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Fusion gene ID: 23549 |
FusionGeneSummary for NCAM2_CYP4F29P |
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Fusion gene information | Fusion gene name: NCAM2_CYP4F29P | Fusion gene ID: 23549 | Hgene | Tgene | Gene symbol | NCAM2 | CYP4F29P | Gene ID | 4685 | 54055 |
Gene name | neural cell adhesion molecule 2 | cytochrome P450 family 4 subfamily F member 29, pseudogene | |
Synonyms | NCAM21 | 4F-se4[6:7:8]|C21orf15|CYP4F-se4[6:7:8]|CYP4F3LP | |
Cytomap | 21q21.1 | 21q11.2 | |
Type of gene | protein-coding | pseudo | |
Description | neural cell adhesion molecule 2N-CAM-2NCAM-2 | cytochrome P450 pseudogenecytochrome P450, family 4, subfamily F, polypeptide 29, pseudogenecytochrome P450, family 4, subfamily F, polypeptide 3-like pseudogenecytochrome P450, subfamily IVF, polypeptide 3-like pseudogene | |
Modification date | 20180523 | 20180329 | |
UniProtAcc | O15394 | ||
Ensembl transtripts involved in fusion gene | ENST00000400546, ENST00000284894, ENST00000535285, ENST00000486367, | ENST00000428301, | |
Fusion gene scores | * DoF score | 9 X 4 X 5=180 | 1 X 1 X 1=1 |
# samples | 9 | 1 | |
** MAII score | log2(9/180*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: NCAM2 [Title/Abstract] AND CYP4F29P [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LGG | TCGA-E1-5304-01A | NCAM2 | chr21 | 22370936 | + | CYP4F29P | chr21 | 15218462 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000400546 | ENST00000428301 | NCAM2 | chr21 | 22370936 | + | CYP4F29P | chr21 | 15218462 | - |
5CDS-5UTR | ENST00000284894 | ENST00000428301 | NCAM2 | chr21 | 22370936 | + | CYP4F29P | chr21 | 15218462 | - |
intron-5UTR | ENST00000535285 | ENST00000428301 | NCAM2 | chr21 | 22370936 | + | CYP4F29P | chr21 | 15218462 | - |
intron-5UTR | ENST00000486367 | ENST00000428301 | NCAM2 | chr21 | 22370936 | + | CYP4F29P | chr21 | 15218462 | - |
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FusionProtFeatures for NCAM2_CYP4F29P |
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Hgene | Tgene |
NCAM2 | CYP4F29P |
May play important roles in selective fasciculation andzone-to-zone projection of the primary olfactory axons. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NCAM2_CYP4F29P |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NCAM2_CYP4F29P |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NCAM2 | QDPR | CYP4F29P |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NCAM2_CYP4F29P |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NCAM2_CYP4F29P |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |