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Fusion gene ID: 23450 |
FusionGeneSummary for NAT8L_MDM4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NAT8L_MDM4 | Fusion gene ID: 23450 | Hgene | Tgene | Gene symbol | NAT8L | MDM4 | Gene ID | 339983 | 4194 |
| Gene name | N-acetyltransferase 8 like | MDM4, p53 regulator | |
| Synonyms | CML3|NACED|NAT8-LIKE | HDMX|MDMX|MRP1 | |
| Cytomap | 4p16.3 | 1q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N-acetylaspartate synthetaseN-acetyltransferase 8-like (GCN5-related, putative)NAA synthetaseShaticamello-like protein 3 | protein Mdm4MDM4 protein variant GMDM4 protein variant YMDM4-related protein 1Mdm4 p53 binding protein homologdouble minute 4, human homolog of; p53-binding proteinmdm2-like p53-binding proteinprotein Mdmx | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8N9F0 | O15151 | |
| Ensembl transtripts involved in fusion gene | ENST00000423729, ENST00000331662, | ENST00000367182, ENST00000463049, ENST00000507825, ENST00000454264, ENST00000367183, ENST00000367180, ENST00000391947, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 7 X 3=126 |
| # samples | 2 | 7 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NAT8L [Title/Abstract] AND MDM4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MDM4 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 9226370 |
| Tgene | MDM4 | GO:0065003 | protein-containing complex assembly | 10608892 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW128860 | NAT8L | chr4 | 2067219 | + | MDM4 | chr1 | 204519186 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000423729 | ENST00000367182 | NAT8L | chr4 | 2067219 | + | MDM4 | chr1 | 204519186 | - |
| 3UTR-3UTR | ENST00000423729 | ENST00000463049 | NAT8L | chr4 | 2067219 | + | MDM4 | chr1 | 204519186 | - |
| 3UTR-intron | ENST00000423729 | ENST00000507825 | NAT8L | chr4 | 2067219 | + | MDM4 | chr1 | 204519186 | - |
| 3UTR-intron | ENST00000423729 | ENST00000454264 | NAT8L | chr4 | 2067219 | + | MDM4 | chr1 | 204519186 | - |
| 3UTR-intron | ENST00000423729 | ENST00000367183 | NAT8L | chr4 | 2067219 | + | MDM4 | chr1 | 204519186 | - |
| 3UTR-intron | ENST00000423729 | ENST00000367180 | NAT8L | chr4 | 2067219 | + | MDM4 | chr1 | 204519186 | - |
| 3UTR-intron | ENST00000423729 | ENST00000391947 | NAT8L | chr4 | 2067219 | + | MDM4 | chr1 | 204519186 | - |
| 3UTR-3UTR | ENST00000331662 | ENST00000367182 | NAT8L | chr4 | 2067219 | + | MDM4 | chr1 | 204519186 | - |
| 3UTR-3UTR | ENST00000331662 | ENST00000463049 | NAT8L | chr4 | 2067219 | + | MDM4 | chr1 | 204519186 | - |
| 3UTR-intron | ENST00000331662 | ENST00000507825 | NAT8L | chr4 | 2067219 | + | MDM4 | chr1 | 204519186 | - |
| 3UTR-intron | ENST00000331662 | ENST00000454264 | NAT8L | chr4 | 2067219 | + | MDM4 | chr1 | 204519186 | - |
| 3UTR-intron | ENST00000331662 | ENST00000367183 | NAT8L | chr4 | 2067219 | + | MDM4 | chr1 | 204519186 | - |
| 3UTR-intron | ENST00000331662 | ENST00000367180 | NAT8L | chr4 | 2067219 | + | MDM4 | chr1 | 204519186 | - |
| 3UTR-intron | ENST00000331662 | ENST00000391947 | NAT8L | chr4 | 2067219 | + | MDM4 | chr1 | 204519186 | - |
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FusionProtFeatures for NAT8L_MDM4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NAT8L | MDM4 |
| Plays a role in the regulation of lipogenesis byproducing N-acetylaspartate acid (NAA), a brain-specificmetabolite. NAA occurs in high concentration in brain and itshydrolysis plays a significant part in the maintenance of intactwhite matter. Promotes dopamine uptake by regulating TNF-alphaexpression. Attenuates methamphetamine-induced inhibition ofdopamine uptake. {ECO:0000269|PubMed:19524112}. | Inhibits p53/TP53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activationdomain. Inhibits degradation of MDM2. Can reverse MDM2-targeteddegradation of TP53 while maintaining suppression of TP53transactivation and apoptotic functions.{ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NAT8L_MDM4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NAT8L_MDM4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NAT8L_MDM4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NAT8L_MDM4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MDM4 | C0017636 | Glioblastoma | 1 | CTD_human |
| Tgene | MDM4 | C0032273 | Pneumoconiosis | 1 | CTD_human |
| Tgene | MDM4 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | MDM4 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | MDM4 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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