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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23448

FusionGeneSummary for NAT1_NAT1

check button Fusion gene summary
Fusion gene informationFusion gene name: NAT1_NAT1
Fusion gene ID: 23448
HgeneTgene
Gene symbol

NAT1

NAT1

Gene ID

10991

10991

Gene namesolute carrier family 38 member 3solute carrier family 38 member 3
SynonymsG17|NAT1|SN1|SNAT3G17|NAT1|SN1|SNAT3
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionsodium-coupled neutral amino acid transporter 3N-system amino acid transporter 1Na(+)-coupled neutral amino acid transporter 3system N amino acid transporter 1system N1 Na+ and H+-coupled glutamine transportersodium-coupled neutral amino acid transporter 3N-system amino acid transporter 1Na(+)-coupled neutral amino acid transporter 3system N amino acid transporter 1system N1 Na+ and H+-coupled glutamine transporter
Modification date2018052320180523
UniProtAcc

P18440

P18440

Ensembl transtripts involved in fusion geneENST00000517441, ENST00000535084, 
ENST00000307719, ENST00000539092, 
ENST00000541942, ENST00000545197, 
ENST00000518029, ENST00000517492, 
ENST00000520546, 		ENST00000517441, 
ENST00000535084, ENST00000307719, 
ENST00000539092, ENST00000541942, 
ENST00000545197, ENST00000518029, 
ENST00000517492, ENST00000520546, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: NAT1 [Title/Abstract] AND NAT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAT1

GO:0006867

asparagine transport

10823827

HgeneNAT1

GO:0006868

glutamine transport

10823827

HgeneNAT1

GO:0015808

L-alanine transport

10823827

HgeneNAT1

GO:0015817

histidine transport

10823827

TgeneNAT1

GO:0006867

asparagine transport

10823827

TgeneNAT1

GO:0006868

glutamine transport

10823827

TgeneNAT1

GO:0015808

L-alanine transport

10823827

TgeneNAT1

GO:0015817

histidine transport

10823827


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE775188NAT1chr8

18080499

+NAT1chr8

18080406

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000517441ENST00000517441NAT1chr8

18080499

+NAT1chr8

18080406

-
intron-intronENST00000517441ENST00000535084NAT1chr8

18080499

+NAT1chr8

18080406

-
intron-intronENST00000517441ENST00000307719NAT1chr8

18080499

+NAT1chr8

18080406

-
intron-intronENST00000517441ENST00000539092NAT1chr8

18080499

+NAT1chr8

18080406

-
intron-intronENST00000517441ENST00000541942NAT1chr8

18080499

+NAT1chr8

18080406

-
intron-intronENST00000517441ENST00000545197NAT1chr8

18080499

+NAT1chr8

18080406

-
intron-intronENST00000517441ENST00000518029NAT1chr8

18080499

+NAT1chr8

18080406

-
intron-intronENST00000517441ENST00000517492NAT1chr8

18080499

+NAT1chr8

18080406

-
intron-intronENST00000517441ENST00000520546NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000535084ENST00000517441NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000535084ENST00000535084NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000535084ENST00000307719NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000535084ENST00000539092NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000535084ENST00000541942NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000535084ENST00000545197NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000535084ENST00000518029NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000535084ENST00000517492NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000535084ENST00000520546NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000307719ENST00000517441NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000307719ENST00000535084NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000307719ENST00000307719NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000307719ENST00000539092NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000307719ENST00000541942NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000307719ENST00000545197NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000307719ENST00000518029NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000307719ENST00000517492NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000307719ENST00000520546NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000539092ENST00000517441NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000539092ENST00000535084NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000539092ENST00000307719NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000539092ENST00000539092NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000539092ENST00000541942NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000539092ENST00000545197NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000539092ENST00000518029NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000539092ENST00000517492NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000539092ENST00000520546NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000541942ENST00000517441NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000541942ENST00000535084NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000541942ENST00000307719NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000541942ENST00000539092NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000541942ENST00000541942NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000541942ENST00000545197NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000541942ENST00000518029NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000541942ENST00000517492NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000541942ENST00000520546NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000545197ENST00000517441NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000545197ENST00000535084NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000545197ENST00000307719NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000545197ENST00000539092NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000545197ENST00000541942NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000545197ENST00000545197NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000545197ENST00000518029NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000545197ENST00000517492NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000545197ENST00000520546NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000518029ENST00000517441NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000518029ENST00000535084NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000518029ENST00000307719NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000518029ENST00000539092NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000518029ENST00000541942NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000518029ENST00000545197NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000518029ENST00000518029NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000518029ENST00000517492NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000518029ENST00000520546NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000517492ENST00000517441NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000517492ENST00000535084NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000517492ENST00000307719NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000517492ENST00000539092NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000517492ENST00000541942NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000517492ENST00000545197NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000517492ENST00000518029NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000517492ENST00000517492NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000517492ENST00000520546NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000520546ENST00000517441NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000520546ENST00000535084NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000520546ENST00000307719NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000520546ENST00000539092NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000520546ENST00000541942NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000520546ENST00000545197NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000520546ENST00000518029NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000520546ENST00000517492NAT1chr8

18080499

+NAT1chr8

18080406

-
3UTR-intronENST00000520546ENST00000520546NAT1chr8

18080499

+NAT1chr8

18080406

-

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FusionProtFeatures for NAT1_NAT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAT1

P18440

NAT1

P18440

Participates in the detoxification of a plethora ofhydrazine and arylamine drugs. Catalyzes the N- or O-acetylationof various arylamine and heterocyclic amine substrates and is ableto bioactivate several known carcinogens. Participates in the detoxification of a plethora ofhydrazine and arylamine drugs. Catalyzes the N- or O-acetylationof various arylamine and heterocyclic amine substrates and is ableto bioactivate several known carcinogens.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAT1_NAT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAT1_NAT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NAT1_NAT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NAT1_NAT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNAT1C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneNAT1C0005695Bladder Neoplasm1CTD_human
HgeneNAT1C0008625Chromosome Aberrations1CTD_human
HgeneNAT1C0028796Dermatitis, Occupational1CTD_human
HgeneNAT1C0033578Prostatic Neoplasms1CTD_human
HgeneNAT1C0041755Adverse reaction to drug1CTD_human
TgeneNAT1C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNAT1C0005695Bladder Neoplasm1CTD_human
TgeneNAT1C0008625Chromosome Aberrations1CTD_human
TgeneNAT1C0028796Dermatitis, Occupational1CTD_human
TgeneNAT1C0033578Prostatic Neoplasms1CTD_human
TgeneNAT1C0041755Adverse reaction to drug1CTD_human