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Fusion gene ID: 23630 |
FusionGeneSummary for NCL_PLXNB1 |
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Fusion gene information | Fusion gene name: NCL_PLXNB1 | Fusion gene ID: 23630 | Hgene | Tgene | Gene symbol | NCL | PLXNB1 | Gene ID | 80331 | 5364 |
Gene name | DnaJ heat shock protein family (Hsp40) member C5 | plexin B1 | |
Synonyms | CLN4|CLN4B|CSP|DNAJC5A|NCL|mir-941-2|mir-941-3|mir-941-4|mir-941-5 | PLEXIN-B1|PLXN5|SEP | |
Cytomap | 20q13.33 | 3p21.31 | |
Type of gene | protein-coding | protein-coding | |
Description | dnaJ homolog subfamily C member 5DnaJ (Hsp40) homolog, subfamily C, member 5ceroid-lipofuscinosis neuronal protein 4cysteine string protein alpha | plexin-B1plexin 5semaphorin receptor SEP | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P19338 | O43157 | |
Ensembl transtripts involved in fusion gene | ENST00000322723, | ENST00000296440, ENST00000358459, ENST00000358536, ENST00000448774, ENST00000456774, ENST00000465117, | |
Fusion gene scores | * DoF score | 18 X 18 X 6=1944 | 6 X 6 X 3=108 |
# samples | 22 | 5 | |
** MAII score | log2(22/1944*10)=-3.14345279008112 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/108*10)=-1.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NCL [Title/Abstract] AND PLXNB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PLXNB1 | GO:0007162 | negative regulation of cell adhesion | 15218527 |
Tgene | PLXNB1 | GO:0008360 | regulation of cell shape | 19843518 |
Tgene | PLXNB1 | GO:0051493 | regulation of cytoskeleton organization | 19843518 |
Tgene | PLXNB1 | GO:0071526 | semaphorin-plexin signaling pathway | 15218527|19843518 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI042033 | NCL | chr2 | 232319949 | + | PLXNB1 | chr3 | 48445976 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000322723 | ENST00000296440 | NCL | chr2 | 232319949 | + | PLXNB1 | chr3 | 48445976 | + |
intron-3CDS | ENST00000322723 | ENST00000358459 | NCL | chr2 | 232319949 | + | PLXNB1 | chr3 | 48445976 | + |
intron-3CDS | ENST00000322723 | ENST00000358536 | NCL | chr2 | 232319949 | + | PLXNB1 | chr3 | 48445976 | + |
intron-3CDS | ENST00000322723 | ENST00000448774 | NCL | chr2 | 232319949 | + | PLXNB1 | chr3 | 48445976 | + |
intron-3CDS | ENST00000322723 | ENST00000456774 | NCL | chr2 | 232319949 | + | PLXNB1 | chr3 | 48445976 | + |
intron-intron | ENST00000322723 | ENST00000465117 | NCL | chr2 | 232319949 | + | PLXNB1 | chr3 | 48445976 | + |
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FusionProtFeatures for NCL_PLXNB1 |
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Hgene | Tgene |
NCL | PLXNB1 |
Nucleolin is the major nucleolar protein of growingeukaryotic cells. It is found associated with intranucleolarchromatin and pre-ribosomal particles. It induces chromatindecondensation by binding to histone H1. It is thought to play arole in pre-rRNA transcription and ribosome assembly. May play arole in the process of transcriptional elongation. Binds RNAoligonucleotides with 5'-UUAGGG-3' repeats more tightly than thetelomeric single-stranded DNA 5'-TTAGGG-3' repeats.{ECO:0000269|PubMed:10393184}. | Receptor for SEMA4D. Plays a role in RHOA activation andsubsequent changes of the actin cytoskeleton. Plays a role in axonguidance, invasive growth and cell migration.{ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496,ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518,ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NCL_PLXNB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NCL_PLXNB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NCL_PLXNB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NCL_PLXNB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NCL | C0151744 | Myocardial Ischemia | 1 | CTD_human |