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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23256

FusionGeneSummary for N4BP2L1_N4BP2L1

check button Fusion gene summary
Fusion gene informationFusion gene name: N4BP2L1_N4BP2L1
Fusion gene ID: 23256
HgeneTgene
Gene symbol

N4BP2L1

N4BP2L1

Gene ID

90634

90634

Gene nameNEDD4 binding protein 2 like 1NEDD4 binding protein 2 like 1
SynonymsCG018CG018
Cytomap

13q13.1

13q13.1

Type of geneprotein-codingprotein-coding
DescriptionNEDD4-binding protein 2-like 1hypothetical gene CG018NEDD4-binding protein 2-like 1hypothetical gene CG018
Modification date2018040320180403
UniProtAcc

Q5TBK1

Q5TBK1

Ensembl transtripts involved in fusion geneENST00000380130, ENST00000380139, 
ENST00000530622, ENST00000459716, 
ENST00000380133, 
ENST00000380130, 
ENST00000380139, ENST00000530622, 
ENST00000459716, ENST00000380133, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 3 X 2=18
# samples 34
** MAII scorelog2(3/4*10)=2.90689059560852log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: N4BP2L1 [Title/Abstract] AND N4BP2L1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE670660N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
ChiTaRS3.1BF433332N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000380130ENST00000380130N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000380130ENST00000380139N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000380130ENST00000530622N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000380130ENST00000459716N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000380130ENST00000380133N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000380139ENST00000380130N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000380139ENST00000380139N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000380139ENST00000530622N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000380139ENST00000459716N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000380139ENST00000380133N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000530622ENST00000380130N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000530622ENST00000380139N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000530622ENST00000530622N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000530622ENST00000459716N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000530622ENST00000380133N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000459716ENST00000380130N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000459716ENST00000380139N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000459716ENST00000530622N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000459716ENST00000459716N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000459716ENST00000380133N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000380133ENST00000380130N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000380133ENST00000380139N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000380133ENST00000530622N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000380133ENST00000459716N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-
intron-intronENST00000380133ENST00000380133N4BP2L1chr13

33002315

+N4BP2L1chr13

32999948

-

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FusionProtFeatures for N4BP2L1_N4BP2L1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
N4BP2L1

Q5TBK1

N4BP2L1

Q5TBK1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for N4BP2L1_N4BP2L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for N4BP2L1_N4BP2L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for N4BP2L1_N4BP2L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for N4BP2L1_N4BP2L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource