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Fusion gene ID: 23577 |
FusionGeneSummary for NCEH1_EEF1G |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NCEH1_EEF1G | Fusion gene ID: 23577 | Hgene | Tgene | Gene symbol | NCEH1 | EEF1G | Gene ID | 57552 | 1937 |
| Gene name | neutral cholesterol ester hydrolase 1 | eukaryotic translation elongation factor 1 gamma | |
| Synonyms | AADACL1|NCEH | EF1G|GIG35 | |
| Cytomap | 3q26.31 | 11q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neutral cholesterol ester hydrolase 1arylacetamide deacetylase-like 1 | elongation factor 1-gammaEF-1-gammaPRO1608eEF-1B gammapancreatic tumor-related proteintranslation elongation factor eEF-1 gamma chain | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6PIU2 | P26641 | |
| Ensembl transtripts involved in fusion gene | ENST00000475381, ENST00000273512, ENST00000538775, ENST00000543711, | ENST00000329251, ENST00000378019, ENST00000532986, | |
| Fusion gene scores | * DoF score | 6 X 3 X 6=108 | 3 X 4 X 4=48 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NCEH1 [Title/Abstract] AND EEF1G [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | COAD | TCGA-G4-6323-01A | NCEH1 | chr3 | 172428637 | - | EEF1G | chr11 | 62327309 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000475381 | ENST00000329251 | NCEH1 | chr3 | 172428637 | - | EEF1G | chr11 | 62327309 | - |
| Frame-shift | ENST00000475381 | ENST00000378019 | NCEH1 | chr3 | 172428637 | - | EEF1G | chr11 | 62327309 | - |
| 5CDS-intron | ENST00000475381 | ENST00000532986 | NCEH1 | chr3 | 172428637 | - | EEF1G | chr11 | 62327309 | - |
| In-frame | ENST00000273512 | ENST00000329251 | NCEH1 | chr3 | 172428637 | - | EEF1G | chr11 | 62327309 | - |
| Frame-shift | ENST00000273512 | ENST00000378019 | NCEH1 | chr3 | 172428637 | - | EEF1G | chr11 | 62327309 | - |
| 5CDS-intron | ENST00000273512 | ENST00000532986 | NCEH1 | chr3 | 172428637 | - | EEF1G | chr11 | 62327309 | - |
| In-frame | ENST00000538775 | ENST00000329251 | NCEH1 | chr3 | 172428637 | - | EEF1G | chr11 | 62327309 | - |
| Frame-shift | ENST00000538775 | ENST00000378019 | NCEH1 | chr3 | 172428637 | - | EEF1G | chr11 | 62327309 | - |
| 5CDS-intron | ENST00000538775 | ENST00000532986 | NCEH1 | chr3 | 172428637 | - | EEF1G | chr11 | 62327309 | - |
| 5UTR-3CDS | ENST00000543711 | ENST00000329251 | NCEH1 | chr3 | 172428637 | - | EEF1G | chr11 | 62327309 | - |
| 5UTR-3CDS | ENST00000543711 | ENST00000378019 | NCEH1 | chr3 | 172428637 | - | EEF1G | chr11 | 62327309 | - |
| 5UTR-intron | ENST00000543711 | ENST00000532986 | NCEH1 | chr3 | 172428637 | - | EEF1G | chr11 | 62327309 | - |
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FusionProtFeatures for NCEH1_EEF1G |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NCEH1 | EEF1G |
| Probably plays a role in anchoring the complex to othercellular components. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NCEH1 | chr3:172428637 | chr11:62327309 | ENST00000475381 | - | 1 | 5 | 1_4 | 46 | 409 | Topological domain | Cytoplasmic |
| Hgene | NCEH1 | chr3:172428637 | chr11:62327309 | ENST00000475381 | - | 1 | 5 | 5_25 | 46 | 409 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NCEH1 | chr3:172428637 | chr11:62327309 | ENST00000475381 | - | 1 | 5 | 113_115 | 46 | 409 | Motif | Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole |
| Hgene | >NCEH1 | chr3:172428637 | chr11:62327309 | ENST00000543711 | - | 1 | 4 | 113_115 | -11 | 276 | Motif | Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole |
| Hgene | >NCEH1 | chr3:172428637 | chr11:62327309 | ENST00000475381 | - | 1 | 5 | 26_408 | 46 | 409 | Topological domain | Lumenal |
| Hgene | >NCEH1 | chr3:172428637 | chr11:62327309 | ENST00000543711 | - | 1 | 4 | 1_4 | -11 | 276 | Topological domain | Cytoplasmic |
| Hgene | >NCEH1 | chr3:172428637 | chr11:62327309 | ENST00000543711 | - | 1 | 4 | 26_408 | -11 | 276 | Topological domain | Lumenal |
| Hgene | >NCEH1 | chr3:172428637 | chr11:62327309 | ENST00000543711 | - | 1 | 4 | 5_25 | -11 | 276 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | EEF1G | chr3:172428637 | chr11:62327309 | ENST00000329251 | - | 8 | 10 | 276_437 | 385 | 438 | Domain | EF-1-gamma C-terminal |
| Tgene | EEF1G | chr3:172428637 | chr11:62327309 | ENST00000329251 | - | 8 | 10 | 2_87 | 385 | 438 | Domain | Note=GST N-terminal |
| Tgene | EEF1G | chr3:172428637 | chr11:62327309 | ENST00000329251 | - | 8 | 10 | 88_216 | 385 | 438 | Domain | Note=GST C-terminal |
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FusionGeneSequence for NCEH1_EEF1G |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NCEH1_ENST00000475381_chr3_172428637_-_EEF1G_ENST00000329251_chr11_62327309_-_99aa MRSSCVLLTALVALAAYYVYIPLPGSVSDPWKLMLLDATFRGAQQVLSPDWQVDYESYTWRKLDPGSEETQTLVREYFSWEGAFQHVGKA >In-frame_NCEH1_ENST00000273512_chr3_172428637_-_EEF1G_ENST00000329251_chr11_62327309_-_131aa MSSCRGQKVAGGLRVVSPFPLCQPAGEPSQGKMRSSCVLLTALVALAAYYVYIPLPGSVSDPWKLMLLDATFRGAQQVLSPDWQVDYESY >In-frame_NCEH1_ENST00000538775_chr3_172428637_-_EEF1G_ENST00000329251_chr11_62327309_-_131aa MSSCRGQKVAGGLRVVSPFPLCQPAGEPSQGKMRSSCVLLTALVALAAYYVYIPLPGSVSDPWKLMLLDATFRGAQQVLSPDWQVDYESY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NCEH1_ENST00000475381_chr3_172428637_-_EEF1G_ENST00000329251_chr11_62327309_-_297nt ATGAGGTCGTCCTGTGTCCTGCTCACCGCCCTGGTGGCGCTGGCCGCCTATTACGTCTACATCCCGCTGCCTGGCTCCGTGTCCGACCCC TGGAAGCTGATGCTGCTGGACGCCACTTTCCGGGGTGCACAGCAAGTGCTGAGTCCAGATTGGCAGGTGGACTACGAGTCATACACATGG CGGAAACTGGATCCTGGCAGCGAGGAGACCCAGACGCTGGTTCGAGAGTACTTTTCCTGGGAGGGGGCCTTCCAGCATGTGGGCAAAGCC >In-frame_NCEH1_ENST00000273512_chr3_172428637_-_EEF1G_ENST00000329251_chr11_62327309_-_393nt ATGAGCAGCTGCCGCGGGCAGAAAGTTGCCGGAGGTCTCCGGGTGGTATCGCCCTTTCCTCTTTGCCAGCCCGCTGGCGAGCCGAGCCAG GGCAAGATGAGGTCGTCCTGTGTCCTGCTCACCGCCCTGGTGGCGCTGGCCGCCTATTACGTCTACATCCCGCTGCCTGGCTCCGTGTCC GACCCCTGGAAGCTGATGCTGCTGGACGCCACTTTCCGGGGTGCACAGCAAGTGCTGAGTCCAGATTGGCAGGTGGACTACGAGTCATAC ACATGGCGGAAACTGGATCCTGGCAGCGAGGAGACCCAGACGCTGGTTCGAGAGTACTTTTCCTGGGAGGGGGCCTTCCAGCATGTGGGC >In-frame_NCEH1_ENST00000538775_chr3_172428637_-_EEF1G_ENST00000329251_chr11_62327309_-_393nt ATGAGCAGCTGCCGCGGGCAGAAAGTTGCCGGAGGTCTCCGGGTGGTATCGCCCTTTCCTCTTTGCCAGCCCGCTGGCGAGCCGAGCCAG GGCAAGATGAGGTCGTCCTGTGTCCTGCTCACCGCCCTGGTGGCGCTGGCCGCCTATTACGTCTACATCCCGCTGCCTGGCTCCGTGTCC GACCCCTGGAAGCTGATGCTGCTGGACGCCACTTTCCGGGGTGCACAGCAAGTGCTGAGTCCAGATTGGCAGGTGGACTACGAGTCATAC ACATGGCGGAAACTGGATCCTGGCAGCGAGGAGACCCAGACGCTGGTTCGAGAGTACTTTTCCTGGGAGGGGGCCTTCCAGCATGTGGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NCEH1_ENST00000475381_chr3_172428637_-_EEF1G_ENST00000329251_chr11_62327309_-_609nt AGAGCAGCGACAGAGCCTTCCTCAAACCTGTAGTGACTGCCACACTTTGCAAGGACACCGTAGAGGGGGCATGTCCGCGCTCCAACTTCC TCCCGACGCAGCCTCTGATTGGCTCCTGGGCTTATAAGAAACGCGTGAATGAGCAGCTGCCGCGGGCAGAAAGTTGCCGGAGGTCTCCGG GTGGTATCGCCCTTTCCTCTTTGCCAGCCCGCTGGCGAGCCGAGCCAGGGCAAGATGAGGTCGTCCTGTGTCCTGCTCACCGCCCTGGTG GCGCTGGCCGCCTATTACGTCTACATCCCGCTGCCTGGCTCCGTGTCCGACCCCTGGAAGCTGATGCTGCTGGACGCCACTTTCCGGGGT GCACAGCAAGTGCTGAGTCCAGATTGGCAGGTGGACTACGAGTCATACACATGGCGGAAACTGGATCCTGGCAGCGAGGAGACCCAGACG CTGGTTCGAGAGTACTTTTCCTGGGAGGGGGCCTTCCAGCATGTGGGCAAAGCCTTCAATCAGGGCAAGATCTTCAAGTGAACATCTCTT >In-frame_NCEH1_ENST00000273512_chr3_172428637_-_EEF1G_ENST00000329251_chr11_62327309_-_609nt AGAGCAGCGACAGAGCCTTCCTCAAACCTGTAGTGACTGCCACACTTTGCAAGGACACCGTAGAGGGGGCATGTCCGCGCTCCAACTTCC TCCCGACGCAGCCTCTGATTGGCTCCTGGGCTTATAAGAAACGCGTGAATGAGCAGCTGCCGCGGGCAGAAAGTTGCCGGAGGTCTCCGG GTGGTATCGCCCTTTCCTCTTTGCCAGCCCGCTGGCGAGCCGAGCCAGGGCAAGATGAGGTCGTCCTGTGTCCTGCTCACCGCCCTGGTG GCGCTGGCCGCCTATTACGTCTACATCCCGCTGCCTGGCTCCGTGTCCGACCCCTGGAAGCTGATGCTGCTGGACGCCACTTTCCGGGGT GCACAGCAAGTGCTGAGTCCAGATTGGCAGGTGGACTACGAGTCATACACATGGCGGAAACTGGATCCTGGCAGCGAGGAGACCCAGACG CTGGTTCGAGAGTACTTTTCCTGGGAGGGGGCCTTCCAGCATGTGGGCAAAGCCTTCAATCAGGGCAAGATCTTCAAGTGAACATCTCTT >In-frame_NCEH1_ENST00000538775_chr3_172428637_-_EEF1G_ENST00000329251_chr11_62327309_-_609nt AGAGCAGCGACAGAGCCTTCCTCAAACCTGTAGTGACTGCCACACTTTGCAAGGACACCGTAGAGGGGGCATGTCCGCGCTCCAACTTCC TCCCGACGCAGCCTCTGATTGGCTCCTGGGCTTATAAGAAACGCGTGAATGAGCAGCTGCCGCGGGCAGAAAGTTGCCGGAGGTCTCCGG GTGGTATCGCCCTTTCCTCTTTGCCAGCCCGCTGGCGAGCCGAGCCAGGGCAAGATGAGGTCGTCCTGTGTCCTGCTCACCGCCCTGGTG GCGCTGGCCGCCTATTACGTCTACATCCCGCTGCCTGGCTCCGTGTCCGACCCCTGGAAGCTGATGCTGCTGGACGCCACTTTCCGGGGT GCACAGCAAGTGCTGAGTCCAGATTGGCAGGTGGACTACGAGTCATACACATGGCGGAAACTGGATCCTGGCAGCGAGGAGACCCAGACG CTGGTTCGAGAGTACTTTTCCTGGGAGGGGGCCTTCCAGCATGTGGGCAAAGCCTTCAATCAGGGCAAGATCTTCAAGTGAACATCTCTT |
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FusionGenePPI for NCEH1_EEF1G |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NCEH1 | LYPD3, EVI2A, TMEM38A, ZNRF1, SGTB, COQ9, UGT3A2, NRN1, LRRC3, TMEM231, ST3GAL6, CANT1, AMIGO1, ALG9, LMF2, STAM, BTN2A2, GLB1L2, UGT8, POMT1, C1QL1, EIF2AK3, CD1E, ITPRIP, FAM69A, TMTC3, CANX, CD151, GALNT7, CCPG1, ITGA7, FAM177A1, HYAL2, SCARB1, ST6GALNAC3, PGAP1, MTFP1 | EEF1G | EEF1DP3, EEF1D, EEF1B2, ILF2, ABCC9, EEF1G, ADAP2, CHFR, CXCL13, HDAC5, FAM195A, MVD, EFNA1, OGFOD2, FOXG1, C1orf174, NUP85, PLEKHA4, PHACTR3, ARF1, CBX8, CRELD1, DKC1, FEN1, ENOX1, NADK, NCK2, RPS28, SNAPIN, SNRPD2, TP53I3, TRIB3, GET4, MED31, ECH1, RECQL5, GSTO1, HMOX2, KARS, RPL4P5, PDCD5, PSMD11, RGL2, WDR33, ARIH2, CCT7, CDC42, CDK5RAP2, CSTF2, DLEU1, HNRNPH3, CCDC106, PTPN4, PTPRS, SAT1, TUBB3, ZNF24, VARS, LZTS1, CARS, LARS, HARS, EGFR, MYC, UCHL5, SNW1, AGO4, YWHAG, SIRT1, NUDT21, GSK3B, ZBED8, NUDT3, PTK2, TNNT1, AKT1, CDK2AP2, GADD45A, C11orf58, NDRG1, ISG15, CUL3, CUL2, CDK2, CUL1, COPS5, CAND1, NEDD8, GADD45G, GRB2, EEF1A1, RPL5, RPL8, HNRNPA3, SNRPA1, SRSF9, PLOD3, FLNC, STRIP1, SMURF1, YWHAE, FN1, VCAM1, MTNR1A, SKIL, MLH1, PAN2, IGSF8, NPM1, RAD52, ADRB2, FBXO6, TARDBP, TRAP1, CCT3, SHFM1, STAU1, TRIM63, TRIM55, FUS, RBM6, KLHL18, PLGRKT, ZDHHC17, CUL7, OBSL1, CCDC8, EED, SUMO2, SIRT6, ABL1, KTN1, INPPL1, EEF1A2, MKKS, RPS6KB2, HNRNPA1, ATL3, GTF2E1, GTF2E2, NACA, NPM3, PABPC1, RANGAP1, RPL38, IPO4, PRPF38B, NTRK1, ERBB2, EXOSC9, PKN2, SLC33A1, KIF20B, CHMP4B, MCM2, CDC73, WWP2, CDH1, CYLD, DLD, DLST, DNM1L, HSD17B10, PARK7, PDHA1, SDHA, SOAT1, SOD1, VDAC1, TRIM25, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NCEH1_EEF1G |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NCEH1_EEF1G |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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