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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23561

FusionGeneSummary for NCAPG2_LYAR

check button Fusion gene summary
Fusion gene informationFusion gene name: NCAPG2_LYAR
Fusion gene ID: 23561
HgeneTgene
Gene symbol

NCAPG2

LYAR

Gene ID

54892

55646

Gene namenon-SMC condensin II complex subunit G2Ly1 antibody reactive
SynonymsCAP-G2|CAPG2|LUZP5|MTB|hCAP-G2ZC2HC2|ZLYAR
Cytomap

7q36.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptioncondensin-2 complex subunit G2chromosome-associated protein G2leucine zipper protein 5more than blood homologcell growth-regulating nucleolar proteinLy1 antibody reactive homolog
Modification date2018051920180519
UniProtAcc

Q86XI2

Q9NX58

Ensembl transtripts involved in fusion geneENST00000356309, ENST00000409423, 
ENST00000275830, ENST00000409339, 
ENST00000449727, ENST00000541468, 
ENST00000479022, 
ENST00000343470, 
ENST00000452476, 
Fusion gene scores* DoF score4 X 4 X 4=646 X 5 X 4=120
# samples 47
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCAPG2 [Title/Abstract] AND LYAR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN337717NCAPG2chr7

158443577

-LYARchr4

4281478

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000356309ENST00000343470NCAPG2chr7

158443577

-LYARchr4

4281478

-
intron-3CDSENST00000356309ENST00000452476NCAPG2chr7

158443577

-LYARchr4

4281478

-
intron-3CDSENST00000409423ENST00000343470NCAPG2chr7

158443577

-LYARchr4

4281478

-
intron-3CDSENST00000409423ENST00000452476NCAPG2chr7

158443577

-LYARchr4

4281478

-
intron-3CDSENST00000275830ENST00000343470NCAPG2chr7

158443577

-LYARchr4

4281478

-
intron-3CDSENST00000275830ENST00000452476NCAPG2chr7

158443577

-LYARchr4

4281478

-
intron-3CDSENST00000409339ENST00000343470NCAPG2chr7

158443577

-LYARchr4

4281478

-
intron-3CDSENST00000409339ENST00000452476NCAPG2chr7

158443577

-LYARchr4

4281478

-
intron-3CDSENST00000449727ENST00000343470NCAPG2chr7

158443577

-LYARchr4

4281478

-
intron-3CDSENST00000449727ENST00000452476NCAPG2chr7

158443577

-LYARchr4

4281478

-
intron-3CDSENST00000541468ENST00000343470NCAPG2chr7

158443577

-LYARchr4

4281478

-
intron-3CDSENST00000541468ENST00000452476NCAPG2chr7

158443577

-LYARchr4

4281478

-
intron-3CDSENST00000479022ENST00000343470NCAPG2chr7

158443577

-LYARchr4

4281478

-
intron-3CDSENST00000479022ENST00000452476NCAPG2chr7

158443577

-LYARchr4

4281478

-

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FusionProtFeatures for NCAPG2_LYAR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCAPG2

Q86XI2

LYAR

Q9NX58

Regulatory subunit of the condensin-2 complex, a complexwhich establishes mitotic chromosome architecture and is involvedin physical rigidity of the chromatid axis.{ECO:0000269|PubMed:14532007}. Plays a role in the maintenance of the appropriateprocessing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and theirsubsequent processing to produce 18S and 28S rRNAs(PubMed:24495227). Also acts at the level of transcriptionregulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2)promoter and represses its expression (PubMed:25092918). Inneuroblastoma cells, may also repress the expression of oxidativestress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41that encodes a small nucleolar RNA (PubMed:28686580).Preferentially binds to a DNA motif containing 5'-GGTTAT-3'(PubMed:25092918). Stimulates phagocytosis of photoreceptor outersegments by retinal pigment epithelial cells (By similarity).Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stemcells (ESCs), which in turn is essential for ESC self-renewal (Bysimilarity). {ECO:0000250|UniProtKB:Q08288,ECO:0000269|PubMed:24495227, ECO:0000269|PubMed:25092918,ECO:0000269|PubMed:28686580}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NCAPG2_LYAR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NCAPG2_LYAR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCAPG2_LYAR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NCAPG2_LYAR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource