|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 23269 |
FusionGeneSummary for NAA15_LPAR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NAA15_LPAR1 | Fusion gene ID: 23269 | Hgene | Tgene | Gene symbol | NAA15 | LPAR1 | Gene ID | 80155 | 1902 |
| Gene name | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | lysophosphatidic acid receptor 1 | |
| Synonyms | Ga19|MRD50|NARG1|NAT1P|NATH|TBDN|TBDN100 | EDG2|GPR26|Gpcr26|LPA1|Mrec1.3|VZG1|edg-2|rec.1.3|vzg-1 | |
| Cytomap | 4q31.1 | 9q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N-alpha-acetyltransferase 15, NatA auxiliary subunitN-terminal acetyltransferaseNMDA receptor regulated 1NMDA receptor-regulated protein 1gastric cancer antigen Ga19protein tubedown-1transcriptional coactivator tubedown-100tubedown-1 | lysophosphatidic acid receptor 1LPA receptor 1LPA-1endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2lysophosphatidic acid receptor Edg-2ventricular zone gene 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9BXJ9 | Q92633 | |
| Ensembl transtripts involved in fusion gene | ENST00000296543, ENST00000398947, ENST00000480277, ENST00000515576, | ENST00000374431, ENST00000541779, ENST00000374430, ENST00000358883, ENST00000538760, | |
| Fusion gene scores | * DoF score | 5 X 4 X 6=120 | 7 X 4 X 5=140 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NAA15 [Title/Abstract] AND LPAR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NAA15 | GO:0006474 | N-terminal protein amino acid acetylation | 15496142 |
| Hgene | NAA15 | GO:0045893 | positive regulation of transcription, DNA-templated | 12145306 |
| Tgene | LPAR1 | GO:0007202 | activation of phospholipase C activity | 19306925 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-06-0129-01A | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000296543 | ENST00000374431 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| In-frame | ENST00000296543 | ENST00000541779 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| Frame-shift | ENST00000296543 | ENST00000374430 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| Frame-shift | ENST00000296543 | ENST00000358883 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| In-frame | ENST00000296543 | ENST00000538760 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| Frame-shift | ENST00000398947 | ENST00000374431 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| In-frame | ENST00000398947 | ENST00000541779 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| Frame-shift | ENST00000398947 | ENST00000374430 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| Frame-shift | ENST00000398947 | ENST00000358883 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| In-frame | ENST00000398947 | ENST00000538760 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| intron-3CDS | ENST00000480277 | ENST00000374431 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| intron-3CDS | ENST00000480277 | ENST00000541779 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| intron-3CDS | ENST00000480277 | ENST00000374430 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| intron-3CDS | ENST00000480277 | ENST00000358883 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| intron-3CDS | ENST00000480277 | ENST00000538760 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| intron-3CDS | ENST00000515576 | ENST00000374431 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| intron-3CDS | ENST00000515576 | ENST00000541779 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| intron-3CDS | ENST00000515576 | ENST00000374430 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| intron-3CDS | ENST00000515576 | ENST00000358883 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
| intron-3CDS | ENST00000515576 | ENST00000538760 | NAA15 | chr4 | 140222985 | + | LPAR1 | chr9 | 113638002 | - |
Top |
FusionProtFeatures for NAA15_LPAR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NAA15 | LPAR1 |
| Auxillary subunit of the N-terminal acetyltransferase A(NatA) complex which displays alpha (N-terminal) acetyltransferaseactivity. The NAT activity may be important for vascular,hematopoietic and neuronal growth and development. Required tocontrol retinal neovascularization in adult ocular endothelialcells. In complex with XRCC6 and XRCC5 (Ku80), up-regulatestranscription from the osteocalcin promoter.{ECO:0000269|PubMed:11687548, ECO:0000269|PubMed:12145306,ECO:0000269|PubMed:15496142}. | Receptor for lysophosphatidic acid (LPA)(PubMed:9070858, PubMed:19306925, PubMed:25025571,PubMed:26091040). Plays a role in the reorganization of the actincytoskeleton, cell migration, differentiation and proliferation,and thereby contributes to the responses to tissue damage andinfectious agents. Activates downstream signaling cascades via theG(i)/G(o), G(12)/G(13), and G(q) families of heteromeric Gproteins. Signaling inhibits adenylyl cyclase activity anddecreases cellular cAMP levels (PubMed:26091040). Signalingtriggers an increase of cytoplasmic Ca(2+) levels(PubMed:19656035, PubMed:19733258, PubMed:26091040). ActivatesRALA; this leads to the activation of phospholipase C (PLC) andthe formation of inositol 1,4,5-trisphosphate (PubMed:19306925).Signaling mediates activation of down-stream MAP kinases (Bysimilarity). Contributes to the regulation of cell shape. PromotesRho-dependent reorganization of the actin cytoskeleton in neuronalcells and neurite retraction (PubMed:26091040). Promotes theactivation of Rho and the formation of actin stress fibers(PubMed:26091040). Promotes formation of lamellipodia at theleading edge of migrating cells via activation of RAC1 (Bysimilarity). Through its function as lysophosphatidic acidreceptor, plays a role in chemotaxis and cell migration, includingresponses to injury and wounding (PubMed:18066075,PubMed:19656035, PubMed:19733258). Plays a role in triggeringinflammation in response to bacterial lipopolysaccharide (LPS) viaits interaction with CD14. Promotes cell proliferation in responseto lysophosphatidic acid. Required for normal skeletondevelopment. May play a role in osteoblast differentiation.Required for normal brain development. Required for normalproliferation, survival and maturation of newly formed neurons inthe adult dentate gyrus. Plays a role in pain perception and inthe initiation of neuropathic pain (By similarity).{ECO:0000250|UniProtKB:P61793, ECO:0000269|PubMed:18066075,ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19656035,ECO:0000269|PubMed:19733258, ECO:0000269|PubMed:25025571,ECO:0000269|PubMed:26091040, ECO:0000269|PubMed:9070858,ECO:0000305|PubMed:11093753, ECO:0000305|PubMed:9069262}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for NAA15_LPAR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NAA15_ENST00000296543_chr4_140222985_+_LPAR1_ENST00000541779_chr9_113638002_-_118aa MPAVSLPPKENALFKRILGPLSSAGLLDWFCYFXTCAVHSATCWPMRNSSFSLLNSTLPXTPSFTPTATKKXAPPLGRSSAASAVRTPPA >In-frame_NAA15_ENST00000296543_chr4_140222985_+_LPAR1_ENST00000538760_chr9_113638002_-_118aa MPAVSLPPKENALFKRILGPLSSAGLLDWFCYFXTCAVHSATCWPMRNSSFSLLNSTLPXTPSFTPTATKKXAPPLGRSSAASAVRTPPA >In-frame_NAA15_ENST00000398947_chr4_140222985_+_LPAR1_ENST00000541779_chr9_113638002_-_118aa MPAVSLPPKENALFKRILGPLSSAGLLDWFCYFXTCAVHSATCWPMRNSSFSLLNSTLPXTPSFTPTATKKXAPPLGRSSAASAVRTPPA >In-frame_NAA15_ENST00000398947_chr4_140222985_+_LPAR1_ENST00000538760_chr9_113638002_-_118aa MPAVSLPPKENALFKRILGPLSSAGLLDWFCYFXTCAVHSATCWPMRNSSFSLLNSTLPXTPSFTPTATKKXAPPLGRSSAASAVRTPPA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NAA15_ENST00000296543_chr4_140222985_+_LPAR1_ENST00000541779_chr9_113638002_-_356nt ATGCCGGCCGTGAGCCTCCCGCCCAAGGAGAATGCGCTCTTCAAGCGGATCTTGGGGCCTTTATCATCTGCTGGACTCCTGGATTGGTTT TGTTACTTCTAGACGTGTGCTGTCCACAGTGCGACGTGCTGGCCTATGAGAAATTCTTCCTTCTCCTTGCTGAATTCAACTCTGCCATGA ACCCCATCATTTACTCCTACCGCGACAAAGAAATGAGCGCCACCTTTAGGCAGATCCTCTGCTGCCAGCGCAGTGAGAACCCCACCGGCC >In-frame_NAA15_ENST00000296543_chr4_140222985_+_LPAR1_ENST00000538760_chr9_113638002_-_356nt ATGCCGGCCGTGAGCCTCCCGCCCAAGGAGAATGCGCTCTTCAAGCGGATCTTGGGGCCTTTATCATCTGCTGGACTCCTGGATTGGTTT TGTTACTTCTAGACGTGTGCTGTCCACAGTGCGACGTGCTGGCCTATGAGAAATTCTTCCTTCTCCTTGCTGAATTCAACTCTGCCATGA ACCCCATCATTTACTCCTACCGCGACAAAGAAATGAGCGCCACCTTTAGGCAGATCCTCTGCTGCCAGCGCAGTGAGAACCCCACCGGCC >In-frame_NAA15_ENST00000398947_chr4_140222985_+_LPAR1_ENST00000541779_chr9_113638002_-_356nt ATGCCGGCCGTGAGCCTCCCGCCCAAGGAGAATGCGCTCTTCAAGCGGATCTTGGGGCCTTTATCATCTGCTGGACTCCTGGATTGGTTT TGTTACTTCTAGACGTGTGCTGTCCACAGTGCGACGTGCTGGCCTATGAGAAATTCTTCCTTCTCCTTGCTGAATTCAACTCTGCCATGA ACCCCATCATTTACTCCTACCGCGACAAAGAAATGAGCGCCACCTTTAGGCAGATCCTCTGCTGCCAGCGCAGTGAGAACCCCACCGGCC >In-frame_NAA15_ENST00000398947_chr4_140222985_+_LPAR1_ENST00000538760_chr9_113638002_-_356nt ATGCCGGCCGTGAGCCTCCCGCCCAAGGAGAATGCGCTCTTCAAGCGGATCTTGGGGCCTTTATCATCTGCTGGACTCCTGGATTGGTTT TGTTACTTCTAGACGTGTGCTGTCCACAGTGCGACGTGCTGGCCTATGAGAAATTCTTCCTTCTCCTTGCTGAATTCAACTCTGCCATGA ACCCCATCATTTACTCCTACCGCGACAAAGAAATGAGCGCCACCTTTAGGCAGATCCTCTGCTGCCAGCGCAGTGAGAACCCCACCGGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NAA15_ENST00000296543_chr4_140222985_+_LPAR1_ENST00000541779_chr9_113638002_-_2836nt GTGTTAGGAAGCGTGACCCGGGTGGGAAAACCCTCCGCGTCCGCCATTTTGGCTGCCTCTGTCGGTCTGTTCAGTTACCACGTGAACCGC CGACGGAGACCCGTAGTGGGGGAGGCGGCGGCAGCGTTAAGTGAGAAAGGAAAAAAGACAACGAGGAAAAAGGAGGTGTCCGGGTAGGGC AACGCGGCGACACCCGAGGCCTGGTGGTGGCGGCGGATCGAGATATTCAAGGCTGAAGCAGCTACGGAACGGCAGCGGCGGCGGTCGGAC AAACTGACTGACCGAGCCGGGTGGTGGCGGGAGCAGCGGGAGCAGCCGGAACGATGCCGGCCGTGAGCCTCCCGCCCAAGGAGAATGCGC TCTTCAAGCGGATCTTGGGGCCTTTATCATCTGCTGGACTCCTGGATTGGTTTTGTTACTTCTAGACGTGTGCTGTCCACAGTGCGACGT GCTGGCCTATGAGAAATTCTTCCTTCTCCTTGCTGAATTCAACTCTGCCATGAACCCCATCATTTACTCCTACCGCGACAAAGAAATGAG CGCCACCTTTAGGCAGATCCTCTGCTGCCAGCGCAGTGAGAACCCCACCGGCCCCACAGAAGGCTCAGACCGCTCGGCTTCCTCCCTCAA CCACACCATCTTGGCTGGAGTTCACAGCAATGACCACTCTGTGGTTTAGAACGGAAACTGAGATGAGGAACCAGCCGTCCTCTCTTGGAG GATAAACAGCCTCCCCCTACCCAATTGCCAGGGCAAGGTGGGGTGTGAGAGAGGAGAAAAGTCAACTCATGTACTTAAACACTAACCAAT GACAGTATTTGTTCCTGGACCCCACAAGACTTGATATATATTGAAAATTAGCTTATGTGACAACCCTCATCTTGATCCCCATCCCTTCTG AAAGTAGGAAGTTGGAGCTCTTGCAATGGAATTCAAGAACAGACTCTGGAGTGTCCATTTAGACTACACTAACTAGACTTTTAAAAGATT TTGTGTGGTTTGGTGCAAGTCAGAATAAATTCTGGCTAGTTGAATCCACAACTTCATTTATATACAGGCTTCCCTTTTTTATTTTTAAAG GATACGTTTCACTTAATAAACACGTTTATGCCTATCAGCATGTTTGTGATGGATGAGACTATGGACTGCTTTTAAACTACCATAATTCCA TTTTTTCCCTTACATAGGAAAACTGTAAGTTGGAATTATCTTTTGTTTAGAAAGCATGCATGTAATGTATGTATGCAGTATGCCTTACTT AAAAAGATTAAAAGGATACTAATGTTAAATCTTCTAGGAAATAGAACCTAGACTTCAAAGCCAGTATTTGTTTAGGTCATGAAGCAAACA ATGCTCTAATCACAATATTAACTGTTTAATTAAAATGTTGTAACAAGTATAAAACAGGGAATGTAAGTTTATTACCAAAGTGATATGTAT TCCAAAAAAGTCATAGAAGATGAAGCACTATAATATTGTTCCCATATATTTAAAATACCCAAGTACATTCTAATTACCAGTATATCAGAG GAAAATTTTCGTAGTCTTTGTAAAATAATATACTCATCATAGAAAACTTGAAAAATGCAGAAATGTATAAAAAAGCAAAAATGATTACTG ATAATATCACAACCCAGAAGTAACCACCTTTAAAAAGCAACCCCCATGTATGCCTATATGTGTATTGTATACTTTTTTTACATAATTGGA GTCATACTGTAAACAGTTTTATAAGTAGATCTTTTTCATTGCAAAATTGCCACATTTTCTTATGGCATTAAAAATTTTACAAAAACATAA TTTTAATGGCTATATTATATTCCATTTAATGGATGCAACTCAGTTTATTTAACCATTCCCATGTTGTTAACTATTTAGGTTGTTTCTAAT TTTCATTATTATAAAGTTGCAGAAATTTGGTGTACATAAAACTGTCTCCATATAATTGATTATTAGGATATATTCCCATGAAGGATTCTT TTTTTAAAAAAATGTGAAATGTCATCTTGTACTTACACCTTTCATGAAAAGGGATTTCCTGCTTTTGTACTGCATGGGTGGCAGTTGTGA GGAAAAGCCAGTCAAATGACCTTTTTACAAAAGAAATGCAGTGGTCACTTCAGTTGAGAGTGACTTTTTAATACAACAAGATCAACTAGA AGAATTCAACTGTCTCAAGAATCAAGGTACCCCAATATATCTCGCAATTCCAAACTTTGTTTGAGGGACTCGTTATCCAGCTCTTGGTAG CCACACCTGCAATGTAAAATGGAAGAAAATGCAAAGAAACCAAATGTGCCGAGTGAATAAAGGATTGTCATATCAATTAGTGTGGGTCCA TCTGTAGCAAATGGGTTGAGTGTGTCAGTATGTGGTTGGTTACTGTGTATTCGCCAGGAATCACCCCGATAGGCTGCCACCCTATTAGGT GATACCTGTTTAATATGTTGTCCAGGTAGACTAGTAGTTGCATCAGTTTGCTGTAACAAGTAACCAGTGAGGTAACACAGTGGTGAAGCA GGTCAGGGGAGGTCAGGAGGATGTCTGAGAGAAAGAAGTCCGGGAGATGAATGGCTGTCTAGGAAGGAGGATGTCAGTGCACGGTTAGTG TTTGAGCAGAGGGCAGACTTGTAAAGTACCTGTAGTGAAAAGAATGTGGGGACCCGATTAGCAGAAAGGTGTTTGCACGTACTTTATACA AAATACAGAATACTTTATATTGGAAGTGAAAGAAATGAACGTGGACTTTTACACATGTGCATATTTTTCTGGAGGCTATATGGATTATTT >In-frame_NAA15_ENST00000296543_chr4_140222985_+_LPAR1_ENST00000538760_chr9_113638002_-_924nt GTGTTAGGAAGCGTGACCCGGGTGGGAAAACCCTCCGCGTCCGCCATTTTGGCTGCCTCTGTCGGTCTGTTCAGTTACCACGTGAACCGC CGACGGAGACCCGTAGTGGGGGAGGCGGCGGCAGCGTTAAGTGAGAAAGGAAAAAAGACAACGAGGAAAAAGGAGGTGTCCGGGTAGGGC AACGCGGCGACACCCGAGGCCTGGTGGTGGCGGCGGATCGAGATATTCAAGGCTGAAGCAGCTACGGAACGGCAGCGGCGGCGGTCGGAC AAACTGACTGACCGAGCCGGGTGGTGGCGGGAGCAGCGGGAGCAGCCGGAACGATGCCGGCCGTGAGCCTCCCGCCCAAGGAGAATGCGC TCTTCAAGCGGATCTTGGGGCCTTTATCATCTGCTGGACTCCTGGATTGGTTTTGTTACTTCTAGACGTGTGCTGTCCACAGTGCGACGT GCTGGCCTATGAGAAATTCTTCCTTCTCCTTGCTGAATTCAACTCTGCCATGAACCCCATCATTTACTCCTACCGCGACAAAGAAATGAG CGCCACCTTTAGGCAGATCCTCTGCTGCCAGCGCAGTGAGAACCCCACCGGCCCCACAGAAGGCTCAGACCGCTCGGCTTCCTCCCTCAA CCACACCATCTTGGCTGGAGTTCACAGCAATGACCACTCTGTGGTTTAGAACGGAAACTGAGATGAGGAACCAGCCGTCCTCTCTTGGAG GATAAACAGCCTCCCCCTACCCAATTGCCAGGGCAAGGTGGGGTGTGAGAGAGGAGAAAAGTCAACTCATGTACTTAAACACTAACCAAT GACAGTATTTGTTCCTGGACCCCACAAGACTTGATATATATTGAAAATTAGCTTATGTGACAACCCTCATCTTGATCCCCATCCCTTCTG >In-frame_NAA15_ENST00000398947_chr4_140222985_+_LPAR1_ENST00000541779_chr9_113638002_-_2703nt AGAAAGGAAAAAAGACAACGAGGAAAAAGGAGGTGTCCGGGTAGGGCAACGCGGCGACACCCGAGGCCTGGTGGTGGCGGCGGATCGAGA TATTCAAGGCTGAAGCAGCTACGGAACGGCAGCGGCGGCGGTCGGACAAACTGACTGACCGAGCCGGGTGGTGGCGGGAGCAGCGGGAGC AGCCGGAACGATGCCGGCCGTGAGCCTCCCGCCCAAGGAGAATGCGCTCTTCAAGCGGATCTTGGGGCCTTTATCATCTGCTGGACTCCT GGATTGGTTTTGTTACTTCTAGACGTGTGCTGTCCACAGTGCGACGTGCTGGCCTATGAGAAATTCTTCCTTCTCCTTGCTGAATTCAAC TCTGCCATGAACCCCATCATTTACTCCTACCGCGACAAAGAAATGAGCGCCACCTTTAGGCAGATCCTCTGCTGCCAGCGCAGTGAGAAC CCCACCGGCCCCACAGAAGGCTCAGACCGCTCGGCTTCCTCCCTCAACCACACCATCTTGGCTGGAGTTCACAGCAATGACCACTCTGTG GTTTAGAACGGAAACTGAGATGAGGAACCAGCCGTCCTCTCTTGGAGGATAAACAGCCTCCCCCTACCCAATTGCCAGGGCAAGGTGGGG TGTGAGAGAGGAGAAAAGTCAACTCATGTACTTAAACACTAACCAATGACAGTATTTGTTCCTGGACCCCACAAGACTTGATATATATTG AAAATTAGCTTATGTGACAACCCTCATCTTGATCCCCATCCCTTCTGAAAGTAGGAAGTTGGAGCTCTTGCAATGGAATTCAAGAACAGA CTCTGGAGTGTCCATTTAGACTACACTAACTAGACTTTTAAAAGATTTTGTGTGGTTTGGTGCAAGTCAGAATAAATTCTGGCTAGTTGA ATCCACAACTTCATTTATATACAGGCTTCCCTTTTTTATTTTTAAAGGATACGTTTCACTTAATAAACACGTTTATGCCTATCAGCATGT TTGTGATGGATGAGACTATGGACTGCTTTTAAACTACCATAATTCCATTTTTTCCCTTACATAGGAAAACTGTAAGTTGGAATTATCTTT TGTTTAGAAAGCATGCATGTAATGTATGTATGCAGTATGCCTTACTTAAAAAGATTAAAAGGATACTAATGTTAAATCTTCTAGGAAATA GAACCTAGACTTCAAAGCCAGTATTTGTTTAGGTCATGAAGCAAACAATGCTCTAATCACAATATTAACTGTTTAATTAAAATGTTGTAA CAAGTATAAAACAGGGAATGTAAGTTTATTACCAAAGTGATATGTATTCCAAAAAAGTCATAGAAGATGAAGCACTATAATATTGTTCCC ATATATTTAAAATACCCAAGTACATTCTAATTACCAGTATATCAGAGGAAAATTTTCGTAGTCTTTGTAAAATAATATACTCATCATAGA AAACTTGAAAAATGCAGAAATGTATAAAAAAGCAAAAATGATTACTGATAATATCACAACCCAGAAGTAACCACCTTTAAAAAGCAACCC CCATGTATGCCTATATGTGTATTGTATACTTTTTTTACATAATTGGAGTCATACTGTAAACAGTTTTATAAGTAGATCTTTTTCATTGCA AAATTGCCACATTTTCTTATGGCATTAAAAATTTTACAAAAACATAATTTTAATGGCTATATTATATTCCATTTAATGGATGCAACTCAG TTTATTTAACCATTCCCATGTTGTTAACTATTTAGGTTGTTTCTAATTTTCATTATTATAAAGTTGCAGAAATTTGGTGTACATAAAACT GTCTCCATATAATTGATTATTAGGATATATTCCCATGAAGGATTCTTTTTTTAAAAAAATGTGAAATGTCATCTTGTACTTACACCTTTC ATGAAAAGGGATTTCCTGCTTTTGTACTGCATGGGTGGCAGTTGTGAGGAAAAGCCAGTCAAATGACCTTTTTACAAAAGAAATGCAGTG GTCACTTCAGTTGAGAGTGACTTTTTAATACAACAAGATCAACTAGAAGAATTCAACTGTCTCAAGAATCAAGGTACCCCAATATATCTC GCAATTCCAAACTTTGTTTGAGGGACTCGTTATCCAGCTCTTGGTAGCCACACCTGCAATGTAAAATGGAAGAAAATGCAAAGAAACCAA ATGTGCCGAGTGAATAAAGGATTGTCATATCAATTAGTGTGGGTCCATCTGTAGCAAATGGGTTGAGTGTGTCAGTATGTGGTTGGTTAC TGTGTATTCGCCAGGAATCACCCCGATAGGCTGCCACCCTATTAGGTGATACCTGTTTAATATGTTGTCCAGGTAGACTAGTAGTTGCAT CAGTTTGCTGTAACAAGTAACCAGTGAGGTAACACAGTGGTGAAGCAGGTCAGGGGAGGTCAGGAGGATGTCTGAGAGAAAGAAGTCCGG GAGATGAATGGCTGTCTAGGAAGGAGGATGTCAGTGCACGGTTAGTGTTTGAGCAGAGGGCAGACTTGTAAAGTACCTGTAGTGAAAAGA ATGTGGGGACCCGATTAGCAGAAAGGTGTTTGCACGTACTTTATACAAAATACAGAATACTTTATATTGGAAGTGAAAGAAATGAACGTG GACTTTTACACATGTGCATATTTTTCTGGAGGCTATATGGATTATTTGAAATGAAAAGCATACTAATTGGACTTTAATAAATCATTTTCA >In-frame_NAA15_ENST00000398947_chr4_140222985_+_LPAR1_ENST00000538760_chr9_113638002_-_791nt AGAAAGGAAAAAAGACAACGAGGAAAAAGGAGGTGTCCGGGTAGGGCAACGCGGCGACACCCGAGGCCTGGTGGTGGCGGCGGATCGAGA TATTCAAGGCTGAAGCAGCTACGGAACGGCAGCGGCGGCGGTCGGACAAACTGACTGACCGAGCCGGGTGGTGGCGGGAGCAGCGGGAGC AGCCGGAACGATGCCGGCCGTGAGCCTCCCGCCCAAGGAGAATGCGCTCTTCAAGCGGATCTTGGGGCCTTTATCATCTGCTGGACTCCT GGATTGGTTTTGTTACTTCTAGACGTGTGCTGTCCACAGTGCGACGTGCTGGCCTATGAGAAATTCTTCCTTCTCCTTGCTGAATTCAAC TCTGCCATGAACCCCATCATTTACTCCTACCGCGACAAAGAAATGAGCGCCACCTTTAGGCAGATCCTCTGCTGCCAGCGCAGTGAGAAC CCCACCGGCCCCACAGAAGGCTCAGACCGCTCGGCTTCCTCCCTCAACCACACCATCTTGGCTGGAGTTCACAGCAATGACCACTCTGTG GTTTAGAACGGAAACTGAGATGAGGAACCAGCCGTCCTCTCTTGGAGGATAAACAGCCTCCCCCTACCCAATTGCCAGGGCAAGGTGGGG TGTGAGAGAGGAGAAAAGTCAACTCATGTACTTAAACACTAACCAATGACAGTATTTGTTCCTGGACCCCACAAGACTTGATATATATTG |
Top |
FusionGenePPI for NAA15_LPAR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NAA15 | UBA5, XRCC6, XRCC5, RAD21, SIRT7, NAA10, HYPK, ASUN, MATR3, FN1, VCAM1, ITGA4, DDI2, STAT1, TSNAX, VPS26A, NAA50, PYCARD, MBD5, CYP1A1, CAND2, CMAS, DHX9, DRG1, FBL, HNRNPR, PSMC3, PSMD12, PSMD3, YARS, NAA20, NTRK1, KRAS, CEP97, CNTRL, DCTN1, POC5, STIL, SRPR, RNF126, ZNF746, NAA16, ARRB2, TRAFD1, FGB, SNRNP27, GTF2E2, USP47, MRPS11, FGF9, BRCA1 | LPAR1 | KRAS, ENPP2, ITGB4, LYPD3, MBOAT7, GOLGA5, TYRO3, PIGO, SLC9A1, GOLGB1, GPRC5B, GPRC5C, SCAP, KTN1, NDUFAF1, COLEC12, GPAA1, LEMD3, ECSIT, GJC1, ABCC4, SLC35B2, SPPL2B, SACM1L, ZDHHC17, REEP5, STX5, SLC30A5, HMGCR, TMEM87B, PIGU, CKAP4, TMEM246, TMEM186, ITPR2, ZMYM3, EXTL3, RMND1, ACP2, ENPP4, TMEM87A, SLC39A1, C4orf32, EXTL2, NOP9, CSGALNACT2, GPR89A, ALG6, SEC62, ALG10, SC5D, ND1, SLC5A3, PTPLB, CD47, ZDHHC9, UQCC1, STX8, KIAA1715, RTN2, LGALS3, B4GALT3, TMPPE, OCIAD1, MRS2, NDC1, SLC30A7, MFSD5, SERINC1, CD97, CERS2, SELT, ENTPD7, CERS6, CERS5, LMBR1, ATP9A, ARV1, FAM134C, TMEM164, RNF170, SCAMP2, VAMP2, CMTM6, TSPAN3, REEP6, PRAF2, CRELD1, LRRC8A, ALG3, ZDHHC18, C10orf35, MFSD8, GP1BB, REEP4, IPPK, TESC, CERS4, TPCN1, LPHN3, ATP2B4, TMEM120B, TMEM161B, FAM210B, MFSD12, GPR50, CMTM4, ELOVL2, ARL10, RNF121, POMK, CXCR4, ND4, TMEM11, GPR21, SLC35F2, SLC19A2, ABCB8, PEX13, NDUFB5, S1PR2, STX7, C3AR1, GPR137, TMEM223, LPCAT3, FITM2, TTYH3, ATP8, NDUFB3, COX3, CTAGE5, ADCY6, ERGIC2, ARL6IP5, ATP5F1, FAM20B, XYLT2, SLC7A3, BRI3BP, COL1A1, SLC39A10, EMC8, NEDD4L |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for NAA15_LPAR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for NAA15_LPAR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | LPAR1 | C0018273 | Growth Disorders | 1 | CTD_human |
| Tgene | LPAR1 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Tgene | LPAR1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | LPAR1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | LPAR1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| Tgene | LPAR1 | C0553757 | Olfaction Disorders | 1 | CTD_human |
| Tgene | LPAR1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|