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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2327

FusionGeneSummary for ARFGAP1_ARFGAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARFGAP1_ARFGAP1
Fusion gene ID: 2327
HgeneTgene
Gene symbol

ARFGAP1

ARFGAP1

Gene ID

55738

55738

Gene nameADP ribosylation factor GTPase activating protein 1ADP ribosylation factor GTPase activating protein 1
SynonymsARF1GAP|HRIHFB2281ARF1GAP|HRIHFB2281
Cytomap

20q13.33

20q13.33

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor GTPase-activating protein 1ARF1-directed GTPase-activating proteinADP-ribosylation factor GTPase-activating protein 1ARF1-directed GTPase-activating protein
Modification date2018052320180523
UniProtAcc

Q8N6T3

Q8N6T3

Ensembl transtripts involved in fusion geneENST00000370283, ENST00000547204, 
ENST00000519604, ENST00000519273, 
ENST00000370275, ENST00000353546, 
ENST00000518794, 		ENST00000370283, 
ENST00000547204, ENST00000519604, 
ENST00000519273, ENST00000370275, 
ENST00000353546, ENST00000518794, 
Fusion gene scores* DoF score2 X 3 X 2=125 X 6 X 3=90
# samples 58
** MAII scorelog2(5/12*10)=2.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/90*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARFGAP1 [Title/Abstract] AND ARFGAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF435836ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
ChiTaRS3.1AA402828ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
ChiTaRS3.1AA456448ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
ChiTaRS3.1AA454556ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000370283ENST00000370283ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-intronENST00000370283ENST00000547204ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-intronENST00000370283ENST00000519604ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370283ENST00000519273ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370283ENST00000370275ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370283ENST00000353546ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370283ENST00000518794ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000547204ENST00000370283ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000547204ENST00000547204ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000547204ENST00000519604ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000547204ENST00000519273ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000547204ENST00000370275ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000547204ENST00000353546ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000547204ENST00000518794ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519604ENST00000370283ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000519604ENST00000547204ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000519604ENST00000519604ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519604ENST00000519273ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519604ENST00000370275ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519604ENST00000353546ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519604ENST00000518794ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519273ENST00000370283ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000519273ENST00000547204ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000519273ENST00000519604ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519273ENST00000519273ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519273ENST00000370275ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519273ENST00000353546ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519273ENST00000518794ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370275ENST00000370283ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-intronENST00000370275ENST00000547204ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-intronENST00000370275ENST00000519604ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370275ENST00000519273ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370275ENST00000370275ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370275ENST00000353546ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370275ENST00000518794ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000353546ENST00000370283ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000353546ENST00000547204ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000353546ENST00000519604ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000353546ENST00000519273ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000353546ENST00000370275ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000353546ENST00000353546ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000353546ENST00000518794ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000518794ENST00000370283ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000518794ENST00000547204ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000518794ENST00000519604ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000518794ENST00000519273ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000518794ENST00000370275ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000518794ENST00000353546ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000518794ENST00000518794ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370283ENST00000370283ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370283ENST00000547204ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370283ENST00000519604ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370283ENST00000519273ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000370283ENST00000370275ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370283ENST00000353546ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370283ENST00000518794ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-3UTRENST00000547204ENST00000370283ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000547204ENST00000547204ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000547204ENST00000519604ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000547204ENST00000519273ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-3UTRENST00000547204ENST00000370275ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000547204ENST00000353546ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000547204ENST00000518794ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-3UTRENST00000519604ENST00000370283ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000519604ENST00000547204ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000519604ENST00000519604ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000519604ENST00000519273ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-3UTRENST00000519604ENST00000370275ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000519604ENST00000353546ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000519604ENST00000518794ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000519273ENST00000370283ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000519273ENST00000547204ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000519273ENST00000519604ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000519273ENST00000519273ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000519273ENST00000370275ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000519273ENST00000353546ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000519273ENST00000518794ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000370275ENST00000370283ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370275ENST00000547204ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370275ENST00000519604ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370275ENST00000519273ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000370275ENST00000370275ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370275ENST00000353546ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370275ENST00000518794ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000353546ENST00000370283ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000353546ENST00000547204ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000353546ENST00000519604ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000353546ENST00000519273ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000353546ENST00000370275ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000353546ENST00000353546ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000353546ENST00000518794ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000518794ENST00000370283ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000518794ENST00000547204ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000518794ENST00000519604ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000518794ENST00000519273ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000518794ENST00000370275ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000518794ENST00000353546ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000518794ENST00000518794ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-

Top

FusionProtFeatures for ARFGAP1_ARFGAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARFGAP1

Q8N6T3

ARFGAP1

Q8N6T3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ARFGAP1_ARFGAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARFGAP1_ARFGAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ARFGAP1_ARFGAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ARFGAP1_ARFGAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARFGAP1C0008073Developmental Disabilities1CTD_human
HgeneARFGAP1C0027765nervous system disorder1CTD_human
TgeneARFGAP1C0008073Developmental Disabilities1CTD_human
TgeneARFGAP1C0027765nervous system disorder1CTD_human