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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23522

FusionGeneSummary for NBPF1_TAPT1

check button Fusion gene summary
Fusion gene informationFusion gene name: NBPF1_TAPT1
Fusion gene ID: 23522
HgeneTgene
Gene symbol

NBPF1

TAPT1

Gene ID

55672

202018

Gene nameNBPF member 1transmembrane anterior posterior transformation 1
SynonymsAB13|AB14|AB23|AD2|NBG|NBPFCMVFR|OCLSBG
Cytomap

1p36.13

4p15.32

Type of geneprotein-codingprotein-coding
Descriptionneuroblastoma breakpoint family member 1transmembrane anterior posterior transformation protein 1 homologcytomegalovirus partial fusion receptor
Modification date2018051920180523
UniProtAcc

Q6NXT6

Ensembl transtripts involved in fusion geneENST00000430580, ENST00000420031, 
ENST00000432949, ENST00000287968, 
ENST00000599908, 
ENST00000405303, 
ENST00000399920, ENST00000304584, 
ENST00000508888, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: NBPF1 [Title/Abstract] AND TAPT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTAPT1

GO:0045724

positive regulation of cilium assembly

26365339


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF885212NBPF1chr1

16931995

-TAPT1chr4

16163189

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000430580ENST00000405303NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-intronENST00000430580ENST00000399920NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-intronENST00000430580ENST00000304584NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-intronENST00000430580ENST00000508888NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-3UTRENST00000420031ENST00000405303NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-intronENST00000420031ENST00000399920NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-intronENST00000420031ENST00000304584NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-intronENST00000420031ENST00000508888NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-3UTRENST00000432949ENST00000405303NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-intronENST00000432949ENST00000399920NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-intronENST00000432949ENST00000304584NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-intronENST00000432949ENST00000508888NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-3UTRENST00000287968ENST00000405303NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-intronENST00000287968ENST00000399920NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-intronENST00000287968ENST00000304584NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-intronENST00000287968ENST00000508888NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-3UTRENST00000599908ENST00000405303NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-intronENST00000599908ENST00000399920NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-intronENST00000599908ENST00000304584NBPF1chr1

16931995

-TAPT1chr4

16163189

-
intron-intronENST00000599908ENST00000508888NBPF1chr1

16931995

-TAPT1chr4

16163189

-

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FusionProtFeatures for NBPF1_TAPT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NBPF1

TAPT1

Q6NXT6

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Plays a role in primary cilia formation(PubMed:26365339). May act as a downstream effector of HOXC8possibly by transducing or transmitting extracellular informationrequired for axial skeletal patterning during development (Bysimilarity). May be involved in cartilage and bone development (Bysimilarity). May play a role in the differentiation of cranialneural crest cells (By similarity). {ECO:0000250|UniProtKB:A2BIE7,ECO:0000250|UniProtKB:Q4VBD2, ECO:0000269|PubMed:26365339}. (Microbial infection) In case of infection, may act as afusion receptor for cytomegalovirus (HCMV) strain AD169.{ECO:0000269|PubMed:10640539}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NBPF1_TAPT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NBPF1_TAPT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NBPF1_TAPT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NBPF1_TAPT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTAPT1C4225162OSTEOCHONDRODYSPLASIA, COMPLEX LETHAL, SYMOENS-BARNES-GISTELINCK TYPE1ORPHANET;UNIPROT