FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 23564

FusionGeneSummary for NCAPG_NCAPG

check button Fusion gene summary
Fusion gene informationFusion gene name: NCAPG_NCAPG
Fusion gene ID: 23564
HgeneTgene
Gene symbol

NCAPG

NCAPG

Gene ID

64151

64151

Gene namenon-SMC condensin I complex subunit Gnon-SMC condensin I complex subunit G
SynonymsCAPG|CHCG|NY-MEL-3|YCG1CAPG|CHCG|NY-MEL-3|YCG1
Cytomap

4p15.31

4p15.31

Type of geneprotein-codingprotein-coding
Descriptioncondensin complex subunit 3XCAP-G homologchromosome condensation protein Gchromosome-associated protein Gcondensin subunit CAP-Gmelanoma antigen NY-MEL-3condensin complex subunit 3XCAP-G homologchromosome condensation protein Gchromosome-associated protein Gcondensin subunit CAP-Gmelanoma antigen NY-MEL-3
Modification date2018052320180523
UniProtAcc

Q9BPX3

Q9BPX3

Ensembl transtripts involved in fusion geneENST00000251496, ENST00000251496, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: NCAPG [Title/Abstract] AND NCAPG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCAPG

GO:0007076

mitotic chromosome condensation

11136719

TgeneNCAPG

GO:0007076

mitotic chromosome condensation

11136719


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW794691NCAPGchr4

17844002

+NCAPGchr4

17841698

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000251496ENST00000251496NCAPGchr4

17844002

+NCAPGchr4

17841698

+

Top

FusionProtFeatures for NCAPG_NCAPG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCAPG

Q9BPX3

NCAPG

Q9BPX3

Regulatory subunit of the condensin complex, a complexrequired for conversion of interphase chromatin into mitotic-likecondense chromosomes. The condensin complex probably introducespositive supercoils into relaxed DNA in the presence of type Itopoisomerases and converts nicked DNA into positive knotted formsin the presence of type II topoisomerases.{ECO:0000269|PubMed:11136719}. Regulatory subunit of the condensin complex, a complexrequired for conversion of interphase chromatin into mitotic-likecondense chromosomes. The condensin complex probably introducespositive supercoils into relaxed DNA in the presence of type Itopoisomerases and converts nicked DNA into positive knotted formsin the presence of type II topoisomerases.{ECO:0000269|PubMed:11136719}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NCAPG_NCAPG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NCAPG_NCAPG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NCAPGPTP4A3, DNMT3B, NPM1, PARP1, XRCC1, FEN1, LIG3, POLD1, POLB, RAD21, NCAPD2, SMC2, NCAPH, SMC4, CDK1, CUL3, PAXIP1, EPS15L1, CCAR2, PLEC, EGFR, TNFSF13B, ARPC1A, MAGIX, GPR137B, ARRDC1, HTR6, NTRK1, MED4, MED20, MED23, FOXA3, FOXL1, ESR1, UBC, DTX3L, HECTD1, NCAPH2, SNW1, PPP3CA, DPEP1, BMP1, INTU, FZD10, MAS1, FUZ, HTR2C, CDH19, CHRM4, C3AR1, AARSD1NCAPGPTP4A3, DNMT3B, NPM1, PARP1, XRCC1, FEN1, LIG3, POLD1, POLB, RAD21, NCAPD2, SMC2, NCAPH, SMC4, CDK1, CUL3, PAXIP1, EPS15L1, CCAR2, PLEC, EGFR, TNFSF13B, ARPC1A, MAGIX, GPR137B, ARRDC1, HTR6, NTRK1, MED4, MED20, MED23, FOXA3, FOXL1, ESR1, UBC, DTX3L, HECTD1, NCAPH2, SNW1, PPP3CA, DPEP1, BMP1, INTU, FZD10, MAS1, FUZ, HTR2C, CDH19, CHRM4, C3AR1, AARSD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NCAPG_NCAPG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NCAPG_NCAPG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource