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Fusion gene ID: 23262 |
FusionGeneSummary for N4BP2L2_SUCLA2 |
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Fusion gene information | Fusion gene name: N4BP2L2_SUCLA2 | Fusion gene ID: 23262 | Hgene | Tgene | Gene symbol | N4BP2L2 | SUCLA2 | Gene ID | 10443 | 8803 |
Gene name | NEDD4 binding protein 2 like 2 | succinate-CoA ligase ADP-forming beta subunit | |
Synonyms | 92M18.3|CG005|CG016|PFAAP5 | A-BETA|A-SCS|MTDPS5|SCS-betaA | |
Cytomap | 13q13.1 | 13q14.2 | |
Type of gene | protein-coding | protein-coding | |
Description | NEDD4-binding protein 2-like 2phosphonoformate immuno-associated protein 5protein from BRCA2 region | succinate--CoA ligase [ADP-forming] subunit beta, mitochondrialATP-specific succinyl-CoA synthetase subunit betaATP-specific succinyl-CoA synthetase, beta subunitmitochondrial succinyl-CoA ligase [ADP-forming] subunit betarenal carcinoma antigen NY-RE | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q92802 | Q9P2R7 | |
Ensembl transtripts involved in fusion gene | ENST00000380121, ENST00000504114, ENST00000357505, ENST00000399396, ENST00000446957, ENST00000267068, | ENST00000378654, ENST00000544100, ENST00000534875, ENST00000543413, ENST00000497202, | |
Fusion gene scores | * DoF score | 7 X 8 X 4=224 | 3 X 3 X 3=27 |
# samples | 20 | 3 | |
** MAII score | log2(20/224*10)=-0.163498732282879 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: N4BP2L2 [Title/Abstract] AND SUCLA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-75-5122-01A | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000380121 | ENST00000378654 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
5UTR-3CDS | ENST00000380121 | ENST00000544100 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
5UTR-3CDS | ENST00000380121 | ENST00000534875 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
5UTR-3CDS | ENST00000380121 | ENST00000543413 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
5UTR-intron | ENST00000380121 | ENST00000497202 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-3CDS | ENST00000504114 | ENST00000378654 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-3CDS | ENST00000504114 | ENST00000544100 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-3CDS | ENST00000504114 | ENST00000534875 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-3CDS | ENST00000504114 | ENST00000543413 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-intron | ENST00000504114 | ENST00000497202 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-3CDS | ENST00000357505 | ENST00000378654 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-3CDS | ENST00000357505 | ENST00000544100 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-3CDS | ENST00000357505 | ENST00000534875 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-3CDS | ENST00000357505 | ENST00000543413 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-intron | ENST00000357505 | ENST00000497202 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-3CDS | ENST00000399396 | ENST00000378654 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-3CDS | ENST00000399396 | ENST00000544100 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-3CDS | ENST00000399396 | ENST00000534875 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-3CDS | ENST00000399396 | ENST00000543413 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-intron | ENST00000399396 | ENST00000497202 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-3CDS | ENST00000446957 | ENST00000378654 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-3CDS | ENST00000446957 | ENST00000544100 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-3CDS | ENST00000446957 | ENST00000534875 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-3CDS | ENST00000446957 | ENST00000543413 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
3UTR-intron | ENST00000446957 | ENST00000497202 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
intron-3CDS | ENST00000267068 | ENST00000378654 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
intron-3CDS | ENST00000267068 | ENST00000544100 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
intron-3CDS | ENST00000267068 | ENST00000534875 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
intron-3CDS | ENST00000267068 | ENST00000543413 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
intron-intron | ENST00000267068 | ENST00000497202 | N4BP2L2 | chr13 | 33010498 | - | SUCLA2 | chr13 | 48517580 | - |
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FusionProtFeatures for N4BP2L2_SUCLA2 |
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Hgene | Tgene |
N4BP2L2 | SUCLA2 |
ATP-specific succinyl-CoA synthetase functions in thecitric acid cycle (TCA), coupling the hydrolysis of succinyl-CoAto the synthesis of ATP and thus represents the only step ofsubstrate-level phosphorylation in the TCA (PubMed:15877282). Thebeta subunit provides nucleotide specificity of the enzyme andbinds the substrate succinate, while the binding sites forcoenzyme A and phosphate are found in the alpha subunit (Bysimilarity). {ECO:0000255|HAMAP-Rule:MF_03220,ECO:0000269|PubMed:15877282}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for N4BP2L2_SUCLA2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for N4BP2L2_SUCLA2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
N4BP2L2 | PRPF4, LGR4, HOXA1, LMO2, PPIH, NAA38, PRMT6, CGRRF1, TMPRSS5, WNT4, PRG2, PPIA, KIAA1683, SIRT6, HNRNPLL, PIGT, LYZL1, RFXANK, LGALS3BP, LYPD4, OLFM2, DNAJC10, NCAPH2, WNT16, PROZ, F11, IRAK2, NXF2 | SUCLA2 | ALAS2, PSMD14, ICT1, AGO4, SUCLG1, SDHA, GRHPR, NIT2, OXCT1, HPDL, S100A16, SEC22B, RRM1, NADK2, MRPL12, RBM4, AGFG1, IDH3A, ARL6IP1, AGTRAP, CMTM5, FAM9B, EGFR, DLST, RAB2A, SSR4, ACADM, ETFA, NFS1, PSMC2, SDHB, NTRK1, UBXN8, FAF2, COQ9, NFATC2, METAP2, RAD21, DNLZ, MTIF2, C17orf80, ZMYND19, IQGAP2, GTPBP10, MKLN1, HARS2, MCCC1, ZNF146, LONP2, GFM1, MTNR1A, TES |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for N4BP2L2_SUCLA2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for N4BP2L2_SUCLA2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | N4BP2L2 | C0037274 | Dermatologic disorders | 1 | CTD_human |
Hgene | N4BP2L2 | C0311375 | Arsenic Poisoning | 1 | CTD_human |
Tgene | SUCLA2 | C2749864 | MITOCHONDRIAL DNA DEPLETION SYNDROME 5 (ENCEPHALOMYOPATHIC WITH OR WITHOUT METHYLMALONIC ACIDURIA) | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | SUCLA2 | C0028754 | Obesity | 1 | CTD_human |