|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 23383 |
FusionGeneSummary for NANS_WNK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NANS_WNK2 | Fusion gene ID: 23383 | Hgene | Tgene | Gene symbol | NANS | WNK2 | Gene ID | 54187 | 65268 |
| Gene name | N-acetylneuraminate synthase | WNK lysine deficient protein kinase 2 | |
| Synonyms | HEL-S-100|SAS|SEMDCG|SEMDG | NY-CO-43|P/OKcl.13|PRKWNK2|SDCCAG43 | |
| Cytomap | 9q22.33 | 9q22.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sialic acid synthaseN-acetylneuraminate-9-phosphate synthaseN-acetylneuraminic acid phosphate synthaseN-acetylneuraminic acid synthaseepididymis secretory protein Li 100sialic acid phosphate synthase | serine/threonine-protein kinase WNK2antigen NY-CO-43mitogen-activated protein kinase kinase kinaseprotein kinase lysine-deficient 2protein kinase with no lysine 2serologically defined colon cancer antigen 43 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NR45 | Q9Y3S1 | |
| Ensembl transtripts involved in fusion gene | ENST00000210444, ENST00000461452, | ENST00000427277, ENST00000297954, ENST00000395475, ENST00000356055, ENST00000349097, ENST00000395477, ENST00000471076, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 7 X 7 X 7=343 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/343*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NANS [Title/Abstract] AND WNK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | WNK2 | GO:0006468 | protein phosphorylation | 21733846 |
| Tgene | WNK2 | GO:0046777 | protein autophosphorylation | 17667937 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-ZG-A9LN-01A | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000210444 | ENST00000427277 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| In-frame | ENST00000210444 | ENST00000297954 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| In-frame | ENST00000210444 | ENST00000395475 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| 5CDS-5UTR | ENST00000210444 | ENST00000356055 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| 5CDS-5UTR | ENST00000210444 | ENST00000349097 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| 5CDS-5UTR | ENST00000210444 | ENST00000395477 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| 5CDS-intron | ENST00000210444 | ENST00000471076 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| intron-3CDS | ENST00000461452 | ENST00000427277 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| intron-3CDS | ENST00000461452 | ENST00000297954 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| intron-3CDS | ENST00000461452 | ENST00000395475 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| intron-5UTR | ENST00000461452 | ENST00000356055 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| intron-5UTR | ENST00000461452 | ENST00000349097 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| intron-5UTR | ENST00000461452 | ENST00000395477 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| intron-intron | ENST00000461452 | ENST00000471076 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
Top |
FusionProtFeatures for NANS_WNK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NANS | WNK2 |
| Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate assubstrates to generate phosphorylated forms of Neu5Ac and KDN,respectively. | Serine/threonine kinase which plays an important role inthe regulation of electrolyte homeostasis, cell signaling,survival, and proliferation. Acts as an activator and inhibitor ofsodium-coupled chloride cotransporters and potassium-coupledchloride cotransporters respectively. Activates SLC12A2, SCNN1A,SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulatesthe EGF-induced activation of the ERK/MAPK-pathway and thedownstream cell cycle progression. Affects MAPK3/MAPK1 activity bymodulating the activity of MAP2K1 and this modulation depends onphosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering withthe activity of PAK1 by controlling the balance of the activity ofupstream regulators of PAK1 activity, RHOA and RAC1, which displayreciprocal activity. {ECO:0000269|PubMed:17667937,ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NANS | chr9:100823279 | chr9:96019230 | ENST00000210444 | + | 2 | 6 | 294_353 | 116 | 360 | Domain | AFP-like |
| Tgene | WNK2 | chr9:100823279 | chr9:96019230 | ENST00000297954 | + | 8 | 30 | 195_453 | 730 | 2298 | Domain | Protein kinase |
| Tgene | WNK2 | chr9:100823279 | chr9:96019230 | ENST00000297954 | + | 8 | 30 | 275_278 | 730 | 2298 | Nucleotide binding | ATP |
Top |
FusionGeneSequence for NANS_WNK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NANS_ENST00000210444_chr9_100823279_+_WNK2_ENST00000427277_chr9_96019230_+_1611aa MPLELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKFNRKALERPYTSKHSWGKTYGEHKRHLEF SHDQYRELQRYAEEVGIFFTASGMDEPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQ MPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATI PLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTR PPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPE LLPQFPSSLATVSASVQSVPTQTATLLPPANPPLPGGPGIASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGGSDVTSGKELSDSCE GAFGGGRLEGRAARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERE TFIEQMKDVMDKAEDMLSEDTDADRGSDPGTSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAEHPAPEAPESSPPLP LSSLPPEASQDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQ GLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQL PSPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLAL PPVPKEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSSSMTAESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDRDGG EAGESSAEPPPSDMGTVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEAPSSPDV KLAVRRAQTASSIEVGVGEPVSSDSGDEGPRARPPVQKQASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPETPSRVGMKVPTISVTSFH SQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPTGRRRKTSKSKLKAGKLLNPLV RQLKVVASSTGHLADSSRGPPAKDPAQASVGLTADSTGLSGKAVQTQQPCSVRASLSSDICSGLASDGGGARGQGWTVYHPTSERVTYKS SSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPALHVQAQVNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLKP >In-frame_NANS_ENST00000210444_chr9_100823279_+_WNK2_ENST00000297954_chr9_96019230_+_1684aa MPLELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKFNRKALERPYTSKHSWGKTYGEHKRHLEF SHDQYRELQRYAEEVGIFFTASGMDEPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQ MPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATI PLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTR PPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPE LLPQFPSSLATVSASVQSVPTQTATLLPPANPPLPGGPGIASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGGSDVTSGKELSDSCE GAFGGGRLEGRAARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERE TFIEQMKDVMDKAEDMLSEDTDADRGSDPGTSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAEHPAPEAPESSPPLP LSSLPPEASQGPCRGLTLPCLPWRRAACGAVFLSLFSAESAQSKQPPDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPS SPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPP PAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPT SSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSSSMTAESSPRSMLGYD RDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDRDGGEAGESSAEPPPSDMGTVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGR FSVVSTQDEWTLASPHSLRYSAPPDVYLDEAPSSPDVKLAVRRAQTASSIEVGVGEPVSSDSGDEGPRARPPVQKQASLPVSGSVAGDFV KKATAFLQRPSRAGSLGPETPSRVGMKVPTISVTSFHSQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLG KPLPPNVGFFHTAPPTGRRRKTSKSKLKAGKLLNPLVRQLKVVASSTGHLADSSRGPPAKDPAQASVGLTADSTGLSGKAVQTQQPCSVR ASLSSDICSGLASDGGGARGQGWTVYHPTSERVTYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPALHV QAQVNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLKPTLNQLKQTQKLQDMEAQAGWAAPGEARAMTAPRAGVGMPRLPPAPGPLSTTVI >In-frame_NANS_ENST00000210444_chr9_100823279_+_WNK2_ENST00000395475_chr9_96019230_+_231aa MPLELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKFNRKALERPYTSKHSWGKTYGEHKRHLEF SHDQYRELQRYAEEVGIFFTASGMDEPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NANS_ENST00000210444_chr9_100823279_+_WNK2_ENST00000427277_chr9_96019230_+_4833nt ATGCCGCTGGAGCTGGAGCTGTGTCCCGGGCGCTGGGTGGGCGGGCAACACCCGTGCTTCATCATTGCCGAGATCGGCCAGAACCACCAG GGCGACCTGGACGTAGCCAAGCGCATGATCCGCATGGCCAAGGAGTGTGGGGCTGATTGTGCTAAGTTCCAGAAGAGTGAGCTAGAATTC AAGTTTAATCGGAAAGCCTTGGAGAGGCCATACACCTCGAAGCATTCCTGGGGGAAGACGTACGGGGAGCACAAACGACATCTGGAGTTC AGCCATGACCAGTACAGGGAGCTGCAGAGGTACGCCGAGGAGGTTGGGATCTTCTTCACTGCCTCTGGCATGGATGAGCCTCCTCCGCTG GCCCAGCCGACACCCCTGCCGCAGGTCCTGGCCCCACAGCCCGTGGTCCCCCTCCAGCCGGTTCCCCCCCACCTGCCACCGTACCTGGCT CCAGCCTCCCAGGTGGGGGCCCCCGCTCAGCTGAAGCCCCTCCAGATGCCACAGGCGCCCCTGCAGCCGCTTGCTCAAGTCCCTCCGCAG ATGCCCCCGATTCCTGTTGTGCCCCCCATCACGCCCCTGGCGGGAATCGACGGCCTCCCTCCGGCCCTCCCAGACCTGCCGACCGCGACT GTGCCTCCCGTGCCACCACCTCAGTATTTCTCTCCAGCCGTGATCTTGCCGAGCCTCGCTGCCCCACTCCCCCCTGCGTCCCCAGCCTTG CCTCTGCAGGCTGTGAAGCTGCCCCACCCCCCTGGGGCGCCCCTGGCCATGCCCTGCCGGACCATTGTGCCAAATGCACCGGCCACTATC CCCCTGCTGGCCGTAGCCCCACCGGGCGTGGCTGCCCTGTCCATTCATTCTGCCGTGGCCCAGCTCCCAGGCCAACCTGTGTACCCAGCG GCCTTCCCACAGATGGCGCCTACTGACGTCCCTCCTTCCCCCCATCACACGGTGCAGAATATGAGGGCCACCCCTCCACAGCCGGCACTG CCTCCACAACCCACACTGCCCCCACAACCCGTGCTGCCCCCGCAACCCACGCTGCCCCCTCAACCTGTGTTGCCCCCGCAACCCACACGG CCCCCTCAACCTGTGCTGCCCCCGCAACCCATGCTGCCCCCACAACCTGTGCTGCCCCCGCAGCCGGCACTGCCTGTGCGCCCTGAGCCC CTCCAGCCCCACCTTCCTGAACAAGCTGCTCCAGCTGCTACACCAGGGAGCCAGATTCTGCTTGGCCACCCAGCTCCCTATGCTGTGGAC GTCGCCGCTCAGGTCCCCACCGTGCCTGTGCCACCGGCTGCGGTCCTCTCGCCGCCTCTGCCGGAAGTGCTGCTGCCTGCCGCCCCTGAG CTCCTGCCTCAGTTCCCCAGCTCCCTGGCCACGGTGTCTGCCTCTGTGCAGAGTGTGCCCACCCAGACTGCCACACTTCTGCCACCAGCA AACCCACCGCTGCCTGGCGGGCCCGGGATCGCCAGCCCTTGCCCAACTGTCCAGCTGACGGTGGAACCAGTCCAAGAGGAGCAGGCCTCA CAGGACAAGCCGCCCGGCCTCCCGCAGAGCTGTGAGAGCTATGGAGGTTCTGATGTCACTTCTGGAAAAGAGCTGAGTGACAGCTGTGAA GGCGCCTTTGGAGGGGGCAGGCTGGAGGGCAGGGCAGCCCGAAAACACCACCGCAGGTCCACGCGTGCGCGCTCCCGGCAGGAGAGGGCC AGCCGGCCCCGGCTTACCATCTTGAACGTGTGCAACACTGGGGACAAGATGGTGGAGTGCCAGCTGGAGACGCACAACCACAAGATGGTG ACCTTCAAGTTCGACTTGGACGGGGACGCACCCGATGAAATTGCCACGTATATGGTGGAGCATGACTTTATCCTGCAGGCCGAGCGGGAA ACGTTCATCGAGCAGATGAAGGATGTCATGGACAAGGCAGAGGACATGCTCAGCGAGGACACAGACGCCGACCGTGGCTCCGACCCAGGG ACCAGCCCGCCACACCTCAGCACCTGCGGCCTGGGCACCGGGGAGGAGAGCCGACAATCCCAAGCCAACGCCCCCGTGTATCAGCAGAAC GTCCTGCACACCGGGAAGAGGTGGTTCATCATCTGTCCGGTGGCTGAGCACCCCGCCCCCGAGGCCCCTGAATCTTCGCCCCCACTTCCT CTAAGCTCCCTGCCGCCAGAAGCCAGCCAAGATTCAGCGCCCTATAAAGACCAGCTGTCCTCGAAGGAACAACCCAGCTTTCTAGCCAGT CAGCAGCTCCTGAGCCAGGCGGGCCCCAGCAACCCTCCTGGGGCACCCCCAGCCCCTTTGGCCCCCTCCTCCCCTCCTGTGACTGCTCTG CCCCAAGATGGAGCAGCTCCAGCCACCAGCACCATGCCAGAGCCAGCGTCAGGAACTGCCAGCCAGGCAGGGGGTCCAGGGACACCTCAG GGGCTGACCAGTGAGCTCGAGACGTCTCAGCCACTAGCGGAGACTCACGAGGCCCCGCTTGCTGTGCAGCCCCTCGTGGTGGGCCTAGCA CCTTGCACTCCAGCTCCAGAGGCTGCCTCAACCAGGGACGCCAGTGCCCCAAGGGAGCCCCTGCCACCTCCTGCACCTGAGCCCAGCCCC CACAGCGGGACCCCACAGCCCGCCTTGGGTCAACCTGCTCCCCTGCTTCCTGCCGCAGTGGGGGCCGTCAGCCTGGCCACCTCCCAGCTC CCAAGCCCACCCCTGGGGCCCACCGTCCCCCCACAGCCACCCTCGGCCCTGGAGTCGGATGGGGAAGGGCCGCCCCCCAGGGTGGGCTTT GTGGACAGCACCATCAAGAGCCTGGACGAGAAGCTGCGGACTCTGCTCTACCAGGAGCACGTGCCCACCTCCTCAGCCTCAGCTGGGACC CCTGTGGAGGTGGGCGACAGAGACTTCACCCTGGAGCCCCTGAGAGGGGACCAGCCCCGCTCAGAGGTCTGCGGGGGGGACCTGGCCCTG CCCCCAGTGCCTAAGGAGGCGGTCTCAGGGCGTGTCCAGCTGCCCCAGCCCTTGGTGGAGAAGTCAGAACTGGCCCCCACTCGAGGGGCC GTGATGGAGCAGGGCACGTCCTCGTCAATGACAGCAGAGTCGTCTCCCAGGAGTATGCTAGGCTATGACAGAGATGGAAGGCAGGTGGCC TCAGACTCCCATGTGGTCCCCAGCGTCCCCCAGGATGTACCTGCTTTTGTGAGACCTGCACGTGTGGAGCCCACAGACAGGGATGGTGGA GAAGCTGGAGAAAGCTCGGCAGAGCCCCCGCCGAGTGACATGGGCACAGTGGGGGGCCAGGCTAGCCACCCCCAGACACTCGGCGCTCGA GCTTTGGGGTCCCCTCGGAAACGTCCAGAGCAGCAGGATGTCAGCTCACCAGCCAAGACTGTGGGCCGTTTCTCGGTGGTCAGCACTCAG GACGAGTGGACCCTGGCCTCCCCCCACAGCCTGAGATACTCTGCCCCACCCGACGTCTACCTGGACGAGGCCCCCTCCAGCCCCGACGTG AAGCTGGCAGTGCGGCGGGCGCAGACGGCCTCCTCCATCGAGGTCGGCGTGGGCGAGCCCGTGTCCAGCGACTCTGGGGACGAGGGCCCT CGGGCGAGACCCCCGGTGCAGAAGCAGGCGTCCCTGCCCGTGAGTGGCAGCGTGGCTGGCGACTTCGTGAAGAAGGCCACCGCCTTCCTG CAGAGGCCTTCTCGGGCCGGCTCGCTGGGCCCCGAGACACCCAGCAGGGTGGGCATGAAGGTCCCCACGATCAGCGTGACCTCCTTCCAT TCCCAGTCGTCCTACATCAGCAGCGACAATGATTCGGAGCTCGAGGATGCTGACATAAAGAAGGAGCTGCAGAGTCTGCGGGAGAAGCAC CTGAAGGAGATCTCGGAGCTGCAGAGCCAGCAGAAGCAGGAGATCGAAGCTCTGTACCGCCGCCTGGGCAAGCCACTGCCCCCCAACGTG GGCTTCTTCCACACGGCACCCCCCACTGGCCGCCGGAGAAAAACCAGCAAGAGCAAGCTGAAGGCAGGCAAGCTGCTAAATCCCCTGGTG CGGCAGCTCAAGGTCGTGGCCTCCAGCACAGGTCACTTGGCTGACTCCAGCAGAGGCCCTCCCGCTAAGGACCCTGCCCAAGCCAGTGTG GGGCTCACTGCAGACAGCACGGGCCTGAGCGGGAAGGCAGTGCAGACCCAGCAGCCCTGCTCCGTCCGGGCCTCCCTGTCTTCGGACATC TGCTCCGGCTTAGCCAGTGATGGAGGCGGAGCGCGTGGCCAAGGCTGGACGGTTTACCACCCAACGTCTGAGAGAGTGACCTATAAGTCT AGTAGCAAACCTCGTGCTCGATTCCTCAGTGGACCCGTATCTGTGTCCATCTGGTCTGCCCTGAAGCGTCTCTGCCTAGGCAAAGAACAC AGCAGTAGGTCCTCCACCAGCAGCCTGGCCCCAGGCCCTGAGCCAGGCCCCCAGCCCGCCCTGCACGTCCAGGCGCAGGTGAACAACAGC AACAACAAGAAGGGTACCTTCACGGACGACCTGCACAAGCTGGTGGACGAGTGGACGAGCAAGACGGTGGGGGCCGCGCAGCTGAAGCCC ACGCTCAACCAGCTGAAGCAGACCCAGAAGCTGCAAGACATGGAGGCCCAGGCAGGCTGGGCTGCCCCTGGCGAGGCGCGGGCTATGACC GCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTG >In-frame_NANS_ENST00000210444_chr9_100823279_+_WNK2_ENST00000297954_chr9_96019230_+_5052nt ATGCCGCTGGAGCTGGAGCTGTGTCCCGGGCGCTGGGTGGGCGGGCAACACCCGTGCTTCATCATTGCCGAGATCGGCCAGAACCACCAG GGCGACCTGGACGTAGCCAAGCGCATGATCCGCATGGCCAAGGAGTGTGGGGCTGATTGTGCTAAGTTCCAGAAGAGTGAGCTAGAATTC AAGTTTAATCGGAAAGCCTTGGAGAGGCCATACACCTCGAAGCATTCCTGGGGGAAGACGTACGGGGAGCACAAACGACATCTGGAGTTC AGCCATGACCAGTACAGGGAGCTGCAGAGGTACGCCGAGGAGGTTGGGATCTTCTTCACTGCCTCTGGCATGGATGAGCCTCCTCCGCTG GCCCAGCCGACACCCCTGCCGCAGGTCCTGGCCCCACAGCCCGTGGTCCCCCTCCAGCCGGTTCCCCCCCACCTGCCACCGTACCTGGCT CCAGCCTCCCAGGTGGGGGCCCCCGCTCAGCTGAAGCCCCTCCAGATGCCACAGGCGCCCCTGCAGCCGCTTGCTCAAGTCCCTCCGCAG ATGCCCCCGATTCCTGTTGTGCCCCCCATCACGCCCCTGGCGGGAATCGACGGCCTCCCTCCGGCCCTCCCAGACCTGCCGACCGCGACT GTGCCTCCCGTGCCACCACCTCAGTATTTCTCTCCAGCCGTGATCTTGCCGAGCCTCGCTGCCCCACTCCCCCCTGCGTCCCCAGCCTTG CCTCTGCAGGCTGTGAAGCTGCCCCACCCCCCTGGGGCGCCCCTGGCCATGCCCTGCCGGACCATTGTGCCAAATGCACCGGCCACTATC CCCCTGCTGGCCGTAGCCCCACCGGGCGTGGCTGCCCTGTCCATTCATTCTGCCGTGGCCCAGCTCCCAGGCCAACCTGTGTACCCAGCG GCCTTCCCACAGATGGCGCCTACTGACGTCCCTCCTTCCCCCCATCACACGGTGCAGAATATGAGGGCCACCCCTCCACAGCCGGCACTG CCTCCACAACCCACACTGCCCCCACAACCCGTGCTGCCCCCGCAACCCACGCTGCCCCCTCAACCTGTGTTGCCCCCGCAACCCACACGG CCCCCTCAACCTGTGCTGCCCCCGCAACCCATGCTGCCCCCACAACCTGTGCTGCCCCCGCAGCCGGCACTGCCTGTGCGCCCTGAGCCC CTCCAGCCCCACCTTCCTGAACAAGCTGCTCCAGCTGCTACACCAGGGAGCCAGATTCTGCTTGGCCACCCAGCTCCCTATGCTGTGGAC GTCGCCGCTCAGGTCCCCACCGTGCCTGTGCCACCGGCTGCGGTCCTCTCGCCGCCTCTGCCGGAAGTGCTGCTGCCTGCCGCCCCTGAG CTCCTGCCTCAGTTCCCCAGCTCCCTGGCCACGGTGTCTGCCTCTGTGCAGAGTGTGCCCACCCAGACTGCCACACTTCTGCCACCAGCA AACCCACCGCTGCCTGGCGGGCCCGGGATCGCCAGCCCTTGCCCAACTGTCCAGCTGACGGTGGAACCAGTCCAAGAGGAGCAGGCCTCA CAGGACAAGCCGCCCGGCCTCCCGCAGAGCTGTGAGAGCTATGGAGGTTCTGATGTCACTTCTGGAAAAGAGCTGAGTGACAGCTGTGAA GGCGCCTTTGGAGGGGGCAGGCTGGAGGGCAGGGCAGCCCGAAAACACCACCGCAGGTCCACGCGTGCGCGCTCCCGGCAGGAGAGGGCC AGCCGGCCCCGGCTTACCATCTTGAACGTGTGCAACACTGGGGACAAGATGGTGGAGTGCCAGCTGGAGACGCACAACCACAAGATGGTG ACCTTCAAGTTCGACTTGGACGGGGACGCACCCGATGAAATTGCCACGTATATGGTGGAGCATGACTTTATCCTGCAGGCCGAGCGGGAA ACGTTCATCGAGCAGATGAAGGATGTCATGGACAAGGCAGAGGACATGCTCAGCGAGGACACAGACGCCGACCGTGGCTCCGACCCAGGG ACCAGCCCGCCACACCTCAGCACCTGCGGCCTGGGCACCGGGGAGGAGAGCCGACAATCCCAAGCCAACGCCCCCGTGTATCAGCAGAAC GTCCTGCACACCGGGAAGAGGTGGTTCATCATCTGTCCGGTGGCTGAGCACCCCGCCCCCGAGGCCCCTGAATCTTCGCCCCCACTTCCT CTAAGCTCCCTGCCGCCAGAAGCCAGCCAAGGTCCATGCAGGGGGCTCACCCTGCCCTGTCTCCCATGGCGCAGAGCAGCCTGTGGGGCT GTGTTCCTATCCTTGTTTTCTGCTGAATCAGCTCAGTCAAAGCAGCCTCCAGATTCAGCGCCCTATAAAGACCAGCTGTCCTCGAAGGAA CAACCCAGCTTTCTAGCCAGTCAGCAGCTCCTGAGCCAGGCGGGCCCCAGCAACCCTCCTGGGGCACCCCCAGCCCCTTTGGCCCCCTCC TCCCCTCCTGTGACTGCTCTGCCCCAAGATGGAGCAGCTCCAGCCACCAGCACCATGCCAGAGCCAGCGTCAGGAACTGCCAGCCAGGCA GGGGGTCCAGGGACACCTCAGGGGCTGACCAGTGAGCTCGAGACGTCTCAGCCACTAGCGGAGACTCACGAGGCCCCGCTTGCTGTGCAG CCCCTCGTGGTGGGCCTAGCACCTTGCACTCCAGCTCCAGAGGCTGCCTCAACCAGGGACGCCAGTGCCCCAAGGGAGCCCCTGCCACCT CCTGCACCTGAGCCCAGCCCCCACAGCGGGACCCCACAGCCCGCCTTGGGTCAACCTGCTCCCCTGCTTCCTGCCGCAGTGGGGGCCGTC AGCCTGGCCACCTCCCAGCTCCCAAGCCCACCCCTGGGGCCCACCGTCCCCCCACAGCCACCCTCGGCCCTGGAGTCGGATGGGGAAGGG CCGCCCCCCAGGGTGGGCTTTGTGGACAGCACCATCAAGAGCCTGGACGAGAAGCTGCGGACTCTGCTCTACCAGGAGCACGTGCCCACC TCCTCAGCCTCAGCTGGGACCCCTGTGGAGGTGGGCGACAGAGACTTCACCCTGGAGCCCCTGAGAGGGGACCAGCCCCGCTCAGAGGTC TGCGGGGGGGACCTGGCCCTGCCCCCAGTGCCTAAGGAGGCGGTCTCAGGGCGTGTCCAGCTGCCCCAGCCCTTGGTGGAGAAGTCAGAA CTGGCCCCCACTCGAGGGGCCGTGATGGAGCAGGGCACGTCCTCGTCAATGACAGCAGAGTCGTCTCCCAGGAGTATGCTAGGCTATGAC AGAGATGGAAGGCAGGTGGCCTCAGACTCCCATGTGGTCCCCAGCGTCCCCCAGGATGTACCTGCTTTTGTGAGACCTGCACGTGTGGAG CCCACAGACAGGGATGGTGGAGAAGCTGGAGAAAGCTCGGCAGAGCCCCCGCCGAGTGACATGGGCACAGTGGGGGGCCAGGCTAGCCAC CCCCAGACACTCGGCGCTCGAGCTTTGGGGTCCCCTCGGAAACGTCCAGAGCAGCAGGATGTCAGCTCACCAGCCAAGACTGTGGGCCGT TTCTCGGTGGTCAGCACTCAGGACGAGTGGACCCTGGCCTCCCCCCACAGCCTGAGATACTCTGCCCCACCCGACGTCTACCTGGACGAG GCCCCCTCCAGCCCCGACGTGAAGCTGGCAGTGCGGCGGGCGCAGACGGCCTCCTCCATCGAGGTCGGCGTGGGCGAGCCCGTGTCCAGC GACTCTGGGGACGAGGGCCCTCGGGCGAGACCCCCGGTGCAGAAGCAGGCGTCCCTGCCCGTGAGTGGCAGCGTGGCTGGCGACTTCGTG AAGAAGGCCACCGCCTTCCTGCAGAGGCCTTCTCGGGCCGGCTCGCTGGGCCCCGAGACACCCAGCAGGGTGGGCATGAAGGTCCCCACG ATCAGCGTGACCTCCTTCCATTCCCAGTCGTCCTACATCAGCAGCGACAATGATTCGGAGCTCGAGGATGCTGACATAAAGAAGGAGCTG CAGAGTCTGCGGGAGAAGCACCTGAAGGAGATCTCGGAGCTGCAGAGCCAGCAGAAGCAGGAGATCGAAGCTCTGTACCGCCGCCTGGGC AAGCCACTGCCCCCCAACGTGGGCTTCTTCCACACGGCACCCCCCACTGGCCGCCGGAGAAAAACCAGCAAGAGCAAGCTGAAGGCAGGC AAGCTGCTAAATCCCCTGGTGCGGCAGCTCAAGGTCGTGGCCTCCAGCACAGGTCACTTGGCTGACTCCAGCAGAGGCCCTCCCGCTAAG GACCCTGCCCAAGCCAGTGTGGGGCTCACTGCAGACAGCACGGGCCTGAGCGGGAAGGCAGTGCAGACCCAGCAGCCCTGCTCCGTCCGG GCCTCCCTGTCTTCGGACATCTGCTCCGGCTTAGCCAGTGATGGAGGCGGAGCGCGTGGCCAAGGCTGGACGGTTTACCACCCAACGTCT GAGAGAGTGACCTATAAGTCTAGTAGCAAACCTCGTGCTCGATTCCTCAGTGGACCCGTATCTGTGTCCATCTGGTCTGCCCTGAAGCGT CTCTGCCTAGGCAAAGAACACAGCAGTAGGTCCTCCACCAGCAGCCTGGCCCCAGGCCCTGAGCCAGGCCCCCAGCCCGCCCTGCACGTC CAGGCGCAGGTGAACAACAGCAACAACAAGAAGGGTACCTTCACGGACGACCTGCACAAGCTGGTGGACGAGTGGACGAGCAAGACGGTG GGGGCCGCGCAGCTGAAGCCCACGCTCAACCAGCTGAAGCAGACCCAGAAGCTGCAAGACATGGAGGCCCAGGCAGGCTGGGCTGCCCCT GGCGAGGCGCGGGCTATGACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACGGTCATT CCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGATGGCGCCCTCGGAACCGCCCGGAGAAACCAGGTGTGGTTTGGCCTCCGAGTC CCCCCCACCGCCTGCTGTGGGCACAGCACTCAGCCGCGAGGGGGACAGCGGGTGGGCAGCAAGACTGCTTCCTTTGCGGCTTCAGACCCT >In-frame_NANS_ENST00000210444_chr9_100823279_+_WNK2_ENST00000395475_chr9_96019230_+_693nt ATGCCGCTGGAGCTGGAGCTGTGTCCCGGGCGCTGGGTGGGCGGGCAACACCCGTGCTTCATCATTGCCGAGATCGGCCAGAACCACCAG GGCGACCTGGACGTAGCCAAGCGCATGATCCGCATGGCCAAGGAGTGTGGGGCTGATTGTGCTAAGTTCCAGAAGAGTGAGCTAGAATTC AAGTTTAATCGGAAAGCCTTGGAGAGGCCATACACCTCGAAGCATTCCTGGGGGAAGACGTACGGGGAGCACAAACGACATCTGGAGTTC AGCCATGACCAGTACAGGGAGCTGCAGAGGTACGCCGAGGAGGTTGGGATCTTCTTCACTGCCTCTGGCATGGATGAGCCTCCTCCGCTG GCCCAGCCGACACCCCTGCCGCAGGTCCTGGCCCCACAGCCCGTGGTCCCCCTCCAGCCGGTTCCCCCCCACCTGCCACCGTACCTGGCT CCAGCCTCCCAGGTGGGGGCCCCCGCTCAGCTGAAGCCCCTCCAGATGCCACAGGCGCCCCTGCAGCCGCTTGCTCAAGTCCCTCCGCAG ATGCCCCCGATTCCTGTTGTGCCCCCCATCACGCCCCTGGCGGGAATCGACGGCCTCCCTCCGGCCCTCCCAGACCTGCCGACCGCGACT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NANS_ENST00000210444_chr9_100823279_+_WNK2_ENST00000427277_chr9_96019230_+_4903nt AGAGTAGAGGCGGCGGCGGCGGCGGCCGGACCCAGACTGGTAGTGAGGCTTTGGACCCCGAGCCGCTGCAATGCCGCTGGAGCTGGAGCT GTGTCCCGGGCGCTGGGTGGGCGGGCAACACCCGTGCTTCATCATTGCCGAGATCGGCCAGAACCACCAGGGCGACCTGGACGTAGCCAA GCGCATGATCCGCATGGCCAAGGAGTGTGGGGCTGATTGTGCTAAGTTCCAGAAGAGTGAGCTAGAATTCAAGTTTAATCGGAAAGCCTT GGAGAGGCCATACACCTCGAAGCATTCCTGGGGGAAGACGTACGGGGAGCACAAACGACATCTGGAGTTCAGCCATGACCAGTACAGGGA GCTGCAGAGGTACGCCGAGGAGGTTGGGATCTTCTTCACTGCCTCTGGCATGGATGAGCCTCCTCCGCTGGCCCAGCCGACACCCCTGCC GCAGGTCCTGGCCCCACAGCCCGTGGTCCCCCTCCAGCCGGTTCCCCCCCACCTGCCACCGTACCTGGCTCCAGCCTCCCAGGTGGGGGC CCCCGCTCAGCTGAAGCCCCTCCAGATGCCACAGGCGCCCCTGCAGCCGCTTGCTCAAGTCCCTCCGCAGATGCCCCCGATTCCTGTTGT GCCCCCCATCACGCCCCTGGCGGGAATCGACGGCCTCCCTCCGGCCCTCCCAGACCTGCCGACCGCGACTGTGCCTCCCGTGCCACCACC TCAGTATTTCTCTCCAGCCGTGATCTTGCCGAGCCTCGCTGCCCCACTCCCCCCTGCGTCCCCAGCCTTGCCTCTGCAGGCTGTGAAGCT GCCCCACCCCCCTGGGGCGCCCCTGGCCATGCCCTGCCGGACCATTGTGCCAAATGCACCGGCCACTATCCCCCTGCTGGCCGTAGCCCC ACCGGGCGTGGCTGCCCTGTCCATTCATTCTGCCGTGGCCCAGCTCCCAGGCCAACCTGTGTACCCAGCGGCCTTCCCACAGATGGCGCC TACTGACGTCCCTCCTTCCCCCCATCACACGGTGCAGAATATGAGGGCCACCCCTCCACAGCCGGCACTGCCTCCACAACCCACACTGCC CCCACAACCCGTGCTGCCCCCGCAACCCACGCTGCCCCCTCAACCTGTGTTGCCCCCGCAACCCACACGGCCCCCTCAACCTGTGCTGCC CCCGCAACCCATGCTGCCCCCACAACCTGTGCTGCCCCCGCAGCCGGCACTGCCTGTGCGCCCTGAGCCCCTCCAGCCCCACCTTCCTGA ACAAGCTGCTCCAGCTGCTACACCAGGGAGCCAGATTCTGCTTGGCCACCCAGCTCCCTATGCTGTGGACGTCGCCGCTCAGGTCCCCAC CGTGCCTGTGCCACCGGCTGCGGTCCTCTCGCCGCCTCTGCCGGAAGTGCTGCTGCCTGCCGCCCCTGAGCTCCTGCCTCAGTTCCCCAG CTCCCTGGCCACGGTGTCTGCCTCTGTGCAGAGTGTGCCCACCCAGACTGCCACACTTCTGCCACCAGCAAACCCACCGCTGCCTGGCGG GCCCGGGATCGCCAGCCCTTGCCCAACTGTCCAGCTGACGGTGGAACCAGTCCAAGAGGAGCAGGCCTCACAGGACAAGCCGCCCGGCCT CCCGCAGAGCTGTGAGAGCTATGGAGGTTCTGATGTCACTTCTGGAAAAGAGCTGAGTGACAGCTGTGAAGGCGCCTTTGGAGGGGGCAG GCTGGAGGGCAGGGCAGCCCGAAAACACCACCGCAGGTCCACGCGTGCGCGCTCCCGGCAGGAGAGGGCCAGCCGGCCCCGGCTTACCAT CTTGAACGTGTGCAACACTGGGGACAAGATGGTGGAGTGCCAGCTGGAGACGCACAACCACAAGATGGTGACCTTCAAGTTCGACTTGGA CGGGGACGCACCCGATGAAATTGCCACGTATATGGTGGAGCATGACTTTATCCTGCAGGCCGAGCGGGAAACGTTCATCGAGCAGATGAA GGATGTCATGGACAAGGCAGAGGACATGCTCAGCGAGGACACAGACGCCGACCGTGGCTCCGACCCAGGGACCAGCCCGCCACACCTCAG CACCTGCGGCCTGGGCACCGGGGAGGAGAGCCGACAATCCCAAGCCAACGCCCCCGTGTATCAGCAGAACGTCCTGCACACCGGGAAGAG GTGGTTCATCATCTGTCCGGTGGCTGAGCACCCCGCCCCCGAGGCCCCTGAATCTTCGCCCCCACTTCCTCTAAGCTCCCTGCCGCCAGA AGCCAGCCAAGATTCAGCGCCCTATAAAGACCAGCTGTCCTCGAAGGAACAACCCAGCTTTCTAGCCAGTCAGCAGCTCCTGAGCCAGGC GGGCCCCAGCAACCCTCCTGGGGCACCCCCAGCCCCTTTGGCCCCCTCCTCCCCTCCTGTGACTGCTCTGCCCCAAGATGGAGCAGCTCC AGCCACCAGCACCATGCCAGAGCCAGCGTCAGGAACTGCCAGCCAGGCAGGGGGTCCAGGGACACCTCAGGGGCTGACCAGTGAGCTCGA GACGTCTCAGCCACTAGCGGAGACTCACGAGGCCCCGCTTGCTGTGCAGCCCCTCGTGGTGGGCCTAGCACCTTGCACTCCAGCTCCAGA GGCTGCCTCAACCAGGGACGCCAGTGCCCCAAGGGAGCCCCTGCCACCTCCTGCACCTGAGCCCAGCCCCCACAGCGGGACCCCACAGCC CGCCTTGGGTCAACCTGCTCCCCTGCTTCCTGCCGCAGTGGGGGCCGTCAGCCTGGCCACCTCCCAGCTCCCAAGCCCACCCCTGGGGCC CACCGTCCCCCCACAGCCACCCTCGGCCCTGGAGTCGGATGGGGAAGGGCCGCCCCCCAGGGTGGGCTTTGTGGACAGCACCATCAAGAG CCTGGACGAGAAGCTGCGGACTCTGCTCTACCAGGAGCACGTGCCCACCTCCTCAGCCTCAGCTGGGACCCCTGTGGAGGTGGGCGACAG AGACTTCACCCTGGAGCCCCTGAGAGGGGACCAGCCCCGCTCAGAGGTCTGCGGGGGGGACCTGGCCCTGCCCCCAGTGCCTAAGGAGGC GGTCTCAGGGCGTGTCCAGCTGCCCCAGCCCTTGGTGGAGAAGTCAGAACTGGCCCCCACTCGAGGGGCCGTGATGGAGCAGGGCACGTC CTCGTCAATGACAGCAGAGTCGTCTCCCAGGAGTATGCTAGGCTATGACAGAGATGGAAGGCAGGTGGCCTCAGACTCCCATGTGGTCCC CAGCGTCCCCCAGGATGTACCTGCTTTTGTGAGACCTGCACGTGTGGAGCCCACAGACAGGGATGGTGGAGAAGCTGGAGAAAGCTCGGC AGAGCCCCCGCCGAGTGACATGGGCACAGTGGGGGGCCAGGCTAGCCACCCCCAGACACTCGGCGCTCGAGCTTTGGGGTCCCCTCGGAA ACGTCCAGAGCAGCAGGATGTCAGCTCACCAGCCAAGACTGTGGGCCGTTTCTCGGTGGTCAGCACTCAGGACGAGTGGACCCTGGCCTC CCCCCACAGCCTGAGATACTCTGCCCCACCCGACGTCTACCTGGACGAGGCCCCCTCCAGCCCCGACGTGAAGCTGGCAGTGCGGCGGGC GCAGACGGCCTCCTCCATCGAGGTCGGCGTGGGCGAGCCCGTGTCCAGCGACTCTGGGGACGAGGGCCCTCGGGCGAGACCCCCGGTGCA GAAGCAGGCGTCCCTGCCCGTGAGTGGCAGCGTGGCTGGCGACTTCGTGAAGAAGGCCACCGCCTTCCTGCAGAGGCCTTCTCGGGCCGG CTCGCTGGGCCCCGAGACACCCAGCAGGGTGGGCATGAAGGTCCCCACGATCAGCGTGACCTCCTTCCATTCCCAGTCGTCCTACATCAG CAGCGACAATGATTCGGAGCTCGAGGATGCTGACATAAAGAAGGAGCTGCAGAGTCTGCGGGAGAAGCACCTGAAGGAGATCTCGGAGCT GCAGAGCCAGCAGAAGCAGGAGATCGAAGCTCTGTACCGCCGCCTGGGCAAGCCACTGCCCCCCAACGTGGGCTTCTTCCACACGGCACC CCCCACTGGCCGCCGGAGAAAAACCAGCAAGAGCAAGCTGAAGGCAGGCAAGCTGCTAAATCCCCTGGTGCGGCAGCTCAAGGTCGTGGC CTCCAGCACAGGTCACTTGGCTGACTCCAGCAGAGGCCCTCCCGCTAAGGACCCTGCCCAAGCCAGTGTGGGGCTCACTGCAGACAGCAC GGGCCTGAGCGGGAAGGCAGTGCAGACCCAGCAGCCCTGCTCCGTCCGGGCCTCCCTGTCTTCGGACATCTGCTCCGGCTTAGCCAGTGA TGGAGGCGGAGCGCGTGGCCAAGGCTGGACGGTTTACCACCCAACGTCTGAGAGAGTGACCTATAAGTCTAGTAGCAAACCTCGTGCTCG ATTCCTCAGTGGACCCGTATCTGTGTCCATCTGGTCTGCCCTGAAGCGTCTCTGCCTAGGCAAAGAACACAGCAGTAGGTCCTCCACCAG CAGCCTGGCCCCAGGCCCTGAGCCAGGCCCCCAGCCCGCCCTGCACGTCCAGGCGCAGGTGAACAACAGCAACAACAAGAAGGGTACCTT CACGGACGACCTGCACAAGCTGGTGGACGAGTGGACGAGCAAGACGGTGGGGGCCGCGCAGCTGAAGCCCACGCTCAACCAGCTGAAGCA GACCCAGAAGCTGCAAGACATGGAGGCCCAGGCAGGCTGGGCTGCCCCTGGCGAGGCGCGGGCTATGACCGCACCTCGAGCAGGAGTGGG GATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGGTTC >In-frame_NANS_ENST00000210444_chr9_100823279_+_WNK2_ENST00000297954_chr9_96019230_+_5366nt AGAGTAGAGGCGGCGGCGGCGGCGGCCGGACCCAGACTGGTAGTGAGGCTTTGGACCCCGAGCCGCTGCAATGCCGCTGGAGCTGGAGCT GTGTCCCGGGCGCTGGGTGGGCGGGCAACACCCGTGCTTCATCATTGCCGAGATCGGCCAGAACCACCAGGGCGACCTGGACGTAGCCAA GCGCATGATCCGCATGGCCAAGGAGTGTGGGGCTGATTGTGCTAAGTTCCAGAAGAGTGAGCTAGAATTCAAGTTTAATCGGAAAGCCTT GGAGAGGCCATACACCTCGAAGCATTCCTGGGGGAAGACGTACGGGGAGCACAAACGACATCTGGAGTTCAGCCATGACCAGTACAGGGA GCTGCAGAGGTACGCCGAGGAGGTTGGGATCTTCTTCACTGCCTCTGGCATGGATGAGCCTCCTCCGCTGGCCCAGCCGACACCCCTGCC GCAGGTCCTGGCCCCACAGCCCGTGGTCCCCCTCCAGCCGGTTCCCCCCCACCTGCCACCGTACCTGGCTCCAGCCTCCCAGGTGGGGGC CCCCGCTCAGCTGAAGCCCCTCCAGATGCCACAGGCGCCCCTGCAGCCGCTTGCTCAAGTCCCTCCGCAGATGCCCCCGATTCCTGTTGT GCCCCCCATCACGCCCCTGGCGGGAATCGACGGCCTCCCTCCGGCCCTCCCAGACCTGCCGACCGCGACTGTGCCTCCCGTGCCACCACC TCAGTATTTCTCTCCAGCCGTGATCTTGCCGAGCCTCGCTGCCCCACTCCCCCCTGCGTCCCCAGCCTTGCCTCTGCAGGCTGTGAAGCT GCCCCACCCCCCTGGGGCGCCCCTGGCCATGCCCTGCCGGACCATTGTGCCAAATGCACCGGCCACTATCCCCCTGCTGGCCGTAGCCCC ACCGGGCGTGGCTGCCCTGTCCATTCATTCTGCCGTGGCCCAGCTCCCAGGCCAACCTGTGTACCCAGCGGCCTTCCCACAGATGGCGCC TACTGACGTCCCTCCTTCCCCCCATCACACGGTGCAGAATATGAGGGCCACCCCTCCACAGCCGGCACTGCCTCCACAACCCACACTGCC CCCACAACCCGTGCTGCCCCCGCAACCCACGCTGCCCCCTCAACCTGTGTTGCCCCCGCAACCCACACGGCCCCCTCAACCTGTGCTGCC CCCGCAACCCATGCTGCCCCCACAACCTGTGCTGCCCCCGCAGCCGGCACTGCCTGTGCGCCCTGAGCCCCTCCAGCCCCACCTTCCTGA ACAAGCTGCTCCAGCTGCTACACCAGGGAGCCAGATTCTGCTTGGCCACCCAGCTCCCTATGCTGTGGACGTCGCCGCTCAGGTCCCCAC CGTGCCTGTGCCACCGGCTGCGGTCCTCTCGCCGCCTCTGCCGGAAGTGCTGCTGCCTGCCGCCCCTGAGCTCCTGCCTCAGTTCCCCAG CTCCCTGGCCACGGTGTCTGCCTCTGTGCAGAGTGTGCCCACCCAGACTGCCACACTTCTGCCACCAGCAAACCCACCGCTGCCTGGCGG GCCCGGGATCGCCAGCCCTTGCCCAACTGTCCAGCTGACGGTGGAACCAGTCCAAGAGGAGCAGGCCTCACAGGACAAGCCGCCCGGCCT CCCGCAGAGCTGTGAGAGCTATGGAGGTTCTGATGTCACTTCTGGAAAAGAGCTGAGTGACAGCTGTGAAGGCGCCTTTGGAGGGGGCAG GCTGGAGGGCAGGGCAGCCCGAAAACACCACCGCAGGTCCACGCGTGCGCGCTCCCGGCAGGAGAGGGCCAGCCGGCCCCGGCTTACCAT CTTGAACGTGTGCAACACTGGGGACAAGATGGTGGAGTGCCAGCTGGAGACGCACAACCACAAGATGGTGACCTTCAAGTTCGACTTGGA CGGGGACGCACCCGATGAAATTGCCACGTATATGGTGGAGCATGACTTTATCCTGCAGGCCGAGCGGGAAACGTTCATCGAGCAGATGAA GGATGTCATGGACAAGGCAGAGGACATGCTCAGCGAGGACACAGACGCCGACCGTGGCTCCGACCCAGGGACCAGCCCGCCACACCTCAG CACCTGCGGCCTGGGCACCGGGGAGGAGAGCCGACAATCCCAAGCCAACGCCCCCGTGTATCAGCAGAACGTCCTGCACACCGGGAAGAG GTGGTTCATCATCTGTCCGGTGGCTGAGCACCCCGCCCCCGAGGCCCCTGAATCTTCGCCCCCACTTCCTCTAAGCTCCCTGCCGCCAGA AGCCAGCCAAGGTCCATGCAGGGGGCTCACCCTGCCCTGTCTCCCATGGCGCAGAGCAGCCTGTGGGGCTGTGTTCCTATCCTTGTTTTC TGCTGAATCAGCTCAGTCAAAGCAGCCTCCAGATTCAGCGCCCTATAAAGACCAGCTGTCCTCGAAGGAACAACCCAGCTTTCTAGCCAG TCAGCAGCTCCTGAGCCAGGCGGGCCCCAGCAACCCTCCTGGGGCACCCCCAGCCCCTTTGGCCCCCTCCTCCCCTCCTGTGACTGCTCT GCCCCAAGATGGAGCAGCTCCAGCCACCAGCACCATGCCAGAGCCAGCGTCAGGAACTGCCAGCCAGGCAGGGGGTCCAGGGACACCTCA GGGGCTGACCAGTGAGCTCGAGACGTCTCAGCCACTAGCGGAGACTCACGAGGCCCCGCTTGCTGTGCAGCCCCTCGTGGTGGGCCTAGC ACCTTGCACTCCAGCTCCAGAGGCTGCCTCAACCAGGGACGCCAGTGCCCCAAGGGAGCCCCTGCCACCTCCTGCACCTGAGCCCAGCCC CCACAGCGGGACCCCACAGCCCGCCTTGGGTCAACCTGCTCCCCTGCTTCCTGCCGCAGTGGGGGCCGTCAGCCTGGCCACCTCCCAGCT CCCAAGCCCACCCCTGGGGCCCACCGTCCCCCCACAGCCACCCTCGGCCCTGGAGTCGGATGGGGAAGGGCCGCCCCCCAGGGTGGGCTT TGTGGACAGCACCATCAAGAGCCTGGACGAGAAGCTGCGGACTCTGCTCTACCAGGAGCACGTGCCCACCTCCTCAGCCTCAGCTGGGAC CCCTGTGGAGGTGGGCGACAGAGACTTCACCCTGGAGCCCCTGAGAGGGGACCAGCCCCGCTCAGAGGTCTGCGGGGGGGACCTGGCCCT GCCCCCAGTGCCTAAGGAGGCGGTCTCAGGGCGTGTCCAGCTGCCCCAGCCCTTGGTGGAGAAGTCAGAACTGGCCCCCACTCGAGGGGC CGTGATGGAGCAGGGCACGTCCTCGTCAATGACAGCAGAGTCGTCTCCCAGGAGTATGCTAGGCTATGACAGAGATGGAAGGCAGGTGGC CTCAGACTCCCATGTGGTCCCCAGCGTCCCCCAGGATGTACCTGCTTTTGTGAGACCTGCACGTGTGGAGCCCACAGACAGGGATGGTGG AGAAGCTGGAGAAAGCTCGGCAGAGCCCCCGCCGAGTGACATGGGCACAGTGGGGGGCCAGGCTAGCCACCCCCAGACACTCGGCGCTCG AGCTTTGGGGTCCCCTCGGAAACGTCCAGAGCAGCAGGATGTCAGCTCACCAGCCAAGACTGTGGGCCGTTTCTCGGTGGTCAGCACTCA GGACGAGTGGACCCTGGCCTCCCCCCACAGCCTGAGATACTCTGCCCCACCCGACGTCTACCTGGACGAGGCCCCCTCCAGCCCCGACGT GAAGCTGGCAGTGCGGCGGGCGCAGACGGCCTCCTCCATCGAGGTCGGCGTGGGCGAGCCCGTGTCCAGCGACTCTGGGGACGAGGGCCC TCGGGCGAGACCCCCGGTGCAGAAGCAGGCGTCCCTGCCCGTGAGTGGCAGCGTGGCTGGCGACTTCGTGAAGAAGGCCACCGCCTTCCT GCAGAGGCCTTCTCGGGCCGGCTCGCTGGGCCCCGAGACACCCAGCAGGGTGGGCATGAAGGTCCCCACGATCAGCGTGACCTCCTTCCA TTCCCAGTCGTCCTACATCAGCAGCGACAATGATTCGGAGCTCGAGGATGCTGACATAAAGAAGGAGCTGCAGAGTCTGCGGGAGAAGCA CCTGAAGGAGATCTCGGAGCTGCAGAGCCAGCAGAAGCAGGAGATCGAAGCTCTGTACCGCCGCCTGGGCAAGCCACTGCCCCCCAACGT GGGCTTCTTCCACACGGCACCCCCCACTGGCCGCCGGAGAAAAACCAGCAAGAGCAAGCTGAAGGCAGGCAAGCTGCTAAATCCCCTGGT GCGGCAGCTCAAGGTCGTGGCCTCCAGCACAGGTCACTTGGCTGACTCCAGCAGAGGCCCTCCCGCTAAGGACCCTGCCCAAGCCAGTGT GGGGCTCACTGCAGACAGCACGGGCCTGAGCGGGAAGGCAGTGCAGACCCAGCAGCCCTGCTCCGTCCGGGCCTCCCTGTCTTCGGACAT CTGCTCCGGCTTAGCCAGTGATGGAGGCGGAGCGCGTGGCCAAGGCTGGACGGTTTACCACCCAACGTCTGAGAGAGTGACCTATAAGTC TAGTAGCAAACCTCGTGCTCGATTCCTCAGTGGACCCGTATCTGTGTCCATCTGGTCTGCCCTGAAGCGTCTCTGCCTAGGCAAAGAACA CAGCAGTAGGTCCTCCACCAGCAGCCTGGCCCCAGGCCCTGAGCCAGGCCCCCAGCCCGCCCTGCACGTCCAGGCGCAGGTGAACAACAG CAACAACAAGAAGGGTACCTTCACGGACGACCTGCACAAGCTGGTGGACGAGTGGACGAGCAAGACGGTGGGGGCCGCGCAGCTGAAGCC CACGCTCAACCAGCTGAAGCAGACCCAGAAGCTGCAAGACATGGAGGCCCAGGCAGGCTGGGCTGCCCCTGGCGAGGCGCGGGCTATGAC CGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACGGTCATTCCCGGAGCCGCCCCGACCCT GTCCGTGCCCACACCAGATGGCGCCCTCGGAACCGCCCGGAGAAACCAGGTGTGGTTTGGCCTCCGAGTCCCCCCCACCGCCTGCTGTGG GCACAGCACTCAGCCGCGAGGGGGACAGCGGGTGGGCAGCAAGACTGCTTCCTTTGCGGCTTCAGACCCTGTTCGCTCCTAGGTTCCTGT GGTCCACGCGCCGTCTCCACACCCACTTCCTATACTTGAGTTGATGGTTAGAACCTTGTCGTCACCCTGCAGAAGTACAGTGCCTTGAAT GCCAGCTTTTCCGTTCCCTGATGAAAAGATATGTTAAAAAAAATTATCGGAAAAGGTTTCATTTGCAATTGGCTTGTGCATTGATAATCT >In-frame_NANS_ENST00000210444_chr9_100823279_+_WNK2_ENST00000395475_chr9_96019230_+_5062nt AGAGTAGAGGCGGCGGCGGCGGCGGCCGGACCCAGACTGGTAGTGAGGCTTTGGACCCCGAGCCGCTGCAATGCCGCTGGAGCTGGAGCT GTGTCCCGGGCGCTGGGTGGGCGGGCAACACCCGTGCTTCATCATTGCCGAGATCGGCCAGAACCACCAGGGCGACCTGGACGTAGCCAA GCGCATGATCCGCATGGCCAAGGAGTGTGGGGCTGATTGTGCTAAGTTCCAGAAGAGTGAGCTAGAATTCAAGTTTAATCGGAAAGCCTT GGAGAGGCCATACACCTCGAAGCATTCCTGGGGGAAGACGTACGGGGAGCACAAACGACATCTGGAGTTCAGCCATGACCAGTACAGGGA GCTGCAGAGGTACGCCGAGGAGGTTGGGATCTTCTTCACTGCCTCTGGCATGGATGAGCCTCCTCCGCTGGCCCAGCCGACACCCCTGCC GCAGGTCCTGGCCCCACAGCCCGTGGTCCCCCTCCAGCCGGTTCCCCCCCACCTGCCACCGTACCTGGCTCCAGCCTCCCAGGTGGGGGC CCCCGCTCAGCTGAAGCCCCTCCAGATGCCACAGGCGCCCCTGCAGCCGCTTGCTCAAGTCCCTCCGCAGATGCCCCCGATTCCTGTTGT GCCCCCCATCACGCCCCTGGCGGGAATCGACGGCCTCCCTCCGGCCCTCCCAGACCTGCCGACCGCGACTGTGCCTCCCGTGCCACCACC TCAGTATTTCTCTCCAGCCGTGATCTTGCCGAGCCTCGCTGCCCCACTCCCCCCTGCGTCCCCAGCCTTGCCTCTGCAGGCTGTGAAGCT GCCCCACCCCCCTGGGGCGCCCCTGGCCATGCCCTGCCGGACCATTGTGCCAAATGCACCGGCCACTATCCCCCTGCTGGCCGTAGCCCC ACCGGGCGTGGCTGCCCTGTCCATTCATTCTGCCGTGGCCCAGCTCCCAGGCCAACCTGTGTACCCAGCGGCCTTCCCACAGATGGCGCC TACTGACGTCCCTCCTTCCCCCCATCACACGGTGCAGAATATGAGGGCCACCCCTCCACAGCCGGCACTGCCTCCACAACCCACACTGCC CCCACAACCCGTGCTGCCCCCGCAACCCACGCTGCCCCCTCAACCTGTGTTGCCCCCGCAACCCACACGGCCCCCTCAACCTGTGCTGCC CCCGCAACCCATGCTGCCCCCACAACCTGTGCTGCCCCCGCAGCCGGCACTGCCTGTGCGCCCTGAGCCCCTCCAGCCCCACCTTCCTGA ACAAGCTGCTCCAGCTGCTACACCAGGGAGCCAGATTCTGCTTGGCCACCCAGCTCCCTATGCTGTGGACGTCGCCGCTCAGGTCCCCAC CGTGCCTGTGCCACCGGCTGCGGTCCTCTCGCCGCCTCTGCCGGAAGTGCTGCTGCCTGCCGCCCCTGAGCTCCTGCCTCAGTTCCCCAG CTCCCTGGCCACGGTGTCTGCCTCTGTGCAGAGTGTGCCCACCCAGACTGCCACACTTCTGCCACCAGCAAACCCACCGCTGCCTGGCGG GCCCGGGATCGCCAGCCCTTGCCCAACTGTCCAGCTGACGGTGGAACCAGTCCAAGAGGAGCAGGCCTCACAGGACAAGCCGCCCGGCCT CCCGCAGAGCTGTGAGAGCTATGGAGGTTCTGATGTCACTTCTGGAAAAGAGCTGAGTGACAGCTGTGAAGGCGCCTTTGGAGGGGGCAG GCTGGAGGGCAGGGCAGCCCGAAAACACCACCGCAGGTCCACGCGTGCGCGCTCCCGGCAGGAGAGGGCCAGCCGGCCCCGGCTTACCAT CTTGAACGTGTGCAACACTGGGGACAAGATGGTGGAGTGCCAGCTGGAGACGCACAACCACAAGATGGTGACCTTCAAGTTCGACTTGGA CGGGGACGCACCCGATGAAATTGCCACGTATATGGTGGAGCATGACTTTATCCTGCAGGCCGAGCGGGAAACGTTCATCGAGCAGATGAA GGATGTCATGGACAAGGCAGAGGACATGCTCAGCGAGGACACAGACGCCGACCGTGGCTCCGACCCAGGGACCAGCCCGCCACACCTCAG CACCTGCGGCCTGGGCACCGGGGAGGAGAGCCGACAATCCCAAGCCAACGCCCCCGTGTATCAGCAGAACGTCCTGCACACCGGGAAGAG GTGGTTCATCATCTGTCCGGTGGCTGAGCACCCCGCCCCCGAGGCCCCTGAATCTTCGCCCCCACTTCCTCTAAGCTCCCTGCCGCCAGA AGCCAGCCAAGATTCAGCGCCCTATAAAGACCAGCTGTCCTCGAAGGAACAACCCAGCTTTCTAGCCAGTCAGCAGCTCCTGAGCCAGGC GGGCCCCAGCAACCCTCCTGGGGCACCCCCAGCCCCTTTGGCCCCCTCCTCCCCTCCTGTGACTGCTCTGCCCCAAGATGGAGCAGCTCC AGCCACCAGCACCATGCCAGAGCCAGCGTCAGGAACTGCCAGCCAGGCAGGGGGTCCAGGGACACCTCAGGGGCTGACCAGTGAGCTCGA GACGTCTCAGCCACTAGCGGAGACTCACGAGGCCCCGCTTGCTGTGCAGCCCCTCGTGGTGGGCCTAGCACCTTGCACTCCAGCTCCAGA GGCTGCCTCAACCAGGGACGCCAGTGCCCCAAGGGAGCCCCTGCCACCTCCTGCACCTGAGCCCAGCCCCCACAGCGGGACCCCACAGCC CGCCTTGGGTCAACCTGCTCCCCTGCTTCCTGCCGCAGTGGGGGCCGTCAGCCTGGCCACCTCCCAGCTCCCAAGCCCACCCCTGGGGCC CACCGTCCCCCCACAGCCACCCTCGGCCCTGGAGTCGGATGGGGAAGGGCCGCCCCCCAGGGTGGGCTTTGTGGACAGCACCATCAAGAG CCTGGACGAGAAGCTGCGGACTCTGCTCTACCAGGAGCACGTGCCCACCTCCTCAGCCTCAGCTGGGACCCCTGTGGAGGTGGGCGACAG AGACTTCACCCTGGAGCCCCTGAGAGGGGACCAGCCCCGCTCAGAGGTCTGCGGGGGGGACCTGGCCCTGCCCCCAGTGCCTAAGGAGGC GGTCTCAGGGCGTGTCCAGCTGCCCCAGCCCTTGGTGGAGAAGTCAGAACTGGCCCCCACTCGAGGGGCCGTGATGGAGCAGGGCACGTC CTCGTCAATGACAGCAGAGTCGTCTCCCAGGAGTATGCTAGGCTATGACAGAGATGGAAGGCAGGTGGCCTCAGACTCCCATGTGGTCCC CAGCGTCCCCCAGGATGTACCTGCTTTTGTGAGACCTGCACGTGTGGAGCCCACAGACAGGGATGGTGGAGAAGCTGGAGAAAGCTCGGC AGAGCCCCCGCCGAGTGACATGGGCACAGTGGGGGGCCAGGCTAGCCACCCCCAGACACTCGGCGCTCGAGCTTTGGGGTCCCCTCGGAA ACGTCCAGAGCAGCAGGATGTCAGCTCACCAGCCAAGACTGTGGGCCGTTTCTCGGTGGTCAGCACTCAGGACGAGTGGACCCTGGCCTC CCCCCACAGCCTGAGATACTCTGCCCCACCCGACGTCTACCTGGACGAGGCCCCCTCCAGCCCCGACGTGAAGCTGGCAGTGCGGCGGGC GCAGACGGCCTCCTCCATCGAGGTCGGCGTGGGCGAGCCCGTGTCCAGCGACTCTGGGGACGAGGGCCCTCGGGCGAGACCCCCGGTGCA GAAGCAGGCGTCCCTGCCCGTGAGTGGCAGCGTGGCTGGCGACTTCGTGAAGAAGGCCACCGCCTTCCTGCAGAGGCCTTCTCGGGCCGG CTCGCTGGGCCCCGAGACACCCAGCAGGGTGGGCATGAAGGTCCCCACGATCAGCGTGACCTCCTTCCATTCCCAGTCGTCCTACATCAG CAGCGACAATGATTCGGAGCTCGAGGATGCTGACATAAAGAAGGAGCTGCAGAGTCTGCGGGAGAAGCACCTGAAGGAGATCTCGGAGCT GCAGAGCCAGCAGAAGCAGGAGATCGAAGCTCTGTACCGCCGCCTGGGCAAGCCACTGCCCCCCAACGTGGGCTTCTTCCACACGGCACC CCCCACTGGCCGCCGGAGAAAAACCAGCAAGAGCAAGCTGAAGGCAGGCAAGCTGCTAAATCCCCTGGTGCGGCAGCTCAAGGTCGTGGC CTCCAGCACAGGTCACTTGGCTGACTCCAGCAGAGGCCCTCCCGCTAAGGACCCTGCCCAAGCCAGTGTGGGGCTCACTGCAGACAGCAC GGGCCTGAGCGGGAAGGCAGTGCAGACCCAGCAGCCCTGCTCCGTCCGGGCCTCCCTGTCTTCGGACATCTGCTCCGGCTTAGCCAGTGA TGGAGGCGGAGCGCGTGGCCAAGGCTGGACGGTTTACCACCCAACGTCTGAGAGAGTGACCTATAAGTCTAGTAGCAAACCTCGTGCTCG ATTCCTCAGTGGACCCGTATCTGTGTCCATCTGGTCTGCCCTGAAGCGTCTCTGCCTAGGCAAAGAACACAGCAGTAGGTCCTCCACCAG CAGCCTGGCCCCAGGCCCTGAGCCAGGCCCCCAGCCCGCCCTGCACGTCCAGGCGCAGGTGAACAACAGCAACAACAAGAAGGGTACCTT CACGGACGACCTGCACAAGCTGGTGGACGAGTGGACGAGCAAGACGGTGGGGGCCGCGCAGCTGAAGCCCACGCTCAACCAGCTGAAGCA GACCCAGAAGCTGCAAGACATGGAGGCCCAGGCAGGCTGGGCTGCCCCTGGCGAGGCGCGGGCTATGACCGCACCTCGAGCAGGAGTGGG GATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGATCC TGAGAGTGAGAAGCCTGACTGACCCCGCCTAGACGCCAGGCCCACTTCACGCCGTCTAAGTGGAGAAGTGACGGACCCTCAGGGCCAGCT GCTCCTCCTGTCCAGTTCACGCTGTTTTGTAACCACTTTCTAAGCATTTTTTATTCACAATTGGAAACACAAATGTAATGCAAGAATAAA |
Top |
FusionGenePPI for NANS_WNK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NANS | DDA1, PCMT1, CRK, RAD23B, HSP90AA1, HSP90AB1, BAG3, EIF4E, GBP2, ASS1, ATG3, CKB, CNDP2, DAK, MVD, NPEPPS, PDIA3, POLE3, RPLP2, SLC9A3R1, SMEK2, SHMT2, NXF1, AKR1A1, FAHD1, GOT1, MPI, CARKD, DAZAP1, FH, GLOD4, PIR, PKM, TKT, PRDX1, PRDX2, NTRK1, PA2G4, ANXA5, GPI, UBE2N, PPA1, HPRT1, PLS3, TRAP1, SND1 | WNK2 | YWHAZ, WNK1, SGK1, ATXN1, KLHL3, KLHL2, DGCR14, TSC22D4, PSMC3, SPATA1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for NANS_WNK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for NANS_WNK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NANS | C0005941 | Bone Diseases, Developmental | 1 | CTD_human |
| Hgene | NANS | C0008073 | Developmental Disabilities | 1 | CTD_human |
| Hgene | NANS | C1864872 | Spondyloepimetaphyseal dysplasia, Genevieve type | 1 | ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|