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Fusion gene ID: 23411 |
FusionGeneSummary for NAPG_GREB1L |
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Fusion gene information | Fusion gene name: NAPG_GREB1L | Fusion gene ID: 23411 | Hgene | Tgene | Gene symbol | NAPG | GREB1L | Gene ID | 8774 | 80000 |
Gene name | NSF attachment protein gamma | GREB1 like retinoic acid receptor coactivator | |
Synonyms | GAMMASNAP | C18orf6|KIAA1772|RHDA3 | |
Cytomap | 18p11.22 | 18q11.1-q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | gamma-soluble NSF attachment proteinN-ethylmaleimide-sensitive factor attachment protein, gammaSNAP-gammasoluble NSF attachment protein | GREB1-like proteingrowth regulation by estrogen in breast cancer 1 likegrowth regulation by estrogen in breast cancer 1-like proteingrowth regulation by estrogen in breast cancer-like | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q99747 | Q9C091 | |
Ensembl transtripts involved in fusion gene | ENST00000542979, ENST00000322897, | ENST00000431264, ENST00000424526, ENST00000400483, ENST00000269218, ENST00000580732, ENST00000578368, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 4 X 4=48 |
# samples | 2 | 4 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NAPG [Title/Abstract] AND GREB1L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GREB1L | GO:0001822 | kidney development | 29100091 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-AN-A04A-01A | NAPG | chr18 | 10530834 | + | GREB1L | chr18 | 19052992 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000542979 | ENST00000431264 | NAPG | chr18 | 10530834 | + | GREB1L | chr18 | 19052992 | + |
intron-intron | ENST00000542979 | ENST00000424526 | NAPG | chr18 | 10530834 | + | GREB1L | chr18 | 19052992 | + |
intron-intron | ENST00000542979 | ENST00000400483 | NAPG | chr18 | 10530834 | + | GREB1L | chr18 | 19052992 | + |
intron-intron | ENST00000542979 | ENST00000269218 | NAPG | chr18 | 10530834 | + | GREB1L | chr18 | 19052992 | + |
intron-intron | ENST00000542979 | ENST00000580732 | NAPG | chr18 | 10530834 | + | GREB1L | chr18 | 19052992 | + |
intron-intron | ENST00000542979 | ENST00000578368 | NAPG | chr18 | 10530834 | + | GREB1L | chr18 | 19052992 | + |
5CDS-intron | ENST00000322897 | ENST00000431264 | NAPG | chr18 | 10530834 | + | GREB1L | chr18 | 19052992 | + |
5CDS-intron | ENST00000322897 | ENST00000424526 | NAPG | chr18 | 10530834 | + | GREB1L | chr18 | 19052992 | + |
5CDS-intron | ENST00000322897 | ENST00000400483 | NAPG | chr18 | 10530834 | + | GREB1L | chr18 | 19052992 | + |
5CDS-intron | ENST00000322897 | ENST00000269218 | NAPG | chr18 | 10530834 | + | GREB1L | chr18 | 19052992 | + |
5CDS-intron | ENST00000322897 | ENST00000580732 | NAPG | chr18 | 10530834 | + | GREB1L | chr18 | 19052992 | + |
5CDS-intron | ENST00000322897 | ENST00000578368 | NAPG | chr18 | 10530834 | + | GREB1L | chr18 | 19052992 | + |
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FusionProtFeatures for NAPG_GREB1L |
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Hgene | Tgene |
NAPG | GREB1L |
Required for vesicular transport between the endoplasmicreticulum and the Golgi apparatus. | Plays a major role in early metanephros and genitaldevelopment. {ECO:0000269|PubMed:29100091}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NAPG_GREB1L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NAPG_GREB1L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NAPG | NSF, ELAVL1, APP, LSM6, MTR, FN1, RAB11FIP5, TUBG1, VTI1B, STX6, STX7, STX12, AKAP11, NAPA, SCFD2, PRKACB, PRKAR1B, VAMP4, STX8, NBAS, PIPOX, FBXW7, STXBP6, FMN1, CPNE5, SEC22B, PRPSAP2, UFSP2, FAM177A1, SPRTN | GREB1L | MOV10, NXF1, TSEN2, LYPD4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NAPG_GREB1L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NAPG_GREB1L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NAPG | C0005586 | Bipolar Disorder | 3 | PSYGENET |