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Fusion gene ID: 23301 |
FusionGeneSummary for NAA50_STATH |
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Fusion gene information | Fusion gene name: NAA50_STATH | Fusion gene ID: 23301 | Hgene | Tgene | Gene symbol | NAA50 | STATH | Gene ID | 80218 | 6779 |
Gene name | N(alpha)-acetyltransferase 50, NatE catalytic subunit | statherin | |
Synonyms | MAK3|NAT13|NAT13P|NAT5|NAT5P|SAN|hNaa50p | STR | |
Cytomap | 3q13.31 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | N-alpha-acetyltransferase 50N-acetyltransferase 13 (GCN5-related)N-acetyltransferase 5N-acetyltransferase san homologN-epsilon-acetyltransferase 50natE catalytic subunit | statherin | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9GZZ1 | P02808 | |
Ensembl transtripts involved in fusion gene | ENST00000240922, ENST00000477813, ENST00000497525, ENST00000497255, ENST00000493454, ENST00000493900, ENST00000467022, | ENST00000246895, ENST00000381060, | |
Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 2 X 2 X 1=4 |
# samples | 6 | 2 | |
** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: NAA50 [Title/Abstract] AND STATH [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NAA50 | GO:0006474 | N-terminal protein amino acid acetylation | 21900231|22311970|27484799 |
Hgene | NAA50 | GO:0034087 | establishment of mitotic sister chromatid cohesion | 27422821 |
Hgene | NAA50 | GO:0071962 | mitotic sister chromatid cohesion, centromeric | 17502424 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CD000349 | NAA50 | chr3 | 113440406 | - | STATH | chr4 | 70866587 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000240922 | ENST00000246895 | NAA50 | chr3 | 113440406 | - | STATH | chr4 | 70866587 | + |
intron-3CDS | ENST00000240922 | ENST00000381060 | NAA50 | chr3 | 113440406 | - | STATH | chr4 | 70866587 | + |
intron-3CDS | ENST00000477813 | ENST00000246895 | NAA50 | chr3 | 113440406 | - | STATH | chr4 | 70866587 | + |
intron-3CDS | ENST00000477813 | ENST00000381060 | NAA50 | chr3 | 113440406 | - | STATH | chr4 | 70866587 | + |
intron-3CDS | ENST00000497525 | ENST00000246895 | NAA50 | chr3 | 113440406 | - | STATH | chr4 | 70866587 | + |
intron-3CDS | ENST00000497525 | ENST00000381060 | NAA50 | chr3 | 113440406 | - | STATH | chr4 | 70866587 | + |
intron-3CDS | ENST00000497255 | ENST00000246895 | NAA50 | chr3 | 113440406 | - | STATH | chr4 | 70866587 | + |
intron-3CDS | ENST00000497255 | ENST00000381060 | NAA50 | chr3 | 113440406 | - | STATH | chr4 | 70866587 | + |
intron-3CDS | ENST00000493454 | ENST00000246895 | NAA50 | chr3 | 113440406 | - | STATH | chr4 | 70866587 | + |
intron-3CDS | ENST00000493454 | ENST00000381060 | NAA50 | chr3 | 113440406 | - | STATH | chr4 | 70866587 | + |
intron-3CDS | ENST00000493900 | ENST00000246895 | NAA50 | chr3 | 113440406 | - | STATH | chr4 | 70866587 | + |
intron-3CDS | ENST00000493900 | ENST00000381060 | NAA50 | chr3 | 113440406 | - | STATH | chr4 | 70866587 | + |
intron-3CDS | ENST00000467022 | ENST00000246895 | NAA50 | chr3 | 113440406 | - | STATH | chr4 | 70866587 | + |
intron-3CDS | ENST00000467022 | ENST00000381060 | NAA50 | chr3 | 113440406 | - | STATH | chr4 | 70866587 | + |
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FusionProtFeatures for NAA50_STATH |
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Hgene | Tgene |
NAA50 | STATH |
N-alpha-acetyltransferase that acetylates the N-terminusof proteins that retain their initiating methionine(PubMed:19744929, PubMed:22311970, PubMed:21900231,PubMed:27484799). Has a broad substrate specificity: able toacetylate the initiator methionine of most peptides, except forthose with a proline in second position (PubMed:27484799). Alsodisplays N-epsilon-acetyltransferase activity by mediatingacetylation of the side chain of specific lysines on proteins(PubMed:19744929). Autoacetylates in vivo (PubMed:19744929). Therelevance of N-epsilon-acetyltransferase activity is howeverunclear: able to acetylate H4 in vitro, but this result has notbeen confirmed in vivo (PubMed:19744929). Component of a N-alpha-acetyltransferase complex containing NAA10 and NAA15, but NAA50does not influence the acetyltransferase activity of NAA10: thismultiprotein complex probably constitutes the major contributorfor N-terminal acetylation at the ribosome exit tunnel, with NAA10acetylating all amino termini that are devoid of methionine andNAA50 acetylating other peptides (PubMed:16507339,PubMed:27484799). Required for sister chromatid cohesion duringmitosis by promoting binding of CDCA5/sororin to cohesin: may actby counteracting the function of NAA10 (PubMed:17502424,PubMed:27422821). {ECO:0000269|PubMed:16507339,ECO:0000269|PubMed:17502424, ECO:0000269|PubMed:19744929,ECO:0000269|PubMed:21900231, ECO:0000269|PubMed:22311970,ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27484799}. | Salivary protein that stabilizes saliva supersaturatedwith calcium salts by inhibiting the precipitation of calciumphosphate salts. It also modulates hydroxyapatite crystalformation on the tooth surface. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NAA50_STATH |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NAA50_STATH |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NAA50_STATH |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NAA50_STATH |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | STATH | C0004352 | Autistic Disorder | 1 | CTD_human |