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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2356

FusionGeneSummary for ARFIP1_DUSP1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARFIP1_DUSP1
Fusion gene ID: 2356
HgeneTgene
Gene symbol

ARFIP1

DUSP1

Gene ID

27236

11266

Gene nameADP ribosylation factor interacting protein 1dual specificity phosphatase 12
SynonymsHSU52521DUSP1|YVH1
Cytomap

4q31.3

1q23.3

Type of geneprotein-codingprotein-coding
Descriptionarfaptin-1dual specificity protein phosphatase 12YVH1 protein-tyrosine phosphatase orthologdual specificity tyrosine phosphatase YVH1serine/threonine specific protein phosphatase
Modification date2018052320180523
UniProtAcc

P53367

P28562

Ensembl transtripts involved in fusion geneENST00000451320, ENST00000429148, 
ENST00000353617, ENST00000405727, 
ENST00000356064, ENST00000511289, 
ENST00000239223, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 5 X 1=20
# samples 35
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARFIP1 [Title/Abstract] AND DUSP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARFIP1

GO:0006886

intracellular protein transport

12606037

HgeneARFIP1

GO:0050708

regulation of protein secretion

12606037

TgeneDUSP1

GO:0016311

dephosphorylation

10446167|24531476


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AV722782ARFIP1chr4

153832600

-DUSP1chr5

172197842

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000451320ENST00000239223ARFIP1chr4

153832600

-DUSP1chr5

172197842

-
intron-3CDSENST00000429148ENST00000239223ARFIP1chr4

153832600

-DUSP1chr5

172197842

-
3UTR-3CDSENST00000353617ENST00000239223ARFIP1chr4

153832600

-DUSP1chr5

172197842

-
intron-3CDSENST00000405727ENST00000239223ARFIP1chr4

153832600

-DUSP1chr5

172197842

-
intron-3CDSENST00000356064ENST00000239223ARFIP1chr4

153832600

-DUSP1chr5

172197842

-
intron-3CDSENST00000511289ENST00000239223ARFIP1chr4

153832600

-DUSP1chr5

172197842

-

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FusionProtFeatures for ARFIP1_DUSP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARFIP1

P53367

DUSP1

P28562

Putative target protein of ADP-ribosylation factor. Dual specificity phosphatase that dephosphorylates MAPkinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating itsactivity during the meiotic cell cycle.{ECO:0000250|UniProtKB:P28563}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARFIP1_DUSP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARFIP1_DUSP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARFIP1_DUSP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARFIP1_DUSP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDUSP1C0011581Depressive disorder5PSYGENET
TgeneDUSP1C0011570Mental Depression4PSYGENET
TgeneDUSP1C0011616Contact Dermatitis1CTD_human
TgeneDUSP1C0014175Endometriosis1CTD_human
TgeneDUSP1C0151744Myocardial Ischemia1CTD_human
TgeneDUSP1C3495559Juvenile arthritis1CTD_human