FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 23280

FusionGeneSummary for NAA25_FMR1

check button Fusion gene summary
Fusion gene informationFusion gene name: NAA25_FMR1
Fusion gene ID: 23280
HgeneTgene
Gene symbol

NAA25

FMR1

Gene ID

80018

2332

Gene nameN(alpha)-acetyltransferase 25, NatB auxiliary subunitfragile X mental retardation 1
SynonymsC12orf30|MDM20|NAP1FMRP|FRAXA|POF|POF1
Cytomap

12q24.13

Xq27.3

Type of geneprotein-codingprotein-coding
DescriptionN-alpha-acetyltransferase 25, NatB auxiliary subunitN-terminal acetyltransferase B complex subunit NAA25mitochondrial distribution and morphology 20natB complex subunit MDM20synaptic functional regulator FMR1fragile X mental retardation protein 1
Modification date2018052320180523
UniProtAcc

Q14CX7

Q06787

Ensembl transtripts involved in fusion geneENST00000261745, ENST00000218200, 
ENST00000370471, ENST00000370477, 
ENST00000334557, ENST00000439526, 
ENST00000370475, ENST00000370470, 
ENST00000440235, ENST00000492846, 
Fusion gene scores* DoF score5 X 5 X 5=1253 X 3 X 1=9
# samples 53
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NAA25 [Title/Abstract] AND FMR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFMR1

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

18653529

TgeneFMR1

GO:0002092

positive regulation of receptor internalization

25561520

TgeneFMR1

GO:0006974

cellular response to DNA damage stimulus

24813610

TgeneFMR1

GO:0033129

positive regulation of histone phosphorylation

24813610

TgeneFMR1

GO:0045727

positive regulation of translation

19097999|19166269

TgeneFMR1

GO:0051489

regulation of filopodium assembly

16631377

TgeneFMR1

GO:0060998

regulation of dendritic spine development

16631377

TgeneFMR1

GO:0098586

cellular response to virus

24514761

TgeneFMR1

GO:0098908

regulation of neuronal action potential

25561520

TgeneFMR1

GO:1902416

positive regulation of mRNA binding

25464849

TgeneFMR1

GO:2000637

positive regulation of gene silencing by miRNA

17057366

TgeneFMR1

GO:2001022

positive regulation of response to DNA damage stimulus

24813610


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW801819NAA25chr12

112488811

-FMR1chrX

147030915

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000261745ENST00000218200NAA25chr12

112488811

-FMR1chrX

147030915

+
intron-3UTRENST00000261745ENST00000370471NAA25chr12

112488811

-FMR1chrX

147030915

+
intron-3UTRENST00000261745ENST00000370477NAA25chr12

112488811

-FMR1chrX

147030915

+
intron-intronENST00000261745ENST00000334557NAA25chr12

112488811

-FMR1chrX

147030915

+
intron-3UTRENST00000261745ENST00000439526NAA25chr12

112488811

-FMR1chrX

147030915

+
intron-3UTRENST00000261745ENST00000370475NAA25chr12

112488811

-FMR1chrX

147030915

+
intron-intronENST00000261745ENST00000370470NAA25chr12

112488811

-FMR1chrX

147030915

+
intron-intronENST00000261745ENST00000440235NAA25chr12

112488811

-FMR1chrX

147030915

+
intron-intronENST00000261745ENST00000492846NAA25chr12

112488811

-FMR1chrX

147030915

+

Top

FusionProtFeatures for NAA25_FMR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAA25

Q14CX7

FMR1

Q06787

Non-catalytic subunit of the NatB complex whichcatalyzes acetylation of the N-terminal methionine residues ofpeptides beginning with Met-Asp-Glu. May play a role in normalcell-cycle progression. {ECO:0000269|PubMed:18570629}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NAA25_FMR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NAA25_FMR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NAA25_FMR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NAA25_FMR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFMR1C0016667Fragile X Syndrome9CTD_human;ORPHANET;UNIPROT
TgeneFMR1C0004352Autistic Disorder5CTD_human;HPO
TgeneFMR1C0036341Schizophrenia2PSYGENET
TgeneFMR1C0041696Unipolar Depression2PSYGENET
TgeneFMR1C0376634Craniofacial Abnormalities2CTD_human
TgeneFMR1C1269683Major Depressive Disorder2PSYGENET
TgeneFMR1C3714756Intellectual Disability2CTD_human
TgeneFMR1C0000768Congenital Abnormality1CTD_human
TgeneFMR1C0005586Bipolar Disorder1PSYGENET
TgeneFMR1C0009241Cognition Disorders1CTD_human
TgeneFMR1C0018051Gonadal Dysgenesis1CTD_human
TgeneFMR1C0086132Depressive Symptoms1PSYGENET
TgeneFMR1C0282631Facies1CTD_human
TgeneFMR1C0338908Mixed anxiety and depressive disorder1PSYGENET
TgeneFMR1C0525045Mood Disorders1PSYGENET
TgeneFMR1C1839780FRAGILE X TREMOR/ATAXIA SYNDROME1CTD_human;ORPHANET
TgeneFMR1C2678248Mood instability1PSYGENET
TgeneFMR1C2749127Primary Ovarian Insufficiency, Fragile X-Associated1CTD_human