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Fusion gene ID: 23482 |
FusionGeneSummary for NBAS_ARL6IP5 |
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Fusion gene information | Fusion gene name: NBAS_ARL6IP5 | Fusion gene ID: 23482 | Hgene | Tgene | Gene symbol | NBAS | ARL6IP5 | Gene ID | 51594 | 10550 |
Gene name | neuroblastoma amplified sequence | ADP ribosylation factor like GTPase 6 interacting protein 5 | |
Synonyms | ILFS2|NAG|SOPH | DERP11|GTRAP3-18|HSPC127|JWA|PRAF3|Yip6b|addicsin|hp22|jmx | |
Cytomap | 2p24.3 | 3p14.1 | |
Type of gene | protein-coding | protein-coding | |
Description | neuroblastoma-amplified sequenceNAG/BC035112 fusionNAG/FAM49A fusionneuroblastoma-amplified gene protein | PRA1 family protein 3ADP-ribosylation factor GTPase 6 interacting protein 5ADP-ribosylation factor-like 6 interacting protein 5ADP-ribosylation factor-like protein 6-interacting protein 5ADP-ribosylation-like factor 6 interacting protein 5ARL-6-inter | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | A2RRP1 | O75915 | |
Ensembl transtripts involved in fusion gene | ENST00000441750, ENST00000281513, | ENST00000273258, ENST00000478935, | |
Fusion gene scores | * DoF score | 11 X 10 X 7=770 | 3 X 3 X 2=18 |
# samples | 12 | 3 | |
** MAII score | log2(12/770*10)=-2.68182403997375 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NBAS [Title/Abstract] AND ARL6IP5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ARL6IP5 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | 18387645 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA934385 | NBAS | chr2 | 15307392 | + | ARL6IP5 | chr3 | 69138902 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000441750 | ENST00000273258 | NBAS | chr2 | 15307392 | + | ARL6IP5 | chr3 | 69138902 | + |
intron-intron | ENST00000441750 | ENST00000478935 | NBAS | chr2 | 15307392 | + | ARL6IP5 | chr3 | 69138902 | + |
intron-intron | ENST00000281513 | ENST00000273258 | NBAS | chr2 | 15307392 | + | ARL6IP5 | chr3 | 69138902 | + |
intron-intron | ENST00000281513 | ENST00000478935 | NBAS | chr2 | 15307392 | + | ARL6IP5 | chr3 | 69138902 | + |
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FusionProtFeatures for NBAS_ARL6IP5 |
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Hgene | Tgene |
NBAS | ARL6IP5 |
Involved in Golgi-to-endoplasmic reticulum (ER)retrograde transport; the function is proposed to depend on itsassociation in the NRZ complex which is believed to play a role inSNARE assembly at the ER (PubMed:19369418).{ECO:0000269|PubMed:19369418, ECO:0000305}. | Regulates intracellular concentrations of taurine andglutamate. Negatively modulates SLC1A1/EAAC1 glutamate transportactivity by decreasing its affinity for glutamate in a PKCactivity-dependent manner. May be involved in membrane traffic.{ECO:0000250|UniProtKB:Q8R5J9, ECO:0000250|UniProtKB:Q9ES40}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NBAS_ARL6IP5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NBAS_ARL6IP5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NBAS_ARL6IP5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NBAS_ARL6IP5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NBAS | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | NBAS | C3541319 | SHORT STATURE, OPTIC NERVE ATROPHY, AND PELGER-HUET ANOMALY | 1 | ORPHANET;UNIPROT |
Hgene | NBAS | C3809651 | INFANTILE LIVER FAILURE SYNDROME 2 | 1 | ORPHANET;UNIPROT |
Tgene | ARL6IP5 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | ARL6IP5 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |