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Fusion gene ID: 2345 |
FusionGeneSummary for ARFGEF1_SORCS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARFGEF1_SORCS2 | Fusion gene ID: 2345 | Hgene | Tgene | Gene symbol | ARFGEF1 | SORCS2 | Gene ID | 10565 | 57537 |
| Gene name | ADP ribosylation factor guanine nucleotide exchange factor 1 | sortilin related VPS10 domain containing receptor 2 | |
| Synonyms | ARFGEP1|BIG1|P200 | - | |
| Cytomap | 8q13.2 | 4p16.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | brefeldin A-inhibited guanine nucleotide-exchange protein 1ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)p200 ARF guanine nucleotide exchange factor | VPS10 domain-containing receptor SorCS2VPS10 domain receptor protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9Y6D6 | Q96PQ0 | |
| Ensembl transtripts involved in fusion gene | ENST00000520381, ENST00000262215, ENST00000517955, ENST00000518230, | ENST00000507866, ENST00000511199, ENST00000329016, | |
| Fusion gene scores | * DoF score | 8 X 7 X 5=280 | 3 X 2 X 3=18 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/280*10)=-1.63742992061529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ARFGEF1 [Title/Abstract] AND SORCS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARFGEF1 | GO:0034260 | negative regulation of GTPase activity | 15644318 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A48O-01A | ARFGEF1 | chr8 | 68255399 | - | SORCS2 | chr4 | 7398015 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000520381 | ENST00000507866 | ARFGEF1 | chr8 | 68255399 | - | SORCS2 | chr4 | 7398015 | + |
| intron-3UTR | ENST00000520381 | ENST00000511199 | ARFGEF1 | chr8 | 68255399 | - | SORCS2 | chr4 | 7398015 | + |
| intron-5UTR | ENST00000520381 | ENST00000329016 | ARFGEF1 | chr8 | 68255399 | - | SORCS2 | chr4 | 7398015 | + |
| In-frame | ENST00000262215 | ENST00000507866 | ARFGEF1 | chr8 | 68255399 | - | SORCS2 | chr4 | 7398015 | + |
| 5CDS-3UTR | ENST00000262215 | ENST00000511199 | ARFGEF1 | chr8 | 68255399 | - | SORCS2 | chr4 | 7398015 | + |
| 5CDS-5UTR | ENST00000262215 | ENST00000329016 | ARFGEF1 | chr8 | 68255399 | - | SORCS2 | chr4 | 7398015 | + |
| intron-3CDS | ENST00000517955 | ENST00000507866 | ARFGEF1 | chr8 | 68255399 | - | SORCS2 | chr4 | 7398015 | + |
| intron-3UTR | ENST00000517955 | ENST00000511199 | ARFGEF1 | chr8 | 68255399 | - | SORCS2 | chr4 | 7398015 | + |
| intron-5UTR | ENST00000517955 | ENST00000329016 | ARFGEF1 | chr8 | 68255399 | - | SORCS2 | chr4 | 7398015 | + |
| intron-3CDS | ENST00000518230 | ENST00000507866 | ARFGEF1 | chr8 | 68255399 | - | SORCS2 | chr4 | 7398015 | + |
| intron-3UTR | ENST00000518230 | ENST00000511199 | ARFGEF1 | chr8 | 68255399 | - | SORCS2 | chr4 | 7398015 | + |
| intron-5UTR | ENST00000518230 | ENST00000329016 | ARFGEF1 | chr8 | 68255399 | - | SORCS2 | chr4 | 7398015 | + |
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FusionProtFeatures for ARFGEF1_SORCS2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARFGEF1 | SORCS2 |
| Promotes guanine-nucleotide exchange on ARF1 and ARF3.Promotes the activation of ARF1/ARF3 through replacement of GDPwith GTP. Involved in vesicular trafficking. Required for themaintenance of Golgi structure; the function may be independent ofits GEF activity. Required for the maturaion of integrin beta-1 inthe Golgi. Involved in the establishment and persistence of cellpolarity during directed cell movement in wound healing. Proposedto act as A kinase-anchoring protein (AKAP) and may mediatecrosstalk between Arf and PKA pathways. Inhibits GAP activity ofMYO9B probably through competetive RhoA binding. The function inthe nucleus remains to be determined.{ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318,ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857,ECO:0000269|PubMed:22084092}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ARFGEF1_SORCS2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ARFGEF1_ENST00000262215_chr8_68255399_-_SORCS2_ENST00000507866_chr4_7398015_+_1041aa MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALGDLDPDEVLPRRHGEGSGKFSVAVIRFRDVLHQAHPPAWCHHRHRQFLH LPDQQEEGHPCQLLTQXPGPEPIPQRRRRRHLSEAAHSLLRGNSDFPPXGGGQGPRLHKGEQALRVIXLGEKVDTSARASDQRPRVLVCV WGGRXPXLGPRGSPRPRWRFSVRHLRNPQLLREDADSPIRRPHXPRVSDRAGRLHLLXGNISKPDKILRLLSSKXICPDEAAEVCIAKGS ADHQHGRESGVRGGAGVVPDGHLQPVPVGPTGRALRAGAAGRAQLTAGGGERAHRHPGGQRGERSLPGKPKNXWESDDAYNLQQGPRLGL PEATQHGHEWKTNQLQASRLPPAPAPALGRQPLRIRHRAHQGHRPRPHHGCRXPGLTAGGIXRRNVHHVRLWSHLAAGVXGRASHPVPGP RRRDRGHQRHLHPFEDPQVQCGRGPHLEHAQLHQHLGVCGRAAEXARGRDAGHDGLWPHQLPLRLGAGQGGLPALILQAVRRGGLQLLGA LQPAGRPLYHGPAEKFPEKKVHVLVHQGEELHVGAHVPRVRVPGLGLPVRLRIXALLLLRVQHQQVLCQLLVXPIVPAXRLCPGPDLHQQ PWVPESGVQRVXGWGGHAAESGAAAVPPHAAPGPAGQHSRRGGGRAAWRGRPVCGAAGAGXCPDYQVPGRPWGRLQGHVREPYTDRGAHP APLREPRHLPRVRQGREHGRPRXGGALCPGQLPPAGPLPGGGSCHWPQPGGEPHSCAASLEPXPHRLLLVDRPQPAAPPFPGXFCDNAVF GHGRRACDGAGRLWELGAAGLQGPPCAGSISSHASAVFQGAGCLQPQHPXVEGRRGPGGHPAALQGDQRPSGASGDCGEAGAAHFGRSVR APAPSQAHKEEEPLEXXEARRHPAGAERTEDQLPPARRSPGPGGPAGHRHRCXAAGRRWRLLGGSGAVCHRALRSGSLHPLQVQKETARQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ARFGEF1_ENST00000262215_chr8_68255399_-_SORCS2_ENST00000507866_chr4_7398015_+_3124nt ATGTATGAGGGGAAGAAGACGAAGAACATGTTCCTGACCCGGGCTCTGGAGAAGATATTGGCCGACAAGGAAGTGAAGAAGGCGCATCAC TCCCAGCTGCGCAAAGCTTGCGAGGTGGCGTTAGGTGATCTTGATCCTGACGAAGTACTACCACGCAGACATGGGGAAGGTTCTGGAAAG TTCTCTGTGGCGGTCATCAGATTTCGGGACGTCCTACACCAAGCTCACCCTCCAGCCTGGTGTCACCACCGTCATCGACAATTTCTACAT CTGCCCGACCAACAAGAGGAAGGTCATCCTTGTCAGCTCCTCACTCAGTGACCGGGACCAGAGCCTATTCCTCAGCGCAGACGAAGGCGC CACCTTTCAGAAGCAGCCCATTCCCTTCTTCGTGGAAACTCTGATTTTCCACCCTAAGGAGGAGGACAAGGTCCTCGCCTACACAAAGGA GAGCAAGCTCTACGTGTCATCTGACTTGGGGAAAAAGTGGACACTTCTGCAAGAGCGAGTGACCAAAGACCACGTGTTCTGGTCTGTGTC TGGGGTGGACGCTGACCCTGACTTGGTCCACGTGGAAGCCCAAGACCTCGGTGGAGATTTTCGGTACGTCACCTGCGCAATCCACAATTG CTCCGAGAAGATGCTGACAGCCCCATTCGCAGGCCCCATTGACCACGGGTCTCTGACCGTGCAGGACGATTACATCTTCTTTAAGGCAAC ATCAGCAAACCAGACAAAATACTACGTCTCTTATCGTCGAAATGAATTTGTCCTGATGAAGCTGCCGAAGTATGCATTGCCAAAGGATCT GCAGATCATCAGCACGGACGAGAGTCAGGTGTTCGTGGCGGTGCAGGAGTGGTACCAGATGGACACCTACAACCTGTACCAGTCGGACCC ACGGGGCGTGCGCTACGCGCTGGTGCTGCAGGACGTGCGCAGCTCACGGCAGGCGGAGGAGAGCGTGCTCATCGACATCCTGGAGGTCAG AGGGGTGAAAGGAGTCTTCCTGGCAAACCAAAAAATTGATGGGAAAGTGATGACGCTTATAACCTACAACAAGGGCCGCGACTGGGATTA CCTGAGGCCACCCAGCATGGACATGAATGGAAAACCAACCAACTGCAAGCCTCCAGACTGCCACCTGCACCTGCACCTGCGCTGGGCAGA CAACCCCTACGTATCAGGCACCGTGCACACCAAGGACACCGCCCCAGGCCTCATCATGGGTGCAGGTAACCTGGGCTCACAGCTGGTGGA ATATAAAGAAGAAATGTACATCACGTCAGACTGTGGTCACACCTGGCGGCAGGTGTTTGAGGAAGAGCATCACATCCTGTACCTGGACCA CGGCGGCGTGATCGTGGCCATCAAAGACACCTCCATCCCTTTGAAGATCCTCAAGTTCAGTGTGGACGAGGGCCTCACCTGGAGCACGCA CAACTTCACCAGCACCTCGGTGTTTGTGGACGGGCTGCTGAGTGAGCCAGGGGACGAGACGCTGGTCATGACGGTCTTTGGCCACATCAG CTTCCGCTCCGATTGGGAGCTGGTCAAGGTGGACTTCCGGCCCTCATTCTCCAGGCAGTGCGGCGAGGAGGACTACAGCTCCTGGGAGCT CTCCAACCTGCAGGGCGACCGCTGTATCATGGGCCAGCAGAGAAGTTTCCGGAAAAGAAAGTCCACGTCCTGGTGCATCAAGGGGAGGAG CTTCACGTCGGCGCTCACGTCCCGCGTGTGCGAGTGCCGGGACTCGGACTTCCTGTGCGACTACGGATTTGAGCGCTCCTCCTCCTCAGA GTCCAGCACCAACAAGTGCTCTGCCAACTTCTGGTTTAACCCATTGTCCCCGCCTGACGACTGTGCCCTGGGCCAGACCTACACCAGCAG CCTTGGGTACCGGAAAGTGGTGTCCAACGTGTGTGAGGGTGGGGTGGACATGCAGCAGAGTCAGGTGCAGCTGCAGTGCCCCCTCACGCC GCCCCGGGGCCTGCAGGTCAGCATTCAAGGCGAGGCGGTGGCCGTGCGGCCTGGAGAGGACGTCCTGTTTGTGGTGCGGCAGGAGCAGGG TGATGTCCTGACTACCAAGTACCAGGTAGACCTTGGGGACGGCTTCAAGGCCATGTACGTGAACCTTACACTGACCGGGGAGCCCATCCG GCACCGCTACGAGAGCCCCGGCATCTACCGCGTGTCCGTCAGGGCAGAGAACACGGCAGGCCACGATGAGGCGGTGCTCTTTGTCCAGGT CAACTCCCCCCTGCAGGCCCTCTACCTGGAGGTGGTTCCTGTCATTGGCCTCAACCAGGAGGTGAACCTCACAGCTGTGCTGCTTCCCTT GAACCCTAACCTCACCGTCTTCTACTGGTGGATCGGCCACAGCCTGCAGCCCCTCCTTTCCCTGGATAATTCTGTGACAACGCGGTTTTC GGACACGGGCGACGTGCGTGTGACGGTGCAGGCCGCCTGTGGGAACTCGGTGCTGCAGGACTCCAGGGTCCTCCGTGTGCTGGATCAATT TCAAGTCATGCCTCTGCAGTTTTCCAAGGAGCTGGATGCCTACAACCCCAACACCCCTGAGTGGAGGGAAGACGTGGGCCTGGTGGTCAC CCGGCTGCTCTCCAAGGAGACCAGCGTCCCTCAGGAGCTTCTGGTGACTGTGGTGAAGCCGGGGCTGCCCACTTTGGCCGATCTGTACGT GCTCCTGCCCCCTCCCAGGCCCACAAGGAAGAGGAGCCTCTCGAGTGATAAGAGGCTCGCCGCCATCCAGCAGGTGCTGAACGCACAGAA GATCAGCTTCCTCCTGCGAGGCGGAGTCCGGGTCCTGGTGGCCCTGCGGGACACAGGCACAGGTGCTGAGCAGCTGGGCGGCGGTGGCGG CTACTGGGCGGTAGTGGTGCTGTTTGTCATCGGGCTCTTCGCAGCGGGAGCCTTCATCCTCTACAAGTTCAAAAGGAAACGGCCAGGCAG GACCGTGTACGCCCAAATGCACAACGAGAAGGAGCAGGAGATGACCAGCCCTGTGAGTCACAGTGAGGACGTCCAGGGCGCTGTCCAGGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ARFGEF1_ENST00000262215_chr8_68255399_-_SORCS2_ENST00000507866_chr4_7398015_+_6077nt GCGGTGCCTCTGAGAGCCGCCGCCACCTCGTCCCTCAGTTCCCGGCAGACAGCCGCCCGGGCCGGGCTCCCTCACCGCCACCAGGGCCGG AGGGACGAGTGAGAGGGGCGGCCGGGACGCGACCCCCGGGCCGGGAGAAGCGGAGGCCCGACGGGCGCGGCCCTCGAGGTACGGCTTCTT GGGGGCGGCGAGGACCTCGACGCCCTTCGCCGACACCGCGGCTGGTCCCGCTCGCCCGCCCCTTCCTGATCCTGCCGCTGCCCTCCACGC CTCCAATCCCCCACCTCCACCCCCTCTCCTTTCTCTCTTCTCTTCCTTCCTCTCCTCCTCCTCCCCTCCAGCCGCTGGGAGCCGCGGGTC GGACGAGCCGCCGCCTCCTTCTCTGCGTCCATGTATGAGGGGAAGAAGACGAAGAACATGTTCCTGACCCGGGCTCTGGAGAAGATATTG GCCGACAAGGAAGTGAAGAAGGCGCATCACTCCCAGCTGCGCAAAGCTTGCGAGGTGGCGTTAGGTGATCTTGATCCTGACGAAGTACTA CCACGCAGACATGGGGAAGGTTCTGGAAAGTTCTCTGTGGCGGTCATCAGATTTCGGGACGTCCTACACCAAGCTCACCCTCCAGCCTGG TGTCACCACCGTCATCGACAATTTCTACATCTGCCCGACCAACAAGAGGAAGGTCATCCTTGTCAGCTCCTCACTCAGTGACCGGGACCA GAGCCTATTCCTCAGCGCAGACGAAGGCGCCACCTTTCAGAAGCAGCCCATTCCCTTCTTCGTGGAAACTCTGATTTTCCACCCTAAGGA GGAGGACAAGGTCCTCGCCTACACAAAGGAGAGCAAGCTCTACGTGTCATCTGACTTGGGGAAAAAGTGGACACTTCTGCAAGAGCGAGT GACCAAAGACCACGTGTTCTGGTCTGTGTCTGGGGTGGACGCTGACCCTGACTTGGTCCACGTGGAAGCCCAAGACCTCGGTGGAGATTT TCGGTACGTCACCTGCGCAATCCACAATTGCTCCGAGAAGATGCTGACAGCCCCATTCGCAGGCCCCATTGACCACGGGTCTCTGACCGT GCAGGACGATTACATCTTCTTTAAGGCAACATCAGCAAACCAGACAAAATACTACGTCTCTTATCGTCGAAATGAATTTGTCCTGATGAA GCTGCCGAAGTATGCATTGCCAAAGGATCTGCAGATCATCAGCACGGACGAGAGTCAGGTGTTCGTGGCGGTGCAGGAGTGGTACCAGAT GGACACCTACAACCTGTACCAGTCGGACCCACGGGGCGTGCGCTACGCGCTGGTGCTGCAGGACGTGCGCAGCTCACGGCAGGCGGAGGA GAGCGTGCTCATCGACATCCTGGAGGTCAGAGGGGTGAAAGGAGTCTTCCTGGCAAACCAAAAAATTGATGGGAAAGTGATGACGCTTAT AACCTACAACAAGGGCCGCGACTGGGATTACCTGAGGCCACCCAGCATGGACATGAATGGAAAACCAACCAACTGCAAGCCTCCAGACTG CCACCTGCACCTGCACCTGCGCTGGGCAGACAACCCCTACGTATCAGGCACCGTGCACACCAAGGACACCGCCCCAGGCCTCATCATGGG TGCAGGTAACCTGGGCTCACAGCTGGTGGAATATAAAGAAGAAATGTACATCACGTCAGACTGTGGTCACACCTGGCGGCAGGTGTTTGA GGAAGAGCATCACATCCTGTACCTGGACCACGGCGGCGTGATCGTGGCCATCAAAGACACCTCCATCCCTTTGAAGATCCTCAAGTTCAG TGTGGACGAGGGCCTCACCTGGAGCACGCACAACTTCACCAGCACCTCGGTGTTTGTGGACGGGCTGCTGAGTGAGCCAGGGGACGAGAC GCTGGTCATGACGGTCTTTGGCCACATCAGCTTCCGCTCCGATTGGGAGCTGGTCAAGGTGGACTTCCGGCCCTCATTCTCCAGGCAGTG CGGCGAGGAGGACTACAGCTCCTGGGAGCTCTCCAACCTGCAGGGCGACCGCTGTATCATGGGCCAGCAGAGAAGTTTCCGGAAAAGAAA GTCCACGTCCTGGTGCATCAAGGGGAGGAGCTTCACGTCGGCGCTCACGTCCCGCGTGTGCGAGTGCCGGGACTCGGACTTCCTGTGCGA CTACGGATTTGAGCGCTCCTCCTCCTCAGAGTCCAGCACCAACAAGTGCTCTGCCAACTTCTGGTTTAACCCATTGTCCCCGCCTGACGA CTGTGCCCTGGGCCAGACCTACACCAGCAGCCTTGGGTACCGGAAAGTGGTGTCCAACGTGTGTGAGGGTGGGGTGGACATGCAGCAGAG