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Fusion gene ID: 23333 |
FusionGeneSummary for NACA_ANK2 |
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Fusion gene information | Fusion gene name: NACA_ANK2 | Fusion gene ID: 23333 | Hgene | Tgene | Gene symbol | NACA | ANK2 | Gene ID | 4666 | 287 |
Gene name | nascent polypeptide associated complex subunit alpha | ankyrin 2 | |
Synonyms | HSD48|NAC-alpha|NACA1|skNAC | ANK-2|LQT4|brank-2 | |
Cytomap | 12q13.3 | 4q25-q26 | |
Type of gene | protein-coding | protein-coding | |
Description | nascent polypeptide-associated complex subunit alphaalpha-NAC, muscle-specific formnascent polypeptide-associated complex alpha subunitnascent-polypeptide-associated complex alpha polypeptide | ankyrin-2ankyrin 2, neuronalankyrin Bankyrin, brainankyrin-2, nonerythrocyticnon-erythroid ankyrin | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q13765 | Q01484 | |
Ensembl transtripts involved in fusion gene | ENST00000454682, ENST00000550952, ENST00000356769, ENST00000552540, ENST00000393891, ENST00000548563, ENST00000546392, ENST00000551793, | ENST00000506722, ENST00000394537, ENST00000357077, ENST00000264366, ENST00000509550, ENST00000510275, ENST00000504887, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 6 X 8 X 3=144 |
# samples | 5 | 9 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/144*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NACA [Title/Abstract] AND ANK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | F00928 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000454682 | ENST00000506722 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000454682 | ENST00000394537 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000454682 | ENST00000357077 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000454682 | ENST00000264366 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000454682 | ENST00000509550 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000454682 | ENST00000510275 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000454682 | ENST00000504887 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000550952 | ENST00000506722 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000550952 | ENST00000394537 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000550952 | ENST00000357077 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000550952 | ENST00000264366 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000550952 | ENST00000509550 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000550952 | ENST00000510275 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000550952 | ENST00000504887 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000356769 | ENST00000506722 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000356769 | ENST00000394537 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000356769 | ENST00000357077 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000356769 | ENST00000264366 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000356769 | ENST00000509550 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000356769 | ENST00000510275 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000356769 | ENST00000504887 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000552540 | ENST00000506722 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000552540 | ENST00000394537 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000552540 | ENST00000357077 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000552540 | ENST00000264366 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000552540 | ENST00000509550 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000552540 | ENST00000510275 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000552540 | ENST00000504887 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000393891 | ENST00000506722 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000393891 | ENST00000394537 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000393891 | ENST00000357077 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000393891 | ENST00000264366 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000393891 | ENST00000509550 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000393891 | ENST00000510275 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000393891 | ENST00000504887 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000548563 | ENST00000506722 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000548563 | ENST00000394537 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000548563 | ENST00000357077 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000548563 | ENST00000264366 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000548563 | ENST00000509550 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000548563 | ENST00000510275 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000548563 | ENST00000504887 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000546392 | ENST00000506722 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000546392 | ENST00000394537 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000546392 | ENST00000357077 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000546392 | ENST00000264366 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000546392 | ENST00000509550 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000546392 | ENST00000510275 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000546392 | ENST00000504887 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000551793 | ENST00000506722 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000551793 | ENST00000394537 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000551793 | ENST00000357077 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-3CDS | ENST00000551793 | ENST00000264366 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000551793 | ENST00000509550 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000551793 | ENST00000510275 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
intron-intron | ENST00000551793 | ENST00000504887 | NACA | chr12 | 57111771 | - | ANK2 | chr4 | 114120242 | - |
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FusionProtFeatures for NACA_ANK2 |
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Hgene | Tgene |
NACA | ANK2 |
Prevents inappropriate targeting of non-secretorypolypeptides to the endoplasmic reticulum (ER). Binds to nascentpolypeptide chains as they emerge from the ribosome and blockstheir interaction with the signal recognition particle (SRP),which normally targets nascent secretory peptides to the ER. Alsoreduces the inherent affinity of ribosomes for proteintranslocation sites in the ER membrane (M sites). May act as aspecific coactivator for JUN, binding to DNA and stabilizing theinteraction of JUN homodimers with target gene promoters.{ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:15784678,ECO:0000269|PubMed:9877153}. | In skeletal muscle, required for proper localization ofDMD and DCTN4 and for the formation and/or stability of a specialsubset of microtubules associated with costameres andneuromuscular junctions. Attaches integral membrane proteins tocytoskeletal elements. Also binds to cytoskeletal proteins.Required for coordinate assembly of Na/Ca exchanger, Na/K ATPaseand InsP3 receptor at sarcoplasmic reticulum sites incardiomyocytes. Required for the coordinated expression of theNa/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in theinner segment of rod photoreceptors (By similarity). Required forexpression and targeting of SPTBN1 in neonatal cardiomyocytes andfor the regulation of neonatal cardiomyocyte contraction rate(PubMed:12571597). Plays a role in endocytosis and intracellularprotein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promotelong-range motility of cells. Recruits RABGAP1L to (PI3P)-positiveearly endosomes, where RABGAP1L inactivates RAB22A, and promotespolarized trafficking to the leading edge of the migrating cells.Part of the ANK2/RABGAP1L complex which is required for thepolarized recycling of fibronectin receptor ITGA5 ITGB1 to theplasma membrane that enables continuous directional cell migration(By similarity). {ECO:0000250|UniProtKB:Q8C8R3,ECO:0000269|PubMed:12571597}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NACA_ANK2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NACA_ANK2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NACA_ANK2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NACA_ANK2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ANK2 | C1970119 | CARDIAC ARRHYTHMIA, ANKYRIN-B-RELATED | 1 | CTD_human;UNIPROT |