|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 23593 |
FusionGeneSummary for NCK2_KDM4C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NCK2_KDM4C | Fusion gene ID: 23593 | Hgene | Tgene | Gene symbol | NCK2 | KDM4C | Gene ID | 8440 | 23081 |
| Gene name | NCK adaptor protein 2 | lysine demethylase 4C | |
| Synonyms | GRB4|NCKbeta | GASC1|JHDM3C|JMJD2C|TDRD14C | |
| Cytomap | 2q12.2 | 9p24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytoplasmic protein NCK2SH2/SH3 adaptor protein NCK-betagrowth factor receptor-bound protein 4noncatalytic region of tyrosine kinase, beta | lysine-specific demethylase 4CJmjC domain-containing histone demethylation protein 3Cgene amplified in squamous cell carcinoma 1 proteinjumonji domain-containing protein 2Clysine (K)-specific demethylase 4Ctudor domain containing 14C | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | O43639 | Q9H3R0 | |
| Ensembl transtripts involved in fusion gene | ENST00000233154, ENST00000451463, ENST00000522586, ENST00000393349, | ENST00000535193, ENST00000543771, ENST00000381306, ENST00000381309, ENST00000442236, ENST00000489243, ENST00000536108, ENST00000428870, ENST00000401787, | |
| Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 5 X 4 X 4=80 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NCK2 [Title/Abstract] AND KDM4C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NCK2 | GO:0033137 | negative regulation of peptidyl-serine phosphorylation | 16835242 |
| Hgene | NCK2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10026169 |
| Hgene | NCK2 | GO:1903912 | negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation | 16835242 |
| Tgene | KDM4C | GO:0006357 | regulation of transcription by RNA polymerase II | 17277772 |
| Tgene | KDM4C | GO:0033169 | histone H3-K9 demethylation | 18066052|21914792 |
| Tgene | KDM4C | GO:0070544 | histone H3-K36 demethylation | 21914792 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-G9-7525-01A | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-intron | ENST00000233154 | ENST00000535193 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-intron | ENST00000233154 | ENST00000543771 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-intron | ENST00000233154 | ENST00000381306 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-intron | ENST00000233154 | ENST00000381309 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-intron | ENST00000233154 | ENST00000442236 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-intron | ENST00000233154 | ENST00000489243 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-3UTR | ENST00000233154 | ENST00000536108 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-3UTR | ENST00000233154 | ENST00000428870 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-intron | ENST00000233154 | ENST00000401787 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-intron | ENST00000451463 | ENST00000535193 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-intron | ENST00000451463 | ENST00000543771 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-intron | ENST00000451463 | ENST00000381306 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-intron | ENST00000451463 | ENST00000381309 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-intron | ENST00000451463 | ENST00000442236 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-intron | ENST00000451463 | ENST00000489243 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-3UTR | ENST00000451463 | ENST00000536108 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-3UTR | ENST00000451463 | ENST00000428870 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| 5UTR-intron | ENST00000451463 | ENST00000401787 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-intron | ENST00000522586 | ENST00000535193 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-intron | ENST00000522586 | ENST00000543771 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-intron | ENST00000522586 | ENST00000381306 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-intron | ENST00000522586 | ENST00000381309 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-intron | ENST00000522586 | ENST00000442236 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-intron | ENST00000522586 | ENST00000489243 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-3UTR | ENST00000522586 | ENST00000536108 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-3UTR | ENST00000522586 | ENST00000428870 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-intron | ENST00000522586 | ENST00000401787 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-intron | ENST00000393349 | ENST00000535193 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-intron | ENST00000393349 | ENST00000543771 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-intron | ENST00000393349 | ENST00000381306 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-intron | ENST00000393349 | ENST00000381309 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-intron | ENST00000393349 | ENST00000442236 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-intron | ENST00000393349 | ENST00000489243 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-3UTR | ENST00000393349 | ENST00000536108 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-3UTR | ENST00000393349 | ENST00000428870 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
| intron-intron | ENST00000393349 | ENST00000401787 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
Top |
FusionProtFeatures for NCK2_KDM4C |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NCK2 | KDM4C |
| Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellularsubstrates. Maintains low levels of EIF2S1 phosphorylation bypromoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Rassignaling. {ECO:0000269|PubMed:10026169,ECO:0000269|PubMed:16835242}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for NCK2_KDM4C |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for NCK2_KDM4C |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NCK2 | ABI2, TRIP6, KIAA1217, NCKIPSD, SF3B4, CBLB, WBP11, CPSF6, FXR2, CPSF7, HNRNPK, EEF1G, EGFR, PDGFRB, DOK1, DOCK1, WIPF2, CD3E, PTK2, PAK1, PKN2, SOS1, NTRK2, LIMS1, ILK, IRS1, MASP1, KHDRBS1, BLNK, FASLG, ATN1, EFNB1, ABI1, AXIN1, DNM1, ERBB2, ERBB3, SRPK2, SRPK1, SYNPO, WAS, CBL, PSMD10, CHN1, DVL1, NR5A1, HOXC4, LCP2, MAGEA6, MEOX2, REL, TRIM27, TCF4, TNR, RASSF7, NCK2, SORBS2, EIF3H, WASL, ARHGAP32, SPRY2, DRAP1, ZBTB7B, ABI3, FAM53C, BCL11A, VARS2, HOMEZ, RBM26, FCRL2, VPS37B, CCDC33, EFHC2, LZTS2, LNX1, TRIM41, PRR20A, LRRIQ3, UBC, DYX1C1, NCK1, SH3PXD2B, ARAP1, NCKAP1, ABL2, GIT2, GIT1, RAPH1, BAIAP2, ASAP2, ASAP1, CYFIP2, CYFIP1, PRRC2A, TNK2, MAP4K4, MINK1, TNIK, PAK2, NHSL1, CASKIN2, PEAK1, ARHGEF7, ARHGEF6, WASF1, WASF2, WASF3, TTC28, PIK3AP1, SHB, WIPF1, KIAA1522, NHSL2, MLLT4, WIPF3, LZTR1, SEMA6A, FAM83H, BRK1, FAM217B, FYB, SORBS1, CEP170, CEP44, CEP19, TRIM15, FGFR1, CDH1, PTPN12, LRFN4, DOK2, CPNE5, YLPM1, SMARCB1 | KDM4C | KDM4A, KDM4C, HIST1H3A, H3F3A, PPARG, HDAC1, HDAC3, HIST2H3C, SHMT2, MOV10, NXF1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for NCK2_KDM4C |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for NCK2_KDM4C |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NCK2 | C0001925 | Albuminuria | 1 | CTD_human |
| Hgene | NCK2 | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
| Hgene | NCK2 | C0033687 | Proteinuria | 1 | CTD_human |
| Tgene | KDM4C | C0025149 | Medulloblastoma | 1 | CTD_human |
| Tgene | KDM4C | C0236663 | Alcohol withdrawal syndrome | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|