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Fusion gene ID: 23496 |
FusionGeneSummary for NBEAL1_TANK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NBEAL1_TANK | Fusion gene ID: 23496 | Hgene | Tgene | Gene symbol | NBEAL1 | TANK | Gene ID | 65065 | 10010 |
| Gene name | neurobeachin like 1 | TRAF family member associated NFKB activator | |
| Synonyms | A530083I02Rik|ALS2CR16|ALS2CR17 | I-TRAF|ITRAF|TRAF2 | |
| Cytomap | 2q33.2 | 2q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neurobeachin-like protein 1amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 16amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 17amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein | TRAF family member-associated NF-kappa-B activatorTRAF-interacting protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q6ZS30 | Q92844 | |
| Ensembl transtripts involved in fusion gene | ENST00000449802, ENST00000478884, | ENST00000259075, ENST00000457476, ENST00000392749, ENST00000461338, ENST00000402568, ENST00000406287, ENST00000405852, ENST00000403609, | |
| Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 3 X 3 X 3=27 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NBEAL1 [Title/Abstract] AND TANK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E2-A14Z-01A | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000449802 | ENST00000259075 | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
| 5CDS-intron | ENST00000449802 | ENST00000457476 | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
| 5CDS-intron | ENST00000449802 | ENST00000392749 | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
| 5CDS-intron | ENST00000449802 | ENST00000461338 | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
| 5CDS-intron | ENST00000449802 | ENST00000402568 | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
| 5CDS-intron | ENST00000449802 | ENST00000406287 | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
| 5CDS-intron | ENST00000449802 | ENST00000405852 | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
| 5CDS-intron | ENST00000449802 | ENST00000403609 | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
| intron-3CDS | ENST00000478884 | ENST00000259075 | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
| intron-intron | ENST00000478884 | ENST00000457476 | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
| intron-intron | ENST00000478884 | ENST00000392749 | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
| intron-intron | ENST00000478884 | ENST00000461338 | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
| intron-intron | ENST00000478884 | ENST00000402568 | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
| intron-intron | ENST00000478884 | ENST00000406287 | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
| intron-intron | ENST00000478884 | ENST00000405852 | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
| intron-intron | ENST00000478884 | ENST00000403609 | NBEAL1 | chr2 | 203975005 | + | TANK | chr2 | 162080426 | + |
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FusionProtFeatures for NBEAL1_TANK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NBEAL1 | TANK |
| Adapter protein involved in I-kappa-B-kinase (IKK)regulation which constitutively binds TBK1 and IKBKE playing arole in antiviral innate immunity. Acts as a regulator of TRAFfunction by maintaining them in a latent state. Blocks TRAF2binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation.Negatively regulates NF-kappaB signaling and cell survival uponDNA damage (PubMed:25861989). Plays a role as an adapter toassemble ZC3H12A, USP10 in a deubiquitination complex which playsa negative feedback response to attenuate NF-kappaB activationthrough the deubiquitination of IKBKG or TRAF6 in response tointerleukin-1-beta (IL1B) stimulation or upon DNA damage(PubMed:25861989). Promotes UBP10-induced deubiquitination ofTRAF6 in response to DNA damage (PubMed:25861989). May controlnegatively TRAF2-mediated NF-kappa-B activation signaled by CD40,TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833,ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TANK | chr2:203975005 | chr2:162080426 | ENST00000403609 | + | 0 | 3 | 22_62 | -14 | 120 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >TANK | chr2:203975005 | chr2:162080426 | ENST00000457476 | + | 0 | 4 | 22_62 | -53 | 120 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >TANK | chr2:203975005 | chr2:162080426 | ENST00000259075 | + | 3 | 8 | 394_420 | 109 | 426 | Zinc finger | Note=C2H2-type |
| Tgene | >TANK | chr2:203975005 | chr2:162080426 | ENST00000392749 | + | 3 | 8 | 394_420 | 109 | 426 | Zinc finger | Note=C2H2-type |
| Tgene | >TANK | chr2:203975005 | chr2:162080426 | ENST00000403609 | + | 0 | 3 | 394_420 | -14 | 120 | Zinc finger | Note=C2H2-type |
| Tgene | >TANK | chr2:203975005 | chr2:162080426 | ENST00000457476 | + | 0 | 4 | 394_420 | -53 | 120 | Zinc finger | Note=C2H2-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NBEAL1 | chr2:203975005 | chr2:162080426 | ENST00000449802 | + | 14 | 55 | 1883_1980 | 665 | 2695 | Domain | BEACH-type PH |
| Hgene | >NBEAL1 | chr2:203975005 | chr2:162080426 | ENST00000449802 | + | 14 | 55 | 1992_2284 | 665 | 2695 | Domain | BEACH |
| Hgene | >NBEAL1 | chr2:203975005 | chr2:162080426 | ENST00000449802 | + | 14 | 55 | 2439_2478 | 665 | 2695 | Repeat | Note=WD 1 |
| Hgene | >NBEAL1 | chr2:203975005 | chr2:162080426 | ENST00000449802 | + | 14 | 55 | 2490_2531 | 665 | 2695 | Repeat | Note=WD 2 |
| Tgene | TANK | chr2:203975005 | chr2:162080426 | ENST00000259075 | + | 3 | 8 | 22_62 | 109 | 426 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | TANK | chr2:203975005 | chr2:162080426 | ENST00000392749 | + | 3 | 8 | 22_62 | 109 | 426 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for NBEAL1_TANK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NBEAL1_ENST00000449802_chr2_203975005_+_TANK_ENST00000259075_chr2_162080426_+_982aa MASRERLFELWMLYCTKKDPDYLKLWLDTFVSSYEQFLDVDFEKLPTRVDDMPPGISLLPDNILQVLRIQLLQCVQKMADGLEEQQQALS ILLVKFFIILCRNLSNVEEIGTCSYINYVITMTTLYIQQLKSKKKEKEMADQTCIEEFVIHALAFCESLYDPYRNWRHRISGRILSTVEK SRQKYKPASLTVEFVPFFYQCFQESEHLKESLKCCLLHLFGAIVAGGQRNALQAISPATMEVLMRVLADCDSWEDGDPEEVGRKAELTLK CLTEVVHILLSSNSDQRQVETSTILENYFKLLNSDHSALPNQRRSRQWENRFIALQIKMLNTITAMLDCTDRPVLQAIFLNSNCFEHLIR LLQNCKVFQGQLDCLAISTIQALTAVMNKSPAAKEVFKERIGYTHMLEVLKSLGQPPLELLKELMNMAVEGDHTSVGILGISNVQPLLLL IQWLPELQSHDLQIFISDWLKRICCINRQSRTTCVNANMGIRIIETLDLHSSLHQTCAENLIAIHGSLGSQSVSSEEIRRLLRLLRVDES ESVHPYVTPVTRAILTMARKLSLESALQYFNLSHSMAGISVPPIQKWPGSAFSFSAWFCLDQDQLTLGIANKGGKRKQLYSFFTGSGMGF EAFITHSGMLVVAVCTKREYATVMLPDHSFCDSLWVRRQEVSSPRKETSARSLGSPLLHERGNIEKTFWDLKEEFHKICMLAKAQKDHLS KLNIPDTATETQCSVPIQCTDKTDKQEALFKPQAKDDINRGAPSITSVTPRGLCRDEEDTSFESLSKFNVKFPPMDNDSTFLHSTPERPG ILSPATSEAVCQEKFNMEFRDNPGNFVKTEETLFEIQGIDPIASAIQNLKTTDKTKPSNLVNTCIRTTLDRAACLPPGDHNALYVNSFPL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NBEAL1_ENST00000449802_chr2_203975005_+_TANK_ENST00000259075_chr2_162080426_+_2946nt ATGGCATCCAGAGAGAGGCTCTTTGAACTTTGGATGCTTTATTGTACAAAGAAAGATCCAGATTACCTGAAGCTGTGGTTGGACACTTTT GTTTCTAGCTATGAACAATTTTTAGACGTTGACTTTGAAAAGCTGCCTACCAGGGTAGATGATATGCCTCCAGGAATATCTCTGCTTCCT GATAATATTCTGCAGGTTCTGAGGATCCAGCTTCTACAGTGTGTTCAGAAAATGGCAGATGGGTTAGAGGAACAACAGCAAGCCTTGTCA ATTTTGCTTGTCAAGTTCTTCATTATTCTTTGCAGAAATCTATCAAATGTGGAAGAAATTGGGACTTGCTCGTACATTAATTATGTCATC ACCATGACAACACTCTATATTCAGCAATTAAAAAGCAAAAAAAAAGAGAAGGAAATGGCAGATCAGACATGTATTGAAGAATTTGTGATC CACGCATTGGCATTTTGTGAAAGCTTATATGATCCATATCGGAATTGGAGACATAGAATTTCAGGACGAATCCTTAGTACTGTGGAAAAG AGCAGACAGAAATATAAACCAGCTTCTCTCACAGTGGAATTCGTCCCTTTCTTTTATCAATGTTTTCAGGAAAGTGAACATCTCAAGGAA AGTCTTAAATGTTGCTTATTGCATCTCTTTGGAGCCATTGTAGCCGGTGGGCAGAGGAATGCTTTGCAAGCAATTTCTCCAGCCACTATG GAAGTTCTTATGCGAGTATTGGCAGATTGTGATTCCTGGGAGGATGGAGATCCTGAAGAAGTGGGTAGGAAGGCAGAACTAACTCTGAAG TGCCTTACAGAAGTGGTACATATCCTTCTCAGTAGCAACTCTGATCAGCGTCAAGTGGAAACCAGTACTATTCTGGAGAACTATTTTAAA TTGCTAAATTCAGATCATTCAGCTTTACCTAATCAAAGGAGGTCCAGACAGTGGGAAAACCGATTTATTGCTCTACAGATCAAAATGCTG AATACCATCACAGCCATGTTAGATTGTACAGATAGACCTGTTCTTCAGGCCATTTTTCTTAACAGCAATTGCTTTGAACATCTCATACGA CTGCTACAGAACTGCAAGGTGTTTCAGGGACAATTGGATTGTTTGGCCATATCAACCATTCAGGCTTTGACCGCAGTAATGAACAAATCT CCAGCTGCTAAGGAAGTATTTAAAGAAAGAATTGGTTATACACATATGCTTGAAGTATTAAAATCCCTGGGTCAGCCACCACTGGAATTA CTTAAAGAACTTATGAATATGGCTGTAGAGGGTGACCACACTTCAGTTGGGATTTTGGGCATTAGTAATGTCCAACCTCTCTTGCTTCTT ATCCAGTGGCTTCCAGAACTACAATCCCATGACCTGCAAATCTTCATCTCTGATTGGCTGAAAAGAATTTGTTGTATTAATAGACAGAGT CGAACTACTTGTGTCAATGCAAACATGGGGATTAGAATCATTGAAACCCTTGACTTGCATTCTTCCCTCCATCAAACTTGTGCTGAGAAC TTGATTGCAATCCATGGTTCCTTGGGGAGTCAGTCAGTGAGCTCAGAAGAAATCCGTCGACTACTGAGATTGCTGAGAGTGGATGAATCT GAGTCTGTTCACCCTTATGTCACTCCCGTGACTCGAGCAATCCTGACAATGGCCCGAAAACTAAGTCTAGAGAGTGCCCTCCAGTATTTC AATTTGTCACATAGTATGGCAGGAATTTCTGTGCCTCCCATACAGAAATGGCCAGGGTCTGCCTTTTCTTTCAGTGCTTGGTTTTGCTTA GACCAGGATCAGTTGACTCTTGGCATTGCTAACAAAGGAGGGAAAAGGAAACAATTGTACAGTTTTTTTACAGGAAGTGGCATGGGTTTT GAAGCCTTTATTACCCATTCAGGTATGTTGGTCGTGGCAGTGTGCACAAAAAGAGAATATGCAACGGTTATGCTTCCTGACCACAGTTTC TGTGATTCCCTCTGGGTAAGAAGACAAGAGGTTTCTTCTCCTAGAAAAGAAACTTCAGCAAGGAGTCTTGGCAGTCCTTTGCTCCATGAA AGGGGTAATATAGAGAAGACTTTCTGGGATCTGAAAGAAGAATTTCATAAAATATGCATGCTAGCAAAAGCACAGAAAGACCACTTAAGC AAACTTAATATACCAGACACTGCAACTGAAACACAGTGCTCTGTGCCTATACAGTGTACGGATAAAACAGATAAACAAGAAGCGCTGTTT AAGCCTCAGGCTAAAGATGATATAAATAGAGGTGCACCATCCATCACATCTGTCACACCAAGAGGACTGTGCAGAGATGAGGAAGACACC TCTTTTGAATCACTTTCTAAATTCAATGTCAAGTTTCCACCTATGGACAATGACTCAACTTTCTTACATAGCACTCCAGAGAGACCCGGC ATCCTTAGTCCTGCCACGTCTGAGGCAGTGTGCCAAGAGAAATTTAATATGGAGTTCAGAGACAACCCAGGGAACTTTGTTAAAACAGAA GAAACTTTATTTGAAATTCAGGGAATTGACCCCATAGCTTCAGCTATACAAAACCTTAAAACAACTGACAAAACAAAGCCCTCAAATCTC GTAAACACTTGTATCAGGACAACTCTGGATAGAGCTGCGTGTTTGCCACCTGGAGACCATAATGCATTATATGTAAATAGCTTCCCACTT CTGGACCCATCTGATGCACCTTTTCCCTCACTCGATTCCCCGGGAAAAGCAATCCGAGGACCACAGCAGCCCATTTGGAAGCCCTTTCCT AATCAAGACAGTGACTCGGTGGTACTAAGTGGCACAGACTCAGAACTGCATATACCTCGAGTATGTGAATTCTGTCAAGCAGTTTTCCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NBEAL1_ENST00000449802_chr2_203975005_+_TANK_ENST00000259075_chr2_162080426_+_3948nt GCTCGTCTGCCTGGCTGCGGGGTGACACGGGGCTTCGCCTTGGGAAGGGGTCGAGGGAAGCAGTTAGACGGCTGCCGGGCGGCGGCTGCC GCGCGGCACACAATATTTATTTAATTGCCCAACTACCACTGATGAAGATATATTGGAGTGACTGCTGAAATTGCCTTTTTGTTTTTAACC AGAGGACAGTCCATTTGTTTCACTTCTTTTTGCTTTCTTTACTGCTATGAGCTTTACTGAACGGCTGAAAAACTTGGAAAATAAAATGGA CATGCTGTAGTCTTGAACATAATTTTTTTAAGGAAAACTTAAAGTGCCAGAGTGAAAGCCAGAATGGCATCCAGAGAGAGGCTCTTTGAA CTTTGGATGCTTTATTGTACAAAGAAAGATCCAGATTACCTGAAGCTGTGGTTGGACACTTTTGTTTCTAGCTATGAACAATTTTTAGAC GTTGACTTTGAAAAGCTGCCTACCAGGGTAGATGATATGCCTCCAGGAATATCTCTGCTTCCTGATAATATTCTGCAGGTTCTGAGGATC CAGCTTCTACAGTGTGTTCAGAAAATGGCAGATGGGTTAGAGGAACAACAGCAAGCCTTGTCAATTTTGCTTGTCAAGTTCTTCATTATT CTTTGCAGAAATCTATCAAATGTGGAAGAAATTGGGACTTGCTCGTACATTAATTATGTCATCACCATGACAACACTCTATATTCAGCAA TTAAAAAGCAAAAAAAAAGAGAAGGAAATGGCAGATCAGACATGTATTGAAGAATTTGTGATCCACGCATTGGCATTTTGTGAAAGCTTA TATGATCCATATCGGAATTGGAGACATAGAATTTCAGGACGAATCCTTAGTACTGTGGAAAAGAGCAGACAGAAATATAAACCAGCTTCT CTCACAGTGGAATTCGTCCCTTTCTTTTATCAATGTTTTCAGGAAAGTGAACATCTCAAGGAAAGTCTTAAATGTTGCTTATTGCATCTC TTTGGAGCCATTGTAGCCGGTGGGCAGAGGAATGCTTTGCAAGCAATTTCTCCAGCCACTATGGAAGTTCTTATGCGAGTATTGGCAGAT TGTGATTCCTGGGAGGATGGAGATCCTGAAGAAGTGGGTAGGAAGGCAGAACTAACTCTGAAGTGCCTTACAGAAGTGGTACATATCCTT CTCAGTAGCAACTCTGATCAGCGTCAAGTGGAAACCAGTACTATTCTGGAGAACTATTTTAAATTGCTAAATTCAGATCATTCAGCTTTA CCTAATCAAAGGAGGTCCAGACAGTGGGAAAACCGATTTATTGCTCTACAGATCAAAATGCTGAATACCATCACAGCCATGTTAGATTGT ACAGATAGACCTGTTCTTCAGGCCATTTTTCTTAACAGCAATTGCTTTGAACATCTCATACGACTGCTACAGAACTGCAAGGTGTTTCAG GGACAATTGGATTGTTTGGCCATATCAACCATTCAGGCTTTGACCGCAGTAATGAACAAATCTCCAGCTGCTAAGGAAGTATTTAAAGAA AGAATTGGTTATACACATATGCTTGAAGTATTAAAATCCCTGGGTCAGCCACCACTGGAATTACTTAAAGAACTTATGAATATGGCTGTA GAGGGTGACCACACTTCAGTTGGGATTTTGGGCATTAGTAATGTCCAACCTCTCTTGCTTCTTATCCAGTGGCTTCCAGAACTACAATCC CATGACCTGCAAATCTTCATCTCTGATTGGCTGAAAAGAATTTGTTGTATTAATAGACAGAGTCGAACTACTTGTGTCAATGCAAACATG GGGATTAGAATCATTGAAACCCTTGACTTGCATTCTTCCCTCCATCAAACTTGTGCTGAGAACTTGATTGCAATCCATGGTTCCTTGGGG AGTCAGTCAGTGAGCTCAGAAGAAATCCGTCGACTACTGAGATTGCTGAGAGTGGATGAATCTGAGTCTGTTCACCCTTATGTCACTCCC GTGACTCGAGCAATCCTGACAATGGCCCGAAAACTAAGTCTAGAGAGTGCCCTCCAGTATTTCAATTTGTCACATAGTATGGCAGGAATT TCTGTGCCTCCCATACAGAAATGGCCAGGGTCTGCCTTTTCTTTCAGTGCTTGGTTTTGCTTAGACCAGGATCAGTTGACTCTTGGCATT GCTAACAAAGGAGGGAAAAGGAAACAATTGTACAGTTTTTTTACAGGAAGTGGCATGGGTTTTGAAGCCTTTATTACCCATTCAGGTATG TTGGTCGTGGCAGTGTGCACAAAAAGAGAATATGCAACGGTTATGCTTCCTGACCACAGTTTCTGTGATTCCCTCTGGGTAAGAAGACAA GAGGTTTCTTCTCCTAGAAAAGAAACTTCAGCAAGGAGTCTTGGCAGTCCTTTGCTCCATGAAAGGGGTAATATAGAGAAGACTTTCTGG GATCTGAAAGAAGAATTTCATAAAATATGCATGCTAGCAAAAGCACAGAAAGACCACTTAAGCAAACTTAATATACCAGACACTGCAACT GAAACACAGTGCTCTGTGCCTATACAGTGTACGGATAAAACAGATAAACAAGAAGCGCTGTTTAAGCCTCAGGCTAAAGATGATATAAAT AGAGGTGCACCATCCATCACATCTGTCACACCAAGAGGACTGTGCAGAGATGAGGAAGACACCTCTTTTGAATCACTTTCTAAATTCAAT GTCAAGTTTCCACCTATGGACAATGACTCAACTTTCTTACATAGCACTCCAGAGAGACCCGGCATCCTTAGTCCTGCCACGTCTGAGGCA GTGTGCCAAGAGAAATTTAATATGGAGTTCAGAGACAACCCAGGGAACTTTGTTAAAACAGAAGAAACTTTATTTGAAATTCAGGGAATT GACCCCATAGCTTCAGCTATACAAAACCTTAAAACAACTGACAAAACAAAGCCCTCAAATCTCGTAAACACTTGTATCAGGACAACTCTG GATAGAGCTGCGTGTTTGCCACCTGGAGACCATAATGCATTATATGTAAATAGCTTCCCACTTCTGGACCCATCTGATGCACCTTTTCCC TCACTCGATTCCCCGGGAAAAGCAATCCGAGGACCACAGCAGCCCATTTGGAAGCCCTTTCCTAATCAAGACAGTGACTCGGTGGTACTA AGTGGCACAGACTCAGAACTGCATATACCTCGAGTATGTGAATTCTGTCAAGCAGTTTTCCCACCATCCATTACATCCAGGGGGGATTTC CTTCGGCATCTTAATTCACACTTCAATGGAGAGACTTAAGACACATTTGAAAACAGACATATCAAGTTCTATGTGATGATTTTGGGTTTT TAATACTATAAATACTTGATTGTAAACTAAATTCAAGATCATTTATAGGAAAATCTAGTTTCACAGCTATTTGAATTTTTTTCTGGATTT ACTATATAACTCTTATTTTTTAAAAGATCATTCTGTTCTTTCAAGGAGAAATAAGCCTAAAAGAAGAAAAACAAAAAAAATTCTGTATAA AACTGTAATCCTTTGTATTCATGTTTACAGTGCTATTACTATAATTCAAAATTATGTATGTGACTTAGAGTTATATAATCATAATTTATG TTTATTTCAAATATCTAAGTTTATTGCTTGGATTTCTAGTGAGAGCTGTTGAATTTGGTGATGTCAAATGTTTCTAGGGTTTTTTTAGTT TGTTTTTATTGAAAAATTTAATTATTTATGCTATAGGTGATATTCTCTTTGAATAAACCTATAATAGAAAATAGCAGACAACATAAACAT CTTTGTAAATATCAAACCTAATACATTTCTTGTCCAGTGATAAAACAACTGGTAGAATTATTTAAACACTTTAGATTTTTAAATAATATA |
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FusionGenePPI for NBEAL1_TANK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NBEAL1 | HIF1A, HNRNPA1, HNRNPU, AP1S2, KIF1C, RGMA, CNTROB, CHMP4B, SDC2 | TANK | ZC3H12A, TRAF3, TBK1, TRAF2, TRAF1, ITGB1BP1, IKBKG, CHUK, IKBKE, IRF7, IRF3, PLK1, MARCH5, APBA3, BIRC2, TICAM1, HERC2, TAB2, CBLB, CD40, MAP3K14, TANK, APP, BIRC3, HLA-C, LAMC1, AIMP2, COPB1, FBLN1, ATP6V1H, BIK, KPNA2, SMAD3, SDC4, RACGAP1, INPP5K, TP53BP2, SRSF11, CEP63, ZFP36, SUMO2, BBOX1, CEP128, USP10, TRAF6, PBXIP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | TANK | chr2:203975005 | chr2:162080426 | ENST00000259075 | + | 3 | 8 | 133_172 | 109 | 426 | TBK1 and IKBKE |
| Tgene | TANK | chr2:203975005 | chr2:162080426 | ENST00000392749 | + | 3 | 8 | 133_172 | 109 | 426 | TBK1 and IKBKE |
| Tgene | TANK | chr2:203975005 | chr2:162080426 | ENST00000403609 | + | 0 | 3 | 133_172 | -14 | 120 | TBK1 and IKBKE |
| Tgene | TANK | chr2:203975005 | chr2:162080426 | ENST00000457476 | + | 0 | 4 | 133_172 | -53 | 120 | TBK1 and IKBKE |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NBEAL1_TANK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NBEAL1_TANK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TANK | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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