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Fusion gene ID: 23594 |
FusionGeneSummary for NCK2_MRPS9 |
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Fusion gene information | Fusion gene name: NCK2_MRPS9 | Fusion gene ID: 23594 | Hgene | Tgene | Gene symbol | NCK2 | MRPS9 | Gene ID | 8440 | 64965 |
Gene name | NCK adaptor protein 2 | mitochondrial ribosomal protein S9 | |
Synonyms | GRB4|NCKbeta | MRP-S9|RPMS9|S9mt | |
Cytomap | 2q12.2 | 2q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cytoplasmic protein NCK2SH2/SH3 adaptor protein NCK-betagrowth factor receptor-bound protein 4noncatalytic region of tyrosine kinase, beta | 28S ribosomal protein S9, mitochondrialmitochondrial small ribosomal subunit protein uS9m | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | O43639 | P82933 | |
Ensembl transtripts involved in fusion gene | ENST00000233154, ENST00000451463, ENST00000522586, ENST00000393349, | ENST00000258455, | |
Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 3 X 3 X 3=27 |
# samples | 6 | 3 | |
** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NCK2 [Title/Abstract] AND MRPS9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NCK2 | GO:0033137 | negative regulation of peptidyl-serine phosphorylation | 16835242 |
Hgene | NCK2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10026169 |
Hgene | NCK2 | GO:1903912 | negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation | 16835242 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-VQ-A925-01A | NCK2 | chr2 | 106361595 | + | MRPS9 | chr2 | 105705442 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000233154 | ENST00000258455 | NCK2 | chr2 | 106361595 | + | MRPS9 | chr2 | 105705442 | + |
5UTR-3CDS | ENST00000451463 | ENST00000258455 | NCK2 | chr2 | 106361595 | + | MRPS9 | chr2 | 105705442 | + |
intron-3CDS | ENST00000522586 | ENST00000258455 | NCK2 | chr2 | 106361595 | + | MRPS9 | chr2 | 105705442 | + |
intron-3CDS | ENST00000393349 | ENST00000258455 | NCK2 | chr2 | 106361595 | + | MRPS9 | chr2 | 105705442 | + |
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FusionProtFeatures for NCK2_MRPS9 |
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Hgene | Tgene |
NCK2 | MRPS9 |
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellularsubstrates. Maintains low levels of EIF2S1 phosphorylation bypromoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Rassignaling. {ECO:0000269|PubMed:10026169,ECO:0000269|PubMed:16835242}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NCK2_MRPS9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NCK2_MRPS9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NCK2 | ABI2, TRIP6, KIAA1217, NCKIPSD, SF3B4, CBLB, WBP11, CPSF6, FXR2, CPSF7, HNRNPK, EEF1G, EGFR, PDGFRB, DOK1, DOCK1, WIPF2, CD3E, PTK2, PAK1, PKN2, SOS1, NTRK2, LIMS1, ILK, IRS1, MASP1, KHDRBS1, BLNK, FASLG, ATN1, EFNB1, ABI1, AXIN1, DNM1, ERBB2, ERBB3, SRPK2, SRPK1, SYNPO, WAS, CBL, PSMD10, CHN1, DVL1, NR5A1, HOXC4, LCP2, MAGEA6, MEOX2, REL, TRIM27, TCF4, TNR, RASSF7, NCK2, SORBS2, EIF3H, WASL, ARHGAP32, SPRY2, DRAP1, ZBTB7B, ABI3, FAM53C, BCL11A, VARS2, HOMEZ, RBM26, FCRL2, VPS37B, CCDC33, EFHC2, LZTS2, LNX1, TRIM41, PRR20A, LRRIQ3, UBC, DYX1C1, NCK1, SH3PXD2B, ARAP1, NCKAP1, ABL2, GIT2, GIT1, RAPH1, BAIAP2, ASAP2, ASAP1, CYFIP2, CYFIP1, PRRC2A, TNK2, MAP4K4, MINK1, TNIK, PAK2, NHSL1, CASKIN2, PEAK1, ARHGEF7, ARHGEF6, WASF1, WASF2, WASF3, TTC28, PIK3AP1, SHB, WIPF1, KIAA1522, NHSL2, MLLT4, WIPF3, LZTR1, SEMA6A, FAM83H, BRK1, FAM217B, FYB, SORBS1, CEP170, CEP44, CEP19, TRIM15, FGFR1, CDH1, PTPN12, LRFN4, DOK2, CPNE5, YLPM1, SMARCB1 | MRPS9 | DDX56, HAP1, ICT1, CUL3, CAND1, MRPL3, MRPS2, MRPS25, MRPL13, MRPL32, MRPL39, MRPL40, MRPL38, MRPS7, MRPL42, MRPL21, MRPL55, MRPL41, MRPS16, MRPL50, MRPL23, MRPS28, MRPS18B, MRPL12, MRPS26, MRPS21, EWSR1, ILF3, HNRNPC, SDHA, HNRNPR, LAMTOR3, SLC3A2, RPS18, NPLOC4, HNRNPM, ESR1, C1QBP, SOX2, HECW2, CEP250, TP53, FBXW11, NOL12, RPL13, NSA2, TRA2A, RPL6, HNRNPDL, ZC3H3, RPS8, TRMT10B, HNRNPA1, ZNF707, LUC7L, MRPS31, MRPS5, MRPS11, NTRK1, MRPS22, MRPS23, DAP3, MRPS35, PSMB1, PTCD3, PSMA4, PSMA5, PSMB2, PSMB8, HNRNPU, TERF1, EMC2, APOL2, ATP6V1C2, ZNF746, MRPS34, MRPS27, MRPS15, AURKAIP1, E4F1, SNRNP70, RBM42, CCDC59, RRS1, PDGFB, ZC3HAV1, GLTSCR2, FGF8, ZNF169, ZBTB48, RPL18, ZNF331, ZNF2, ZNF574, STRBP, ZNF550, CDX1, KBTBD7, U2AF2, BHLHA15, RBM3, PARK7 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NCK2_MRPS9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NCK2_MRPS9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NCK2 | C0001925 | Albuminuria | 1 | CTD_human |
Hgene | NCK2 | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
Hgene | NCK2 | C0033687 | Proteinuria | 1 | CTD_human |