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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23491

FusionGeneSummary for NBAS_THADA

check button Fusion gene summary
Fusion gene informationFusion gene name: NBAS_THADA
Fusion gene ID: 23491
HgeneTgene
Gene symbol

NBAS

THADA

Gene ID

51594

63892

Gene nameneuroblastoma amplified sequenceTHADA, armadillo repeat containing
SynonymsILFS2|NAG|SOPHARMC13|GITA
Cytomap

2p24.3

2p21

Type of geneprotein-codingprotein-coding
Descriptionneuroblastoma-amplified sequenceNAG/BC035112 fusionNAG/FAM49A fusionneuroblastoma-amplified gene proteinthyroid adenoma-associated proteindeath receptor-interacting proteingene inducing thyroid adenomas protein
Modification date2018051920180523
UniProtAcc

A2RRP1

Q6YHU6

Ensembl transtripts involved in fusion geneENST00000441750, ENST00000281513, 
ENST00000330266, ENST00000405975, 
ENST00000415080, ENST00000405006, 
ENST00000485353, ENST00000402360, 
ENST00000404790, ENST00000403856, 
Fusion gene scores* DoF score11 X 10 X 7=7709 X 9 X 7=567
# samples 1210
** MAII scorelog2(12/770*10)=-2.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/567*10)=-2.5033487351675
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NBAS [Title/Abstract] AND THADA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AO-A0J4-01ANBASchr2

15467874

-THADAchr2

43819555

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000441750ENST00000330266NBASchr2

15467874

-THADAchr2

43819555

-
5CDS-5UTRENST00000441750ENST00000405975NBASchr2

15467874

-THADAchr2

43819555

-
5CDS-5UTRENST00000441750ENST00000415080NBASchr2

15467874

-THADAchr2

43819555

-
5CDS-5UTRENST00000441750ENST00000405006NBASchr2

15467874

-THADAchr2

43819555

-
5CDS-intronENST00000441750ENST00000485353NBASchr2

15467874

-THADAchr2

43819555

-
5CDS-intronENST00000441750ENST00000402360NBASchr2

15467874

-THADAchr2

43819555

-
5CDS-5UTRENST00000441750ENST00000404790NBASchr2

15467874

-THADAchr2

43819555

-
5CDS-5UTRENST00000441750ENST00000403856NBASchr2

15467874

-THADAchr2

43819555

-
5CDS-intronENST00000281513ENST00000330266NBASchr2

15467874

-THADAchr2

43819555

-
5CDS-5UTRENST00000281513ENST00000405975NBASchr2

15467874

-THADAchr2

43819555

-
5CDS-5UTRENST00000281513ENST00000415080NBASchr2

15467874

-THADAchr2

43819555

-
5CDS-5UTRENST00000281513ENST00000405006NBASchr2

15467874

-THADAchr2

43819555

-
5CDS-intronENST00000281513ENST00000485353NBASchr2

15467874

-THADAchr2

43819555

-
5CDS-intronENST00000281513ENST00000402360NBASchr2

15467874

-THADAchr2

43819555

-
5CDS-5UTRENST00000281513ENST00000404790NBASchr2

15467874

-THADAchr2

43819555

-
5CDS-5UTRENST00000281513ENST00000403856NBASchr2

15467874

-THADAchr2

43819555

-

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FusionProtFeatures for NBAS_THADA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NBAS

A2RRP1

THADA

Q6YHU6

Involved in Golgi-to-endoplasmic reticulum (ER)retrograde transport; the function is proposed to depend on itsassociation in the NRZ complex which is believed to play a role inSNARE assembly at the ER (PubMed:19369418).{ECO:0000269|PubMed:19369418, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NBAS_THADA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NBAS_THADA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NBASVTI1B, STX6, USE1, STX12, NAPG, STX18, HSPB1, NTRK1, AK1, DVL2, RINT1, SCFD2, SEC22B, VAMP4, TEX28THADACUL3, UBA2, AHCYL1, SRXN1, SSSCA1, SEC24A, SEC23A, SULT1A1, NUBP2, STAM, IGBP1, PSAT1, SIN3A, TES, EGFR, USHBP1, CD274, VSIG2, CA14, LYPD3, SCN2B, ALDH3A2, NTRK1, VASN, TMEM206, TNFRSF1A, OPRM1, SIGLECL1, CHRM4, FZD10, ILVBL, EDNRB, NAA10, CCKBR, CD83, APLNR, MLST8, MTOR, XPO6, XPO4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NBAS_THADA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NBAS_THADA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNBASC0038356Stomach Neoplasms1CTD_human
HgeneNBASC3541319SHORT STATURE, OPTIC NERVE ATROPHY, AND PELGER-HUET ANOMALY1ORPHANET;UNIPROT
HgeneNBASC3809651INFANTILE LIVER FAILURE SYNDROME 21ORPHANET;UNIPROT
TgeneTHADAC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human