TCAGGTGCAGCTGCAGTGCCCCCTCACGCCGCCCCGGGGCCTGCAGGTCAGCATTCAAGGCGAGGCGGTGGCCGTGCGGCCTGGAGAGGA CGTCCTGTTTGTGGTGCGGCAGGAGCAGGGTGATGTCCTGACTACCAAGTACCAGGTAGACCTTGGGGACGGCTTCAAGGCCATGTACGT GAACCTTACACTGACCGGGGAGCCCATCCGGCACCGCTACGAGAGCCCCGGCATCTACCGCGTGTCCGTCAGGGCAGAGAACACGGCAGG CCACGATGAGGCGGTGCTCTTTGTCCAGGTCAACTCCCCCCTGCAGGCCCTCTACCTGGAGGTGGTTCCTGTCATTGGCCTCAACCAGGA GGTGAACCTCACAGCTGTGCTGCTTCCCTTGAACCCTAACCTCACCGTCTTCTACTGGTGGATCGGCCACAGCCTGCAGCCCCTCCTTTC CCTGGATAATTCTGTGACAACGCGGTTTTCGGACACGGGCGACGTGCGTGTGACGGTGCAGGCCGCCTGTGGGAACTCGGTGCTGCAGGA CTCCAGGGTCCTCCGTGTGCTGGATCAATTTCAAGTCATGCCTCTGCAGTTTTCCAAGGAGCTGGATGCCTACAACCCCAACACCCCTGA GTGGAGGGAAGACGTGGGCCTGGTGGTCACCCGGCTGCTCTCCAAGGAGACCAGCGTCCCTCAGGAGCTTCTGGTGACTGTGGTGAAGCC GGGGCTGCCCACTTTGGCCGATCTGTACGTGCTCCTGCCCCCTCCCAGGCCCACAAGGAAGAGGAGCCTCTCGAGTGATAAGAGGCTCGC CGCCATCCAGCAGGTGCTGAACGCACAGAAGATCAGCTTCCTCCTGCGAGGCGGAGTCCGGGTCCTGGTGGCCCTGCGGGACACAGGCAC AGGTGCTGAGCAGCTGGGCGGCGGTGGCGGCTACTGGGCGGTAGTGGTGCTGTTTGTCATCGGGCTCTTCGCAGCGGGAGCCTTCATCCT CTACAAGTTCAAAAGGAAACGGCCAGGCAGGACCGTGTACGCCCAAATGCACAACGAGAAGGAGCAGGAGATGACCAGCCCTGTGAGTCA CAGTGAGGACGTCCAGGGCGCTGTCCAGGGCAACCACTCAGGCGTGGTCCTGAGCATCAACTCCCGAGAGATGCACAGCTACCTGGTGAG CTGATGCCACCCCAGCATCTGTCTTTTCACCCACGGAGGGCACAGAACCACCAGCAAAGCCGGCGGCTGGACTGGCGCCCCTCAGAGACC TGCGGAAAGCCCCCTCCCTGAGTCGTCGCCACACCAGGCGACAGGCACCACCCCCTCTGATAAATCCAAGCCCGCCCAGGCCCACGGGGG GCCCACGGGACCCCCCGGGACTCCCCGGACATGGCCCTGCCCCTATGGGACACCAGGCCTGACTCAGGCAGGTTCTGCCCCCCAGACCCC ACACACGGCCGCCCCACGTGCTGTCGCTCAGCCCGAGGCCTGACTTCTCTGGGCTGAGGCTGGTCGTCCTGGAGCCCTCCCAGTACCTCG GGCTGCAAGAGCTGCAGACCCGTTCAGACACTGCGTTGCGGGCTCCTTCCCCGCAGAGGCCGGGGCCTCCCTGACTTTGCTTCTTCACTC CCACCTGTGCGGCCACCCAGTCCCTCTGTGGGAGCCCGGGTGCCAGGCCCTCCCAACACCACACCACCCTCCAGGCCCCCCTGCCCTCCG GCTGGAAACTGCAGCTCTGTAAATGCCTCTCTAGGTAGCTGCTGGCGGTGGTGGGGGTGTCTCACTCTCTGTCTTTATAGCCGGCGGTAG CCACCGGGGTGGCTCTGTCAGAGTTCCGTACTCGGGAGCCCCTTTCCCTGAGTGCCCAGGGTGTCTCCTCTGCCCAGAGGGGCAGCAGCT CTCCCTGGTTCTCCCCAGGGCAGACGGGGTAGGGCGGGCTCAGGACCCAGTGCCCATGGTTCCTCACTCCTACCAGCAAGCAGCACCATC CCGCAGGCTTCTCCCACCTGATGGCTGTTCTCCCACCGGGTCTGGGCTCTGGAAGGAGCCAGATGCCCCCAGAAAGGTGGGTGGTGGAGA CGGCACCAGATGTACCAGTTTTCTGCAGTTCCTTATAGGCGAAGGGAACCGGGTGGAAACCAAGCTGGGAGAGGCTGAGGATGGCAGGGC TGGAAGGGCCATCAGCGTGACCCTCATTTTCAAGAAGGGGAAACTGAGGCCCAGGGAGGAGAGTAACTGAAGGTCACAGCACGGTCACAG CAGAGGTGGCCGAACCCAGCCCTCTGCGCGCCAGTGCTGTGCGGTCTCCACACCCTTACGGTTTCCTAGAATCAGGGATGTTAGTGTAAG TCTATAGGAATATAGGGGGGTGGGGGGGTCACCTTTTGCCTTGAAATGGGAAGTCAGTAGCCCCTTCCTCCTCCTCCCTCCTCCCCCTCC TCTCTGGCAGGGATCTCAGATGACCGTGGCCTCCCTCTCAGAGGGGGAGAACGCCAGAGCCCTGGCTGGTGATGTGCTGGCTGGGGGTGA ATCCCAATGAGGGTCCCTCTCAGAGCGGGAGAACGCCAGAGCCCTGGATGGTGATGCGCTGGCTGGGGGTGAATCCCAATGAGGGTCCCT CTCAGAAAGGGAGAACGCCAGAGCCCTGGCTGGTGACATGCTGGCTGGGGGTGAATCCGAATGACAGTGCAGACGTTCTCCCATCCACCA TGTCTGAGCTTGGGGGAATTGCCTCATTTCCCCTGGAAAAGAAACATGGTCCATTAGAGGGGAAAGCCCAGGGGTGAATCTTCACGCCCC AAACAGTGCCCGGTGGGGAGGAGGCACCCGCTCCTTGTTGAGTAAAACCACCCATGGAGACTGGAACCTCATCTCCCTGGGTCGGGGGGT GTTCAAGGCCACAGGACAAGGGGAGCACCCTGGGCCACACAGGCGTGGAGGTGTCCCCACCCCTTCCACCTGTCCCCCAGACCCAAAGCT CTCTCCCCACCCTACCTGCCCACCTGGGGCTCCTGTGCCCCCTCCCCACTCCAGAGGCCACCCTACAAGTTGTCCTCAAGGTCATCCTGG AGATGGGATCCAGGACGTGGGGCCATGACTCTCTGGGACCTTGCCACAGCCCCCATTCCCCTGCTTGCAGTCTGCAAGGACACCTTTGCA GGGATTCTTGTCCTGCTGGCCACCCCACCCACACCTGTCCCTGGCCAGCAGGCCGCCTGCAAGCGTCAGGCACACAGGGACAGACATGGC GAGCACAGTGCAGGCCCGGGGCCCACGGGCAACATGGAACCCTGGGAACTGCCCTCCCCCTTAGCTCACAGTGCCTGCGGTAGCCACTCT AGGTCGTTGGCCTTCCTTGACCACTCCATTTAATTCTCTCTGCTGTTTGGGTTGGGTTTTTCCCCTTAGTTATCTGTGGGTTTCCTGTAT TTTATGTTAATATTTCTATTAAGAACATGTTGGGCATGTGGACCCAAGCACCTGGGAAGGAGGTGGCATCTGAGACAGCCTGATACGTTC CCGTCTGTGCACCCATGGAGATCCAGGCGTGGGCCCGTGTCTGTCCCTGGTTGTAAATTCGAGGGTCTGCATATCTGATGTTCAGGTAGA CCTGGGCGCCTGGGAACGAGGCCATCAGCTGCCATGCACATAACAAAGAGACAATGCATTCCTTCTTATTTTTCCTTTTTAAAAATCGAT |
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FusionGenePPI for ARFGEF1_SORCS2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ARFGEF1 | FKBP2, PRKAR1A, ARFGEF2, DPY30, NCL, FBL, NUP62, SSB, EGFR, SPINT2, CSGALNACT1, PVRIG, HLA-B, CD244, SLAMF1, TBC1D22A, ALDH3A2, TCL1B, NTRK1, SIGLECL1, EDNRB, LAMP3, NPY2R, BRCA1 | SORCS2 | TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARFGEF1_SORCS2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARFGEF1_SORCS2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SORCS2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
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