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Fusion gene ID: 23506 |
FusionGeneSummary for NBEA_RANBP6 |
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Fusion gene information | Fusion gene name: NBEA_RANBP6 | Fusion gene ID: 23506 | Hgene | Tgene | Gene symbol | NBEA | RANBP6 | Gene ID | 26960 | 26953 |
Gene name | neurobeachin | RAN binding protein 6 | |
Synonyms | BCL8B|LYST2 | - | |
Cytomap | 13q13.3 | 9p24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | neurobeachinlysosomal-trafficking regulator 2 | ran-binding protein 6Ran-GTP binding protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8NFP9 | O60518 | |
Ensembl transtripts involved in fusion gene | ENST00000540320, ENST00000400445, ENST00000310336, ENST00000379939, ENST00000537702, ENST00000379922, ENST00000461581, | ENST00000259569, ENST00000485372, | |
Fusion gene scores | * DoF score | 7 X 7 X 6=294 | 1 X 1 X 1=1 |
# samples | 7 | 1 | |
** MAII score | log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: NBEA [Title/Abstract] AND RANBP6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU686613 | NBEA | chr13 | 35827247 | - | RANBP6 | chr9 | 6013844 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000540320 | ENST00000259569 | NBEA | chr13 | 35827247 | - | RANBP6 | chr9 | 6013844 | + |
intron-5UTR | ENST00000540320 | ENST00000485372 | NBEA | chr13 | 35827247 | - | RANBP6 | chr9 | 6013844 | + |
intron-3CDS | ENST00000400445 | ENST00000259569 | NBEA | chr13 | 35827247 | - | RANBP6 | chr9 | 6013844 | + |
intron-5UTR | ENST00000400445 | ENST00000485372 | NBEA | chr13 | 35827247 | - | RANBP6 | chr9 | 6013844 | + |
intron-3CDS | ENST00000310336 | ENST00000259569 | NBEA | chr13 | 35827247 | - | RANBP6 | chr9 | 6013844 | + |
intron-5UTR | ENST00000310336 | ENST00000485372 | NBEA | chr13 | 35827247 | - | RANBP6 | chr9 | 6013844 | + |
intron-3CDS | ENST00000379939 | ENST00000259569 | NBEA | chr13 | 35827247 | - | RANBP6 | chr9 | 6013844 | + |
intron-5UTR | ENST00000379939 | ENST00000485372 | NBEA | chr13 | 35827247 | - | RANBP6 | chr9 | 6013844 | + |
intron-3CDS | ENST00000537702 | ENST00000259569 | NBEA | chr13 | 35827247 | - | RANBP6 | chr9 | 6013844 | + |
intron-5UTR | ENST00000537702 | ENST00000485372 | NBEA | chr13 | 35827247 | - | RANBP6 | chr9 | 6013844 | + |
intron-3CDS | ENST00000379922 | ENST00000259569 | NBEA | chr13 | 35827247 | - | RANBP6 | chr9 | 6013844 | + |
intron-5UTR | ENST00000379922 | ENST00000485372 | NBEA | chr13 | 35827247 | - | RANBP6 | chr9 | 6013844 | + |
intron-3CDS | ENST00000461581 | ENST00000259569 | NBEA | chr13 | 35827247 | - | RANBP6 | chr9 | 6013844 | + |
intron-5UTR | ENST00000461581 | ENST00000485372 | NBEA | chr13 | 35827247 | - | RANBP6 | chr9 | 6013844 | + |
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FusionProtFeatures for NBEA_RANBP6 |
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Hgene | Tgene |
NBEA | RANBP6 |
Binds to type II regulatory subunits of protein kinase Aand anchors/targets them to the membrane. May anchor the kinase tocytoskeletal and/or organelle-associated proteins (By similarity).{ECO:0000250}. | May function in nuclear protein import as nucleartransport receptor. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NBEA_RANBP6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NBEA_RANBP6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NBEA_RANBP6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NBEA_RANBP6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NBEA | C0004352 | Autistic Disorder | 2 | CTD_human |
Hgene | NBEA | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |