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Fusion gene ID: 2357 |
FusionGeneSummary for ARFIP1_FGB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARFIP1_FGB | Fusion gene ID: 2357 | Hgene | Tgene | Gene symbol | ARFIP1 | FGB | Gene ID | 27236 | 2244 |
| Gene name | ADP ribosylation factor interacting protein 1 | fibrinogen beta chain | |
| Synonyms | HSU52521 | HEL-S-78p | |
| Cytomap | 4q31.3 | 4q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | arfaptin-1 | fibrinogen beta chainbeta-fibrinogenepididymis secretory sperm binding protein Li 78pfibrinogen, B beta polypeptide | |
| Modification date | 20180523 | 20180520 | |
| UniProtAcc | P53367 | P02675 | |
| Ensembl transtripts involved in fusion gene | ENST00000451320, ENST00000429148, ENST00000353617, ENST00000405727, ENST00000356064, ENST00000511289, | ENST00000302068, ENST00000509493, ENST00000502545, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 4 X 2=24 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/24*10)=1.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ARFIP1 [Title/Abstract] AND FGB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARFIP1 | GO:0006886 | intracellular protein transport | 12606037 |
| Hgene | ARFIP1 | GO:0050708 | regulation of protein secretion | 12606037 |
| Tgene | FGB | GO:0007160 | cell-matrix adhesion | 10903502 |
| Tgene | FGB | GO:0031639 | plasminogen activation | 16846481 |
| Tgene | FGB | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 8100742 |
| Tgene | FGB | GO:0034622 | cellular protein-containing complex assembly | 8910396 |
| Tgene | FGB | GO:0042730 | fibrinolysis | 16846481 |
| Tgene | FGB | GO:0043152 | induction of bacterial agglutination | 24367264 |
| Tgene | FGB | GO:0045907 | positive regulation of vasoconstriction | 15739255 |
| Tgene | FGB | GO:0045921 | positive regulation of exocytosis | 19193866 |
| Tgene | FGB | GO:0050714 | positive regulation of protein secretion | 19193866 |
| Tgene | FGB | GO:0051258 | protein polymerization | 12706644 |
| Tgene | FGB | GO:0051592 | response to calcium ion | 6777381 |
| Tgene | FGB | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10903502|19193866 |
| Tgene | FGB | GO:0070527 | platelet aggregation | 6281794 |
| Tgene | FGB | GO:0072378 | blood coagulation, fibrin clot formation | 16846481 |
| Tgene | FGB | GO:0090277 | positive regulation of peptide hormone secretion | 19193866 |
| Tgene | FGB | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 10903502 |
| Tgene | FGB | GO:2000352 | negative regulation of endothelial cell apoptotic process | 10903502 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-D8-A13Z-01A | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000451320 | ENST00000302068 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| 5CDS-intron | ENST00000451320 | ENST00000509493 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| 5CDS-3UTR | ENST00000451320 | ENST00000502545 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| In-frame | ENST00000429148 | ENST00000302068 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| 5CDS-intron | ENST00000429148 | ENST00000509493 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| 5CDS-3UTR | ENST00000429148 | ENST00000502545 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| In-frame | ENST00000353617 | ENST00000302068 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| 5CDS-intron | ENST00000353617 | ENST00000509493 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| 5CDS-3UTR | ENST00000353617 | ENST00000502545 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| In-frame | ENST00000405727 | ENST00000302068 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| 5CDS-intron | ENST00000405727 | ENST00000509493 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| 5CDS-3UTR | ENST00000405727 | ENST00000502545 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| In-frame | ENST00000356064 | ENST00000302068 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| 5CDS-intron | ENST00000356064 | ENST00000509493 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| 5CDS-3UTR | ENST00000356064 | ENST00000502545 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| intron-3CDS | ENST00000511289 | ENST00000302068 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| intron-intron | ENST00000511289 | ENST00000509493 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
| intron-3UTR | ENST00000511289 | ENST00000502545 | ARFIP1 | chr4 | 153750878 | + | FGB | chr4 | 155486960 | + |
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FusionProtFeatures for ARFIP1_FGB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARFIP1 | FGB |
| Putative target protein of ADP-ribosylation factor. | Cleaved by the protease thrombin to yield monomerswhich, together with fibrinogen alpha (FGA) and fibrinogen gamma(FGG), polymerize to form an insoluble fibrin matrix. Fibrin has amajor function in hemostasis as one of the primary components ofblood clots. In addition, functions during the early stages ofwound repair to stabilize the lesion and guide cell migrationduring re-epithelialization. Was originally thought to beessential for platelet aggregation, based on in vitro studiesusing anticoagulated blood. However subsequent studies have shownthat it is not absolutely required for thrombus formation in vivo.Enhances expression of SELP in activated platelets. Maternalfibrinogen is essential for successful pregnancy. Fibrindeposition is also associated with infection, where it protectsagainst IFNG-mediated hemorrhage. May also facilitate theantibacterial immune response via both innate and T-cell mediatedpathways. {ECO:0000250|UniProtKB:E9PV24}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >FGB | chr4:153750878 | chr4:155486960 | ENST00000302068 | + | 0 | 8 | 157_222 | 38 | 492 | Coiled coil | Ontology_term=ECO:0000305,ECO:0000305,ECO:0000305 |
| Tgene | >FGB | chr4:153750878 | chr4:155486960 | ENST00000302068 | + | 0 | 8 | 232_488 | 38 | 492 | Domain | Fibrinogen C-terminal |
| Tgene | >FGB | chr4:153750878 | chr4:155486960 | ENST00000302068 | + | 0 | 8 | 45_47 | 38 | 492 | Region | Note=Beta-chain polymerization%2C binding distal domain of another fibrin |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ARFIP1 | chr4:153750878 | chr4:155486960 | ENST00000353617 | + | 2 | 9 | 153_353 | 31 | 374 | Domain | AH |
| Hgene | >ARFIP1 | chr4:153750878 | chr4:155486960 | ENST00000356064 | + | 2 | 8 | 153_353 | 31 | 342 | Domain | AH |
| Hgene | >ARFIP1 | chr4:153750878 | chr4:155486960 | ENST00000405727 | + | 2 | 8 | 153_353 | 31 | 342 | Domain | AH |
| Hgene | >ARFIP1 | chr4:153750878 | chr4:155486960 | ENST00000451320 | + | 2 | 9 | 153_353 | 31 | 374 | Domain | AH |
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FusionGeneSequence for ARFIP1_FGB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ARFIP1_ENST00000451320_chr4_153750878_+_FGB_ENST00000302068_chr4_155486960_+_485aa MAQESPKNSAAEIPVTSNGEVDDSREHSFNRGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLH ADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETV NSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENG GWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANK YQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMA >In-frame_ARFIP1_ENST00000429148_chr4_153750878_+_FGB_ENST00000302068_chr4_155486960_+_485aa MAQESPKNSAAEIPVTSNGEVDDSREHSFNRGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLH ADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETV NSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENG GWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANK YQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMA >In-frame_ARFIP1_ENST00000353617_chr4_153750878_+_FGB_ENST00000302068_chr4_155486960_+_485aa MAQESPKNSAAEIPVTSNGEVDDSREHSFNRGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLH ADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETV NSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENG GWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANK YQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMA >In-frame_ARFIP1_ENST00000405727_chr4_153750878_+_FGB_ENST00000302068_chr4_155486960_+_485aa MAQESPKNSAAEIPVTSNGEVDDSREHSFNRGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLH ADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETV NSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENG GWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANK YQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMA >In-frame_ARFIP1_ENST00000356064_chr4_153750878_+_FGB_ENST00000302068_chr4_155486960_+_485aa MAQESPKNSAAEIPVTSNGEVDDSREHSFNRGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLH ADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETV NSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENG GWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANK YQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ARFIP1_ENST00000451320_chr4_153750878_+_FGB_ENST00000302068_chr4_155486960_+_1455nt ATGGCTCAAGAATCTCCCAAAAATTCAGCAGCAGAAATTCCAGTGACTAGTAATGGAGAAGTTGATGACTCTCGTGAACATAGCTTTAAT AGGGGTTTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGT GGAGGTGGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCAC GCTGACCCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTT GATGAGTTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAG AGGCAGAAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTG AATAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCA GCTCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAA GGAGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGA GGATGGACAGTGATTCAGAACCGTCAAGACGGTAGTGTTGACTTTGGCAGGAAATGGGATCCATATAAACAGGGATTTGGAAATGTTGCA ACCAACACAGATGGGAAGAATTACTGTGGCCTACCAGGTGAATATTGGCTTGGAAATGATAAAATTAGCCAGCTTACCAGGATGGGACCC ACAGAACTTTTGATAGAAATGGAGGACTGGAAAGGAGACAAAGTAAAGGCTCACTATGGAGGATTCACTGTACAGAATGAAGCCAACAAA TACCAGATCTCAGTGAACAAATACAGAGGAACAGCCGGTAATGCCCTCATGGATGGAGCATCTCAGCTGATGGGAGAAAACAGGACCATG ACCATTCACAACGGCATGTTCTTCAGCACGTATGACAGAGACAATGACGGCTGGTTAACATCAGATCCCAGAAAACAGTGTTCTAAAGAA GACGGTGGTGGATGGTGGTATAATAGATGTCATGCAGCCAATCCAAACGGCAGATACTACTGGGGTGGACAGTACACCTGGGACATGGCA AAGCATGGCACAGATGATGGTGTAGTATGGATGAATTGGAAGGGGTCATGGTACTCAATGAGGAAGATGAGTATGAAGATCAGGCCCTTC >In-frame_ARFIP1_ENST00000429148_chr4_153750878_+_FGB_ENST00000302068_chr4_155486960_+_1455nt ATGGCTCAAGAATCTCCCAAAAATTCAGCAGCAGAAATTCCAGTGACTAGTAATGGAGAAGTTGATGACTCTCGTGAACATAGCTTTAAT AGGGGTTTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGT GGAGGTGGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCAC GCTGACCCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTT GATGAGTTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAG AGGCAGAAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTG AATAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCA GCTCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAA GGAGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGA GGATGGACAGTGATTCAGAACCGTCAAGACGGTAGTGTTGACTTTGGCAGGAAATGGGATCCATATAAACAGGGATTTGGAAATGTTGCA ACCAACACAGATGGGAAGAATTACTGTGGCCTACCAGGTGAATATTGGCTTGGAAATGATAAAATTAGCCAGCTTACCAGGATGGGACCC ACAGAACTTTTGATAGAAATGGAGGACTGGAAAGGAGACAAAGTAAAGGCTCACTATGGAGGATTCACTGTACAGAATGAAGCCAACAAA TACCAGATCTCAGTGAACAAATACAGAGGAACAGCCGGTAATGCCCTCATGGATGGAGCATCTCAGCTGATGGGAGAAAACAGGACCATG ACCATTCACAACGGCATGTTCTTCAGCACGTATGACAGAGACAATGACGGCTGGTTAACATCAGATCCCAGAAAACAGTGTTCTAAAGAA GACGGTGGTGGATGGTGGTATAATAGATGTCATGCAGCCAATCCAAACGGCAGATACTACTGGGGTGGACAGTACACCTGGGACATGGCA AAGCATGGCACAGATGATGGTGTAGTATGGATGAATTGGAAGGGGTCATGGTACTCAATGAGGAAGATGAGTATGAAGATCAGGCCCTTC >In-frame_ARFIP1_ENST00000353617_chr4_153750878_+_FGB_ENST00000302068_chr4_155486960_+_1455nt ATGGCTCAAGAATCTCCCAAAAATTCAGCAGCAGAAATTCCAGTGACTAGTAATGGAGAAGTTGATGACTCTCGTGAACATAGCTTTAAT AGGGGTTTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGT GGAGGTGGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCAC GCTGACCCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTT GATGAGTTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAG AGGCAGAAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTG AATAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCA GCTCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAA GGAGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGA GGATGGACAGTGATTCAGAACCGTCAAGACGGTAGTGTTGACTTTGGCAGGAAATGGGATCCATATAAACAGGGATTTGGAAATGTTGCA ACCAACACAGATGGGAAGAATTACTGTGGCCTACCAGGTGAATATTGGCTTGGAAATGATAAAATTAGCCAGCTTACCAGGATGGGACCC ACAGAACTTTTGATAGAAATGGAGGACTGGAAAGGAGACAAAGTAAAGGCTCACTATGGAGGATTCACTGTACAGAATGAAGCCAACAAA TACCAGATCTCAGTGAACAAATACAGAGGAACAGCCGGTAATGCCCTCATGGATGGAGCATCTCAGCTGATGGGAGAAAACAGGACCATG ACCATTCACAACGGCATGTTCTTCAGCACGTATGACAGAGACAATGACGGCTGGTTAACATCAGATCCCAGAAAACAGTGTTCTAAAGAA GACGGTGGTGGATGGTGGTATAATAGATGTCATGCAGCCAATCCAAACGGCAGATACTACTGGGGTGGACAGTACACCTGGGACATGGCA AAGCATGGCACAGATGATGGTGTAGTATGGATGAATTGGAAGGGGTCATGGTACTCAATGAGGAAGATGAGTATGAAGATCAGGCCCTTC >In-frame_ARFIP1_ENST00000405727_chr4_153750878_+_FGB_ENST00000302068_chr4_155486960_+_1455nt ATGGCTCAAGAATCTCCCAAAAATTCAGCAGCAGAAATTCCAGTGACTAGTAATGGAGAAGTTGATGACTCTCGTGAACATAGCTTTAAT AGGGGTTTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGT GGAGGTGGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCAC GCTGACCCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTT GATGAGTTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAG AGGCAGAAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTG AATAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCA GCTCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAA GGAGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGA GGATGGACAGTGATTCAGAACCGTCAAGACGGTAGTGTTGACTTTGGCAGGAAATGGGATCCATATAAACAGGGATTTGGAAATGTTGCA ACCAACACAGATGGGAAGAATTACTGTGGCCTACCAGGTGAATATTGGCTTGGAAATGATAAAATTAGCCAGCTTACCAGGATGGGACCC ACAGAACTTTTGATAGAAATGGAGGACTGGAAAGGAGACAAAGTAAAGGCTCACTATGGAGGATTCACTGTACAGAATGAAGCCAACAAA TACCAGATCTCAGTGAACAAATACAGAGGAACAGCCGGTAATGCCCTCATGGATGGAGCATCTCAGCTGATGGGAGAAAACAGGACCATG ACCATTCACAACGGCATGTTCTTCAGCACGTATGACAGAGACAATGACGGCTGGTTAACATCAGATCCCAGAAAACAGTGTTCTAAAGAA GACGGTGGTGGATGGTGGTATAATAGATGTCATGCAGCCAATCCAAACGGCAGATACTACTGGGGTGGACAGTACACCTGGGACATGGCA AAGCATGGCACAGATGATGGTGTAGTATGGATGAATTGGAAGGGGTCATGGTACTCAATGAGGAAGATGAGTATGAAGATCAGGCCCTTC >In-frame_ARFIP1_ENST00000356064_chr4_153750878_+_FGB_ENST00000302068_chr4_155486960_+_1455nt ATGGCTCAAGAATCTCCCAAAAATTCAGCAGCAGAAATTCCAGTGACTAGTAATGGAGAAGTTGATGACTCTCGTGAACATAGCTTTAAT AGGGGTTTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGT GGAGGTGGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCAC GCTGACCCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTT GATGAGTTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAG AGGCAGAAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTG AATAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCA GCTCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAA GGAGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGA GGATGGACAGTGATTCAGAACCGTCAAGACGGTAGTGTTGACTTTGGCAGGAAATGGGATCCATATAAACAGGGATTTGGAAATGTTGCA ACCAACACAGATGGGAAGAATTACTGTGGCCTACCAGGTGAATATTGGCTTGGAAATGATAAAATTAGCCAGCTTACCAGGATGGGACCC ACAGAACTTTTGATAGAAATGGAGGACTGGAAAGGAGACAAAGTAAAGGCTCACTATGGAGGATTCACTGTACAGAATGAAGCCAACAAA TACCAGATCTCAGTGAACAAATACAGAGGAACAGCCGGTAATGCCCTCATGGATGGAGCATCTCAGCTGATGGGAGAAAACAGGACCATG ACCATTCACAACGGCATGTTCTTCAGCACGTATGACAGAGACAATGACGGCTGGTTAACATCAGATCCCAGAAAACAGTGTTCTAAAGAA GACGGTGGTGGATGGTGGTATAATAGATGTCATGCAGCCAATCCAAACGGCAGATACTACTGGGGTGGACAGTACACCTGGGACATGGCA AAGCATGGCACAGATGATGGTGTAGTATGGATGAATTGGAAGGGGTCATGGTACTCAATGAGGAAGATGAGTATGAAGATCAGGCCCTTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ARFIP1_ENST00000451320_chr4_153750878_+_FGB_ENST00000302068_chr4_155486960_+_2055nt ACAACGCTACTTCCGGTCTCCTCACTTCCGGCTTCGCTGCTCTTGGTTCTGGTTCTGGAGGCTGGGTTGAGAGGTCGCCGGTCCGACTGT CCTCGGCGGTTGGTCAGTGTGAATTTGTGACAGCTGCAGTTGCTCCCCGCCCCCGAGCAGCCGAGGAGTCTACCATGGCTCAAGAATCTC CCAAAAATTCAGCAGCAGAAATTCCAGTGACTAGTAATGGAGAAGTTGATGACTCTCGTGAACATAGCTTTAATAGGGGTTTCTTCAGTG CCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGTGGCTATCGGG CTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGACCCAGACCTGG GGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAGTTAAATAACA ATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAGAAGCAAGTAA AAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGCAATATCCCAA CTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAAATGGAATATT GTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGTGAAACATCTG AAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGATGGACAGTGATTC AGAACCGTCAAGACGGTAGTGTTGACTTTGGCAGGAAATGGGATCCATATAAACAGGGATTTGGAAATGTTGCAACCAACACAGATGGGA AGAATTACTGTGGCCTACCAGGTGAATATTGGCTTGGAAATGATAAAATTAGCCAGCTTACCAGGATGGGACCCACAGAACTTTTGATAG AAATGGAGGACTGGAAAGGAGACAAAGTAAAGGCTCACTATGGAGGATTCACTGTACAGAATGAAGCCAACAAATACCAGATCTCAGTGA ACAAATACAGAGGAACAGCCGGTAATGCCCTCATGGATGGAGCATCTCAGCTGATGGGAGAAAACAGGACCATGACCATTCACAACGGCA TGTTCTTCAGCACGTATGACAGAGACAATGACGGCTGGTTAACATCAGATCCCAGAAAACAGTGTTCTAAAGAAGACGGTGGTGGATGGT GGTATAATAGATGTCATGCAGCCAATCCAAACGGCAGATACTACTGGGGTGGACAGTACACCTGGGACATGGCAAAGCATGGCACAGATG ATGGTGTAGTATGGATGAATTGGAAGGGGTCATGGTACTCAATGAGGAAGATGAGTATGAAGATCAGGCCCTTCTTCCCACAGCAATAGT CCCCAATACGTAGATTTTTGCTCTTCTGTATGTGACAACATTTTTGTACATTATGTTATTGGAATTTTCTTTCATACATTATATTCCTCT AAAACTCTCAAGCAGACGTGAGTGTGACTTTTTGAAAAAAGTATAGGATAAATTACATTAAAATAGCACATGATTTTCTTTTGTTTTCTT CATTTCTCTTGCTCACCAAGAAGTAACAAAAGTATAGTTTTGACAGAGTTGGTGTTCATAATTTCAGTTCTAGTTGATTGCGAGAATTTT CAAATAAGGAAGAGGGGTCTTTTATCCTTGTCGTAGGAAAACCATGACGGAAAGGAAAAACTGATGTTTAAAAGTCCACTTTTAAAACTA >In-frame_ARFIP1_ENST00000429148_chr4_153750878_+_FGB_ENST00000302068_chr4_155486960_+_2053nt AACGCTACTTCCGGTCTCCTCACTTCCGGCTTCGCTGCTCTTGGTTCTGGTTCTGGAGGCTGGGTTGAGAGGTCGCCGGTCCGACTGTCC TCGGCGGTTGGTCAGTGTGAATTTGTGACAGCTGCAGTTGCTCCCCGCCCCCGAGCAGCCGAGGAGTCTACCATGGCTCAAGAATCTCCC AAAAATTCAGCAGCAGAAATTCCAGTGACTAGTAATGGAGAAGTTGATGACTCTCGTGAACATAGCTTTAATAGGGGTTTCTTCAGTGCC CGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGTGGCTATCGGGCT CGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGACCCAGACCTGGGG GTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAGTTAAATAACAAT GTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAGAAGCAAGTAAAA GATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGCAATATCCCAACT AACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAAATGGAATATTGT CGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGTGAAACATCTGAA ATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGATGGACAGTGATTCAG AACCGTCAAGACGGTAGTGTTGACTTTGGCAGGAAATGGGATCCATATAAACAGGGATTTGGAAATGTTGCAACCAACACAGATGGGAAG AATTACTGTGGCCTACCAGGTGAATATTGGCTTGGAAATGATAAAATTAGCCAGCTTACCAGGATGGGACCCACAGAACTTTTGATAGAA ATGGAGGACTGGAAAGGAGACAAAGTAAAGGCTCACTATGGAGGATTCACTGTACAGAATGAAGCCAACAAATACCAGATCTCAGTGAAC AAATACAGAGGAACAGCCGGTAATGCCCTCATGGATGGAGCATCTCAGCTGATGGGAGAAAACAGGACCATGACCATTCACAACGGCATG TTCTTCAGCACGTATGACAGAGACAATGACGGCTGGTTAACATCAGATCCCAGAAAACAGTGTTCTAAAGAAGACGGTGGTGGATGGTGG TATAATAGATGTCATGCAGCCAATCCAAACGGCAGATACTACTGGGGTGGACAGTACACCTGGGACATGGCAAAGCATGGCACAGATGAT GGTGTAGTATGGATGAATTGGAAGGGGTCATGGTACTCAATGAGGAAGATGAGTATGAAGATCAGGCCCTTCTTCCCACAGCAATAGTCC CCAATACGTAGATTTTTGCTCTTCTGTATGTGACAACATTTTTGTACATTATGTTATTGGAATTTTCTTTCATACATTATATTCCTCTAA AACTCTCAAGCAGACGTGAGTGTGACTTTTTGAAAAAAGTATAGGATAAATTACATTAAAATAGCACATGATTTTCTTTTGTTTTCTTCA TTTCTCTTGCTCACCAAGAAGTAACAAAAGTATAGTTTTGACAGAGTTGGTGTTCATAATTTCAGTTCTAGTTGATTGCGAGAATTTTCA AATAAGGAAGAGGGGTCTTTTATCCTTGTCGTAGGAAAACCATGACGGAAAGGAAAAACTGATGTTTAAAAGTCCACTTTTAAAACTATA >In-frame_ARFIP1_ENST00000353617_chr4_153750878_+_FGB_ENST00000302068_chr4_155486960_+_2167nt ACTTCCGGCTTCGCTGCTCTTGGTTCTGGTTCTGGAGGCTGGGTTGAGAGGTCGCCGGTCCGACTGTCCTCGGCGGTTGGTCAGTGTGAA TTTGTGACAGCTGCAGTTGCTCCCCGCCCCCGAGCAGCCGAGGTGCGTGGGGGAAGGGGAAGAAGGAAAAGGTCCGGGTCGCGTTTCCGC TCAGTTTTTGCCAGGGTTGAGGCGATTCCAGAGAGCGGCGGAAAGGATAAGCCTCGACTTAGAAGCTACCGAGTTACCCTAAGAAAGGAG TCTACCATGGCTCAAGAATCTCCCAAAAATTCAGCAGCAGAAATTCCAGTGACTAGTAATGGAGAAGTTGATGACTCTCGTGAACATAGC TTTAATAGGGGTTTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCC ATCAGTGGAGGTGGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGT CTTCACGCTGACCCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAAT AGTGTTGATGAGTTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGG CAAAAGAGGCAGAAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAG ACTGTGAATAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGAT GTCTCAGCTCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATC AGGAAAGGAGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAA AATGGAGGATGGACAGTGATTCAGAACCGTCAAGACGGTAGTGTTGACTTTGGCAGGAAATGGGATCCATATAAACAGGGATTTGGAAAT GTTGCAACCAACACAGATGGGAAGAATTACTGTGGCCTACCAGGTGAATATTGGCTTGGAAATGATAAAATTAGCCAGCTTACCAGGATG GGACCCACAGAACTTTTGATAGAAATGGAGGACTGGAAAGGAGACAAAGTAAAGGCTCACTATGGAGGATTCACTGTACAGAATGAAGCC AACAAATACCAGATCTCAGTGAACAAATACAGAGGAACAGCCGGTAATGCCCTCATGGATGGAGCATCTCAGCTGATGGGAGAAAACAGG