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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23261

FusionGeneSummary for N4BP2L2_N4BP2L2

check button Fusion gene summary
Fusion gene informationFusion gene name: N4BP2L2_N4BP2L2
Fusion gene ID: 23261
HgeneTgene
Gene symbol

N4BP2L2

N4BP2L2

Gene ID

10443

10443

Gene nameNEDD4 binding protein 2 like 2NEDD4 binding protein 2 like 2
Synonyms92M18.3|CG005|CG016|PFAAP592M18.3|CG005|CG016|PFAAP5
Cytomap

13q13.1

13q13.1

Type of geneprotein-codingprotein-coding
DescriptionNEDD4-binding protein 2-like 2phosphonoformate immuno-associated protein 5protein from BRCA2 regionNEDD4-binding protein 2-like 2phosphonoformate immuno-associated protein 5protein from BRCA2 region
Modification date2018051920180519
UniProtAcc

Q92802

Q92802

Ensembl transtripts involved in fusion geneENST00000380121, ENST00000504114, 
ENST00000357505, ENST00000399396, 
ENST00000446957, ENST00000267068, 
ENST00000380121, ENST00000504114, 
ENST00000357505, ENST00000399396, 
ENST00000446957, ENST00000267068, 
Fusion gene scores* DoF score7 X 8 X 4=2245 X 6 X 1=30
# samples 2018
** MAII scorelog2(20/224*10)=-0.163498732282879
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/30*10)=2.58496250072116
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: N4BP2L2 [Title/Abstract] AND N4BP2L2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ331268N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
ChiTaRS3.1BQ331574N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
ChiTaRS3.1BF992139N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
ChiTaRS3.1BG982035N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
ChiTaRS3.1BG982040N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
ChiTaRS3.1BQ331541N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
ChiTaRS3.1BQ331272N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
ChiTaRS3.1AU117208N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
ChiTaRS3.1BI014308N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
ChiTaRS3.1BI014309N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
ChiTaRS3.1BQ331566N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
ChiTaRS3.1BQ331294N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
ChiTaRS3.1BI015483N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000380121ENST00000380121N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000380121ENST00000504114N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000380121ENST00000357505N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000380121ENST00000399396N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000380121ENST00000446957N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000380121ENST00000267068N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000504114ENST00000380121N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000504114ENST00000504114N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000504114ENST00000357505N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000504114ENST00000399396N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000504114ENST00000446957N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000504114ENST00000267068N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000357505ENST00000380121N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000357505ENST00000504114N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000357505ENST00000357505N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000357505ENST00000399396N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000357505ENST00000446957N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000357505ENST00000267068N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000399396ENST00000380121N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000399396ENST00000504114N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000399396ENST00000357505N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000399396ENST00000399396N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000399396ENST00000446957N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000399396ENST00000267068N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000446957ENST00000380121N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000446957ENST00000504114N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000446957ENST00000357505N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000446957ENST00000399396N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000446957ENST00000446957N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000446957ENST00000267068N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000267068ENST00000380121N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000267068ENST00000504114N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000267068ENST00000357505N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000267068ENST00000399396N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000267068ENST00000446957N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000267068ENST00000267068N4BP2L2chr13

33101671

+N4BP2L2chr13

33091994

+
intron-intronENST00000380121ENST00000380121N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
intron-5UTRENST00000380121ENST00000504114N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
intron-5UTRENST00000380121ENST00000357505N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
intron-5UTRENST00000380121ENST00000399396N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
intron-5UTRENST00000380121ENST00000446957N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
intron-5UTRENST00000380121ENST00000267068N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-intronENST00000504114ENST00000380121N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000504114ENST00000504114N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000504114ENST00000357505N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000504114ENST00000399396N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000504114ENST00000446957N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000504114ENST00000267068N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-intronENST00000357505ENST00000380121N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000357505ENST00000504114N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000357505ENST00000357505N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000357505ENST00000399396N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000357505ENST00000446957N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000357505ENST00000267068N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-intronENST00000399396ENST00000380121N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000399396ENST00000504114N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000399396ENST00000357505N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000399396ENST00000399396N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000399396ENST00000446957N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000399396ENST00000267068N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-intronENST00000446957ENST00000380121N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000446957ENST00000504114N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000446957ENST00000357505N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000446957ENST00000399396N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000446957ENST00000446957N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
5CDS-5UTRENST00000446957ENST00000267068N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
intron-intronENST00000267068ENST00000380121N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
intron-5UTRENST00000267068ENST00000504114N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
intron-5UTRENST00000267068ENST00000357505N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
intron-5UTRENST00000267068ENST00000399396N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
intron-5UTRENST00000267068ENST00000446957N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
intron-5UTRENST00000267068ENST00000267068N4BP2L2chr13

33091994

-N4BP2L2chr13

33101671

-
intron-intronENST00000380121ENST00000380121N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000380121ENST00000504114N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000380121ENST00000357505N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-5UTRENST00000380121ENST00000399396N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000380121ENST00000446957N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000380121ENST00000267068N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000504114ENST00000380121N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000504114ENST00000504114N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000504114ENST00000357505N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-5UTRENST00000504114ENST00000399396N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000504114ENST00000446957N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000504114ENST00000267068N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000357505ENST00000380121N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000357505ENST00000504114N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000357505ENST00000357505N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-5UTRENST00000357505ENST00000399396N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000357505ENST00000446957N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000357505ENST00000267068N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000399396ENST00000380121N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000399396ENST00000504114N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000399396ENST00000357505N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-5UTRENST00000399396ENST00000399396N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000399396ENST00000446957N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000399396ENST00000267068N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000446957ENST00000380121N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000446957ENST00000504114N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000446957ENST00000357505N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-5UTRENST00000446957ENST00000399396N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000446957ENST00000446957N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000446957ENST00000267068N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000267068ENST00000380121N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000267068ENST00000504114N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000267068ENST00000357505N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-5UTRENST00000267068ENST00000399396N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000267068ENST00000446957N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-
intron-intronENST00000267068ENST00000267068N4BP2L2chr13

33099205

-N4BP2L2chr13

33112929

-

Top

FusionProtFeatures for N4BP2L2_N4BP2L2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
N4BP2L2

Q92802

N4BP2L2

Q92802


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for N4BP2L2_N4BP2L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for N4BP2L2_N4BP2L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
N4BP2L2PRPF4, LGR4, HOXA1, LMO2, PPIH, NAA38, PRMT6, CGRRF1, TMPRSS5, WNT4, PRG2, PPIA, KIAA1683, SIRT6, HNRNPLL, PIGT, LYZL1, RFXANK, LGALS3BP, LYPD4, OLFM2, DNAJC10, NCAPH2, WNT16, PROZ, F11, IRAK2, NXF2N4BP2L2PRPF4, LGR4, HOXA1, LMO2, PPIH, NAA38, PRMT6, CGRRF1, TMPRSS5, WNT4, PRG2, PPIA, KIAA1683, SIRT6, HNRNPLL, PIGT, LYZL1, RFXANK, LGALS3BP, LYPD4, OLFM2, DNAJC10, NCAPH2, WNT16, PROZ, F11, IRAK2, NXF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for N4BP2L2_N4BP2L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for N4BP2L2_N4BP2L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneN4BP2L2C0037274Dermatologic disorders1CTD_human
HgeneN4BP2L2C0311375Arsenic Poisoning1CTD_human
TgeneN4BP2L2C0037274Dermatologic disorders1CTD_human
TgeneN4BP2L2C0311375Arsenic Poisoning1CTD_human