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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23334

FusionGeneSummary for NACA_CSN2

check button Fusion gene summary
Fusion gene informationFusion gene name: NACA_CSN2
Fusion gene ID: 23334
HgeneTgene
Gene symbol

NACA

CSN2

Gene ID

4666

9318

Gene namenascent polypeptide associated complex subunit alphaCOP9 signalosome subunit 2
SynonymsHSD48|NAC-alpha|NACA1|skNACALIEN|CSN2|SGN2|TRIP15
Cytomap

12q13.3

15q21.1

Type of geneprotein-codingprotein-coding
Descriptionnascent polypeptide-associated complex subunit alphaalpha-NAC, muscle-specific formnascent polypeptide-associated complex alpha subunitnascent-polypeptide-associated complex alpha polypeptideCOP9 signalosome complex subunit 2COP9 constitutive photomorphogenic homolog subunit 2JAB1-containing signalosome subunit 2TR-interacting protein 15TRIP-15alien homologsignalosome subunit 2thyroid receptor-interacting protein 15
Modification date2018051920180523
UniProtAcc

Q13765

P05814

Ensembl transtripts involved in fusion geneENST00000454682, ENST00000550952, 
ENST00000356769, ENST00000552540, 
ENST00000393891, ENST00000548563, 
ENST00000546392, ENST00000551793, 
ENST00000353151, 
Fusion gene scores* DoF score5 X 5 X 3=7514 X 11 X 2=308
# samples 53
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/308*10)=-3.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NACA [Title/Abstract] AND CSN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCSN2

GO:0000338

protein deneddylation

19141280


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AO-A1KO-01ANACAchr12

57106670

-CSN2chr4

70823069

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000454682ENST00000353151NACAchr12

57106670

-CSN2chr4

70823069

-
intron-3CDSENST00000550952ENST00000353151NACAchr12

57106670

-CSN2chr4

70823069

-
intron-3CDSENST00000356769ENST00000353151NACAchr12

57106670

-CSN2chr4

70823069

-
intron-3CDSENST00000552540ENST00000353151NACAchr12

57106670

-CSN2chr4

70823069

-
intron-3CDSENST00000393891ENST00000353151NACAchr12

57106670

-CSN2chr4

70823069

-
intron-3CDSENST00000548563ENST00000353151NACAchr12

57106670

-CSN2chr4

70823069

-
intron-3CDSENST00000546392ENST00000353151NACAchr12

57106670

-CSN2chr4

70823069

-
intron-3CDSENST00000551793ENST00000353151NACAchr12

57106670

-CSN2chr4

70823069

-

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FusionProtFeatures for NACA_CSN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NACA

Q13765

CSN2

P05814

Prevents inappropriate targeting of non-secretorypolypeptides to the endoplasmic reticulum (ER). Binds to nascentpolypeptide chains as they emerge from the ribosome and blockstheir interaction with the signal recognition particle (SRP),which normally targets nascent secretory peptides to the ER. Alsoreduces the inherent affinity of ribosomes for proteintranslocation sites in the ER membrane (M sites). May act as aspecific coactivator for JUN, binding to DNA and stabilizing theinteraction of JUN homodimers with target gene promoters.{ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:15784678,ECO:0000269|PubMed:9877153}. Important role in determination of the surfaceproperties of the casein micelles.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NACA_CSN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NACA_CSN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NACAFADD, APLP1, FUNDC2, CCDC90B, IGSF21, ZHX1, LRIF1, FOS, JUN, H2AFX, UBC, UCHL5, TXLNA, RAD21, HDGF, ISG15, SPP1, CUL3, NACA2, PC, FN1, ATF2, MDM2, TARDBP, PARK2, PPP2R1A, BTF3, HUWE1, NUPR1, CCDC8, FBXW11, EEF1G, BTF3L4, DDX5, HSPA8, PRPF8, SUB1, NTRK1, EWSR1, DCTN1, RPL10, MCM2, DPPA4, DLD, DNM1L, HSD17B10, SOD1, BRCA1, FBXL13CSN2CDC42, GRB2, NFYC, RAC1, TOLLIP, PLK1, ARRB1, ARRB2, CUL1, CUL4B, COPS7A, CSNK2A1, CDK1, HTRA2, NEK2, AURKA, CSNK2B, FHL2, NEK9, CORO2A, PPP3CC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NACA_CSN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NACA_CSN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCSN2C0024667Animal Mammary Neoplasms2CTD_human
TgeneCSN2C0024668Mammary Neoplasms, Experimental2CTD_human