPQADPPGGGRAPRHRADHVFSCGPXPVHAAGCEILKAVRPSELAAHQCHQRPDHHGGSAGPXVPLHQKQRLRGH LPGSXQWDTPGQRHRDPPDLSHXHQRQRPXAAAQGGADLREAQPERHQHHGGRRXRRPQHRPLRLRAALCPGGRAEELDHHPPERXLCPT QLAHPVPGGRDVXRPHHRHRLWKPSPVQHVHHQSQGVPMXXQRGLHHHWRSGSGWSGHRCHRGHPHLHPHPADHGPAVCHVDEAAREGAP HEAAAHXPRGRRPRQHPQVXRGRRWRGGPGLRPQPAAAAGSHGARAKQSPWRASRGXAAGGRXAPVPDQAHGAAPRRHRXLHQXGTPRCX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NCOA5_ENST00000290231_chr20_44708026_-_CDH4_ENST00000360469_chr20_60318619_+_2620nt ATGAATACGGCTCCATCAAGACCCAGCCCCACACGAAGTCAAGTTCAGCAGCTGTGTGGGGACCAAGGGGACACAATATGAGACCAACAG CATGGACTTCAAAGTTGGGGCAGATGGGACAGTCTTCGCCACCCGGGAGCTGCAGGTCCCCTCCGAGCAGGTGGCGTTCACGGTGACTGC ATGGGACAGCCAGACAGCAGAGAAATGGGACGCCGTGGTGCGGTTGCTGGTGGCCCAGACCTCGTCCCCGCACTCTGGACACAAGCCGCA GAAAGGAAAGAAGGTCGTGGCTCTGGACCCCTCTCCGCCTCCGAAGGACACCCTGCTGCCGTGGCCCCAGCACCAGAACGCCAACGGGCT GAGGCGGCGCAAACGGGACTGGGTCATCCCGCCCATCAACGTGCCCGAGAACTCGCGCGGGCCCTTCCCGCAGCAGCTCGTGAGGATCCG GTCCGACAAAGACAATGACATCCCCATCCGGTACAGCATCACGGGAGTGGGCGCCGACCAGCCCCCCATGGAGGTCTTCAGCATTGACTC CATGTCCGGCCGGATGTACGTCACAAGGCCCATGGACCGGGAGGAGCACGCCTCTTACCACCTCCGAGCCCACGCTGTGGACATGAATGG CAACAAGGTGGAGAACCCCATCGACCTGTACATCTACGTCATCGACATGAATGACAACCGCCCTGAGTTCATCAACCAGGTCTACAACGG CTCCGTGGACGAGGGCTCCAAGCCAGGCACCTACGTGATGACCGTCACGGCCAACGATGCTGACGACAGCACCACGGCCAACGGGATGGT GCGGTACCGGATCGTGACCCAGACCCCACAGAGCCCGTCCCAGAATATGTTCACCATCAACAGCGAGACTGGAGATATCGTCACAGTGGC GGCTGGCCTGGACCGAGAGAAAGTTCAGCAGTACACAGTCATCGTTCAGGCCACAGATATGGAAGGAAATCTCAACTATGGCCTCTCAAA CACAGCCACAGCCATCATCACGGTGACAGATGTGAATGACAACCCGCCAGAATTTACCGCCAGCACGTTTGCAGGGGAGGTCCCCGAAAA CCGCGTGGAGACCGTGGTCGCAAACCTCACGGTGATGGACCGAGATCAGCCCCACTCTCCAAACTGGAATGCCGTTTACCGCATCATCAG TGGGGATCCATCCGGGCACTTCAGCGTCCGCACAGACCCCGTAACCAACGAGGGCATGGTCACCGTGGTGAAGGCAGTCGACTACGAGCT CAACAGAGCTTTCATGCTGACAGTGATGGTGTCCAACCAGGCGCCCCTGGCCAGCGGAATCCAGATGTCCTTCCAGTCCACGGCAGGGGT GACCATCTCCATCATGGACATCAACGAGGCTCCCTACTTCCCCTCAAACCACAAGCTGATCCGCCTGGAGGAGGGCGTGCCCCCCGGCAC CGTGCTGACCACGTTTTCAGCTGTGGACCCTGACCGGTTCATGCAGCAGGCTGTGAGATACTCAAAGCTGTCAGACCCAGCGAGCTGGCT GCACATCAATGCCACCAACGGCCAGATCACCACGGCGGCAGTGCTGGACCGTGAGTCCCTCTACACCAAAAACAACGTCTACGAGGCCAC