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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23307

FusionGeneSummary for NAAA_NAAA

check button Fusion gene summary
Fusion gene informationFusion gene name: NAAA_NAAA
Fusion gene ID: 23307
HgeneTgene
Gene symbol

NAAA

NAAA

Gene ID

27163

27163

Gene nameN-acylethanolamine acid amidaseN-acylethanolamine acid amidase
SynonymsASAHL|PLTASAHL|PLT
Cytomap

4q21.1

4q21.1

Type of geneprotein-codingprotein-coding
DescriptionN-acylethanolamine-hydrolyzing acid amidaseASAH-like proteinacid ceramidase-like proteinN-acylethanolamine-hydrolyzing acid amidaseASAH-like proteinacid ceramidase-like protein
Modification date2018052920180529
UniProtAcc

Q02083

Q02083

Ensembl transtripts involved in fusion geneENST00000399497, ENST00000286733, 
ENST00000511606, ENST00000507956, 
ENST00000505594, ENST00000507187, 
ENST00000399497, ENST00000286733, 
ENST00000511606, ENST00000507956, 
ENST00000505594, ENST00000507187, 
Fusion gene scores* DoF score1 X 2 X 1=22 X 3 X 2=12
# samples 23
** MAII scorelog2(2/2*10)=3.32192809488736log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NAAA [Title/Abstract] AND NAAA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK024677NAAAchr4

76838070

-NAAAchr4

76862128

-
ChiTaRS3.1BG164058NAAAchr4

76838875

-NAAAchr4

76857318

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000399497ENST00000399497NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000399497ENST00000286733NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000399497ENST00000511606NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000399497ENST00000507956NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000399497ENST00000505594NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000399497ENST00000507187NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000286733ENST00000399497NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000286733ENST00000286733NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000286733ENST00000511606NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000286733ENST00000507956NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000286733ENST00000505594NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000286733ENST00000507187NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000511606ENST00000399497NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000511606ENST00000286733NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000511606ENST00000511606NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000511606ENST00000507956NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000511606ENST00000505594NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000511606ENST00000507187NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000507956ENST00000399497NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000507956ENST00000286733NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000507956ENST00000511606NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000507956ENST00000507956NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000507956ENST00000505594NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000507956ENST00000507187NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000505594ENST00000399497NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000505594ENST00000286733NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000505594ENST00000511606NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000505594ENST00000507956NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000505594ENST00000505594NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000505594ENST00000507187NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000507187ENST00000399497NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000507187ENST00000286733NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000507187ENST00000511606NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000507187ENST00000507956NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-intronENST00000507187ENST00000505594NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-5UTRENST00000507187ENST00000507187NAAAchr4

76838070

-NAAAchr4

76862128

-
intron-3CDSENST00000399497ENST00000399497NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-3CDSENST00000399497ENST00000286733NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000399497ENST00000511606NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000399497ENST00000507956NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000399497ENST00000505594NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000399497ENST00000507187NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-3CDSENST00000286733ENST00000399497NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-3CDSENST00000286733ENST00000286733NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000286733ENST00000511606NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000286733ENST00000507956NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000286733ENST00000505594NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000286733ENST00000507187NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-3CDSENST00000511606ENST00000399497NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-3CDSENST00000511606ENST00000286733NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000511606ENST00000511606NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000511606ENST00000507956NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000511606ENST00000505594NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000511606ENST00000507187NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-3CDSENST00000507956ENST00000399497NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-3CDSENST00000507956ENST00000286733NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000507956ENST00000511606NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000507956ENST00000507956NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000507956ENST00000505594NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000507956ENST00000507187NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-3CDSENST00000505594ENST00000399497NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-3CDSENST00000505594ENST00000286733NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000505594ENST00000511606NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000505594ENST00000507956NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000505594ENST00000505594NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000505594ENST00000507187NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-3CDSENST00000507187ENST00000399497NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-3CDSENST00000507187ENST00000286733NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000507187ENST00000511606NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000507187ENST00000507956NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000507187ENST00000505594NAAAchr4

76838875

-NAAAchr4

76857318

-
intron-intronENST00000507187ENST00000507187NAAAchr4

76838875

-NAAAchr4

76857318

-

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FusionProtFeatures for NAAA_NAAA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAAA

Q02083

NAAA

Q02083

Degrades bioactive fatty acid amides to theircorresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibitsweak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.{ECO:0000269|PubMed:15655246}. Degrades bioactive fatty acid amides to theircorresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibitsweak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.{ECO:0000269|PubMed:15655246}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAAA_NAAA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAAA_NAAA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAAA_NAAA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAAA_NAAA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource