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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23258

FusionGeneSummary for N4BP2L2_ADAMTS3

check button Fusion gene summary
Fusion gene informationFusion gene name: N4BP2L2_ADAMTS3
Fusion gene ID: 23258
HgeneTgene
Gene symbol

N4BP2L2

ADAMTS3

Gene ID

10443

9508

Gene nameNEDD4 binding protein 2 like 2ADAM metallopeptidase with thrombospondin type 1 motif 3
Synonyms92M18.3|CG005|CG016|PFAAP5ADAMTS-4
Cytomap

13q13.1

4q13.3

Type of geneprotein-codingprotein-coding
DescriptionNEDD4-binding protein 2-like 2phosphonoformate immuno-associated protein 5protein from BRCA2 regionA disintegrin and metalloproteinase with thrombospondin motifs 3ADAM-TS 3ADAM-TS3ADAMTS-3PC II-NPa disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 3procollagen II N-proteinaseprocollagen II amino propeptide-
Modification date2018051920180522
UniProtAcc

Q92802

O15072

Ensembl transtripts involved in fusion geneENST00000380121, ENST00000504114, 
ENST00000357505, ENST00000399396, 
ENST00000446957, ENST00000267068, 
ENST00000286657, ENST00000505193, 
Fusion gene scores* DoF score7 X 8 X 4=2242 X 3 X 2=12
# samples 203
** MAII scorelog2(20/224*10)=-0.163498732282879
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: N4BP2L2 [Title/Abstract] AND ADAMTS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADAMTS3

GO:0010573

vascular endothelial growth factor production

24552833

TgeneADAMTS3

GO:0016485

protein processing

11408482|24552833

TgeneADAMTS3

GO:0032964

collagen biosynthetic process

11408482

TgeneADAMTS3

GO:1900748

positive regulation of vascular endothelial growth factor signaling pathway

24552833


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI014307N4BP2L2chr13

33101671

+ADAMTS3chr4

73284951

+
ChiTaRS3.1BQ332326N4BP2L2chr13

33091994

-ADAMTS3chr4

73284970

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000380121ENST00000286657N4BP2L2chr13

33101671

+ADAMTS3chr4

73284951

+
intron-intronENST00000380121ENST00000505193N4BP2L2chr13

33101671

+ADAMTS3chr4

73284951

+
intron-intronENST00000504114ENST00000286657N4BP2L2chr13

33101671

+ADAMTS3chr4

73284951

+
intron-intronENST00000504114ENST00000505193N4BP2L2chr13

33101671

+ADAMTS3chr4

73284951

+
intron-intronENST00000357505ENST00000286657N4BP2L2chr13

33101671

+ADAMTS3chr4

73284951

+
intron-intronENST00000357505ENST00000505193N4BP2L2chr13

33101671

+ADAMTS3chr4

73284951

+
intron-intronENST00000399396ENST00000286657N4BP2L2chr13

33101671

+ADAMTS3chr4

73284951

+
intron-intronENST00000399396ENST00000505193N4BP2L2chr13

33101671

+ADAMTS3chr4

73284951

+
intron-intronENST00000446957ENST00000286657N4BP2L2chr13

33101671

+ADAMTS3chr4

73284951

+
intron-intronENST00000446957ENST00000505193N4BP2L2chr13

33101671

+ADAMTS3chr4

73284951

+
intron-intronENST00000267068ENST00000286657N4BP2L2chr13

33101671

+ADAMTS3chr4

73284951

+
intron-intronENST00000267068ENST00000505193N4BP2L2chr13

33101671

+ADAMTS3chr4

73284951

+
intron-intronENST00000380121ENST00000286657N4BP2L2chr13

33091994

-ADAMTS3chr4

73284970

-
intron-intronENST00000380121ENST00000505193N4BP2L2chr13

33091994

-ADAMTS3chr4

73284970

-
5CDS-intronENST00000504114ENST00000286657N4BP2L2chr13

33091994

-ADAMTS3chr4

73284970

-
5CDS-intronENST00000504114ENST00000505193N4BP2L2chr13

33091994

-ADAMTS3chr4

73284970

-
5CDS-intronENST00000357505ENST00000286657N4BP2L2chr13

33091994

-ADAMTS3chr4

73284970

-
5CDS-intronENST00000357505ENST00000505193N4BP2L2chr13

33091994

-ADAMTS3chr4

73284970

-
5CDS-intronENST00000399396ENST00000286657N4BP2L2chr13

33091994

-ADAMTS3chr4

73284970

-
5CDS-intronENST00000399396ENST00000505193N4BP2L2chr13

33091994

-ADAMTS3chr4

73284970

-
5CDS-intronENST00000446957ENST00000286657N4BP2L2chr13

33091994

-ADAMTS3chr4

73284970

-
5CDS-intronENST00000446957ENST00000505193N4BP2L2chr13

33091994

-ADAMTS3chr4

73284970

-
intron-intronENST00000267068ENST00000286657N4BP2L2chr13

33091994

-ADAMTS3chr4

73284970

-
intron-intronENST00000267068ENST00000505193N4BP2L2chr13

33091994

-ADAMTS3chr4

73284970

-

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FusionProtFeatures for N4BP2L2_ADAMTS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
N4BP2L2

Q92802

ADAMTS3

O15072

Cleaves the propeptides of type II collagen prior tofibril assembly. Does not act on types I and III collagens.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for N4BP2L2_ADAMTS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for N4BP2L2_ADAMTS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for N4BP2L2_ADAMTS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for N4BP2L2_ADAMTS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneN4BP2L2C0037274Dermatologic disorders1CTD_human
HgeneN4BP2L2C0311375Arsenic Poisoning1CTD_human
TgeneADAMTS3C0036341Schizophrenia1CTD_human