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Fusion gene ID: 23595 |
FusionGeneSummary for NCK2_NUP93 |
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Fusion gene information | Fusion gene name: NCK2_NUP93 | Fusion gene ID: 23595 | Hgene | Tgene | Gene symbol | NCK2 | NUP93 | Gene ID | 8440 | 9688 |
Gene name | NCK adaptor protein 2 | nucleoporin 93 | |
Synonyms | GRB4|NCKbeta | NIC96 | |
Cytomap | 2q12.2 | 16q13 | |
Type of gene | protein-coding | protein-coding | |
Description | cytoplasmic protein NCK2SH2/SH3 adaptor protein NCK-betagrowth factor receptor-bound protein 4noncatalytic region of tyrosine kinase, beta | nuclear pore complex protein Nup9393 kDa nucleoporinnucleoporin 93kDanucleoporin Nup93 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | O43639 | Q8N1F7 | |
Ensembl transtripts involved in fusion gene | ENST00000233154, ENST00000451463, ENST00000522586, ENST00000393349, | ENST00000308159, ENST00000569842, ENST00000564887, ENST00000569595, ENST00000542526, | |
Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 8 X 8 X 5=320 |
# samples | 6 | 7 | |
** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/320*10)=-2.1926450779424 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NCK2 [Title/Abstract] AND NUP93 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NCK2 | GO:0033137 | negative regulation of peptidyl-serine phosphorylation | 16835242 |
Hgene | NCK2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10026169 |
Hgene | NCK2 | GO:1903912 | negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation | 16835242 |
Tgene | NUP93 | GO:0006998 | nuclear envelope organization | 26878725 |
Tgene | NUP93 | GO:0051292 | nuclear pore complex assembly | 26878725 |
Tgene | NUP93 | GO:0060391 | positive regulation of SMAD protein signal transduction | 26878725 |
Tgene | NUP93 | GO:0060395 | SMAD protein signal transduction | 26878725 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | MESO | TCGA-ZN-A9VP-01A | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000233154 | ENST00000308159 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-5UTR | ENST00000233154 | ENST00000569842 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-intron | ENST00000233154 | ENST00000564887 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-intron | ENST00000233154 | ENST00000569595 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-intron | ENST00000233154 | ENST00000542526 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-5UTR | ENST00000451463 | ENST00000308159 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-5UTR | ENST00000451463 | ENST00000569842 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-intron | ENST00000451463 | ENST00000564887 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-intron | ENST00000451463 | ENST00000569595 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-intron | ENST00000451463 | ENST00000542526 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-5UTR | ENST00000522586 | ENST00000308159 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-5UTR | ENST00000522586 | ENST00000569842 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-intron | ENST00000522586 | ENST00000564887 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-intron | ENST00000522586 | ENST00000569595 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-intron | ENST00000522586 | ENST00000542526 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-5UTR | ENST00000393349 | ENST00000308159 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-5UTR | ENST00000393349 | ENST00000569842 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-intron | ENST00000393349 | ENST00000564887 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-intron | ENST00000393349 | ENST00000569595 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
5CDS-intron | ENST00000393349 | ENST00000542526 | NCK2 | chr2 | 106471745 | + | NUP93 | chr16 | 56782146 | + |
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FusionProtFeatures for NCK2_NUP93 |
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Hgene | Tgene |
NCK2 | NUP93 |
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellularsubstrates. Maintains low levels of EIF2S1 phosphorylation bypromoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Rassignaling. {ECO:0000269|PubMed:10026169,ECO:0000269|PubMed:16835242}. | Plays a role in the nuclear pore complex (NPC) assemblyand/or maintenance (PubMed:9348540). May anchor nucleoporins, butnot NUP153 and TPR, to the NPC. During renal development,regulates podocyte migration and proliferation through SMAD4signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283,ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725,ECO:0000269|PubMed:9348540}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NCK2_NUP93 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NCK2_NUP93 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NCK2 | ABI2, TRIP6, KIAA1217, NCKIPSD, SF3B4, CBLB, WBP11, CPSF6, FXR2, CPSF7, HNRNPK, EEF1G, EGFR, PDGFRB, DOK1, DOCK1, WIPF2, CD3E, PTK2, PAK1, PKN2, SOS1, NTRK2, LIMS1, ILK, IRS1, MASP1, KHDRBS1, BLNK, FASLG, ATN1, EFNB1, ABI1, AXIN1, DNM1, ERBB2, ERBB3, SRPK2, SRPK1, SYNPO, WAS, CBL, PSMD10, CHN1, DVL1, NR5A1, HOXC4, LCP2, MAGEA6, MEOX2, REL, TRIM27, TCF4, TNR, RASSF7, NCK2, SORBS2, EIF3H, WASL, ARHGAP32, SPRY2, DRAP1, ZBTB7B, ABI3, FAM53C, BCL11A, VARS2, HOMEZ, RBM26, FCRL2, VPS37B, CCDC33, EFHC2, LZTS2, LNX1, TRIM41, PRR20A, LRRIQ3, UBC, DYX1C1, NCK1, SH3PXD2B, ARAP1, NCKAP1, ABL2, GIT2, GIT1, RAPH1, BAIAP2, ASAP2, ASAP1, CYFIP2, CYFIP1, PRRC2A, TNK2, MAP4K4, MINK1, TNIK, PAK2, NHSL1, CASKIN2, PEAK1, ARHGEF7, ARHGEF6, WASF1, WASF2, WASF3, TTC28, PIK3AP1, SHB, WIPF1, KIAA1522, NHSL2, MLLT4, WIPF3, LZTR1, SEMA6A, FAM83H, BRK1, FAM217B, FYB, SORBS1, CEP170, CEP44, CEP19, TRIM15, FGFR1, CDH1, PTPN12, LRFN4, DOK2, CPNE5, YLPM1, SMARCB1 | NUP93 | PHLDA3, GIPC1, CASP4, PNKP, NEK6, TSC22D1, PHB2, BRF2, MYC, TPR, PAN2, RAE1, AIRE, CLN3, RYK, HDAC5, PIDD1, ELAVL1, SIRT7, CUL3, NXF1, TLN2, ECT2, VCAM1, ITGA4, AICDA, SOX2, HDAC9, HDAC11, ADRB2, BAG3, NUP62, EGFR, FBXO6, CUL7, OBSL1, CCDC8, SUZ12, EED, RNF2, KCMF1, FGG, MTPN, NUP205, NUP188, UBA1, UBA6, UCHL3, NTRK1, SCARNA22, KRAS, IFI16, NUP35, KPNB1, UBE2I, XRCC3, NUPL1, NUP153, NUP107, SEH1L, CDC5L, SENP3, RNF126, OTUB1, BMI1, CTDSPL2, DLST, PDHA1, SOD1, BRCA1, TES |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NCK2_NUP93 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NCK2_NUP93 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NCK2 | C0001925 | Albuminuria | 1 | CTD_human |
Hgene | NCK2 | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
Hgene | NCK2 | C0033687 | Proteinuria | 1 | CTD_human |
Tgene | NUP93 | C1868672 | NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE | 1 | CTD_human |
Tgene | NUP93 | C4225166 | NEPHROTIC SYNDROME, TYPE 12 | 1 | UNIPROT |