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Fusion gene ID: 23264 |
FusionGeneSummary for N4BP2L2_ZMYM5 |
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Fusion gene information | Fusion gene name: N4BP2L2_ZMYM5 | Fusion gene ID: 23264 | Hgene | Tgene | Gene symbol | N4BP2L2 | ZMYM5 | Gene ID | 10443 | 9205 |
Gene name | NEDD4 binding protein 2 like 2 | zinc finger MYM-type containing 5 | |
Synonyms | 92M18.3|CG005|CG016|PFAAP5 | HSPC050|MYM|ZNF198L1|ZNF237 | |
Cytomap | 13q13.1 | 13q12.11 | |
Type of gene | protein-coding | protein-coding | |
Description | NEDD4-binding protein 2-like 2phosphonoformate immuno-associated protein 5protein from BRCA2 region | zinc finger MYM-type protein 5zinc finger protein 198-like 1zinc finger protein 237zinc finger, MYM-type 5 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q92802 | Q9UJ78 | |
Ensembl transtripts involved in fusion gene | ENST00000380121, ENST00000504114, ENST00000357505, ENST00000399396, ENST00000446957, ENST00000267068, | ENST00000337963, ENST00000382907, ENST00000382905, | |
Fusion gene scores | * DoF score | 7 X 8 X 4=224 | 1 X 1 X 1=1 |
# samples | 20 | 1 | |
** MAII score | log2(20/224*10)=-0.163498732282879 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: N4BP2L2 [Title/Abstract] AND ZMYM5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-ER-A42L-06A | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000380121 | ENST00000337963 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
intron-intron | ENST00000380121 | ENST00000382907 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
intron-intron | ENST00000380121 | ENST00000382905 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
5UTR-3CDS | ENST00000504114 | ENST00000337963 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
5UTR-intron | ENST00000504114 | ENST00000382907 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
5UTR-intron | ENST00000504114 | ENST00000382905 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
5UTR-3CDS | ENST00000357505 | ENST00000337963 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
5UTR-intron | ENST00000357505 | ENST00000382907 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
5UTR-intron | ENST00000357505 | ENST00000382905 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
intron-3CDS | ENST00000399396 | ENST00000337963 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
intron-intron | ENST00000399396 | ENST00000382907 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
intron-intron | ENST00000399396 | ENST00000382905 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
intron-3CDS | ENST00000446957 | ENST00000337963 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
intron-intron | ENST00000446957 | ENST00000382907 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
intron-intron | ENST00000446957 | ENST00000382905 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
5UTR-3CDS | ENST00000267068 | ENST00000337963 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
5UTR-intron | ENST00000267068 | ENST00000382907 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
5UTR-intron | ENST00000267068 | ENST00000382905 | N4BP2L2 | chr13 | 33112755 | - | ZMYM5 | chr13 | 20413125 | - |
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FusionProtFeatures for N4BP2L2_ZMYM5 |
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Hgene | Tgene |
N4BP2L2 | ZMYM5 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for N4BP2L2_ZMYM5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for N4BP2L2_ZMYM5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
N4BP2L2 | PRPF4, LGR4, HOXA1, LMO2, PPIH, NAA38, PRMT6, CGRRF1, TMPRSS5, WNT4, PRG2, PPIA, KIAA1683, SIRT6, HNRNPLL, PIGT, LYZL1, RFXANK, LGALS3BP, LYPD4, OLFM2, DNAJC10, NCAPH2, WNT16, PROZ, F11, IRAK2, NXF2 | ZMYM5 | APP, SUMO1, SUMO2, PRMT1, ACAD11, RPS6KA2, RPS6KA3, GTF2IRD1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for N4BP2L2_ZMYM5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for N4BP2L2_ZMYM5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | N4BP2L2 | C0037274 | Dermatologic disorders | 1 | CTD_human |
Hgene | N4BP2L2 | C0311375 | Arsenic Poisoning | 1 | CTD_human |
Tgene | ZMYM5 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |