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Fusion gene ID: 2364 |
FusionGeneSummary for ARHGAP10_EDNRA |
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Fusion gene information | Fusion gene name: ARHGAP10_EDNRA | Fusion gene ID: 2364 | Hgene | Tgene | Gene symbol | ARHGAP10 | EDNRA | Gene ID | 79658 | 1909 |
Gene name | Rho GTPase activating protein 10 | endothelin receptor type A | |
Synonyms | GRAF2|PS-GAP|PSGAP | ET-A|ETA|ETA-R|ETAR|ETRA|MFDA|hET-AR | |
Cytomap | 4q31.23 | 4q31.22-q31.23 | |
Type of gene | protein-coding | protein-coding | |
Description | rho GTPase-activating protein 10GTPase regulator associated with focal adhesion kinase 2graf-related protein 2rho-type GTPase-activating protein 10 | endothelin-1 receptorG protein-coupled receptorendothelin receptor subtype Aendothelin-1-specific receptor | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | A1A4S6 | P25101 | |
Ensembl transtripts involved in fusion gene | ENST00000336498, ENST00000414545, ENST00000510076, | ENST00000339690, ENST00000358556, ENST00000511804, ENST00000324300, ENST00000506066, ENST00000503721, | |
Fusion gene scores | * DoF score | 4 X 5 X 5=100 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ARHGAP10 [Title/Abstract] AND EDNRA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-A3LS-01A | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000336498 | ENST00000339690 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
5CDS-intron | ENST00000336498 | ENST00000358556 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
5CDS-5UTR | ENST00000336498 | ENST00000511804 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
5CDS-5UTR | ENST00000336498 | ENST00000324300 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
5CDS-intron | ENST00000336498 | ENST00000506066 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
5CDS-intron | ENST00000336498 | ENST00000503721 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
5CDS-intron | ENST00000414545 | ENST00000339690 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
5CDS-intron | ENST00000414545 | ENST00000358556 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
5CDS-5UTR | ENST00000414545 | ENST00000511804 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
5CDS-5UTR | ENST00000414545 | ENST00000324300 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
5CDS-intron | ENST00000414545 | ENST00000506066 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
5CDS-intron | ENST00000414545 | ENST00000503721 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
intron-intron | ENST00000510076 | ENST00000339690 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
intron-intron | ENST00000510076 | ENST00000358556 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
intron-5UTR | ENST00000510076 | ENST00000511804 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
intron-5UTR | ENST00000510076 | ENST00000324300 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
intron-intron | ENST00000510076 | ENST00000506066 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
intron-intron | ENST00000510076 | ENST00000503721 | ARHGAP10 | chr4 | 148887990 | + | EDNRA | chr4 | 148441003 | + |
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FusionProtFeatures for ARHGAP10_EDNRA |
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Hgene | Tgene |
ARHGAP10 | EDNRA |
GTPase activator for the small GTPases RhoA and Cdc42 byconverting them to an inactive GDP-bound state. Essential forPTKB2 regulation of cytoskeletal organization via Rho familyGTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinaseactivity and changes its localization from the nucleus to theperinuclear region. Stabilizes PAK-2p34 thereby increasingstimulation of cell death (By similarity). {ECO:0000250,ECO:0000269|PubMed:11432776}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ARHGAP10_EDNRA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ARHGAP10_EDNRA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ARHGAP10 | PKN3, RHOA, CDC42, YWHAQ, C2CD2, SH3BP2, ANKS1A, FOXQ1, PTPN12, ARHGAP26, NRXN1, ARF6 | EDNRA | KAT5, HDAC7, GNA11, COPS5, ARRB1, ARRB2, SRC, VPS11, EDN1, ARL5B, SYNGR2, ND1, SLC5A3, EBP, MTX1, LMBR1, COX1, PXMP2, MCL1, VKORC1L1, BCL2L11 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARHGAP10_EDNRA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | EDNRA | P25101 | DB08932 | Macitentan | Endothelin-1 receptor {ECO:0000305} | small molecule | approved |
Tgene | EDNRA | P25101 | DB00559 | Bosentan | Endothelin-1 receptor {ECO:0000305} | small molecule | approved|investigational |
Tgene | EDNRA | P25101 | DB06403 | Ambrisentan | Endothelin-1 receptor {ECO:0000305} | small molecule | approved|investigational |
Tgene | EDNRA | P25101 | DB06268 | Sitaxentan | Endothelin-1 receptor {ECO:0000305} | small molecule | approved|investigational|withdrawn |
Tgene | EDNRA | P25101 | DB00945 | Acetylsalicylic acid | Endothelin-1 receptor {ECO:0000305} | small molecule | approved|vet_approved |
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RelatedDiseases for ARHGAP10_EDNRA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | EDNRA | C0019284 | Diaphragmatic Hernia | 2 | CTD_human |
Tgene | EDNRA | C0376634 | Craniofacial Abnormalities | 2 | CTD_human |
Tgene | EDNRA | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Tgene | EDNRA | C0018798 | Congenital Heart Defects | 1 | CTD_human |
Tgene | EDNRA | C0020538 | Hypertensive disease | 1 | CTD_human |
Tgene | EDNRA | C0027439 | Nasopharyngeal Neoplasms | 1 | CTD_human |
Tgene | EDNRA | C0242350 | Erectile dysfunction | 1 | CTD_human |
Tgene | EDNRA | C0520679 | Sleep Apnea, Obstructive | 1 | CTD_human |
Tgene | EDNRA | C0919267 | ovarian neoplasm | 1 | CTD_human |
Tgene | EDNRA | C4225349 | MANDIBULOFACIAL DYSOSTOSIS WITH ALOPECIA | 1 | ORPHANET;UNIPROT |