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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23376

FusionGeneSummary for NAIP_NFIL3

check button Fusion gene summary
Fusion gene informationFusion gene name: NAIP_NFIL3
Fusion gene ID: 23376
HgeneTgene
Gene symbol

NAIP

NFIL3

Gene ID

4671

4783

Gene nameNLR family apoptosis inhibitory proteinnuclear factor, interleukin 3 regulated
SynonymsBIRC1|NLRB1|psiNAIPE4BP4|IL3BP1|NF-IL3A|NFIL3A
Cytomap

5q13.2

9q22.31

Type of geneprotein-codingprotein-coding
Descriptionbaculoviral IAP repeat-containing protein 1neuronal apoptosis inhibitory proteinnucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1psi neuronal apoptosis inhibitory proteinnuclear factor interleukin-3-regulated proteinE4 promoter-binding protein 4interleukin-3 promoter transcriptional activatorinterleukin-3-binding protein 1transcriptional activator NF-IL3A
Modification date2018052220180523
UniProtAcc

Q13075

Q16649

Ensembl transtripts involved in fusion geneENST00000194097, ENST00000517649, 
ENST00000523981, ENST00000508426, 
ENST00000503719, 
ENST00000297689, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 2=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NAIP [Title/Abstract] AND NFIL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAIP

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

11896143


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA676009NAIPchr5

70316486

-NFIL3chr9

94173191

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000194097ENST00000297689NAIPchr5

70316486

-NFIL3chr9

94173191

-
5UTR-5UTRENST00000517649ENST00000297689NAIPchr5

70316486

-NFIL3chr9

94173191

-
5CDS-5UTRENST00000523981ENST00000297689NAIPchr5

70316486

-NFIL3chr9

94173191

-
5UTR-5UTRENST00000508426ENST00000297689NAIPchr5

70316486

-NFIL3chr9

94173191

-
5CDS-5UTRENST00000503719ENST00000297689NAIPchr5

70316486

-NFIL3chr9

94173191

-

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FusionProtFeatures for NAIP_NFIL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAIP

Q13075

NFIL3

Q16649

Anti-apoptotic protein which acts by inhibiting theactivities of CASP3, CASP7 and CASP9. Can inhibit the autocleavageof pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable ofinhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing therate of auto proteolysis at 'Asp-330'. Acts as a mediator ofneuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role inthe prevention of spinal muscular atrophy that seems to be causedby inappropriate persistence of motor-neuron apoptosis: mutated ordeleted forms of NAIP have been found in individuals with severespinal muscular atrophy. Acts as a sensor component of the NLRC4 inflammasomethat specifically recognizes and binds needle protein CprI frompathogenic bacteria C.violaceum. Association of pathogenicbacteria proteins drives in turn drive assembly and activation ofthe NLRC4 inflammasome, promoting caspase-1 activation, cytokineproduction and macrophage pyroptosis. The NLRC4 inflammasome isactivated as part of the innate immune response to a range ofintracellular bacteria such as C.violaceum and L.pneumophila. Acts as a transcriptional regulator that recognizes andbinds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequencepresent in many cellular and viral promoters. Repressestranscription from promoters with activating transcription factor(ATF) sites. Represses promoter activity in osteoblasts (Bysimilarity). Represses transcriptional activity of PER1 (Bysimilarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription fromthe interleukin-3 promoter in T-cells. Competes for the sameconsensus-binding site with PAR DNA-binding factors (DBP, HLF andTEF) (By similarity). Component of the circadian clock that actsas a negative regulator for the circadian expression of PER2oscillation in the cell-autonomous core clock (By similarity).Protects pro-B cells from programmed cell death (By similarity).{ECO:0000250, ECO:0000269|PubMed:1620116,ECO:0000269|PubMed:7565758, ECO:0000269|PubMed:8836190}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAIP_NFIL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAIP_NFIL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NAIPCASP9, DIABLO, NLRC4, HPCA, XAF1, COMMD1, MAP3K7, HECW2, TAB1NFIL3DR1, CBX8, MAFG, MAFF, BATF, NFIL3, DDIT3, TRAF2, AMOTL2, DEC1, CREB1, DNMT3L, RFWD2, STK40, ATF1, MCM9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAIP_NFIL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAIP_NFIL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNFIL3C0877792Sleep Disorders, Circadian Rhythm1CTD_human