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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23506

FusionGeneSummary for NBEA_RANBP6

check button Fusion gene summary
Fusion gene informationFusion gene name: NBEA_RANBP6
Fusion gene ID: 23506
HgeneTgene
Gene symbol

NBEA

RANBP6

Gene ID

26960

26953

Gene nameneurobeachinRAN binding protein 6
SynonymsBCL8B|LYST2-
Cytomap

13q13.3

9p24.1

Type of geneprotein-codingprotein-coding
Descriptionneurobeachinlysosomal-trafficking regulator 2ran-binding protein 6Ran-GTP binding protein
Modification date2018051920180523
UniProtAcc

Q8NFP9

O60518

Ensembl transtripts involved in fusion geneENST00000540320, ENST00000400445, 
ENST00000310336, ENST00000379939, 
ENST00000537702, ENST00000379922, 
ENST00000461581, 
ENST00000259569, 
ENST00000485372, 
Fusion gene scores* DoF score7 X 7 X 6=2941 X 1 X 1=1
# samples 71
** MAII scorelog2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: NBEA [Title/Abstract] AND RANBP6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU686613NBEAchr13

35827247

-RANBP6chr9

6013844

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000540320ENST00000259569NBEAchr13

35827247

-RANBP6chr9

6013844

+
intron-5UTRENST00000540320ENST00000485372NBEAchr13

35827247

-RANBP6chr9

6013844

+
intron-3CDSENST00000400445ENST00000259569NBEAchr13

35827247

-RANBP6chr9

6013844

+
intron-5UTRENST00000400445ENST00000485372NBEAchr13

35827247

-RANBP6chr9

6013844

+
intron-3CDSENST00000310336ENST00000259569NBEAchr13

35827247

-RANBP6chr9

6013844

+
intron-5UTRENST00000310336ENST00000485372NBEAchr13

35827247

-RANBP6chr9

6013844

+
intron-3CDSENST00000379939ENST00000259569NBEAchr13

35827247

-RANBP6chr9

6013844

+
intron-5UTRENST00000379939ENST00000485372NBEAchr13

35827247

-RANBP6chr9

6013844

+
intron-3CDSENST00000537702ENST00000259569NBEAchr13

35827247

-RANBP6chr9

6013844

+
intron-5UTRENST00000537702ENST00000485372NBEAchr13

35827247

-RANBP6chr9

6013844

+
intron-3CDSENST00000379922ENST00000259569NBEAchr13

35827247

-RANBP6chr9

6013844

+
intron-5UTRENST00000379922ENST00000485372NBEAchr13

35827247

-RANBP6chr9

6013844

+
intron-3CDSENST00000461581ENST00000259569NBEAchr13

35827247

-RANBP6chr9

6013844

+
intron-5UTRENST00000461581ENST00000485372NBEAchr13

35827247

-RANBP6chr9

6013844

+

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FusionProtFeatures for NBEA_RANBP6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NBEA

Q8NFP9

RANBP6

O60518

Binds to type II regulatory subunits of protein kinase Aand anchors/targets them to the membrane. May anchor the kinase tocytoskeletal and/or organelle-associated proteins (By similarity).{ECO:0000250}. May function in nuclear protein import as nucleartransport receptor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NBEA_RANBP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NBEA_RANBP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NBEA_RANBP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NBEA_RANBP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNBEAC0004352Autistic Disorder2CTD_human
HgeneNBEAC0023893Liver Cirrhosis, Experimental1CTD_human