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Fusion gene ID: 23575 |
FusionGeneSummary for NCDN_TMSB10 |
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Fusion gene information | Fusion gene name: NCDN_TMSB10 | Fusion gene ID: 23575 | Hgene | Tgene | Gene symbol | NCDN | TMSB10 | Gene ID | 23154 | 9168 |
Gene name | neurochondrin | thymosin beta 10 | |
Synonyms | - | MIG12|TB10 | |
Cytomap | 1p34.3 | 2p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | neurochondrin | thymosin beta-10migration-inducing gene 12migration-inducing protein 12 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9UBB6 | P63313 | |
Ensembl transtripts involved in fusion gene | ENST00000373253, ENST00000356090, ENST00000373243, ENST00000459931, | ENST00000233143, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 9 X 9 X 1=81 |
# samples | 3 | 11 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/81*10)=0.441509710640035 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NCDN [Title/Abstract] AND TMSB10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | M79087 | NCDN | chr1 | 36031945 | - | TMSB10 | chr2 | 85132788 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-5UTR | ENST00000373253 | ENST00000233143 | NCDN | chr1 | 36031945 | - | TMSB10 | chr2 | 85132788 | + |
3UTR-5UTR | ENST00000356090 | ENST00000233143 | NCDN | chr1 | 36031945 | - | TMSB10 | chr2 | 85132788 | + |
3UTR-5UTR | ENST00000373243 | ENST00000233143 | NCDN | chr1 | 36031945 | - | TMSB10 | chr2 | 85132788 | + |
intron-5UTR | ENST00000459931 | ENST00000233143 | NCDN | chr1 | 36031945 | - | TMSB10 | chr2 | 85132788 | + |
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FusionProtFeatures for NCDN_TMSB10 |
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Hgene | Tgene |
NCDN | TMSB10 |
Probably involved in signal transduction, in the nervoussystem, via increasing cell surface localization of GRM5 andpositively regulating its signaling (By similarity). Required forthe spatial learning process. Acts as a negative regulator ofCa(2+)-calmodulin-dependent protein kinase 2 (CaMK2)phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction withMCHR1 that interferes with G protein-coupled signal transduction.May be involved in bone metabolism. May also be involved inneurite outgrowth. {ECO:0000250, ECO:0000269|PubMed:16945926}. | Plays an important role in the organization of thecytoskeleton. Binds to and sequesters actin monomers (G actin) andtherefore inhibits actin polymerization (By similarity).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NCDN_TMSB10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NCDN_TMSB10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NCDN_TMSB10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NCDN_TMSB10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TMSB10 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | TMSB10 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | TMSB10 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | TMSB10 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |