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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23680

FusionGeneSummary for NCOA3_SLAIN1

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOA3_SLAIN1
Fusion gene ID: 23680
HgeneTgene
Gene symbol

NCOA3

SLAIN1

Gene ID

8202

122060

Gene namenuclear receptor coactivator 3SLAIN motif family member 1
SynonymsACTR|AIB-1|AIB1|CAGH16|CTG26|KAT13B|RAC3|SRC-3|SRC3|TNRC14|TNRC16|TRAM-1|bHLHe42|pCIPC13orf32
Cytomap

20q13.12

13q22.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor coactivator 3CBP-interacting proteinamplified in breast cancer 1 proteinclass E basic helix-loop-helix protein 42receptor-associated coactivator 3steroid receptor coactivator protein 3thyroid hormone receptor activator molecule 1SLAIN motif-containing protein 1
Modification date2018052320180519
UniProtAcc

Q9Y6Q9

Q8ND83

Ensembl transtripts involved in fusion geneENST00000341724, ENST00000372004, 
ENST00000371998, ENST00000371997, 
ENST00000497292, 
ENST00000466548, 
ENST00000418532, ENST00000488699, 
ENST00000267219, ENST00000351546, 
ENST00000465831, ENST00000314070, 
ENST00000358679, 
Fusion gene scores* DoF score17 X 8 X 9=12244 X 4 X 2=32
# samples 214
** MAII scorelog2(21/1224*10)=-2.54314232502653
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NCOA3 [Title/Abstract] AND SLAIN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOA3

GO:0045944

positive regulation of transcription by RNA polymerase II

9267036

HgeneNCOA3

GO:0071392

cellular response to estradiol stimulus

15831516


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA523336NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000341724ENST00000466548NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-5UTRENST00000341724ENST00000418532NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-5UTRENST00000341724ENST00000488699NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000341724ENST00000267219NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000341724ENST00000351546NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000341724ENST00000465831NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000341724ENST00000314070NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000341724ENST00000358679NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-3CDSENST00000372004ENST00000466548NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-5UTRENST00000372004ENST00000418532NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-5UTRENST00000372004ENST00000488699NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000372004ENST00000267219NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000372004ENST00000351546NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000372004ENST00000465831NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000372004ENST00000314070NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000372004ENST00000358679NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-3CDSENST00000371998ENST00000466548NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-5UTRENST00000371998ENST00000418532NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-5UTRENST00000371998ENST00000488699NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000371998ENST00000267219NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000371998ENST00000351546NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000371998ENST00000465831NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000371998ENST00000314070NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000371998ENST00000358679NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-3CDSENST00000371997ENST00000466548NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-5UTRENST00000371997ENST00000418532NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-5UTRENST00000371997ENST00000488699NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000371997ENST00000267219NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000371997ENST00000351546NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000371997ENST00000465831NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000371997ENST00000314070NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
5UTR-intronENST00000371997ENST00000358679NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
intron-3CDSENST00000497292ENST00000466548NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
intron-5UTRENST00000497292ENST00000418532NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
intron-5UTRENST00000497292ENST00000488699NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
intron-intronENST00000497292ENST00000267219NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
intron-intronENST00000497292ENST00000351546NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
intron-intronENST00000497292ENST00000465831NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
intron-intronENST00000497292ENST00000314070NCOA3chr20

46130765

+SLAIN1chr13

78293665

+
intron-intronENST00000497292ENST00000358679NCOA3chr20

46130765

+SLAIN1chr13

78293665

+

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FusionProtFeatures for NCOA3_SLAIN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOA3

Q9Y6Q9

SLAIN1

Q8ND83

Microtubule plus-end tracking protein that might beinvolved in the regulation of cytoplasmic microtubule dynamics,microtubule organization and microtubule elongation.{ECO:0000269|PubMed:21646404}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NCOA3_SLAIN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NCOA3_SLAIN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NCOA3AR, BRCA1, EP300, ANKRD11, NPAS2, NR3C1, YWHAQ, PRMT1, NR4A1, NR2F1, RXRA, CCND1, ESRRA, ESRRB, NKX2-1, CREBBP, ESR1, ESR2, NR0B2, NR5A2, NCOA2, TRIM21, IKBKG, IKBKB, CHUK, VDR, PGR, HIST3H3, HIST4H4, CARM1, ABL1, FOS, NCOR1, ETS1, ETS2, PPARG, NCOA1, THRA, STAT6, SMAD2, SMAD3, ATAD2, KAT2B, RARA, NCOR2, SPOP, CDKN3, IQCK, BRE, DCTN6, CSNK1E, RARG, NR1H3, NR1H2, THRB, SPTA1, MYH9, ACTA1, ANXA2, TPR, MORC2, NFATC3, PSME3, EIF3E, CUL3, NFKB1, MAPK14, MAPK1, MAPK8, GSK3B, RFX1, TP53BP1, PSMC5, PRKCZ, TFF1, PSMA3, MYOCD, CEBPA, CEBPD, UBE3A, E2F1, PIN1, ELAVL1, TP53, KANK2, NR1I2, ALB, MMS19, PTEN, FBXW7, ARNT2, PSMB9, ETV1, PPARD, PPARA, NR1I3, MN1, MKL1, MKL2, HNF1A, RELA, EWSR1, XPO1, XRCC5, TMEM132A, PIAS1, RAB28, FOXA1SLAIN1FHL3, PSMA3, POTEB3, ALOX5, KLHL40, HSPA9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCOA3_SLAIN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NCOA3_SLAIN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOA3C0023418leukemia2CTD_human
HgeneNCOA3C0033578Prostatic Neoplasms2CTD_human
HgeneNCOA3C0001418Adenocarcinoma1CTD_human
HgeneNCOA3C0004114Astrocytoma1CTD_human
HgeneNCOA3C0005967Bone neoplasms1CTD_human
HgeneNCOA3C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneNCOA3C0007137Squamous cell carcinoma1CTD_human
HgeneNCOA3C1458155Mammary Neoplasms1CTD_human