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Fusion gene ID: 23684 |
FusionGeneSummary for NCOA4_ARHGAP44 |
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Fusion gene information | Fusion gene name: NCOA4_ARHGAP44 | Fusion gene ID: 23684 | Hgene | Tgene | Gene symbol | NCOA4 | ARHGAP44 | Gene ID | 8031 | 9912 |
Gene name | nuclear receptor coactivator 4 | Rho GTPase activating protein 44 | |
Synonyms | ARA70|ELE1|PTC3|RFG | NPC-A-10|RICH2 | |
Cytomap | 10q11.22 | 17p12 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear receptor coactivator 470 kDa AR-activator70 kDa androgen receptor coactivatorNCoA-4RET-activating gene ELE1androgen receptor-associated protein of 70 kDaret fused | rho GTPase-activating protein 44Rho-type GTPase-activating protein RICH2RhoGAP interacting with CIP4 homologs protein 2rho GTPase-activating protein RICH2 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q13772 | Q17R89 | |
Ensembl transtripts involved in fusion gene | ENST00000438493, ENST00000452682, ENST00000498586, ENST00000430396, ENST00000374087, ENST00000414907, ENST00000344348, ENST00000374082, ENST00000443446, | ENST00000379672, ENST00000340825, ENST00000262444, ENST00000578087, | |
Fusion gene scores | * DoF score | 8 X 4 X 7=224 | 4 X 4 X 4=64 |
# samples | 12 | 5 | |
** MAII score | log2(12/224*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NCOA4 [Title/Abstract] AND ARHGAP44 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NCOA4 | GO:0006622 | protein targeting to lysosome | 25327288 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-V1-A8ML-01A | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000438493 | ENST00000379672 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-3CDS | ENST00000438493 | ENST00000340825 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-3CDS | ENST00000438493 | ENST00000262444 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-intron | ENST00000438493 | ENST00000578087 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-3CDS | ENST00000452682 | ENST00000379672 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-3CDS | ENST00000452682 | ENST00000340825 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-3CDS | ENST00000452682 | ENST00000262444 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-intron | ENST00000452682 | ENST00000578087 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
3UTR-3CDS | ENST00000498586 | ENST00000379672 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
3UTR-3CDS | ENST00000498586 | ENST00000340825 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
3UTR-3CDS | ENST00000498586 | ENST00000262444 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
3UTR-intron | ENST00000498586 | ENST00000578087 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-3CDS | ENST00000430396 | ENST00000379672 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-3CDS | ENST00000430396 | ENST00000340825 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-3CDS | ENST00000430396 | ENST00000262444 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-intron | ENST00000430396 | ENST00000578087 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-3CDS | ENST00000374087 | ENST00000379672 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-3CDS | ENST00000374087 | ENST00000340825 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-3CDS | ENST00000374087 | ENST00000262444 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-intron | ENST00000374087 | ENST00000578087 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-3CDS | ENST00000414907 | ENST00000379672 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-3CDS | ENST00000414907 | ENST00000340825 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-3CDS | ENST00000414907 | ENST00000262444 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
5UTR-intron | ENST00000414907 | ENST00000578087 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
intron-3CDS | ENST00000344348 | ENST00000379672 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
intron-3CDS | ENST00000344348 | ENST00000340825 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
intron-3CDS | ENST00000344348 | ENST00000262444 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
intron-intron | ENST00000344348 | ENST00000578087 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
intron-3CDS | ENST00000374082 | ENST00000379672 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
intron-3CDS | ENST00000374082 | ENST00000340825 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
intron-3CDS | ENST00000374082 | ENST00000262444 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
intron-intron | ENST00000374082 | ENST00000578087 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
intron-3CDS | ENST00000443446 | ENST00000379672 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
intron-3CDS | ENST00000443446 | ENST00000340825 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
intron-3CDS | ENST00000443446 | ENST00000262444 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
intron-intron | ENST00000443446 | ENST00000578087 | NCOA4 | chr10 | 51565296 | - | ARHGAP44 | chr17 | 12862034 | + |
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FusionProtFeatures for NCOA4_ARHGAP44 |
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Hgene | Tgene |
NCOA4 | ARHGAP44 |
Enhances the androgen receptor transcriptional activityin prostate cancer cells. Ligand-independent coactivator of theperoxisome proliferator-activated receptor (PPAR) gamma.{ECO:0000269|PubMed:10347167}. | GTPase-activating protein (GAP) that stimulates theGTPase activity of Rho-type GTPases. Thereby, controls Rho-typeGTPases cycling between their active GTP-bound and inactive GDP-bound states. May act as a GAP for CDC42 and RAC1. Endosomalrecycling protein which, in association with SHANK3, is involvedin synaptic plasticity. Promotes GRIA1 exocytosis from recyclingendosomes and spine morphological changes associated to long-termpotentiation. {ECO:0000269|PubMed:11431473}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NCOA4_ARHGAP44 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NCOA4_ARHGAP44 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NCOA4 | AR, PPARG, ESR1, GTF2B, KAT2B, NR3C1, VDR, AKT1, ATXN2, RXRA, HERC2, XPO1, GRIA2, KDR, KIFC3, PSMC1, XRCC3, HUWE1, PSMD14, TFG, KIF21A, USP43, FTH1, FTL, GMCL1, NEURL4 | ARHGAP44 | HN1, CDC42, RAC1, TRIP10, TIPRL, ARHGAP17, FNBP1L, SH3BP1, SH3KBP1, CD2AP, CASP5, PPP3CC, WDTC1, VPS26A, SLC9A3R2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NCOA4_ARHGAP44 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NCOA4_ARHGAP44 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NCOA4 | C0040136 | Thyroid Neoplasm | 1 | CTD_human |