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Fusion gene ID: 23400 |
FusionGeneSummary for NAP1L4_RPAP1 |
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Fusion gene information | Fusion gene name: NAP1L4_RPAP1 | Fusion gene ID: 23400 | Hgene | Tgene | Gene symbol | NAP1L4 | RPAP1 | Gene ID | 4676 | 26015 |
Gene name | nucleosome assembly protein 1 like 4 | RNA polymerase II associated protein 1 | |
Synonyms | NAP1L4b|NAP2|NAP2L|hNAP2 | - | |
Cytomap | 11p15.4 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | nucleosome assembly protein 1-like 4NAP-2nucleosome assembly protein 1-like 4bnucleosome assembly protein 2 | RNA polymerase II-associated protein 1 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q99733 | Q9BWH6 | |
Ensembl transtripts involved in fusion gene | ENST00000380542, ENST00000469089, ENST00000526115, | ENST00000561603, ENST00000304330, ENST00000568413, | |
Fusion gene scores | * DoF score | 8 X 9 X 5=360 | 2 X 1 X 2=4 |
# samples | 10 | 2 | |
** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: NAP1L4 [Title/Abstract] AND RPAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NAP1L4 | GO:0006334 | nucleosome assembly | 9325046 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-E2-A1LL-01A | NAP1L4 | chr11 | 3013484 | - | RPAP1 | chr15 | 41829399 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000380542 | ENST00000561603 | NAP1L4 | chr11 | 3013484 | - | RPAP1 | chr15 | 41829399 | - |
5UTR-5UTR | ENST00000380542 | ENST00000304330 | NAP1L4 | chr11 | 3013484 | - | RPAP1 | chr15 | 41829399 | - |
5UTR-intron | ENST00000380542 | ENST00000568413 | NAP1L4 | chr11 | 3013484 | - | RPAP1 | chr15 | 41829399 | - |
intron-5UTR | ENST00000469089 | ENST00000561603 | NAP1L4 | chr11 | 3013484 | - | RPAP1 | chr15 | 41829399 | - |
intron-5UTR | ENST00000469089 | ENST00000304330 | NAP1L4 | chr11 | 3013484 | - | RPAP1 | chr15 | 41829399 | - |
intron-intron | ENST00000469089 | ENST00000568413 | NAP1L4 | chr11 | 3013484 | - | RPAP1 | chr15 | 41829399 | - |
5UTR-5UTR | ENST00000526115 | ENST00000561603 | NAP1L4 | chr11 | 3013484 | - | RPAP1 | chr15 | 41829399 | - |
5UTR-5UTR | ENST00000526115 | ENST00000304330 | NAP1L4 | chr11 | 3013484 | - | RPAP1 | chr15 | 41829399 | - |
5UTR-intron | ENST00000526115 | ENST00000568413 | NAP1L4 | chr11 | 3013484 | - | RPAP1 | chr15 | 41829399 | - |
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FusionProtFeatures for NAP1L4_RPAP1 |
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Hgene | Tgene |
NAP1L4 | RPAP1 |
Acts as histone chaperone in nucleosome assembly.{ECO:0000269|PubMed:9325046}. | Forms an interface between the RNA polymerase II enzymeand chaperone/scaffolding protein, suggesting that it is requiredto connect RNA polymerase II to regulators of protein complexformation. Required for interaction of the RNA polymerase IIcomplex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NAP1L4_RPAP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NAP1L4_RPAP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NAP1L4 | HIST1H1A, HIST2H4A, HIST3H3, HIST1H2AE, HIST2H2BE, EP300, NAP1L4, HIST2H2AC, HIST2H3C, ELAVL1, CUL3, CUL5, CUL1, CAND1, CSNK2A1, NAP1L1, EIF3A, EIF3E, NCL, PES1, NPM1, EIF3C, SOX2, KARS, KHSRP, NCBP1, FTSJ3, CEP250, MAGED2, ENO1, MOV10, NXF1, JAK3, ESR1, UNK, ANAPC1, ANAPC10, ANAPC7, CDC16, CDC23, TAF3, TAF4, NTRK1, LCA5, OFD1, SSX2IP, CEP120, SPICE1, DCTN1, RPGRIP1, XPO1, CAPZA2, DBN1, DSP, MATR3, SYNPO, ASPM, BCOR, CDKN3, RPL18, NAP1L5, MRPL35, HIST1H2BA, MTNR1A, HSD17B10, SOD1, TRIM25, TES, BRD1 | RPAP1 | MEPCE, POLR2J, ARHGAP23, HNRNPA1, IGF2BP1, GPN1, POLR2B, HSPD1, POLR2C, SRP72, EFTUD2, ZFR, POLR3A, ELAVL1, CENPC, ILF3, POLR3B, HSPA8, BAG6, KIF11, CCT6A, DDX3Y, PHF8, NUMA1, IPO9, SLFN11, CSNK2B, MAGED2, HLTF, MCM10, SYTL2, ERBB2IP, ANAPC1, TERF2IP, POT1, LAGE3, IGBP1, PPIL3, PAICS, POLR2L, CCDC8, GPN2, POLR2M, NHP2L1, NTRK1, XPO1, POLK, C1orf94, POLR1C |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NAP1L4_RPAP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NAP1L4_RPAP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NAP1L4 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |