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Fusion gene ID: 2366 |
FusionGeneSummary for ARHGAP10_SPATA5 |
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Fusion gene information | Fusion gene name: ARHGAP10_SPATA5 | Fusion gene ID: 2366 | Hgene | Tgene | Gene symbol | ARHGAP10 | SPATA5 | Gene ID | 79658 | 166378 |
Gene name | Rho GTPase activating protein 10 | spermatogenesis associated 5 | |
Synonyms | GRAF2|PS-GAP|PSGAP | AFG2|EHLMRS|SPAF | |
Cytomap | 4q31.23 | 4q28.1 | |
Type of gene | protein-coding | protein-coding | |
Description | rho GTPase-activating protein 10GTPase regulator associated with focal adhesion kinase 2graf-related protein 2rho-type GTPase-activating protein 10 | spermatogenesis-associated protein 5ATPase family gene 2 homologATPase family protein 2 homologspermatogenesis associated factor SPAFspermatogenesis-associated factor protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | A1A4S6 | Q8NB90 | |
Ensembl transtripts involved in fusion gene | ENST00000336498, ENST00000414545, ENST00000510076, | ENST00000274008, ENST00000422835, | |
Fusion gene scores | * DoF score | 4 X 5 X 5=100 | 3 X 3 X 2=18 |
# samples | 6 | 4 | |
** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ARHGAP10 [Title/Abstract] AND SPATA5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A2-A0CL-01A | ARHGAP10 | chr4 | 148778805 | + | SPATA5 | chr4 | 124235043 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000336498 | ENST00000274008 | ARHGAP10 | chr4 | 148778805 | + | SPATA5 | chr4 | 124235043 | + |
5CDS-intron | ENST00000336498 | ENST00000422835 | ARHGAP10 | chr4 | 148778805 | + | SPATA5 | chr4 | 124235043 | + |
intron-3CDS | ENST00000414545 | ENST00000274008 | ARHGAP10 | chr4 | 148778805 | + | SPATA5 | chr4 | 124235043 | + |
intron-intron | ENST00000414545 | ENST00000422835 | ARHGAP10 | chr4 | 148778805 | + | SPATA5 | chr4 | 124235043 | + |
intron-3CDS | ENST00000510076 | ENST00000274008 | ARHGAP10 | chr4 | 148778805 | + | SPATA5 | chr4 | 124235043 | + |
intron-intron | ENST00000510076 | ENST00000422835 | ARHGAP10 | chr4 | 148778805 | + | SPATA5 | chr4 | 124235043 | + |
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FusionProtFeatures for ARHGAP10_SPATA5 |
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Hgene | Tgene |
ARHGAP10 | SPATA5 |
GTPase activator for the small GTPases RhoA and Cdc42 byconverting them to an inactive GDP-bound state. Essential forPTKB2 regulation of cytoskeletal organization via Rho familyGTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinaseactivity and changes its localization from the nucleus to theperinuclear region. Stabilizes PAK-2p34 thereby increasingstimulation of cell death (By similarity). {ECO:0000250,ECO:0000269|PubMed:11432776}. | May be involved in morphological and functionalmitochondrial transformations during spermatogenesis.{ECO:0000250|UniProtKB:Q3UMC0}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ARHGAP10_SPATA5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ARHGAP10_SPATA5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ARHGAP10 | PKN3, RHOA, CDC42, YWHAQ, C2CD2, SH3BP2, ANKS1A, FOXQ1, PTPN12, ARHGAP26, NRXN1, ARF6 | SPATA5 | FAS, DNASE2B, FBXW11, NTRK1, BTRC, CEP135, PSMD14, SNW1, CDC5L, SPATA5, SPATA5L1, CINP, C1orf109, WBSCR16, PFDN5, ATAD3A, RCN2, AIFM1, PFDN2, DKKL1, C15orf26 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARHGAP10_SPATA5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARHGAP10_SPATA5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SPATA5 | C0036341 | Schizophrenia | 1 | CTD_human |
Tgene | SPATA5 | C4225276 | EPILEPSY, HEARING LOSS, AND MENTAL RETARDATION SYNDROME | 1 | ORPHANET;UNIPROT |