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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23270

FusionGeneSummary for NAA15_MGST2

check button Fusion gene summary
Fusion gene informationFusion gene name: NAA15_MGST2
Fusion gene ID: 23270
HgeneTgene
Gene symbol

NAA15

MGST2

Gene ID

80155

4258

Gene nameN(alpha)-acetyltransferase 15, NatA auxiliary subunitmicrosomal glutathione S-transferase 2
SynonymsGa19|MRD50|NARG1|NAT1P|NATH|TBDN|TBDN100GST2|MGST-II
Cytomap

4q31.1

4q31.1

Type of geneprotein-codingprotein-coding
DescriptionN-alpha-acetyltransferase 15, NatA auxiliary subunitN-terminal acetyltransferaseNMDA receptor regulated 1NMDA receptor-regulated protein 1gastric cancer antigen Ga19protein tubedown-1transcriptional coactivator tubedown-100tubedown-1microsomal glutathione S-transferase 2microsomal GST-2microsomal GST-II
Modification date2018052320180523
UniProtAcc

Q9BXJ9

Q99735

Ensembl transtripts involved in fusion geneENST00000296543, ENST00000398947, 
ENST00000480277, ENST00000515576, 
ENST00000515137, ENST00000265498, 
ENST00000506797, 
Fusion gene scores* DoF score5 X 4 X 6=1207 X 4 X 6=168
# samples 68
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAA15 [Title/Abstract] AND MGST2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAA15

GO:0006474

N-terminal protein amino acid acetylation

15496142

HgeneNAA15

GO:0045893

positive regulation of transcription, DNA-templated

12145306

TgeneMGST2

GO:0006629

lipid metabolic process

9278457

TgeneMGST2

GO:0006750

glutathione biosynthetic process

8703034

TgeneMGST2

GO:0019370

leukotriene biosynthetic process

8703034|9092565|23409838

TgeneMGST2

GO:0046466

membrane lipid catabolic process

23409838


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-18-3414-01ANAA15chr4

140265493

+MGST2chr4

140599697

+
TCGALDSTADTCGA-BR-7715-01ANAA15chr4

140222985

+MGST2chr4

140661366

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000296543ENST00000515137NAA15chr4

140265493

+MGST2chr4

140599697

+
5CDS-intronENST00000296543ENST00000265498NAA15chr4

140265493

+MGST2chr4

140599697

+
5CDS-intronENST00000296543ENST00000506797NAA15chr4

140265493

+MGST2chr4

140599697

+
5CDS-intronENST00000398947ENST00000515137NAA15chr4

140265493

+MGST2chr4

140599697

+
5CDS-intronENST00000398947ENST00000265498NAA15chr4

140265493

+MGST2chr4

140599697

+
5CDS-intronENST00000398947ENST00000506797NAA15chr4

140265493

+MGST2chr4

140599697

+
3UTR-intronENST00000480277ENST00000515137NAA15chr4

140265493

+MGST2chr4

140599697

+
3UTR-intronENST00000480277ENST00000265498NAA15chr4

140265493

+MGST2chr4

140599697

+
3UTR-intronENST00000480277ENST00000506797NAA15chr4

140265493

+MGST2chr4

140599697

+
intron-intronENST00000515576ENST00000515137NAA15chr4

140265493

+MGST2chr4

140599697

+
intron-intronENST00000515576ENST00000265498NAA15chr4

140265493

+MGST2chr4

140599697

+
intron-intronENST00000515576ENST00000506797NAA15chr4

140265493

+MGST2chr4

140599697

+
5CDS-3UTRENST00000296543ENST00000515137NAA15chr4

140222985

+MGST2chr4

140661366

+
5CDS-intronENST00000296543ENST00000265498NAA15chr4

140222985

+MGST2chr4

140661366

+
5CDS-intronENST00000296543ENST00000506797NAA15chr4

140222985

+MGST2chr4

140661366

+
5CDS-3UTRENST00000398947ENST00000515137NAA15chr4

140222985

+MGST2chr4

140661366

+
5CDS-intronENST00000398947ENST00000265498NAA15chr4

140222985

+MGST2chr4

140661366

+
5CDS-intronENST00000398947ENST00000506797NAA15chr4

140222985

+MGST2chr4

140661366

+
intron-3UTRENST00000480277ENST00000515137NAA15chr4

140222985

+MGST2chr4

140661366

+
intron-intronENST00000480277ENST00000265498NAA15chr4

140222985

+MGST2chr4

140661366

+
intron-intronENST00000480277ENST00000506797NAA15chr4

140222985

+MGST2chr4

140661366

+
intron-3UTRENST00000515576ENST00000515137NAA15chr4

140222985

+MGST2chr4

140661366

+
intron-intronENST00000515576ENST00000265498NAA15chr4

140222985

+MGST2chr4

140661366

+
intron-intronENST00000515576ENST00000506797NAA15chr4

140222985

+MGST2chr4

140661366

+

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FusionProtFeatures for NAA15_MGST2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAA15

Q9BXJ9

MGST2

Q99735

Auxillary subunit of the N-terminal acetyltransferase A(NatA) complex which displays alpha (N-terminal) acetyltransferaseactivity. The NAT activity may be important for vascular,hematopoietic and neuronal growth and development. Required tocontrol retinal neovascularization in adult ocular endothelialcells. In complex with XRCC6 and XRCC5 (Ku80), up-regulatestranscription from the osteocalcin promoter.{ECO:0000269|PubMed:11687548, ECO:0000269|PubMed:12145306,ECO:0000269|PubMed:15496142}. Can catalyze the production of LTC4 from LTA4 andreduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAA15_MGST2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAA15_MGST2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NAA15UBA5, XRCC6, XRCC5, RAD21, SIRT7, NAA10, HYPK, ASUN, MATR3, FN1, VCAM1, ITGA4, DDI2, STAT1, TSNAX, VPS26A, NAA50, PYCARD, MBD5, CYP1A1, CAND2, CMAS, DHX9, DRG1, FBL, HNRNPR, PSMC3, PSMD12, PSMD3, YARS, NAA20, NTRK1, KRAS, CEP97, CNTRL, DCTN1, POC5, STIL, SRPR, RNF126, ZNF746, NAA16, ARRB2, TRAFD1, FGB, SNRNP27, GTF2E2, USP47, MRPS11, FGF9, BRCA1MGST2MGST2, RELL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAA15_MGST2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMGST2Q99735DB00143GlutathioneMicrosomal glutathione S-transferase 2small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for NAA15_MGST2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource