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Fusion gene ID: 23258 |
FusionGeneSummary for N4BP2L2_ADAMTS3 |
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Fusion gene information | Fusion gene name: N4BP2L2_ADAMTS3 | Fusion gene ID: 23258 | Hgene | Tgene | Gene symbol | N4BP2L2 | ADAMTS3 | Gene ID | 10443 | 9508 |
Gene name | NEDD4 binding protein 2 like 2 | ADAM metallopeptidase with thrombospondin type 1 motif 3 | |
Synonyms | 92M18.3|CG005|CG016|PFAAP5 | ADAMTS-4 | |
Cytomap | 13q13.1 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | NEDD4-binding protein 2-like 2phosphonoformate immuno-associated protein 5protein from BRCA2 region | A disintegrin and metalloproteinase with thrombospondin motifs 3ADAM-TS 3ADAM-TS3ADAMTS-3PC II-NPa disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 3procollagen II N-proteinaseprocollagen II amino propeptide- | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q92802 | O15072 | |
Ensembl transtripts involved in fusion gene | ENST00000380121, ENST00000504114, ENST00000357505, ENST00000399396, ENST00000446957, ENST00000267068, | ENST00000286657, ENST00000505193, | |
Fusion gene scores | * DoF score | 7 X 8 X 4=224 | 2 X 3 X 2=12 |
# samples | 20 | 3 | |
** MAII score | log2(20/224*10)=-0.163498732282879 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: N4BP2L2 [Title/Abstract] AND ADAMTS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ADAMTS3 | GO:0010573 | vascular endothelial growth factor production | 24552833 |
Tgene | ADAMTS3 | GO:0016485 | protein processing | 11408482|24552833 |
Tgene | ADAMTS3 | GO:0032964 | collagen biosynthetic process | 11408482 |
Tgene | ADAMTS3 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway | 24552833 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI014307 | N4BP2L2 | chr13 | 33101671 | + | ADAMTS3 | chr4 | 73284951 | + | ||
ChiTaRS3.1 | BQ332326 | N4BP2L2 | chr13 | 33091994 | - | ADAMTS3 | chr4 | 73284970 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000380121 | ENST00000286657 | N4BP2L2 | chr13 | 33101671 | + | ADAMTS3 | chr4 | 73284951 | + |
intron-intron | ENST00000380121 | ENST00000505193 | N4BP2L2 | chr13 | 33101671 | + | ADAMTS3 | chr4 | 73284951 | + |
intron-intron | ENST00000504114 | ENST00000286657 | N4BP2L2 | chr13 | 33101671 | + | ADAMTS3 | chr4 | 73284951 | + |
intron-intron | ENST00000504114 | ENST00000505193 | N4BP2L2 | chr13 | 33101671 | + | ADAMTS3 | chr4 | 73284951 | + |
intron-intron | ENST00000357505 | ENST00000286657 | N4BP2L2 | chr13 | 33101671 | + | ADAMTS3 | chr4 | 73284951 | + |
intron-intron | ENST00000357505 | ENST00000505193 | N4BP2L2 | chr13 | 33101671 | + | ADAMTS3 | chr4 | 73284951 | + |
intron-intron | ENST00000399396 | ENST00000286657 | N4BP2L2 | chr13 | 33101671 | + | ADAMTS3 | chr4 | 73284951 | + |
intron-intron | ENST00000399396 | ENST00000505193 | N4BP2L2 | chr13 | 33101671 | + | ADAMTS3 | chr4 | 73284951 | + |
intron-intron | ENST00000446957 | ENST00000286657 | N4BP2L2 | chr13 | 33101671 | + | ADAMTS3 | chr4 | 73284951 | + |
intron-intron | ENST00000446957 | ENST00000505193 | N4BP2L2 | chr13 | 33101671 | + | ADAMTS3 | chr4 | 73284951 | + |
intron-intron | ENST00000267068 | ENST00000286657 | N4BP2L2 | chr13 | 33101671 | + | ADAMTS3 | chr4 | 73284951 | + |
intron-intron | ENST00000267068 | ENST00000505193 | N4BP2L2 | chr13 | 33101671 | + | ADAMTS3 | chr4 | 73284951 | + |
intron-intron | ENST00000380121 | ENST00000286657 | N4BP2L2 | chr13 | 33091994 | - | ADAMTS3 | chr4 | 73284970 | - |
intron-intron | ENST00000380121 | ENST00000505193 | N4BP2L2 | chr13 | 33091994 | - | ADAMTS3 | chr4 | 73284970 | - |
5CDS-intron | ENST00000504114 | ENST00000286657 | N4BP2L2 | chr13 | 33091994 | - | ADAMTS3 | chr4 | 73284970 | - |
5CDS-intron | ENST00000504114 | ENST00000505193 | N4BP2L2 | chr13 | 33091994 | - | ADAMTS3 | chr4 | 73284970 | - |
5CDS-intron | ENST00000357505 | ENST00000286657 | N4BP2L2 | chr13 | 33091994 | - | ADAMTS3 | chr4 | 73284970 | - |
5CDS-intron | ENST00000357505 | ENST00000505193 | N4BP2L2 | chr13 | 33091994 | - | ADAMTS3 | chr4 | 73284970 | - |
5CDS-intron | ENST00000399396 | ENST00000286657 | N4BP2L2 | chr13 | 33091994 | - | ADAMTS3 | chr4 | 73284970 | - |
5CDS-intron | ENST00000399396 | ENST00000505193 | N4BP2L2 | chr13 | 33091994 | - | ADAMTS3 | chr4 | 73284970 | - |
5CDS-intron | ENST00000446957 | ENST00000286657 | N4BP2L2 | chr13 | 33091994 | - | ADAMTS3 | chr4 | 73284970 | - |
5CDS-intron | ENST00000446957 | ENST00000505193 | N4BP2L2 | chr13 | 33091994 | - | ADAMTS3 | chr4 | 73284970 | - |
intron-intron | ENST00000267068 | ENST00000286657 | N4BP2L2 | chr13 | 33091994 | - | ADAMTS3 | chr4 | 73284970 | - |
intron-intron | ENST00000267068 | ENST00000505193 | N4BP2L2 | chr13 | 33091994 | - | ADAMTS3 | chr4 | 73284970 | - |
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FusionProtFeatures for N4BP2L2_ADAMTS3 |
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Hgene | Tgene |
N4BP2L2 | ADAMTS3 |
Cleaves the propeptides of type II collagen prior tofibril assembly. Does not act on types I and III collagens. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for N4BP2L2_ADAMTS3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for N4BP2L2_ADAMTS3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for N4BP2L2_ADAMTS3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for N4BP2L2_ADAMTS3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | N4BP2L2 | C0037274 | Dermatologic disorders | 1 | CTD_human |
Hgene | N4BP2L2 | C0311375 | Arsenic Poisoning | 1 | CTD_human |
Tgene | ADAMTS3 | C0036341 | Schizophrenia | 1 | CTD_human |