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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23517

FusionGeneSummary for NBPF12_USP32

check button Fusion gene summary
Fusion gene informationFusion gene name: NBPF12_USP32
Fusion gene ID: 23517
HgeneTgene
Gene symbol

NBPF12

USP32

Gene ID

149013

84669

Gene nameNBPF member 12ubiquitin specific peptidase 32
SynonymsCOAS1|KIAA1245NY-REN-60|USP10
Cytomap

1q21.1

17q23.1-q23.2

Type of geneprotein-codingprotein-coding
Descriptionneuroblastoma breakpoint family member 12chomosome one amplified sequence 1 cyclophilinchromosome 1 amplified sequence 1ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32
Modification date2018051920180523
UniProtAcc

Q5TAG4

Q8NFA0

Ensembl transtripts involved in fusion geneENST00000446760, ENST00000442909, 
ENST00000309471, ENST00000439206, 
ENST00000446080, ENST00000447862, 
ENST00000438910, ENST00000414957, 
ENST00000438411, ENST00000537773, 
ENST00000300896, ENST00000592339, 
ENST00000393003, ENST00000586881, 
Fusion gene scores* DoF score1 X 1 X 1=112 X 7 X 6=504
# samples 112
** MAII scorelog2(1/1*10)=3.32192809488736log2(12/504*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NBPF12 [Title/Abstract] AND USP32 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A1FW-01ANBPF12chr1

146374324

+USP32chr17

58348842

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000446760ENST00000300896NBPF12chr1

146374324

+USP32chr17

58348842

-
5UTR-intronENST00000446760ENST00000592339NBPF12chr1

146374324

+USP32chr17

58348842

-
5UTR-intronENST00000446760ENST00000393003NBPF12chr1

146374324

+USP32chr17

58348842

-
5UTR-intronENST00000446760ENST00000586881NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-3CDSENST00000442909ENST00000300896NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000442909ENST00000592339NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000442909ENST00000393003NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000442909ENST00000586881NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-3CDSENST00000309471ENST00000300896NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000309471ENST00000592339NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000309471ENST00000393003NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000309471ENST00000586881NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-3CDSENST00000439206ENST00000300896NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000439206ENST00000592339NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000439206ENST00000393003NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000439206ENST00000586881NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-3CDSENST00000446080ENST00000300896NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000446080ENST00000592339NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000446080ENST00000393003NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000446080ENST00000586881NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-3CDSENST00000447862ENST00000300896NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000447862ENST00000592339NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000447862ENST00000393003NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000447862ENST00000586881NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-3CDSENST00000438910ENST00000300896NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000438910ENST00000592339NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000438910ENST00000393003NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000438910ENST00000586881NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-3CDSENST00000414957ENST00000300896NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000414957ENST00000592339NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000414957ENST00000393003NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000414957ENST00000586881NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-3CDSENST00000438411ENST00000300896NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000438411ENST00000592339NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000438411ENST00000393003NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000438411ENST00000586881NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-3CDSENST00000537773ENST00000300896NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000537773ENST00000592339NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000537773ENST00000393003NBPF12chr1

146374324

+USP32chr17

58348842

-
intron-intronENST00000537773ENST00000586881NBPF12chr1

146374324

+USP32chr17

58348842

-

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FusionProtFeatures for NBPF12_USP32


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NBPF12

Q5TAG4

USP32

Q8NFA0


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NBPF12_USP32


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NBPF12_USP32


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NBPF12UBCUSP32CDK1, FARSA, KRT8, KRT18, KRT19, ABCD3, YWHAB, TUBA1A, SMC1A, USP6, TRIP13, ERP44, UBXN1, MRPL39, VPS35, LRRC47, USP32P2, USP4, CUL3, CAND1, RBCK1, TRIM46, RNF144A, TRIM74, ZDHHC17, RAP1B, SORT1, SYNCRIP, BAG6, FDFT1, RAB6B, TPCN2, MANSC1, ENTPD7, ALDH3B1, CD83, NME4, HSPA12A, UBC, MTNR1A, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NBPF12_USP32


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NBPF12_USP32


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource