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Fusion gene ID: 23270 |
FusionGeneSummary for NAA15_MGST2 |
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Fusion gene information | Fusion gene name: NAA15_MGST2 | Fusion gene ID: 23270 | Hgene | Tgene | Gene symbol | NAA15 | MGST2 | Gene ID | 80155 | 4258 |
Gene name | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | microsomal glutathione S-transferase 2 | |
Synonyms | Ga19|MRD50|NARG1|NAT1P|NATH|TBDN|TBDN100 | GST2|MGST-II | |
Cytomap | 4q31.1 | 4q31.1 | |
Type of gene | protein-coding | protein-coding | |
Description | N-alpha-acetyltransferase 15, NatA auxiliary subunitN-terminal acetyltransferaseNMDA receptor regulated 1NMDA receptor-regulated protein 1gastric cancer antigen Ga19protein tubedown-1transcriptional coactivator tubedown-100tubedown-1 | microsomal glutathione S-transferase 2microsomal GST-2microsomal GST-II | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9BXJ9 | Q99735 | |
Ensembl transtripts involved in fusion gene | ENST00000296543, ENST00000398947, ENST00000480277, ENST00000515576, | ENST00000515137, ENST00000265498, ENST00000506797, | |
Fusion gene scores | * DoF score | 5 X 4 X 6=120 | 7 X 4 X 6=168 |
# samples | 6 | 8 | |
** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NAA15 [Title/Abstract] AND MGST2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NAA15 | GO:0006474 | N-terminal protein amino acid acetylation | 15496142 |
Hgene | NAA15 | GO:0045893 | positive regulation of transcription, DNA-templated | 12145306 |
Tgene | MGST2 | GO:0006629 | lipid metabolic process | 9278457 |
Tgene | MGST2 | GO:0006750 | glutathione biosynthetic process | 8703034 |
Tgene | MGST2 | GO:0019370 | leukotriene biosynthetic process | 8703034|9092565|23409838 |
Tgene | MGST2 | GO:0046466 | membrane lipid catabolic process | 23409838 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-18-3414-01A | NAA15 | chr4 | 140265493 | + | MGST2 | chr4 | 140599697 | + |
TCGA | LD | STAD | TCGA-BR-7715-01A | NAA15 | chr4 | 140222985 | + | MGST2 | chr4 | 140661366 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000296543 | ENST00000515137 | NAA15 | chr4 | 140265493 | + | MGST2 | chr4 | 140599697 | + |
5CDS-intron | ENST00000296543 | ENST00000265498 | NAA15 | chr4 | 140265493 | + | MGST2 | chr4 | 140599697 | + |
5CDS-intron | ENST00000296543 | ENST00000506797 | NAA15 | chr4 | 140265493 | + | MGST2 | chr4 | 140599697 | + |
5CDS-intron | ENST00000398947 | ENST00000515137 | NAA15 | chr4 | 140265493 | + | MGST2 | chr4 | 140599697 | + |
5CDS-intron | ENST00000398947 | ENST00000265498 | NAA15 | chr4 | 140265493 | + | MGST2 | chr4 | 140599697 | + |
5CDS-intron | ENST00000398947 | ENST00000506797 | NAA15 | chr4 | 140265493 | + | MGST2 | chr4 | 140599697 | + |
3UTR-intron | ENST00000480277 | ENST00000515137 | NAA15 | chr4 | 140265493 | + | MGST2 | chr4 | 140599697 | + |
3UTR-intron | ENST00000480277 | ENST00000265498 | NAA15 | chr4 | 140265493 | + | MGST2 | chr4 | 140599697 | + |
3UTR-intron | ENST00000480277 | ENST00000506797 | NAA15 | chr4 | 140265493 | + | MGST2 | chr4 | 140599697 | + |
intron-intron | ENST00000515576 | ENST00000515137 | NAA15 | chr4 | 140265493 | + | MGST2 | chr4 | 140599697 | + |
intron-intron | ENST00000515576 | ENST00000265498 | NAA15 | chr4 | 140265493 | + | MGST2 | chr4 | 140599697 | + |
intron-intron | ENST00000515576 | ENST00000506797 | NAA15 | chr4 | 140265493 | + | MGST2 | chr4 | 140599697 | + |
5CDS-3UTR | ENST00000296543 | ENST00000515137 | NAA15 | chr4 | 140222985 | + | MGST2 | chr4 | 140661366 | + |
5CDS-intron | ENST00000296543 | ENST00000265498 | NAA15 | chr4 | 140222985 | + | MGST2 | chr4 | 140661366 | + |
5CDS-intron | ENST00000296543 | ENST00000506797 | NAA15 | chr4 | 140222985 | + | MGST2 | chr4 | 140661366 | + |
5CDS-3UTR | ENST00000398947 | ENST00000515137 | NAA15 | chr4 | 140222985 | + | MGST2 | chr4 | 140661366 | + |
5CDS-intron | ENST00000398947 | ENST00000265498 | NAA15 | chr4 | 140222985 | + | MGST2 | chr4 | 140661366 | + |
5CDS-intron | ENST00000398947 | ENST00000506797 | NAA15 | chr4 | 140222985 | + | MGST2 | chr4 | 140661366 | + |
intron-3UTR | ENST00000480277 | ENST00000515137 | NAA15 | chr4 | 140222985 | + | MGST2 | chr4 | 140661366 | + |
intron-intron | ENST00000480277 | ENST00000265498 | NAA15 | chr4 | 140222985 | + | MGST2 | chr4 | 140661366 | + |
intron-intron | ENST00000480277 | ENST00000506797 | NAA15 | chr4 | 140222985 | + | MGST2 | chr4 | 140661366 | + |
intron-3UTR | ENST00000515576 | ENST00000515137 | NAA15 | chr4 | 140222985 | + | MGST2 | chr4 | 140661366 | + |
intron-intron | ENST00000515576 | ENST00000265498 | NAA15 | chr4 | 140222985 | + | MGST2 | chr4 | 140661366 | + |
intron-intron | ENST00000515576 | ENST00000506797 | NAA15 | chr4 | 140222985 | + | MGST2 | chr4 | 140661366 | + |
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FusionProtFeatures for NAA15_MGST2 |
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Hgene | Tgene |
NAA15 | MGST2 |
Auxillary subunit of the N-terminal acetyltransferase A(NatA) complex which displays alpha (N-terminal) acetyltransferaseactivity. The NAT activity may be important for vascular,hematopoietic and neuronal growth and development. Required tocontrol retinal neovascularization in adult ocular endothelialcells. In complex with XRCC6 and XRCC5 (Ku80), up-regulatestranscription from the osteocalcin promoter.{ECO:0000269|PubMed:11687548, ECO:0000269|PubMed:12145306,ECO:0000269|PubMed:15496142}. | Can catalyze the production of LTC4 from LTA4 andreduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NAA15_MGST2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NAA15_MGST2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NAA15 | UBA5, XRCC6, XRCC5, RAD21, SIRT7, NAA10, HYPK, ASUN, MATR3, FN1, VCAM1, ITGA4, DDI2, STAT1, TSNAX, VPS26A, NAA50, PYCARD, MBD5, CYP1A1, CAND2, CMAS, DHX9, DRG1, FBL, HNRNPR, PSMC3, PSMD12, PSMD3, YARS, NAA20, NTRK1, KRAS, CEP97, CNTRL, DCTN1, POC5, STIL, SRPR, RNF126, ZNF746, NAA16, ARRB2, TRAFD1, FGB, SNRNP27, GTF2E2, USP47, MRPS11, FGF9, BRCA1 | MGST2 | MGST2, RELL2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NAA15_MGST2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | MGST2 | Q99735 | DB00143 | Glutathione | Microsomal glutathione S-transferase 2 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for NAA15_MGST2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |