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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23411

FusionGeneSummary for NAPG_GREB1L

check button Fusion gene summary
Fusion gene informationFusion gene name: NAPG_GREB1L
Fusion gene ID: 23411
HgeneTgene
Gene symbol

NAPG

GREB1L

Gene ID

8774

80000

Gene nameNSF attachment protein gammaGREB1 like retinoic acid receptor coactivator
SynonymsGAMMASNAPC18orf6|KIAA1772|RHDA3
Cytomap

18p11.22

18q11.1-q11.2

Type of geneprotein-codingprotein-coding
Descriptiongamma-soluble NSF attachment proteinN-ethylmaleimide-sensitive factor attachment protein, gammaSNAP-gammasoluble NSF attachment proteinGREB1-like proteingrowth regulation by estrogen in breast cancer 1 likegrowth regulation by estrogen in breast cancer 1-like proteingrowth regulation by estrogen in breast cancer-like
Modification date2018052320180519
UniProtAcc

Q99747

Q9C091

Ensembl transtripts involved in fusion geneENST00000542979, ENST00000322897, 
ENST00000431264, ENST00000424526, 
ENST00000400483, ENST00000269218, 
ENST00000580732, ENST00000578368, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 4 X 4=48
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAPG [Title/Abstract] AND GREB1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGREB1L

GO:0001822

kidney development

29100091


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AN-A04A-01ANAPGchr18

10530834

+GREB1Lchr18

19052992

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000542979ENST00000431264NAPGchr18

10530834

+GREB1Lchr18

19052992

+
intron-intronENST00000542979ENST00000424526NAPGchr18

10530834

+GREB1Lchr18

19052992

+
intron-intronENST00000542979ENST00000400483NAPGchr18

10530834

+GREB1Lchr18

19052992

+
intron-intronENST00000542979ENST00000269218NAPGchr18

10530834

+GREB1Lchr18

19052992

+
intron-intronENST00000542979ENST00000580732NAPGchr18

10530834

+GREB1Lchr18

19052992

+
intron-intronENST00000542979ENST00000578368NAPGchr18

10530834

+GREB1Lchr18

19052992

+
5CDS-intronENST00000322897ENST00000431264NAPGchr18

10530834

+GREB1Lchr18

19052992

+
5CDS-intronENST00000322897ENST00000424526NAPGchr18

10530834

+GREB1Lchr18

19052992

+
5CDS-intronENST00000322897ENST00000400483NAPGchr18

10530834

+GREB1Lchr18

19052992

+
5CDS-intronENST00000322897ENST00000269218NAPGchr18

10530834

+GREB1Lchr18

19052992

+
5CDS-intronENST00000322897ENST00000580732NAPGchr18

10530834

+GREB1Lchr18

19052992

+
5CDS-intronENST00000322897ENST00000578368NAPGchr18

10530834

+GREB1Lchr18

19052992

+

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FusionProtFeatures for NAPG_GREB1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAPG

Q99747

GREB1L

Q9C091

Required for vesicular transport between the endoplasmicreticulum and the Golgi apparatus. Plays a major role in early metanephros and genitaldevelopment. {ECO:0000269|PubMed:29100091}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAPG_GREB1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAPG_GREB1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NAPGNSF, ELAVL1, APP, LSM6, MTR, FN1, RAB11FIP5, TUBG1, VTI1B, STX6, STX7, STX12, AKAP11, NAPA, SCFD2, PRKACB, PRKAR1B, VAMP4, STX8, NBAS, PIPOX, FBXW7, STXBP6, FMN1, CPNE5, SEC22B, PRPSAP2, UFSP2, FAM177A1, SPRTNGREB1LMOV10, NXF1, TSEN2, LYPD4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAPG_GREB1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAPG_GREB1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNAPGC0005586Bipolar Disorder3PSYGENET