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Fusion gene ID: 2356 |
FusionGeneSummary for ARFIP1_DUSP1 |
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Fusion gene information | Fusion gene name: ARFIP1_DUSP1 | Fusion gene ID: 2356 | Hgene | Tgene | Gene symbol | ARFIP1 | DUSP1 | Gene ID | 27236 | 11266 |
Gene name | ADP ribosylation factor interacting protein 1 | dual specificity phosphatase 12 | |
Synonyms | HSU52521 | DUSP1|YVH1 | |
Cytomap | 4q31.3 | 1q23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | arfaptin-1 | dual specificity protein phosphatase 12YVH1 protein-tyrosine phosphatase orthologdual specificity tyrosine phosphatase YVH1serine/threonine specific protein phosphatase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P53367 | P28562 | |
Ensembl transtripts involved in fusion gene | ENST00000451320, ENST00000429148, ENST00000353617, ENST00000405727, ENST00000356064, ENST00000511289, | ENST00000239223, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 5 X 1=20 |
# samples | 3 | 5 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ARFIP1 [Title/Abstract] AND DUSP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ARFIP1 | GO:0006886 | intracellular protein transport | 12606037 |
Hgene | ARFIP1 | GO:0050708 | regulation of protein secretion | 12606037 |
Tgene | DUSP1 | GO:0016311 | dephosphorylation | 10446167|24531476 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AV722782 | ARFIP1 | chr4 | 153832600 | - | DUSP1 | chr5 | 172197842 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000451320 | ENST00000239223 | ARFIP1 | chr4 | 153832600 | - | DUSP1 | chr5 | 172197842 | - |
intron-3CDS | ENST00000429148 | ENST00000239223 | ARFIP1 | chr4 | 153832600 | - | DUSP1 | chr5 | 172197842 | - |
3UTR-3CDS | ENST00000353617 | ENST00000239223 | ARFIP1 | chr4 | 153832600 | - | DUSP1 | chr5 | 172197842 | - |
intron-3CDS | ENST00000405727 | ENST00000239223 | ARFIP1 | chr4 | 153832600 | - | DUSP1 | chr5 | 172197842 | - |
intron-3CDS | ENST00000356064 | ENST00000239223 | ARFIP1 | chr4 | 153832600 | - | DUSP1 | chr5 | 172197842 | - |
intron-3CDS | ENST00000511289 | ENST00000239223 | ARFIP1 | chr4 | 153832600 | - | DUSP1 | chr5 | 172197842 | - |
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FusionProtFeatures for ARFIP1_DUSP1 |
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Hgene | Tgene |
ARFIP1 | DUSP1 |
Putative target protein of ADP-ribosylation factor. | Dual specificity phosphatase that dephosphorylates MAPkinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating itsactivity during the meiotic cell cycle.{ECO:0000250|UniProtKB:P28563}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ARFIP1_DUSP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ARFIP1_DUSP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARFIP1_DUSP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARFIP1_DUSP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | DUSP1 | C0011581 | Depressive disorder | 5 | PSYGENET |
Tgene | DUSP1 | C0011570 | Mental Depression | 4 | PSYGENET |
Tgene | DUSP1 | C0011616 | Contact Dermatitis | 1 | CTD_human |
Tgene | DUSP1 | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | DUSP1 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | DUSP1 | C3495559 | Juvenile arthritis | 1 | CTD_human |