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Fusion gene ID: 23280 |
FusionGeneSummary for NAA25_FMR1 |
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Fusion gene information | Fusion gene name: NAA25_FMR1 | Fusion gene ID: 23280 | Hgene | Tgene | Gene symbol | NAA25 | FMR1 | Gene ID | 80018 | 2332 |
Gene name | N(alpha)-acetyltransferase 25, NatB auxiliary subunit | fragile X mental retardation 1 | |
Synonyms | C12orf30|MDM20|NAP1 | FMRP|FRAXA|POF|POF1 | |
Cytomap | 12q24.13 | Xq27.3 | |
Type of gene | protein-coding | protein-coding | |
Description | N-alpha-acetyltransferase 25, NatB auxiliary subunitN-terminal acetyltransferase B complex subunit NAA25mitochondrial distribution and morphology 20natB complex subunit MDM20 | synaptic functional regulator FMR1fragile X mental retardation protein 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q14CX7 | Q06787 | |
Ensembl transtripts involved in fusion gene | ENST00000261745, | ENST00000218200, ENST00000370471, ENST00000370477, ENST00000334557, ENST00000439526, ENST00000370475, ENST00000370470, ENST00000440235, ENST00000492846, | |
Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 3 X 3 X 1=9 |
# samples | 5 | 3 | |
** MAII score | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NAA25 [Title/Abstract] AND FMR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FMR1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 18653529 |
Tgene | FMR1 | GO:0002092 | positive regulation of receptor internalization | 25561520 |
Tgene | FMR1 | GO:0006974 | cellular response to DNA damage stimulus | 24813610 |
Tgene | FMR1 | GO:0033129 | positive regulation of histone phosphorylation | 24813610 |
Tgene | FMR1 | GO:0045727 | positive regulation of translation | 19097999|19166269 |
Tgene | FMR1 | GO:0051489 | regulation of filopodium assembly | 16631377 |
Tgene | FMR1 | GO:0060998 | regulation of dendritic spine development | 16631377 |
Tgene | FMR1 | GO:0098586 | cellular response to virus | 24514761 |
Tgene | FMR1 | GO:0098908 | regulation of neuronal action potential | 25561520 |
Tgene | FMR1 | GO:1902416 | positive regulation of mRNA binding | 25464849 |
Tgene | FMR1 | GO:2000637 | positive regulation of gene silencing by miRNA | 17057366 |
Tgene | FMR1 | GO:2001022 | positive regulation of response to DNA damage stimulus | 24813610 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW801819 | NAA25 | chr12 | 112488811 | - | FMR1 | chrX | 147030915 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000261745 | ENST00000218200 | NAA25 | chr12 | 112488811 | - | FMR1 | chrX | 147030915 | + |
intron-3UTR | ENST00000261745 | ENST00000370471 | NAA25 | chr12 | 112488811 | - | FMR1 | chrX | 147030915 | + |
intron-3UTR | ENST00000261745 | ENST00000370477 | NAA25 | chr12 | 112488811 | - | FMR1 | chrX | 147030915 | + |
intron-intron | ENST00000261745 | ENST00000334557 | NAA25 | chr12 | 112488811 | - | FMR1 | chrX | 147030915 | + |
intron-3UTR | ENST00000261745 | ENST00000439526 | NAA25 | chr12 | 112488811 | - | FMR1 | chrX | 147030915 | + |
intron-3UTR | ENST00000261745 | ENST00000370475 | NAA25 | chr12 | 112488811 | - | FMR1 | chrX | 147030915 | + |
intron-intron | ENST00000261745 | ENST00000370470 | NAA25 | chr12 | 112488811 | - | FMR1 | chrX | 147030915 | + |
intron-intron | ENST00000261745 | ENST00000440235 | NAA25 | chr12 | 112488811 | - | FMR1 | chrX | 147030915 | + |
intron-intron | ENST00000261745 | ENST00000492846 | NAA25 | chr12 | 112488811 | - | FMR1 | chrX | 147030915 | + |
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FusionProtFeatures for NAA25_FMR1 |
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Hgene | Tgene |
NAA25 | FMR1 |
Non-catalytic subunit of the NatB complex whichcatalyzes acetylation of the N-terminal methionine residues ofpeptides beginning with Met-Asp-Glu. May play a role in normalcell-cycle progression. {ECO:0000269|PubMed:18570629}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NAA25_FMR1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NAA25_FMR1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NAA25_FMR1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NAA25_FMR1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | FMR1 | C0016667 | Fragile X Syndrome | 9 | CTD_human;ORPHANET;UNIPROT |
Tgene | FMR1 | C0004352 | Autistic Disorder | 5 | CTD_human;HPO |
Tgene | FMR1 | C0036341 | Schizophrenia | 2 | PSYGENET |
Tgene | FMR1 | C0041696 | Unipolar Depression | 2 | PSYGENET |
Tgene | FMR1 | C0376634 | Craniofacial Abnormalities | 2 | CTD_human |
Tgene | FMR1 | C1269683 | Major Depressive Disorder | 2 | PSYGENET |
Tgene | FMR1 | C3714756 | Intellectual Disability | 2 | CTD_human |
Tgene | FMR1 | C0000768 | Congenital Abnormality | 1 | CTD_human |
Tgene | FMR1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | FMR1 | C0009241 | Cognition Disorders | 1 | CTD_human |
Tgene | FMR1 | C0018051 | Gonadal Dysgenesis | 1 | CTD_human |
Tgene | FMR1 | C0086132 | Depressive Symptoms | 1 | PSYGENET |
Tgene | FMR1 | C0282631 | Facies | 1 | CTD_human |
Tgene | FMR1 | C0338908 | Mixed anxiety and depressive disorder | 1 | PSYGENET |
Tgene | FMR1 | C0525045 | Mood Disorders | 1 | PSYGENET |
Tgene | FMR1 | C1839780 | FRAGILE X TREMOR/ATAXIA SYNDROME | 1 | CTD_human;ORPHANET |
Tgene | FMR1 | C2678248 | Mood instability | 1 | PSYGENET |
Tgene | FMR1 | C2749127 | Primary Ovarian Insufficiency, Fragile X-Associated | 1 | CTD_human |