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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23681

FusionGeneSummary for NCOA3_SULF2

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOA3_SULF2
Fusion gene ID: 23681
HgeneTgene
Gene symbol

NCOA3

SULF2

Gene ID

8202

55959

Gene namenuclear receptor coactivator 3sulfatase 2
SynonymsACTR|AIB-1|AIB1|CAGH16|CTG26|KAT13B|RAC3|SRC-3|SRC3|TNRC14|TNRC16|TRAM-1|bHLHe42|pCIPHSULF-2
Cytomap

20q13.12

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor coactivator 3CBP-interacting proteinamplified in breast cancer 1 proteinclass E basic helix-loop-helix protein 42receptor-associated coactivator 3steroid receptor coactivator protein 3thyroid hormone receptor activator molecule 1extracellular sulfatase Sulf-2
Modification date2018052320180519
UniProtAcc

Q9Y6Q9

Q8IWU5

Ensembl transtripts involved in fusion geneENST00000341724, ENST00000372004, 
ENST00000371998, ENST00000371997, 
ENST00000497292, 		ENST00000359930, 
ENST00000484875, ENST00000361612, 
ENST00000467815, ENST00000478766, 
Fusion gene scores* DoF score17 X 8 X 9=12243 X 3 X 4=36
# samples 214
** MAII scorelog2(21/1224*10)=-2.54314232502653
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NCOA3 [Title/Abstract] AND SULF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOA3

GO:0045944

positive regulation of transcription by RNA polymerase II

9267036

HgeneNCOA3

GO:0071392

cellular response to estradiol stimulus

15831516

TgeneSULF2

GO:0030177

positive regulation of Wnt signaling pathway

19520866

TgeneSULF2

GO:0030201

heparan sulfate proteoglycan metabolic process

18687675


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-N6-A4VE-01ANCOA3chr20

46276110

+SULF2chr20

46331414

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000341724ENST00000359930NCOA3chr20

46276110

+SULF2chr20

46331414

-
Frame-shiftENST00000341724ENST00000484875NCOA3chr20

46276110

+SULF2chr20

46331414

-
Frame-shiftENST00000341724ENST00000361612NCOA3chr20

46276110

+SULF2chr20

46331414

-
Frame-shiftENST00000341724ENST00000467815NCOA3chr20

46276110

+SULF2chr20

46331414

-
5CDS-intronENST00000341724ENST00000478766NCOA3chr20

46276110

+SULF2chr20

46331414

-
Frame-shiftENST00000372004ENST00000359930NCOA3chr20

46276110

+SULF2chr20

46331414

-
Frame-shiftENST00000372004ENST00000484875NCOA3chr20

46276110

+SULF2chr20

46331414

-
Frame-shiftENST00000372004ENST00000361612NCOA3chr20

46276110

+SULF2chr20

46331414

-
Frame-shiftENST00000372004ENST00000467815NCOA3chr20

46276110

+SULF2chr20

46331414

-
5CDS-intronENST00000372004ENST00000478766NCOA3chr20

46276110

+SULF2chr20

46331414

-
Frame-shiftENST00000371998ENST00000359930NCOA3chr20

46276110

+SULF2chr20

46331414

-
Frame-shiftENST00000371998ENST00000484875NCOA3chr20

46276110

+SULF2chr20

46331414

-
Frame-shiftENST00000371998ENST00000361612NCOA3chr20

46276110

+SULF2chr20

46331414

-
Frame-shiftENST00000371998ENST00000467815NCOA3chr20

46276110

+SULF2chr20

46331414

-
5CDS-intronENST00000371998ENST00000478766NCOA3chr20

46276110

+SULF2chr20

46331414

-
Frame-shiftENST00000371997ENST00000359930NCOA3chr20

46276110

+SULF2chr20

46331414

-
Frame-shiftENST00000371997ENST00000484875NCOA3chr20

46276110

+SULF2chr20

46331414

-
Frame-shiftENST00000371997ENST00000361612NCOA3chr20

46276110

+SULF2chr20

46331414

-
Frame-shiftENST00000371997ENST00000467815NCOA3chr20

46276110

+SULF2chr20

46331414

-
5CDS-intronENST00000371997ENST00000478766NCOA3chr20

46276110

+SULF2chr20

46331414

-
intron-3CDSENST00000497292ENST00000359930NCOA3chr20

46276110

+SULF2chr20

46331414

-
intron-3CDSENST00000497292ENST00000484875NCOA3chr20

46276110

+SULF2chr20

46331414

-
intron-3CDSENST00000497292ENST00000361612NCOA3chr20

46276110

+SULF2chr20

46331414

-
intron-3CDSENST00000497292ENST00000467815NCOA3chr20

46276110

+SULF2chr20

46331414

-
intron-intronENST00000497292ENST00000478766NCOA3chr20

46276110

+SULF2chr20

46331414

-

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FusionProtFeatures for NCOA3_SULF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOA3

Q9Y6Q9

SULF2

Q8IWU5

Exhibits arylsulfatase activity and highly specificendoglucosamine-6-sulfatase activity. It can remove sulfate fromthe C-6 position of glucosamine within specific subregions ofintact heparin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NCOA3_SULF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NCOA3_SULF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NCOA3AR, BRCA1, EP300, ANKRD11, NPAS2, NR3C1, YWHAQ, PRMT1, NR4A1, NR2F1, RXRA, CCND1, ESRRA, ESRRB, NKX2-1, CREBBP, ESR1, ESR2, NR0B2, NR5A2, NCOA2, TRIM21, IKBKG, IKBKB, CHUK, VDR, PGR, HIST3H3, HIST4H4, CARM1, ABL1, FOS, NCOR1, ETS1, ETS2, PPARG, NCOA1, THRA, STAT6, SMAD2, SMAD3, ATAD2, KAT2B, RARA, NCOR2, SPOP, CDKN3, IQCK, BRE, DCTN6, CSNK1E, RARG, NR1H3, NR1H2, THRB, SPTA1, MYH9, ACTA1, ANXA2, TPR, MORC2, NFATC3, PSME3, EIF3E, CUL3, NFKB1, MAPK14, MAPK1, MAPK8, GSK3B, RFX1, TP53BP1, PSMC5, PRKCZ, TFF1, PSMA3, MYOCD, CEBPA, CEBPD, UBE3A, E2F1, PIN1, ELAVL1, TP53, KANK2, NR1I2, ALB, MMS19, PTEN, FBXW7, ARNT2, PSMB9, ETV1, PPARD, PPARA, NR1I3, MN1, MKL1, MKL2, HNF1A, RELA, EWSR1, XPO1, XRCC5, TMEM132A, PIAS1, RAB28, FOXA1SULF2MYC, PTCH1, CASQ2, NAAA, PON2, CSGALNACT2, APP, LRRC4C, DEFA1, GPR156, OS9, KBTBD7, SDC2, DKK3, DEFA5, TRPC4AP, GNS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCOA3_SULF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NCOA3_SULF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOA3C0023418leukemia2CTD_human
HgeneNCOA3C0033578Prostatic Neoplasms2CTD_human
HgeneNCOA3C0001418Adenocarcinoma1CTD_human
HgeneNCOA3C0004114Astrocytoma1CTD_human
HgeneNCOA3C0005967Bone neoplasms1CTD_human
HgeneNCOA3C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneNCOA3C0007137Squamous cell carcinoma1CTD_human
HgeneNCOA3C1458155Mammary Neoplasms1CTD_human
TgeneSULF2C0014175Endometriosis2CTD_human