ACCATGACCATTCACAACGGCATGTTCTTCAGCACGTATGACAGAGACAATGACGGCTGGTTAACATCAGATCCCAGAAAACAGTGTTCT AAAGAAGACGGTGGTGGATGGTGGTATAATAGATGTCATGCAGCCAATCCAAACGGCAGATACTACTGGGGTGGACAGTACACCTGGGAC ATGGCAAAGCATGGCACAGATGATGGTGTAGTATGGATGAATTGGAAGGGGTCATGGTACTCAATGAGGAAGATGAGTATGAAGATCAGG CCCTTCTTCCCACAGCAATAGTCCCCAATACGTAGATTTTTGCTCTTCTGTATGTGACAACATTTTTGTACATTATGTTATTGGAATTTT CTTTCATACATTATATTCCTCTAAAACTCTCAAGCAGACGTGAGTGTGACTTTTTGAAAAAAGTATAGGATAAATTACATTAAAATAGCA CATGATTTTCTTTTGTTTTCTTCATTTCTCTTGCTCACCAAGAAGTAACAAAAGTATAGTTTTGACAGAGTTGGTGTTCATAATTTCAGT TCTAGTTGATTGCGAGAATTTTCAAATAAGGAAGAGGGGTCTTTTATCCTTGTCGTAGGAAAACCATGACGGAAAGGAAAAACTGATGTT TAAAAGTCCACTTTTAAAACTATATTTATTTATGTAGGATCTGTCAAAGAAAACTTCCAAAAAGATTTATTAATTAAACCAGACTCTGTT >In-frame_ARFIP1_ENST00000405727_chr4_153750878_+_FGB_ENST00000302068_chr4_155486960_+_2021nt CGCTGCTCTTGGTTCTGGTTCTGGAGGCTGGGTTGAGAGGTCGCCGGTCCGACTGTCCTCGGCGGTTGGTCAGTGTGAATTTGTGACAGC TGCAGTTGCTCCCCGCCCCCGAGCAGCCGAGGAGTCTACCATGGCTCAAGAATCTCCCAAAAATTCAGCAGCAGAAATTCCAGTGACTAG TAATGGAGAAGTTGATGACTCTCGTGAACATAGCTTTAATAGGGGTTTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGA AGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGTGGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAA AGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGACCCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGA GGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAGTTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTC CTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAGAAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTC AGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAA CCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCC TGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAA ACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGATGGACAGTGATTCAGAACCGTCAAGACGGTAGTGTTGACTTTGGCAG GAAATGGGATCCATATAAACAGGGATTTGGAAATGTTGCAACCAACACAGATGGGAAGAATTACTGTGGCCTACCAGGTGAATATTGGCT TGGAAATGATAAAATTAGCCAGCTTACCAGGATGGGACCCACAGAACTTTTGATAGAAATGGAGGACTGGAAAGGAGACAAAGTAAAGGC TCACTATGGAGGATTCACTGTACAGAATGAAGCCAACAAATACCAGATCTCAGTGAACAAATACAGAGGAACAGCCGGTAATGCCCTCAT GGATGGAGCATCTCAGCTGATGGGAGAAAACAGGACCATGACCATTCACAACGGCATGTTCTTCAGCACGTATGACAGAGACAATGACGG CTGGTTAACATCAGATCCCAGAAAACAGTGTTCTAAAGAAGACGGTGGTGGATGGTGGTATAATAGATGTCATGCAGCCAATCCAAACGG CAGATACTACTGGGGTGGACAGTACACCTGGGACATGGCAAAGCATGGCACAGATGATGGTGTAGTATGGATGAATTGGAAGGGGTCATG GTACTCAATGAGGAAGATGAGTATGAAGATCAGGCCCTTCTTCCCACAGCAATAGTCCCCAATACGTAGATTTTTGCTCTTCTGTATGTG ACAACATTTTTGTACATTATGTTATTGGAATTTTCTTTCATACATTATATTCCTCTAAAACTCTCAAGCAGACGTGAGTGTGACTTTTTG AAAAAAGTATAGGATAAATTACATTAAAATAGCACATGATTTTCTTTTGTTTTCTTCATTTCTCTTGCTCACCAAGAAGTAACAAAAGTA TAGTTTTGACAGAGTTGGTGTTCATAATTTCAGTTCTAGTTGATTGCGAGAATTTTCAAATAAGGAAGAGGGGTCTTTTATCCTTGTCGT AGGAAAACCATGACGGAAAGGAAAAACTGATGTTTAAAAGTCCACTTTTAAAACTATATTTATTTATGTAGGATCTGTCAAAGAAAACTT >In-frame_ARFIP1_ENST00000356064_chr4_153750878_+_FGB_ENST00000302068_chr4_155486960_+_2142nt CTGGTTCTGGAGGCTGGGTTGAGAGGTCGCCGGTCCGACTGTCCTCGGCGGTTGGTCAGTGTGAATTTGTGACAGCTGCAGTTGCTCCCC GCCCCCGAGCAGCCGAGGTGCGTGGGGGAAGGGGAAGAAGGAAAAGGTCCGGGTCGCGTTTCCGCTCAGTTTTTGCCAGGGTTGAGGCGA TTCCAGAGAGCGGCGGAAAGGATAAGCCTCGACTTAGAAGCTACCGAGTTACCCTAAGAAAGGAGTCTACCATGGCTCAAGAATCTCCCA AAAATTCAGCAGCAGAAATTCCAGTGACTAGTAATGGAGAAGTTGATGACTCTCGTGAACATAGCTTTAATAGGGGTTTCTTCAGTGCCC GTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGTGGCTATCGGGCTC GTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGACCCAGACCTGGGGG TGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAGTTAAATAACAATG TGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAGAAGCAAGTAAAAG ATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGCAATATCCCAACTA ACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAAATGGAATATTGTC GCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGTGAAACATCTGAAA TGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGATGGACAGTGATTCAGA ACCGTCAAGACGGTAGTGTTGACTTTGGCAGGAAATGGGATCCATATAAACAGGGATTTGGAAATGTTGCAACCAACACAGATGGGAAGA ATTACTGTGGCCTACCAGGTGAATATTGGCTTGGAAATGATAAAATTAGCCAGCTTACCAGGATGGGACCCACAGAACTTTTGATAGAAA TGGAGGACTGGAAAGGAGACAAAGTAAAGGCTCACTATGGAGGATTCACTGTACAGAATGAAGCCAACAAATACCAGATCTCAGTGAACA AATACAGAGGAACAGCCGGTAATGCCCTCATGGATGGAGCATCTCAGCTGATGGGAGAAAACAGGACCATGACCATTCACAACGGCATGT TCTTCAGCACGTATGACAGAGACAATGACGGCTGGTTAACATCAGATCCCAGAAAACAGTGTTCTAAAGAAGACGGTGGTGGATGGTGGT ATAATAGATGTCATGCAGCCAATCCAAACGGCAGATACTACTGGGGTGGACAGTACACCTGGGACATGGCAAAGCATGGCACAGATGATG GTGTAGTATGGATGAATTGGAAGGGGTCATGGTACTCAATGAGGAAGATGAGTATGAAGATCAGGCCCTTCTTCCCACAGCAATAGTCCC CAATACGTAGATTTTTGCTCTTCTGTATGTGACAACATTTTTGTACATTATGTTATTGGAATTTTCTTTCATACATTATATTCCTCTAAA ACTCTCAAGCAGACGTGAGTGTGACTTTTTGAAAAAAGTATAGGATAAATTACATTAAAATAGCACATGATTTTCTTTTGTTTTCTTCAT TTCTCTTGCTCACCAAGAAGTAACAAAAGTATAGTTTTGACAGAGTTGGTGTTCATAATTTCAGTTCTAGTTGATTGCGAGAATTTTCAA ATAAGGAAGAGGGGTCTTTTATCCTTGTCGTAGGAAAACCATGACGGAAAGGAAAAACTGATGTTTAAAAGTCCACTTTTAAAACTATAT |
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FusionGenePPI for ARFIP1_FGB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ARFIP1 | ARF3, ARF1, ARF5, SLC2A4, ATP6V1C1, TBC1D15, TSNAX, YAP1, DNM1L, HIST1H4A, IDE, LUC7L2, PRMT3, PSMG3, SEC24A, SHMT2, STAT3, ARFIP2, PICK1, AACS, AKR1A1, ADSS, DPYSL2, G6PD, GART, HSD17B8, MVB12A, PFKM, PFKP, PPP3CA, PROSC, SARS, SEC24D, SHMT1, TSTA3, TXNDC9, USP14, ATOX1, ECH1, FLNB, LYPLA1, PAFAH1B2, PDCD6, PGM2L1, QDPR, STIP1, TBCA, DYNLT1, TMEM17, TMEM216, CDC5L, CDH1, CLPB, HSPA8, HSPBP1 | FGB | CALR, FGG, FGA, NID1, FBLN1, LPA, KHDRBS2, MIS12, GRB7, AIMP2, TK1, CDKN1A, SMN1, PIK3R3, ANXA7, FN1, CSNK2B, ASB6, ASB7, ASCC1, DDX19B, TMEM237, ALDH2, HIST1H2BJ, SBDS, MAPK6, SNX27, SPR, ADK, NARS, OXSR1, RING1, NAA15, NME2, POU2F1, SLK, TCEA1, EIF2A, BLVRB, CTNNBL1, TBC1D24, MAP2K1, UBLCP1, SNX3, ARHGAP1, ATG3, CCNYL1, VRK1, PMVK, PPID, MCTS1, PUS7, C6orf211, EEF1A2, PIR, PAK2, ITPA, LZIC, DUSP3, HDLBP, ADSL, DENR, HMGCS1, KIF2A, ETF1, FEN1, UBE2T, GCA, LETM1, WIBG, PSME2, CTH, OTUB1, FTO, HDGFRP2, GPKOW, PNPO, VPS26A, NAA50, RBM12, KIAA1143, EIF3J, HSP90AA4P, PRKCI, SF3A1, RPRD1A, PAPSS1, TLN1, UBA1, RPRD1B, FARSB, NME2P1, USO1, DDAH1, PBK, CAB39, RHOA, PTPN11, TES, PYGB, DIS3, SCRN1, PAK1, GNAQ, SYAP1, SNX6, PAPOLA, LSM1, GLS, GTF2F1, GNL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARFIP1_FGB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | FGB | P02675 | DB00364 | Sucralfate | Fibrinogen beta chain | small molecule | approved |
| Tgene | FGB | P02675 | DB13151 | Anti-inhibitor coagulant complex | Fibrinogen beta chain | biotech | approved|investigational |
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RelatedDiseases for ARFIP1_FGB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | FGB | C2584774 | Congenital hypofibrinogenemia | 4 | ORPHANET;UNIPROT |
| Tgene | FGB | C0029456 | Osteoporosis | 1 | CTD_human |
| Tgene | FGB | C0030567 | Parkinson Disease | 1 | CTD_human |
| Tgene | FGB | C0272350 | Dysfibrinogenemia, Congenital | 1 | ORPHANET;UNIPROT |
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