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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23488

FusionGeneSummary for NBAS_PRRC2C

check button Fusion gene summary
Fusion gene informationFusion gene name: NBAS_PRRC2C
Fusion gene ID: 23488
HgeneTgene
Gene symbol

NBAS

PRRC2C

Gene ID

51594

23215

Gene nameneuroblastoma amplified sequenceproline rich coiled-coil 2C
SynonymsILFS2|NAG|SOPHBAT2-iso|BAT2D1|BAT2L2|XTP2
Cytomap

2p24.3

1q24.3

Type of geneprotein-codingprotein-coding
Descriptionneuroblastoma-amplified sequenceNAG/BC035112 fusionNAG/FAM49A fusionneuroblastoma-amplified gene proteinprotein PRRC2CBAT2 domain containing 1BAT2 domain-containing protein 1HBV X-transactivated gene 2 proteinHBV XAg-transactivated protein 2HBxAg transactivated protein 2HLA-B-associated transcript 2-like 2proline-rich and coiled-coil-containing prote
Modification date2018051920180523
UniProtAcc

A2RRP1

Q9Y520

Ensembl transtripts involved in fusion geneENST00000441750, ENST00000281513, 
ENST00000426496, ENST00000392078, 
ENST00000476522, ENST00000367742, 
ENST00000338920, 
Fusion gene scores* DoF score11 X 10 X 7=77011 X 13 X 4=572
# samples 1216
** MAII scorelog2(12/770*10)=-2.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/572*10)=-1.83794324189103
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NBAS [Title/Abstract] AND PRRC2C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG015456NBASchr2

15319158

+PRRC2Cchr1

171553138

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000441750ENST00000426496NBASchr2

15319158

+PRRC2Cchr1

171553138

-
intron-3CDSENST00000441750ENST00000392078NBASchr2

15319158

+PRRC2Cchr1

171553138

-
intron-intronENST00000441750ENST00000476522NBASchr2

15319158

+PRRC2Cchr1

171553138

-
intron-intronENST00000441750ENST00000367742NBASchr2

15319158

+PRRC2Cchr1

171553138

-
intron-intronENST00000441750ENST00000338920NBASchr2

15319158

+PRRC2Cchr1

171553138

-
intron-3CDSENST00000281513ENST00000426496NBASchr2

15319158

+PRRC2Cchr1

171553138

-
intron-3CDSENST00000281513ENST00000392078NBASchr2

15319158

+PRRC2Cchr1

171553138

-
intron-intronENST00000281513ENST00000476522NBASchr2

15319158

+PRRC2Cchr1

171553138

-
intron-intronENST00000281513ENST00000367742NBASchr2

15319158

+PRRC2Cchr1

171553138

-
intron-intronENST00000281513ENST00000338920NBASchr2

15319158

+PRRC2Cchr1

171553138

-

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FusionProtFeatures for NBAS_PRRC2C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NBAS

A2RRP1

PRRC2C

Q9Y520

Involved in Golgi-to-endoplasmic reticulum (ER)retrograde transport; the function is proposed to depend on itsassociation in the NRZ complex which is believed to play a role inSNARE assembly at the ER (PubMed:19369418).{ECO:0000269|PubMed:19369418, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NBAS_PRRC2C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NBAS_PRRC2C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NBAS_PRRC2C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NBAS_PRRC2C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNBASC0038356Stomach Neoplasms1CTD_human
HgeneNBASC3541319SHORT STATURE, OPTIC NERVE ATROPHY, AND PELGER-HUET ANOMALY1ORPHANET;UNIPROT
HgeneNBASC3809651INFANTILE LIVER FAILURE SYNDROME 21ORPHANET;UNIPROT