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Fusion gene ID: 23593 |
FusionGeneSummary for NCK2_KDM4C |
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Fusion gene information | Fusion gene name: NCK2_KDM4C | Fusion gene ID: 23593 | Hgene | Tgene | Gene symbol | NCK2 | KDM4C | Gene ID | 8440 | 23081 |
Gene name | NCK adaptor protein 2 | lysine demethylase 4C | |
Synonyms | GRB4|NCKbeta | GASC1|JHDM3C|JMJD2C|TDRD14C | |
Cytomap | 2q12.2 | 9p24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cytoplasmic protein NCK2SH2/SH3 adaptor protein NCK-betagrowth factor receptor-bound protein 4noncatalytic region of tyrosine kinase, beta | lysine-specific demethylase 4CJmjC domain-containing histone demethylation protein 3Cgene amplified in squamous cell carcinoma 1 proteinjumonji domain-containing protein 2Clysine (K)-specific demethylase 4Ctudor domain containing 14C | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | O43639 | Q9H3R0 | |
Ensembl transtripts involved in fusion gene | ENST00000233154, ENST00000451463, ENST00000522586, ENST00000393349, | ENST00000535193, ENST00000543771, ENST00000381306, ENST00000381309, ENST00000442236, ENST00000489243, ENST00000536108, ENST00000428870, ENST00000401787, | |
Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 5 X 4 X 4=80 |
# samples | 6 | 5 | |
** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NCK2 [Title/Abstract] AND KDM4C [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NCK2 | GO:0033137 | negative regulation of peptidyl-serine phosphorylation | 16835242 |
Hgene | NCK2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10026169 |
Hgene | NCK2 | GO:1903912 | negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation | 16835242 |
Tgene | KDM4C | GO:0006357 | regulation of transcription by RNA polymerase II | 17277772 |
Tgene | KDM4C | GO:0033169 | histone H3-K9 demethylation | 18066052|21914792 |
Tgene | KDM4C | GO:0070544 | histone H3-K36 demethylation | 21914792 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-G9-7525-01A | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-intron | ENST00000233154 | ENST00000535193 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-intron | ENST00000233154 | ENST00000543771 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-intron | ENST00000233154 | ENST00000381306 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-intron | ENST00000233154 | ENST00000381309 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-intron | ENST00000233154 | ENST00000442236 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-intron | ENST00000233154 | ENST00000489243 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-3UTR | ENST00000233154 | ENST00000536108 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-3UTR | ENST00000233154 | ENST00000428870 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-intron | ENST00000233154 | ENST00000401787 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-intron | ENST00000451463 | ENST00000535193 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-intron | ENST00000451463 | ENST00000543771 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-intron | ENST00000451463 | ENST00000381306 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-intron | ENST00000451463 | ENST00000381309 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-intron | ENST00000451463 | ENST00000442236 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-intron | ENST00000451463 | ENST00000489243 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-3UTR | ENST00000451463 | ENST00000536108 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-3UTR | ENST00000451463 | ENST00000428870 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
5UTR-intron | ENST00000451463 | ENST00000401787 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-intron | ENST00000522586 | ENST00000535193 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-intron | ENST00000522586 | ENST00000543771 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-intron | ENST00000522586 | ENST00000381306 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-intron | ENST00000522586 | ENST00000381309 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-intron | ENST00000522586 | ENST00000442236 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-intron | ENST00000522586 | ENST00000489243 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-3UTR | ENST00000522586 | ENST00000536108 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-3UTR | ENST00000522586 | ENST00000428870 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-intron | ENST00000522586 | ENST00000401787 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-intron | ENST00000393349 | ENST00000535193 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-intron | ENST00000393349 | ENST00000543771 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-intron | ENST00000393349 | ENST00000381306 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-intron | ENST00000393349 | ENST00000381309 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-intron | ENST00000393349 | ENST00000442236 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-intron | ENST00000393349 | ENST00000489243 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-3UTR | ENST00000393349 | ENST00000536108 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-3UTR | ENST00000393349 | ENST00000428870 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
intron-intron | ENST00000393349 | ENST00000401787 | NCK2 | chr2 | 106361595 | + | KDM4C | chr9 | 7165238 | + |
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FusionProtFeatures for NCK2_KDM4C |
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Hgene | Tgene |
NCK2 | KDM4C |
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellularsubstrates. Maintains low levels of EIF2S1 phosphorylation bypromoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Rassignaling. {ECO:0000269|PubMed:10026169,ECO:0000269|PubMed:16835242}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NCK2_KDM4C |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NCK2_KDM4C |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NCK2 | ABI2, TRIP6, KIAA1217, NCKIPSD, SF3B4, CBLB, WBP11, CPSF6, FXR2, CPSF7, HNRNPK, EEF1G, EGFR, PDGFRB, DOK1, DOCK1, WIPF2, CD3E, PTK2, PAK1, PKN2, SOS1, NTRK2, LIMS1, ILK, IRS1, MASP1, KHDRBS1, BLNK, FASLG, ATN1, EFNB1, ABI1, AXIN1, DNM1, ERBB2, ERBB3, SRPK2, SRPK1, SYNPO, WAS, CBL, PSMD10, CHN1, DVL1, NR5A1, HOXC4, LCP2, MAGEA6, MEOX2, REL, TRIM27, TCF4, TNR, RASSF7, NCK2, SORBS2, EIF3H, WASL, ARHGAP32, SPRY2, DRAP1, ZBTB7B, ABI3, FAM53C, BCL11A, VARS2, HOMEZ, RBM26, FCRL2, VPS37B, CCDC33, EFHC2, LZTS2, LNX1, TRIM41, PRR20A, LRRIQ3, UBC, DYX1C1, NCK1, SH3PXD2B, ARAP1, NCKAP1, ABL2, GIT2, GIT1, RAPH1, BAIAP2, ASAP2, ASAP1, CYFIP2, CYFIP1, PRRC2A, TNK2, MAP4K4, MINK1, TNIK, PAK2, NHSL1, CASKIN2, PEAK1, ARHGEF7, ARHGEF6, WASF1, WASF2, WASF3, TTC28, PIK3AP1, SHB, WIPF1, KIAA1522, NHSL2, MLLT4, WIPF3, LZTR1, SEMA6A, FAM83H, BRK1, FAM217B, FYB, SORBS1, CEP170, CEP44, CEP19, TRIM15, FGFR1, CDH1, PTPN12, LRFN4, DOK2, CPNE5, YLPM1, SMARCB1 | KDM4C | KDM4A, KDM4C, HIST1H3A, H3F3A, PPARG, HDAC1, HDAC3, HIST2H3C, SHMT2, MOV10, NXF1, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NCK2_KDM4C |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NCK2_KDM4C |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NCK2 | C0001925 | Albuminuria | 1 | CTD_human |
Hgene | NCK2 | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
Hgene | NCK2 | C0033687 | Proteinuria | 1 | CTD_human |
Tgene | KDM4C | C0025149 | Medulloblastoma | 1 | CTD_human |
Tgene | KDM4C | C0236663 | Alcohol withdrawal syndrome | 1 | PSYGENET |