CTTCCTGGCAGCTGACAATGGGATACCCCCGGCCAGCGGCACCGGGACCCTCCAGATCTATCTCATTGACATCAACGACAACGCCCCTGA GCTGCTGCCCAAGGAGGCGCAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACGGCGGCCGACGCTGACGTCGACCCCAACAT CGGCCCCTACGTCTTCGAGCTGCCCTTTGTCCCGGCGGCCGTGCGGAAGAACTGGACCATCACCCGCCTGAACGGTGACTATGCCCAACT CAGCTTGCGCATCCTGTACCTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGACTCTGGAAACCCTCCCCTGTCCAACACGTC CATCATCAAAGTCAAGGTGTGCCCATGTGATGACAACGGGGACTGCACCACCATTGGCGCAGTGGCAGCGGCTGGTCTGGGCACCGGTGC CATCGTGGCCATCCTCATCTGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATGTGGATGAAGCGGCGAGAGAAGGAGCGCCA CACGAAGCAGCTGCTCATTGACCCCGAGGACGACGTCCGCGACAACATCCTCAAGTATGACGAGGAAGGCGGTGGCGAGGAGGACCAGGA CTACGACCTCAGCCAGCTGCAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCTGGCGTGCGTCGCGTGGATGAGCGGCCGGT GGGCGCTGAGCCCCAGTACCCGATCAGGCCCATGGTGCCGCACCCAGGCGACATCGGTGACTTCATCAATGAGGGACTCCGCGCTGCTGA CAACGACCCCACGGCACCCCCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGCTCCACCGCAGGCTCCGTCAGCTCCCTGAA CTCATCCAGTTCCGGGGACCAAGACTACGATTACCTCAACGACTGGGGGCCCAGATTCAAGAAGCTGGCGGACATGTATGGAGGTGGTGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NCOA5_ENST00000290231_chr20_44708026_-_CDH4_ENST00000360469_chr20_60318619_+_6457nt CGGCCGCCATTGCCTCGTGCCCGCGCCGGTCGGTTGGTGGCGCCTTTGTCCTACGGCGGGCAGGTGGGCCGACGCGGAGGCGGCAGCGGC GGGCCTGAGGCGAAGGAGCGGCCGGGAGCCCGCCGCGCTGGTAGCGATATTAATAAGGCAGCGGAAAGAAGAAATATGAATACGGCTCCA TCAAGACCCAGCCCCACACGAAGTCAAGTTCAGCAGCTGTGTGGGGACCAAGGGGACACAATATGAGACCAACAGCATGGACTTCAAAGT TGGGGCAGATGGGACAGTCTTCGCCACCCGGGAGCTGCAGGTCCCCTCCGAGCAGGTGGCGTTCACGGTGACTGCATGGGACAGCCAGAC AGCAGAGAAATGGGACGCCGTGGTGCGGTTGCTGGTGGCCCAGACCTCGTCCCCGCACTCTGGACACAAGCCGCAGAAAGGAAAGAAGGT CGTGGCTCTGGACCCCTCTCCGCCTCCGAAGGACACCCTGCTGCCGTGGCCCCAGCACCAGAACGCCAACGGGCTGAGGCGGCGCAAACG GGACTGGGTCATCCCGCCCATCAACGTGCCCGAGAACTCGCGCGGGCCCTTCCCGCAGCAGCTCGTGAGGATCCGGTCCGACAAAGACAA TGACATCCCCATCCGGTACAGCATCACGGGAGTGGGCGCCGACCAGCCCCCCATGGAGGTCTTCAGCATTGACTCCATGTCCGGCCGGAT GTACGTCACAAGGCCCATGGACCGGGAGGAGCACGCCTCTTACCACCTCCGAGCCCACGCTGTGGACATGAATGGCAACAAGGTGGAGAA CCCCATCGACCTGTACATCTACGTCATCGACATGAATGACAACCGCCCTGAGTTCATCAACCAGGTCTACAACGGCTCCGTGGACGAGGG CTCCAAGCCAGGCACCTACGTGATGACCGTCACGGCCAACGATGCTGACGACAGCACCACGGCCAACGGGATGGTGCGGTACCGGATCGT GACCCAGACCCCACAGAGCCCGTCCCAGAATATGTTCACCATCAACAGCGAGACTGGAGATATCGTCACAGTGGCGGCTGGCCTGGACCG AGAGAAAGTTCAGCAGTACACAGTCATCGTTCAGGCCACAGATATGGAAGGAAATCTCAACTATGGCCTCTCAAACACAGCCACAGCCAT CATCACGGTGACAGATGTGAATGACAACCCGCCAGAATTTACCGCCAGCACGTTTGCAGGGGAGGTCCCCGAAAACCGCGTGGAGACCGT GGTCGCAAACCTCACGGTGATGGACCGAGATCAGCCCCACTCTCCAAACTGGAATGCCGTTTACCGCATCATCAGTGGGGATCCATCCGG GCACTTCAGCGTCCGCACAGACCCCGTAACCAACGAGGGCATGGTCACCGTGGTGAAGGCAGTCGACTACGAGCTCAACAGAGCTTTCAT GCTGACAGTGATGGTGTCCAACCAGGCGCCCCTGGCCAGCGGAATCCAGATGTCCTTCCAGTCCACGGCAGGGGTGACCATCTCCATCAT GGACATCAACGAGGCTCCCTACTTCCCCTCAAACCACAAGCTGATCCGCCTGGAGGAGGGCGTGCCCCCCGGCACCGTGCTGACCACGTT TTCAGCTGTGGACCCTGACCGGTTCATGCAGCAGGCTGTGAGATACTCAAAGCTGTCAGACCCAGCGAGCTGGCTGCACATCAATGCCAC CAACGGCCAGATCACCACGGCGGCAGTGCTGGACCGTGAGTCCCTCTACACCAAAAACAACGTCTACGAGGCCACCTTCCTGGCAGCTGA CAATGGGATACCCCCGGCCAGCGGCACCGGGACCCTCCAGATCTATCTCATTGACATCAACGACAACGCCCCTGAGCTGCTGCCCAAGGA GGCGCAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACGGCGGCCGACGCTGACGTCGACCCCAACATCGGCCCCTACGTCTT CGAGCTGCCCTTTGTCCCGGCGGCCGTGCGGAAGAACTGGACCATCACCCGCCTGAACGGTGACTATGCCCAACTCAGCTTGCGCATCCT GTACCTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGACTCTGGAAACCCTCCCCTGTCCAACACGTCCATCATCAAAGTCAA GGTGTGCCCATGTGATGACAACGGGGACTGCACCACCATTGGCGCAGTGGCAGCGGCTGGTCTGGGCACCGGTGCCATCGTGGCCATCCT CATCTGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATGTGGATGAAGCGGCGAGAGAAGGAGCGCCACACGAAGCAGCTGCT CATTGACCCCGAGGACGACGTCCGCGACAACATCCTCAAGTATGACGAGGAAGGCGGTGGCGAGGAGGACCAGGACTACGACCTCAGCCA GCTGCAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCTGGCGTGCGTCGCGTGGATGAGCGGCCGGTGGGCGCTGAGCCCCA GTACCCGATCAGGCCCATGGTGCCGCACCCAGGCGACATCGGTGACTTCATCAATGAGGGACTCCGCGCTGCTGACAACGACCCCACGGC ACCCCCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGCTCCACCGCAGGCTCCGTCAGCTCCCTGAACTCATCCAGTTCCGG GGACCAAGACTACGATTACCTCAACGACTGGGGGCCCAGATTCAAGAAGCTGGCGGACATGTATGGAGGTGGTGAAGAGGATTGACTGAC CTCGCATCTTCGGACCGAAGTGAGAGCCGTGCTCGGACGCCGGAGGAGCAGGACTGAGCAGAGGCGGCCGGTCTTCCCGACTCCCTGCGG CTGTGTCCTTAGTGCTGTTAGGAGGCCCCCCAATCCCCACGTTGAGCTGTCTAGCATGAGCACCCACCCCCACAGCGCCCTGCACCCGGC CGCTGCCCAGCACCGCGCTGGCTGGCACTGAAGGACAGCAAGAGGCACTCTGTCTTCACTTGAATTTCCTAGAACAGAAGCACTGTTTTT AAAAAAAAAAAAAAAAAAAGAAGAAAGAAAGAAAAAAAAAAAAAAAAGAAAGTGCCTTTTGGTATGTATCAGATTCCCTCAAACTCAGGA GTGTCTAAAGCAGACAGACCGTCCCCACCTTCCCATCCCGAGCGGCCTCCAACCCCAGCTAGTCCCAGCTCTGAAGGCATCATTCAGAAA TGGGGGAGACTGTGTCTGTCTTTCTTACTTTTTTTTTGGTCTTTTATTAAGAAAAAGAAAGTGGGTGACTTGTTTGAAAACAGAGTGGGG TTCAAATCCCAGCAGCCTTTGCTGTACACAGCTGGGGGTCTCTTGAGCCTCTTGGGAGTCAAGGCCAGCTGGGAGGCTTAGCCCTTCAGC CCCAGCAGAAGGCCCTGGGGCTGGTGGGGCTCAGAATACCCCTACCTTGTGGCTGCTCCCCACCCCTCCCGGATGCTGTGAGGAGCTCAG GCAGGGGCCTGGAGGGGAACAGGGGTCATCCTGAAGGGGCTCCACCCCCAGTCAACCCAGGCCTCCCTCAGGGACACCTGTCACCCTGAG TGCCACCAGGTCCCCTCTGCCTTTGGTCCAGAAGAGTGAGTTGTCCAAACCAGCCAGCATCTGGCTCCAGCCCTCCAACCCTGGCGACCA GACCCCATGGGGTGCCATCAACGGCCCCGCGACAGGCATCAATTCAAACCCCAGGACACTCTCGACAGCTCCAACCATCCGGAGGGCTGT GCAGATGGCAGGAACCAAGGACCCTCCCTGGCAGCTGAAGAGGGCAGTTACGGTTGGGCGTGGTGACCAGAACACACCCAGCAGCCTGCG AAGCCTCCCCGTCCCCAGCCTGTGCTCCTGATTCCCGCCAGACGCTTGTGAGCCTGTGTGGGTGGCAGGAGGCCCCGTCTTGCCGTGCCT ACCTGTCGCACAGATGCCTCTGCACGCTGCAGACGGTGCCTCTCCTCTCCTATGGACCCTCGTCGGGGGCAGGCAGCGGCCGGGTCCAAA CTTGCTGCTGTCCTCGAGGCTGGCACTGCTATCTCCAGGGCTGGGTTGACTCAAGCCAGACAGGGGGAAGGAATTGGTTCTGCAGGACAG TGAGAGGGTCTGTGTCCCGGCACCCCTGGGACAGCGCTCGGCTGCCTGTGCTCACTGCATGAGAAAACTCAGAGGGTGCATTCTCCCTCT GGCATGGCTGTGTCTGGGCGCCTTGGGCTGCGGCAGGGGGCAGGCCCCACGTGGGGAAGCCTCGTGCTTGGTCAGCTTTCTGTCTCTCCC AGGCCAGTGACAACTGGCTTCCCGAGGAAGGAGGTGAGGTACCAGGGACCCTGGGCAGGACCTGGTGTCGGGCAGGGCGGTGCCAGCACT GGGGAAGGACAGGGAGCCCTCCCGGAGCCCCACCCTGCACCTGCCACTGGGGTCAGGGAGTGTCTCGGGGTGCCTTTGGGGGCAGCATGA GCTCCACCAGGGGCCCCGGCCCCCACCTCAGCCTATGGCCCTTCCCCATGGCTAAGGTCATGCCTTTTCTGAACAGCTTTGGCCTTGAGT GCACACATCTGTGCCAGGCTCACGGCATGTTCCCGTTGGATGTCAGGGTCCTTGTCCAAACCAAACTCACAGCTGCCCCTGTGCAGCCTT CAGAGTTGAGCTGGGGTCTCAGTCTCCAACCTGTCCTTTCTGACCCTCCCATGGCTGCCCAGGGAGGGCGGGGTTCACTGTGCCACGTGC TGGGTGCCCCCCTCTGCAGACAGCCAGTCCAGGAGATGGACCAACAGAGGTCAAGGGGCAGCTGGCCAGGCCGCACCGGGGTCCCCGAGT TCTGAGCTGTGCTATGCAAACAAGAATGCTCCTGTGTGGGGGGGCATGGCCGTTGGAGGTATAGCTGGGCGGGTAGTGGAAGGACTGGAA ATCTCTGTTGTTGTTTGGGGAAGTCCATGCTTCAGTCCTTCGGAGTATGCGTGGATTGTTCGAAGTGTGACTATGGCCCGGGAGCCAGGG CAGCATGAACTCCTTTCTCTGAAATTTCGAGGCCTCCTTGGGTTCCCTGAACTCCGGGCTGATGTTCCCAGGACCCAGCACCAGGAGACC CCAGTCCCGCCAGCAGCCGCCGCTACCCAGGAGGGCTGGGCGACATTGGCCGCCTCCCACTAGCTCCCCCTCCTCGCCCACAGCCTCTTG TCACTGCCAAGCCCCCGTTCCTTTTGCCCAAATCACGCAGGCGGAAGCTGCAGTGCCAGCTGGAGGGATGTTCATAGGGCTTCCTGTGCC CATCCCTGCTCCAAACAGCTGGACAGCTTCCCCTCTACCCCCACCCTGGTGAGCCCCTGGGGGCCAGAGAAAGATGGGGTTCCTGCACCT TCCCAGCTCCACCTCTGAACTTGAGTTAGCGTTAGCTAAGCATACAATCAGTGTCGAACGTCTCTCTTCCTTAAGCTTGTAGATACGACT GCCTATAATCAGGGGACTCCCACTGGAGGCCGGGAGGCCAATGCTGGCCAGGTGCGAGGGCATGGTTTGGTTCCTTTAGGGAATTTTTGT TTTGCAAACAGGAGAAACCTGTGCTGCAGGTTGGAGTGGCAGGAACGACTGGCCTTGGTCAGCAGGCAGCCCCCAGCCTAGGGCCACAGT CCTCTTCAGGGCCTGGGCAGCCCCAATTTCTGGCCCAGCAGGTTTCTCTTTGTAGTGTCTTTCAGCACATCCAAAATGCTAGGCCTCCTG CCACCAACGTGTCAGAGCAATGTCCAACTGTCAGGCTCTCAGAGATGCCTCAGTTTCCCTAGCATGAGCACCAGCCGACACACACAGTCC ACTGAGATGATAATTCTGTTCTCTCCAAAGCAAAAAGCTGGGCGAGGGGTAGTCTCAATTTCTGTCAGTGCTCAAAGGAATAACACCAAA AGAATCAACACAGAATCTCCCAGACACACGTGACCCAGCTCGTGGCGCCGTGGGTCCGTAGGAGGGACAGTACCTCACAACAGGCCCAGC GGGGGACCACCTCTCTGTACAATTGGAATGCGTTTTACTTTTCTTTTCTCTCCTTTTTTCATTCCGATTTTTTTTGCATGTTTCTTTTTG AAATGGGCAAAATGTGTAGCAGCCTGCATGAGCACAGTTGTTTTGGGGAAAGATACTGGAGTATGATGTACTCACACCTGCAAATCTGAG CATCGCGAGGTTAAACGTTCCACCTTTTTTTGTAATCGTCAACAGCACAACTATTTTGTATTGTTGTTTGTATCATTTTGTACCAAAAAA AAAAAGGAAAAAAAAAGGGAAGAGAGTTGATGTTTTCAGTGTGTTTCCAGTGCCAGACAGTCTTGGTCCTGAACTCAGTAGACCCTTGCG |
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FusionGenePPI for NCOA5_CDH4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NCOA5 | NCOA5, SRRM1, HTATIP2, CDC37, TSC22D1, DYNC1H1, EIF2S1, DDB1, CEP135, HECW2, KHDRBS3, WDYHV1, SYT16, KHDRBS2, MOV10, NXF1, CUL7, OBSL1, BMI1, RBMX, AMZ2, GALC, NUDT12, B9D2, HNRNPA1, PPP1CB, PPP1CC, MATR3, FAN1, MPHOSPH8, C10orf2, U2AF2, SSU72, CLK2, LRRC4C, SFPQ, TRA2A, DLST | CDH4 | CDH2, CDK5RAP3, FUS, UBE2I, CTNNA3, MTNR1B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NCOA5_CDH4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NCOA5_CDH4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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